检索结果-南通市图书馆

Interrelationship of soil moisture and temperature to sylvatic plague cycle among prairie dogs in the Western United States

引用

Integrative Zoology 2021年第6期16卷 852-867页

作者： Cassandra D.PAULING deborah L.FINKE deborah M.ANDERSON Department of Veterinary Pathobiology University of MissouriColumbiaMissouriUSA Division of Plant Sciences University of MissouriColumbiaMissouriUSA

Plague,caused by Yersinia pestis,is a flea-borne disease that is endemic in areas throughout the world due to its successful maintenance in a sylvatic cycle,mainly in areas with temperate *** rodents are thought to play a key role in the enzootic maintenance as well as epizootic outbreaks of *** the United States,prairie dogs(Cynomys),rodents(Muridae),and ground squirrels(Spermophilus)are susceptible to infection and are parasitized by fleas that transmit *** particular,prairie dogs can experience outbreaks that rapidly spread,which can lead to extirpation of colonies.A number of ecological parameters,including climate,are associated with these *** this study,we asked whether soil parameters,primarily moisture and temperature,are associated with outbreaks of plague in black-tailed prairie dogs and Gunnison’s prairie dogs in the Western United States,and at what depth these associations were *** collected publicly available county-level information on the occurrence of population declines or colony extirpation,while historical soil data was collected from SCAN and USCRN stations in counties and states where prairie dogs have been *** analysis suggests that soil moisture at lower depths correlates with colony die-offs,in addition to temperature near the surface,with key differences within the landscape ecology that impact the occurrence of ***,the model suggests that the burrow environment may play a significant role in the epizootic spread of disease amongst black-tailed and Gunnison’s prairie dogs.

关键词： plague prairie dogs soil moisture soil temperature sylvatic cycle Yersinia pestis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Graphics Evolutionary Computations in Higher Order Parametric Bezier Curves

引用

Computer Systems Science & Engineering 2022年第5期41卷 595-609页

作者： Monday Eze Charles Okunbor deborah Aleburu Olubukola Adekola Ibrahim Ramon Nneka Richard-Nnabu Oghenetega Avwokuruaye Abisola Olayiwola Rume Yoro Esomu Solomon Department of Computer Science Babcock UniversityOgunNigeria Department of Computer Science Admiralty UniversityDeltaNigeria Department of Computer Science Caleb UniversityImotaLagosNigeria Department of Computer Science Education Federal College of Education(Tech)AkokaLagosNigeria Department of Computer Science Alex Ekwueme Federal UniversityEbonyiNigeria Department of Cyber Security Admiralty UniversityDeltaNigeria Department of Computer Science School of ICTDelta State PolytechnicOgwashi-UkuDeltaNigeria Department of Computer Science National Open UniversityNigeria

This work demonstrates in practical terms the evolutionary concepts and computational applications of Parametric *** cases were drawn from higher order parametric Bezier curves of degrees 2 and *** curves find real life applications in diverse areas of Engineering and Computer Science,such as computer graphics,robotics,animations,virtual reality,among *** of the evolutionary issues explored in this work are in the areas of parametric equations derivations,proof of related theorems,first and second order calculus related computations,among others.A Practical case is demonstrated using a graphical design,physical hand sketching,and programmatic implementation of two opposite-faced handless cups,all evolved using quadratic Bezier *** actual drawing was realized using web graphics canvas programming based on HTML 5 and *** work will no doubt find relevance in computational researches in the areas of graphics,web programming,automated theorem proofs,robotic motions,among others.

关键词： Parametric curve computer graphics bezier curve blending function robotics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Association of types of diabetes and insulin dependency on birth outcomes

引用

World Journal of Clinical Cases 2022年第7期10卷 2147-2158页

作者： Pamela K Xaverius Steven W Howard deborah Kiel Jerry E Thurman Ethan Wankum Catherine Carter Clairy Fang Romi Carriere Department of Epidemiology and Biostatistics Saint Louis UniversitySt.LouisMO 63104United States Department of Health Management and Policy Saint Louis UniversitySt.LouisMO 63104United States Department of Endocrinology Diabetes and MetabolismSSM HealthSt.CharlesMO 63303United States Division of Epidemiology Institute for Health and EquityMedical College of WisconsinMilwaukeeWI 53226United States Department of Epidemiology Fielding School of Public HealthUniversity of CaliforniaLos AngelesCA 90095United States Population Health Sciences Institute Centre for Ageing and VitalityNewcastle UniversityNewcastle upon TyneEngland NE45PLUnited Kingdom

