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Transcriptional coactivator MED1 in the interface of anti-estrogen and anti-Her2 therapeutic resistance

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Cancer Drug Resistance 2022年第2期5卷 498-510页

作者： gregory Bick Jasmine Zhang Elyse E.Lower Xiaoting Zhang Department of Cancer Biology Vontz Center for Molecular StudiesUniversity of Cincinnati College of MedicineCincinnatiOH 45267USA Department of Internal Medicine University of Cincinnati College of MedicineCincinnatiOH 45267USA. University of Cincinnati Cancer Center University of Cincinnati College of MedicineCincinnatiOH 45267USA.

Breast cancer is one of the most common cancer and leading causes of death in women in the United States and *** 90%of breast cancers belong to er+or Her2+subtypes and are driven by key breast cancer genes Estrogen Receptor and Her2,*** the advances in anti-estrogen(endocrine)and anti-Her2 therapies for the treatment of these breast cancer subtypes,unwanted side effects,frequent recurrence and resistance to these treatments remain major clinical *** studies have identified er coactivator MED1 as a key mediator of er functions and anti-estrogen treatment ***,MED1 is also coamplified with Her2 and activated by the Her2 signaling cascade,and plays critical roles in Her2-mediated tumorigenesis and response to anti-Her2 treatment as ***,MED1 represents a novel crosstalk point of the Her2 and er pathways and a highly promising new therapeutic target for er+and Her2+breast cancer *** this review,we will discuss the recent progress on the role of this key er/Her2 downstream effector MED1 in breast cancer therapy resistance and our development of an innovative RNA nanotechnology-based approach to target MED1 for potential future breast cancer therapy to overcome treatment resistance.

关键词： MED1 transcription cofactor estrogen receptor Her2 therapy resistance RNA nanotechnology

Improvement in the calculation of anti-Stokes energy transfer and experimental justification based on er_(0.01)Yb_xY_(1 0.01 x)VO_4 crystal

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Chinese Physics B 2010年第9期19卷 604-611页

作者：陈晓波卢建张蕴芝徐小灵冯宝华王策 gregory J. Salamo 杨国建 Nuclear Science&Technology School and Analytical Testing Center Applied Optics Beijing Area Major LaboratoryBeijing Normal University Institute of Physics Chinese Academy of Sciences University Arkansas Department of PhysicsFayetteville

The improvement on the calculation of anti-Stokes energy transfer rate is studied in the present work. The additional proportion coefficient between Stokes and anti-Stokes light intensities of quantum Raman scattering theory as compared with the classical Raman theory is introduced to successfully describe the anti-Stokes energy transfer. The theoretical formula for the improvement on the calculation of anti-Stokes energy transfer rate is derived for the first time in this study. The correctness of introducing coefficient exp{△E/kT} from well-known Raman scatter theory is demonstrated also. Moreover, the experimental lifetime measurement in er0.01YbxY1-0.01-xVO4 crystal is performed to justify the validity of our important improvement in the original phonon-assisted energy transfer theory for the first time.

关键词： improvement of anti-Stokes energy transfer Raman scattering quantum and classical theory er0.01YbxY1-0.01-xVO4 crystal

Improved anti-Stokes energy transfer between rare earth ions in er(0.5)Yb(9.5):FOV oxyfluoride vitroceramics explains the strong color reversal

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Chinese Physics B 2009年第12期18卷 5523-5533页

作者：陈晓波王策 gregory J.Salamo Naruhito Sawanobori 康栋国 Masaaki Ohtsuka 杨国建彭芳麟 Applied Optics Beijing Area Major Laboratory Beijing Normal University University of Arkansas Department of PhysicsFayettevilleAR 72701USA Sumita Optical Glass Inc.4-7-25 HarigayaUrawaSaitama338Japan Beijing Institute of Applied Physics and Computational Mathematics Applied Optics Beijing Area Major Laboratory and Physics Department Beijing Normal University

The widely used energy transfer theory is a foundation of luminescence, in which the rates of Stokes and anti-Stokes processes have the same calculation formula. An improvement on the anti-Stokes energy transfer to explain the fluorescence intensity reversal between the red and green fluorescence of er（0.5）Yb（9.5）：FOV is reported in the present article. The range of the intensity reversal Z was measured to be 877. Dynamic processes for 16 levels were simulated. A coefficient, the improvement factor of the intensity ratio of Stokes to anti-Stokes processes in quantum Raman theory compared to classical Raman theory, is introduced to successfully describe the anti-Stokes energy transfer. A new method to calculate the distance between the rare earth ions, which is critical for the energy transfer calculation, is proposed. The validity of these important improvements is also proved by experiment.

