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Tale of mitochondria and mitochondria-associated ER membrane in patient-derived neuronal models of Wolfram syndrome

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Neural Regeneration Research 2025年第9期20卷 2587-2588页

作者： Laetitia Aubry Timothy Barrett Sovan sarkar I-STEM CECSCorbeil-EssonnesFrance UniversitéParis-Saclay Universitéd’EvryINSERMI-STEMUMR861Corbeil-EssonnesFrance Institute of Cancer and Genomic Sciences Institute of Biomedical ResearchCollege of Medical and Dental SciencesUniversity of BirminghamEdgbastonBirminghamUK Department of Endocrinology Birmingham Women’s and Children’s HospitalSteelhouse LaneBirminghamUK

Mitochondria and mitochondria-associated endoplasmic reticulum membrane in neurodegenerative diseases:Mitochondria generate most of the chemical energy needed to power the biochemical reactions of cells,and thus are often referred to as the"powerhouse"of the ***,this organelle is also involved in a pleth,ora of different cellular functions such as calcium(Ca^(2+))homeostasis,apoptosis,oxidative stress,and several metabolic pathways including oxidative phosphorylation,tricarboxylic acid cycle,andβ-oxidation of fatty acids.

关键词： oxidative cycle carboxylic

Spatio-temporal evaluation of Zr plasma parameters in a single-beam-splitting double-pulse laser-induced plasma

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Plasma Science and Technology 2021年第2期23卷 47-56页

作者： Arnab sarkar Manjeet SINGH Fuel Chemistry Division Bhabha Atomic Research CentreMumbai 400085India Homi Bhabha National Institute AnushaktinagarMumbai 400094India

The plasma shielding effect is one of the major weaknesses of laser-induced breakdown spectroscopy(LIBS)as it causes non-linearity in signal *** LIBS is typically carried out in constant laser energy,this non-linearity causes a reduction in *** this work,we systematically examine laser-induced plasma,formed by two different excitation source modes,*** pulse(SP)-excitation and single-beam-splitting double-pulse(SBS-DP)-excitation over Zr-2.5%Nb *** two most important plasma parameters influencing the emission line intensity,plasma temperature(Te)and electron density(Ne)were studied and compared for both modes of laser *** of the results conclusively demonstrates that due to the splitting of the laser energy in the SBS-DP mode,the plasma shielding effect is significantly *** reduced plasma shielding translates to an increased laser–sample coupling under SBS-DP *** imaging of the total intensity of the laser-induced plasma in both excitation modes was also *** study shows how the plasma shielding effect can be reduced to improve the analytical quality of the LIBS methodology.

关键词： LIBS single-beam-splitting double pulse spatial-temporal evolution plasma temperature electron density

Seismic bearing capacity of strip footing on partially saturated soil using modal response analysis

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Earthquake Engineering and Engineering Vibration 2022年第3期21卷 641-662页

作者： Abhijit Anand Rajib sarkar Department of Civil Engineering IIT(ISM)DhanbadDhanbad 826004India

The present study proposes a novel and simplified methodology to assess the seismic bearing capacity(SBC) of a shallow strip footing by incorporating strength non-linearity arising due to partial saturation of a soil matrix. Furthermore, developed methodology incorporates the modal response analysis of soil layers to assess SBC. A constant matric suction distribution profile has been considered throughout the depth of the soil. The Van Genuchten equation and corresponding fitting parameters have been considered to quantify matric suction in the analysis. SBC has been obtained for three different geomaterials;viz. sand, fly ash and clay, based on their predominant grain size and diverse soil water characteristics curve(SWCC) attributes. Variation of SBC with different modes of vibration and damping ratio are reported for ranges of matric suction pertinent to the geomaterials considered in the study. The relative significance of matric suction on SBC has been reported for suction values within the transition zone of each geomaterial. It is observed that the SBC of sand is drastically reduced, with matric suction reaching beyond the residual suction value. The SBC of fly ash remains constant beyond the residual suction value, whereas the SBC of clay shows an increasing trend toward the practical range of matric suction values.