BACKGROUND Diabetes rates among pregnant women in the United States have been increasing and are associated with adverse pregnancy *** To investigate differences in birth outcomes(preterm birth,macrosomia,and neonatal death)by diabetes *** Cross-sectional design,using linked Missouri birth and death certificates(singleton births only),2010 to 2012(n=204057).Exposure was diabetes non-diabetic,pre-pregnancy diabetes-insulin dependent(PD-I),pre-pregnancy diabetes-non-insulin dependent(PD-NI),gestational diabetes-insulin dependent(GD-I),and gestational diabetes-non-insulin dependent(GD-NI).Outcomes included preterm birth,macrosomia,and infant *** included demographic characteristics,adequacy of prenatal care,body mass index,smoking,hypertension,and previous preterm *** and multivariate logistic regression assessed differences in outcomes by diabetes *** Women with PD-I,PD-NI,and GD-I remained at a significantly increased odds for preterm birth(aOR 2.87,aOR 1.77,and aOR 1.73,respectively)and having a very large baby[macrosomia](aOR 3.01,aOR 2.12,and aOR 1.96,respectively);in reference to non-diabetic *** with GDNI were at a significantly increased risk for macrosomia(aOR1.53),decreased risk for their baby to die before their first birthday(aOR 0.41)and no difference in risk for preterm birth in reference to non-diabetic *** Diabetes is associated with the poor birth *** management of diabetes during pregnancy and healthy lifestyle behaviors before pregnancy can reduce the risk for diabetes and poor birth outcomes.

关键词： Epidemiology Pregnancy Health care delivery Birth outcomes Gestational diabetes Insulin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Functionality indexes assessed through a simple model of muscle activation, fatigue and recovery

引用

International Journal of Biomathematics 2014年第2期7卷 189-210页

作者： Luigi Fattorini deborah Lacitignola Department of Physiology and Pharmacology University Sapienza of Rome Piazz.le Aldo Moro No. 5 00185 Roma Italy Department of Electrical and Information Engineering University of Cassino and Southern Lazio Via di Biasio No. 43 03043 Cassino Italy

A nonlinear dynamical system is proposed as a qualitative mathematical model with the twofold aim to reasonably describe the force behavior in a fatiguing sub-maximal contraction and to be possibly employed in assessing muscular activation indexes. The model's properties are studied in terms of its equilibria and their stability properties and the existence of the fatigue equilibrium is ensured as the only system's attractor in the feasibility range of the parameters. Suitable mathematical indicators — related to the dynamical properties of resilience and reactivity — are introduced to characterize the asymptotic and the transient system's behavior. The practical impact of the analytical results is elucidated and a connection is established between the introduced mathematical indicators and muscle functionality indexes as rate of force development, task failure time and complete restore time. Experimental validation with handgrip force signal at high load and possible practical applications are also presented.

关键词：数学模型功能指标肌肉疲劳活化评估非线性动力系统受力行为

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bioaccumulation of toxic hydrophobic organic compounds at the primary trophic level

引用

Journal of Environmental Sciences 1991年第3期3卷 15-21页

作者： deborah L.Swackhamer Environmental and Occupational Health School of Public Health University of Minnesota Minneapolis USA.

The prevailing hypothesis, which states that the uptake of HOCs by phytoplankton is controlled by the compound's lipophilicity (Kow) was tested. The approach taken was to determine the factors that controlled the uptake of PCBs by phytoplankton under controlled laboratory conditions, and to develop a model that would describe bioaccumulation of PCBs in *** results demonstrate a relationship of BAF to Kow and to phytoplankton surface properties, as well as the data presented here, support the hypothesis that the mechanism of HOC uptake is a rapid surface sorption followed by a slower transfer into lipids in the cell matrix. The work on the kinetics of uptake indicates that equilibrium is reached slowly and that the rate of uptake is of similar magnitude as phytoplankton growth under normal field *** a critical factor that controls the bioaccumulation of HOCs reach equilibrium in phytoplankton itself.

关键词： bioaccumulation hydrophobic organic compounds PCBs phytoplankton dynamic approach.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Drug resistance in metastatic castration-resistant prostate cancer:an update on the status quo

引用

Cancer Drug Resistance 2022年第3期5卷 667-690页

作者： Amani Yehya Fatima Ghamlouche Amin Zahwe Yousef Zeid Kevork Wakimian deborah Mukherji Wassim Abou-Kheir Department of Anatomy Cell Biology and Physiological SciencesFaculty of MedicineAmerican University of BeirutBeirut 1107-2020Lebanon Division of Hematology/Oncology Faculty of MedicineAmerican University of Beirut Medical CenterBeirut 1107-2020Lebanon

Prostate cancer(PCa)is a leading cause of cancer-related morbidity and mortality in men *** improvements in the diagnosis and treatment of PCa,a significant proportion of patients with high-risk localized disease and all patients with advanced disease at diagnosis will experience progression to metastatic castration-resistant prostate cancer(mCRPC).Multiple drugs are now approved as the standard of care treatments for patients with mCRPC that have been shown to prolong *** the majority of patients will respond initially,primary and secondary resistance to these therapies make mCRPC an incurable *** molecular mechanisms underlie the development of mCRPC,with the androgen receptor(AR)axis being the main driver as well as the key drug *** resistance mechanisms is crucial for discovering novel therapeutic strategies to delay or reverse the progression of the *** this review,we address the diverse mechanisms of drug resistance in *** addition,we shed light on emerging targeted therapies currently being tested in clinical trials with promising potential to overcome mCRPC-drug resistance.

