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DNA damage and metabolic mechanisms of cancer drug resistance

Cancer Drug Resistance 2022年第2期5卷 368-379页

作者： deanna tiek Shi-Yuan Cheng The Ken&Ruth Davee Department of Neurology Lou and Jean Malnati Brain Tumor Institute at Northwestern MedicineRobert H.Lurie Comprehensive Cancer Centerand Simpson Querry Institute for EpigeneticsNorthwestern UniversityFeinberg School of Medicine303 E Superior StChicagoIL 60611USA

Cancer drug resistance is one of the main barriers to overcome to ensure durable treatment *** many pivotal advances have been made in first combination therapies,then targeted therapies,and now broadening out to immunomodulatory drugs or metabolic targeting compounds,drug resistance is still ultimately universally *** this brief review,we will discuss different strategies that have been used to fight drug resistance from synthetic lethality to tumor microenvironment modulation,focusing on the DNA damage response and tumor metabolism both within tumor cells and their surrounding *** this way,with a better understanding of both targetable mutations in combination with the metabolism,smarter drugs may be designed to combat cancer drug resistance.

关键词： metabolism damage drugs

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Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第2期17卷 84-90页

作者： Eric Tzyy Jiann Chong Joveen Wan Fen Neoh tiek Ying Lau Kek Heng Chua Yvonne Ai-Lian Lim Ping-Chin Lee Biotechnology Research Institute Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia Department of Biomedical Science Faculty of Medicine BuildingUniversity of Malaya50603 Kuala LumpurMalaysia Centre of Excellence for Research in AIDS(CERiA) University of Malaya50603 Kuala LumpurMalaysia Faculty of Science and Natural Resources Universiti Malaysia SabahJalan UMS88400 Kota KinabaluSabahMalaysia

Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and ***:Thirty-nine blood samples infected with *** were collected in Sabah,Malaysian Borneo and Peninsular *** S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and *** natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK *** study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA ***:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of *** isolates from different areas in Malaysia based on the S-type SSU rRNA gene *** S-type SSU rRNA gene sequences were relatively conserved and with a purifying *** sharing of the S-type SSU rRNA gene was observed between the *** isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular ***:This study suggests that the S-type SSU rRNA gene of *** isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the *** features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among *** species.

关键词： Plasmodium knowlesi S-type small subunit ribosomal RNA Genetic diversity Natural selection Haplotype

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