关键词： seismic bearing capacity modal analysis matric suction

Spectral lags of flaring events in LS I+61°303 from RXTE Observations

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Research in Astronomy and Astrophysics 2016年第7期16卷 29-38页

作者： Tamal sarkar Samir sarkar Arunava Bhadra High Energy&Cosmic Ray Research Centre University of North BengalSiliguriWB 734013India University Science Instrumentation Centre University of North BengalSiliguriWB 734013India

This work reports the first discovery of（negative） spectral lags in X-ray emission below 10 ke V from the gamma ray binary LS I＋61？303 during large flaring episodes using Rossi X-ray Timing Explorer（RXTE） observations. It is found from the RXTE data that during the flares, low energy（3–5 ke V） variations lead the higher energy（8–10 ke V） variations by a few tens of seconds whereas no significant time lag is observed during the non-flaring states. The observed spectral lag features for flaring events suggest that inverse Compton scattering may be operating, at least in some part of the system. Another possibility is that the sites of particle acceleration may be different for flaring and non-flaring events such as in the microquasar model, in which the flaring radiation may come from hot spots sitting above the black hole while steady state emissions are due to the jets.

关键词： X-rays:binaries X-rays:individual(LS I+61?303)

Study of flow characteristics within randomly distributed submerged rigid vegetation

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Journal of Hydrodynamics 2019年第2期31卷 358-367页

作者： Paromita Chakraborty Arindam sarkar School of Civil Engineering Kalinga Institute of Industrial Technology(KIIT)Deemed to be UniversityBhubaneswarOdishaIndia School of Infrastructure Indian Institute of Technology(IIT)Bhubaneswar AurgulBhubaneswarOdishaIndia

Flow through submerged rigid vegetation has been studied both analytically and *** Reynolds stress,present in the governing equation,has been modeled using one of the turbulent stress equations,adopted in numerous *** adva ntage of this turbulent stress model is to replace the mixing length non linear term of the stress with a linear relatio n between stress and the velocity *** velocity field and shear stress are obtained by solving the governing force balance equation numerically.A correlation,validated with the experimental results,has been developed for the relevant non-dimensional numbers.

关键词： Submerged vegetation Reynolds stress drag force stream wise velocity

Laser-induced plasma electron number density:Stark broadening method versus the Saha-Boltzmann equation

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Plasma Science and Technology 2017年第2期19卷 43-51页

作者： Arnab sarkar Manjeet SINGH Fuel Chemistry Division Bhabha Atomic Research CentreMumbai 400 085India

We report spectroscopic studies on plasma electron number density of laser-induced plasma produced by ns-Nd：YAG laser light pulses on an aluminum sample in air at atmospheric pressure. The effect of different laser energy and the effect of different laser wavelengths were compared. The experimentally observed line profiles of neutral aluminum have been used to extract the excitation temperature using the Boltzmann plot method, whereas the electron number density has been determined from the Stark broadened as well as using the Saha-Boltzmann equation （SBE）. Each approach was also carried out by using the AI emission line and Mg emission lines. It was observed that the,SBE method generated a little higher electron number density value than the Stark broadening, method, but within the experimental uncertainty range. Comparisons of Ne determined by the two methods show the presence of a linear relation which is independent of laser energy or laser wavelength. These results show the applicability of the SBE method for Are determination, especially when the system does not have any pure emission lines whose electron impact factor is known, Also use of Mg lines gives superior results than Al lines.

关键词： plasma parameter laser induced plasma plasma electron density Saha-Boltzmannmethod Stark broadening method

Time-resolved evaluation of uranium plasma in different atmospheres by laser-induced breakdown spectroscopy

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Plasma Science and Technology 2018年第12期20卷 65-74页

作者： Manjeet SINGH Arnab sarkar Fuel Chemistry Division Bhabha Atomic Research CentreMumbai 400 085India Homi Bhabha National Institute AnushaktinagarMumbai 400 094India

This work reports spectroscopic studies of uranium containing plasma generated in air and argon environments. The 532 nm Q-switched Nd：YAG laser generates the optical breakdown plasma, which was recorded by a spectrometer and an intensified charge coupled device having a resolution of 25 pm. Neutral and ionized uranium lines in the wavelength range of 385.8-391.9 nm indicate significant width and shift variations during the first few microseconds. Electron temperature and density of the plasma are determined using the Boltzmann plot and the Saha-Boltzmann equation at various time delay. The study reveals the power law decay pattern of electron temperature and density, which changes to exponential decay pattern if large gate- width is used to acquire the signal, due to an averaging effect.