关键词： Prostate cancer mCRPC androgen receptor drug resistance novel targeted therapeutics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Piperine,an active ingredient of black pepper attenuates acetaminophen-induced hepatotoxicity in mice

引用

Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 971-976页

作者： Evan Prince Sabina Annie deborah Harris Souriyan deborah Jackline Mahaboob Khan Rasool School of Biological Sciences and Technology VIT University Vellore - 632 014Tamil NaduIndia

Objective:To explore the hepatoprotective and antioxidant effects of piperine against acetaminophen-induced hepatotoxicity in ***:In mice,hepatotoxicity was induced by a single dose of acetaminophen(900 mg/kg b.w.i.p.).Piperine(25 mg/kg b.w.i.p.) and standard drug silymarin(25 mg/kg b.w.i.p.) were given to mice,30 min after the single injection of *** 4 h,the mice were *** of liver marker enzymes [(aspartate transaminase(AST),alanine transaminase(ALT),and alkaline phosphatase(ALP)]and inflammatory mediator tumour necrosis factor-alpha(TNF-α) were estimated in serum,while lipid peroxidation and antioxidant status(superoxide dismutase,catalase,glutathione peroxidase, glutathione reductase,glutathione-s-transferase and glutathione) were determined in liver homogenate of control and experimental ***:Acetaminophen induction(900 mg/kg b.w.i.p.) significantly increased the levels of liver marker enzymes,TNF-α,and lipid peroxidation,and caused the depletion of antioxidant *** and silymarin treatment to acetaminophen challenged mice resulted in decreased liver marker enzymes activity,TNF-αand lipid peroxidation levels with increase in antioxidant ***:The results clearly demonstrate that piperine shows promising hepatoprotective effect as comparable to standard drug silymarin.

关键词： Pipeline Hepatoprotective Antioxidant enzymes Lipid peroxidation TNF-α

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Intervertebral disc degeneration is rescued by TGFβ/BMP signaling modulation in an ex vivo flamin B mouse model

引用

Bone Research 2022年第3期10卷 524-535页

作者： Jennifer Zieba Kimberly N.Forlenza Kelly Heard Jorge H.Martin Michaela Bosakova Daniel H.Cohn Stephen P.Robertson Pavel Krejci deborah Krakow Department of Orthopedic Surgery Los AngelesCA 90095USA Department of Biology Faculty of MedicineMasaryk University62500 BrnoCzech Republic International Clinical Research Center St.Anne’s University Hospital65691 BrnoCzech Republic Institute of Animal Physiology and Genetics Czech Academy of Sciences60200 BrnoCzech Republic Department of Molecular Cell and Developmental Biology University of CaliforniaLos AngelesLos AngelesCA 90095USA Department of Women’s and Children’s Health Dunedin School of MedicineUniversity of OtagoDunedinNew Zealand Department of Human Genetics Los AngelesCA 90095USA Department of Obstetrics and Gynecology Los AngelesCA 90095USA Department of Pediatrics David Geffen School of Medicine at University of CaliforniaLos AngelesLos AngelesCA 90095USA

Spondylocarpotarsal syndrome(SCT) is a rare musculoskeletal disorder characterized by short stature and vertebral, carpal, and tarsal fusions resulting from biallelic nonsense mutations in the gene encoding filamin B(FLNB). Utilizing a FLNB knockout mouse,we showed that the vertebral fusions in SCT evolved from intervertebral disc(IVD) degeneration and ossification of the annulus fibrosus(AF), eventually leading to full trabecular bone formation. This resulted from alterations in the TGFβ/BMP signaling pathway that included increased canonical TGFβ and noncanonical BMP signaling. In this study, the role of FLNB in the TGFβ/BMP pathway was elucidated using in vitro, in vivo, and ex vivo treatment methodologies. The data demonstrated that FLNB interacts with inhibitory Smads 6 and 7(i-Smads) to regulate TGFβ/BMP signaling and that loss of FLNB produces increased TGFβ receptor activity and decreased Smad 1 ubiquitination. Through the use of small molecule inhibitors in an ex vivo spine model, TGFβ/BMP signaling was modulated to design a targeted treatment for SCT and disc degeneration. Inhibition of canonical and noncanonical TGFβ/BMP pathway activity restored Flnb-/-IVD morphology. These most effective improvements resulted from specific inhibition of TGFβand p38 signaling activation. FLNB acts as a bridge for TGFβ/BMP signaling crosstalk through i-Smads and is key for the critical balance in TGFβ/BMP signaling that maintains the IVD. These findings further our understanding of IVD biology and reveal new molecular targets for disc degeneration as well as congenital vertebral fusion disorders.