关键词： uranium laser induced plasma plasma parameter temporal evaluation electron temperature electron density LIBS

Targeting multiple signal pathways by chemopreventive agents for cancer prevention and therapy

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Acta Pharmacologica Sinica 2007年第9期28卷 1305-1315页

作者： Fazlul H sarkar Department of Pathology.Karmanos Cancer Institute Wayne State University School of MedicineDetroitMI 48201USA

In recent years,growing interest has been focused on the field of cancer *** prevention by chemopreventive agents offers significant promise for re-ducing the incidence and mortality of *** agents may exerttheir effects either by blocking or metabolizing carcinogens or by inhibiting tumorcell *** important benefit of chemopreventive agents is their non-toxic ***,chemopreventive agents have recently been used forcancer treatment in combination with chemotherapeutics or radiotherapy,uncov-ering a novel strategy for cancer *** strategy opens a new avenue fromcancer prevention to cancer *** vitro and in vivo studies have demon-strated that chemopreventive agents could enhance the antitumor activity ofchemotherapeutics,improving the treatment *** evidence hasshown that chemopreventive agents potentiate the efficacy of chemotherapy andradiotherapy through the regulation of multiple signaling pathways,includingAkt,NF-kB,c-Myc,cyclooxygenase-2,apoptosis,and others,suggesting amultitargeted nature of chemopreventive ***,further in-depth mecha-nistic studies,in vivo animal experiments,and clinical trials are needed to investi-gate the effects of chemopreventive agents in combination treatment of cancerwith conventional cancer *** potent natural and synthetic chemo-preventive agents are also needed to improve the efficacy of mechanism-basedand targeted therapeutic strategies against cancer,which are likely to make asignificant impact on saving ***,we have briefly reviewed the role ofchemopreventive agents in cancer prevention,but most importantly,we havereviewed how they could be useful for cancer therapy in combination with con-ventional therapies.

关键词： chemoprevention chemotherapy Akt NF-kB c-Myc cyclooxygenase-2

Assessment of the fraction of bed load concentration towards the sediment transport of a monsoon-dominated river basin of Eastern India

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Journal of Geographical Sciences 2023年第5期33卷 1023-1054页

作者： KAR Rohan sarkar Arindam School of Infrastructure Indian Institute of Technology BhubaneswarArgulKhordhaOdisha 752050India

Given the challenges of re-creating complex bed load(BL)transport processes in rivers,models are preferred over gathering and examining field *** highlight of the present research is to develop an approach to determine the ungauged bed load concentration(BLC_(u))utilizing the measured suspended sediment concentration(SSC)and hydraulic variables of the last four decades for the Mahanadi River *** technique employs shear stress and SSC equations for turbulent open channel ***,the predicted BLC_(u)is correlated with SSC using a power relation to estimate BLC_(u)on the river and ***,different BL functions(BLF)efficiency is assessed across *** model predicted BLC_(u)is comparable with the published data for sandy rivers and falls within±20%.Outliers in hydraulic and sedimentological statistics significantly influence estimating the BL fraction apart from higher relative ratios and catchment *** constants of power functions are physically linked to sediment transport configuration,mechanism,and inflow to the *** stream power-based BLF best predicts the BL transport,followed by shear stress and unit discharge *** disparity in the estimation of BLC_(u)results from station-specific physical factors,sampling data dispersion,and associated uncertainties.

关键词： Mahanadi River Basin ungauged bed load concentration suspended sediment concentration correlations bed load functions