关键词： TGFβ vivo BMP treatment

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Effect of organic acids—essential oils blend and oat fiber combination on broiler chicken growth performance, blood parameters, and intestinal health

引用

Animal Nutrition 2021年第4期7卷 1039-1051页

作者： deborah I.Adewole Samson Oladokun Elizabeth Santin Department of Animal Science and Aquaculture Faculty of AgricultureDalhousie UniversityTruroNSB2N 5E3Canada b JEFO Nutrition Inc.Saint-HyacintheQC J2R 2E7Canada

This study evaluated the effect of organic acids-essential oils blend with or without oat hulls(OH)on growth performance,organ weights,blood parameters,gut morphology,microbiota,and short-chain fatty acids(SC FA)in ***-old broiler chickens were randomly allocated to 4 dieta ry treatments consisting of 1)a corn-soybean meal-wheat based diet(BAS),2)BAS+0.05%bacitracin methylene disalicylate(BMD),3)BAS+protected organic acids-essential oils at 300 g/1,000 kg of feed(OE),and 4)BAS+protected organic acids-essential oils at 300 g/1,000 kg of feed+3%OH(OEOH),in 8 replicate *** was in starter(d0 to 14),grower(d 14 to 24),and finisher(d 24 to 36)*** weight(BW),feed intake(FI),feed conversion ratio(FCR),and mortality were determined *** d 36,8 chickens per treatment were sampled for blood biochemistry,organ weights,cecal SCFA production,and *** had no effect on FI and FCR at all *** OE and OEOH treatments reduced(P<0.001)the body weight gain of birds at the starter *** fed the OEOH treatment had higher(P<0.001)gizzard weight,while those offered the BMD diet showed a tendency(P=0.08)to have higher cecal *** in the OEOH treatment recorded increased ileal villus height and villus height-to-crypt depth ratio,as well as reduced duodenal crypt depth,while birds in the OE treatment had increased j ej unal villus height and villus height-to-crypt depth *** OEOH and OE treatments increased the number of goblet cells produced in the duodenum and *** had no effecton SCFA *** in the OE treatment recorded the lowest concentration of blood urea(P=0.05)and cholesterol(P<0.05).Both OE and OEOH treatments increased(P<0.05)the relative abundance of potentially beneficial bacteria in the genus Firmicutesunclassified,Ruminococcus,Turicibacter,and Erysipelotrichaceaeunclassified,while reducing(P<0.001)the relative abundance of potentially harmful ***,bo

关键词： Organic acid Essential oil Oat hull Broiler chicken Ceca microbiota

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Vitamin C ameliorated cardiac autonomic neuropathy in type 2 diabetic rats

引用

World Journal of Diabetes 2020年第3期11卷 52-65页

作者： Temitope deborah Fabiyi-Edebor Department of Physiology Afe Babalola University Ado Ekiti

BACKGROUND Vitamin C(VC)is a common antioxidant with cell protection ***,its possible protective effect on cardiac autonomic nerves from diabetic induced insults is yet to be *** To investigate the effects of VC on diabetic cardiac autonomic *** Thirty male Wistar rats were equally grouped into control,diabetic and diabetic+*** 2 diabetes was induced with fructose diet and ***(1 g/kg)was administered for 4 wk via oral *** pressure and heart rate were measured non-invasively using tail flick blood pressure *** analysis of heart rate variability(HRV)was used to assess cardiac autonomic *** was collected from the ocular sinus for biochemical ***(1 g/kg-ip)was used for anaesthesia prior to HRV and cervical dislocation to harvest *** autonomic nerve was assessed using tyrosine hydroxylase immunohistochemistry on fixed heart *** Results were analysed using ANOVA atα*** VC and control groups,diabetic rats showed significantly(P<0.0001)reduced HRV,increased heart-rate and blood pressure,initial increase in cardiac tyrosine hydroxylase activities at week-2 and sparse activity at week-4 of ***,apolipoprotein B,Oxidative stress and inflammatory markers were significantly(P<0.01)reduced in VC treated *** VC possesses cardio-autonomic nerve protective potential and ameliorates the symptoms of cardiac autonomic neuropathy in type 2 *** possible mechanisms via which VC exert these effects may be via downregulation of oxidative stress,inflammation and apolipoprotein B.

关键词： Vitamin C Oxidative stress Heart rate variability Tyrosine hydroxylase Autonomic nerve Neuropathy Type 2 diabetes

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：