关键词： improvement of anti-Stokes energy transfer nanomaterial era+yb^3+ co-doped rare earth ion material

Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells

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World Journal of Gastroenterology 2007年第6期13卷 851-857页

作者： Yucel Ustundag Steven F Bronk gregory J Gores Mayo Clinic College of Medicine Rochester MN 55905 United States

AIM: To determine if proteasome inhibition induces apoptosis in human cholangiocarcinoma cells, and if so, to elucidate the cellular mechanisms. METHODS: Studies were performed in the human KMCH, KMBC, and Mz-ChA-1 cholangiocarcinoma, and normal rat cell lines. MG132, a peptide aldehyde, which inhibits the chymotrypsin-like activity of the proteaosome was employed for this study. Apoptosis was assessed morphologically by 4'-6-Diamidino-2-phenylindole (DAPI) nuclear staining and fluorescence microscopy. Mitochondrial membrane potential was examined using a fluorescent unquenching assay. Ultrastructural changes during cell death were examined using transmission electron microscopy (TEM). Caspase 3/7 activity was assessed using an enzymatic-based fluorescent assay. Cytosolic-free calcium concentrations were measured using Fura-2 and digitized fluorescent microscopy. RESULTS: MG132, a proteasome inhibitor, induced apoptosis in all the cholangiocarcinoma cell lines examined. In contrast, minimal cytotoxicity was observed in normal rat cholangiocytes. Apoptosis was time-and -concentration-dependent. There was no change in the mitochondrial membrane potential between treated and untreated cells. Ultrastructural examination by transmission electron microscopy displayed the classic features of apoptosis, but in addition, there was also dramatic vacuolization of the endoplasmic reticulum (er). Unexpectedly, no increase in caspase 3/7 activity was observed in MG132 treated cells, nor did the pancaspase inhibitor, Q-VD-OPh prevent cell death. The protein synthesis inhibitor, cycloheximide, blocked apoptosis induced by proteosome inhibitor indicating that er dysfunction was dependent upon the formation of new proteins. CONCLUSION: Proteosome inhibition induces erdysfunction and caspase-independent cell death selectively in human cholangiocarcinoma cells. Proteasome inhibitors warrant evaluation as anticancer agents for the treatment of human cholangiocarcinoma.

关键词： MG132 Cholangiocarcinoma Proteosome Apoptosis Calcium

Theoretical Simulation on a Nonlinear Photonics Process of er(1%)Yb(8%):FOV Oxyfluoride Nanophase Vitroceramics

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Communications in Computational Physics 2010年第3期7卷 580-596页

作者： Ce Wang Xiaobo Chen gregory J.Salamo Naruhito Sawanobori Chenjuan He Hongyu Zhou Hongmei Jing Yongzhi Zeng Song Li Xiaoling Xu Applied Optics Beijing Area Major Laboratory Beijing Normal UniversityBeijing100875China Applied Optics Beijing Area Major Laboratory Department of Physics&Material CollegeBeijing Normal UniversityBeijing100875China Department of Physics University ArkansasFayettevilleAR 72701USA Sumita Optical Glass Inc.4-7-25 HarigayaUrawaSaitama338Japan Department of Physics Fuzhou UniversityFuzhouFujian350002China

We numerically simulate a photonics phenomenon of what we call intensity inversion between red and green fluorescence in oxyfluoride nanophase vitroceramics er(1%)Yb(8%):FOV through the integration of whole fluorescence’s *** found that it is essential to introduce a coefficient presenting the difference between the Stokes energy transfer and anti-Stokes energy transfer processes in nano-material when calculating the energy transfer *** this consideration,and with the total crystallized volume ratio set to be 17.6%,the simulation results of the population probabilities values of all energy levels of er^(3+) ion are coincident with the experimental result perfectly.

关键词： Energy transfer theoretical simulation Stokes and anti-Stokes processes rare earth ions oxyfluoride nanophase vitroceramics

一个白菜型油菜细胞质雄性不育的遗传研究(英文)

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作物学报 1998年第6期24卷 705-710页

作者：杨光圣傅廷栋 gregory G.Brown 华中农业大学农学系武汉430070 Department of Biology McGill University1205 Doctor Penfield AvenueMontrealQuebecH3A 1Bl Canada

1993年春在白菜型油菜品种“浠水白”中发现了几株雄性不育株。遗传研究结果表明,“浠水白”雄性不育株为细胞质雄性不育,所有调查过的白菜型油菜品种(系)均是这种雄性不育的保持系。与pol CMS和nap CMS的保持系和恢复系的测交结果表明... 详细信息

1993年春在白菜型油菜品种“浠水白”中发现了几株雄性不育株。遗传研究结果表明,“浠水白”雄性不育株为细胞质雄性不育,所有调查过的白菜型油菜品种(系)均是这种雄性不育的保持系。与pol CMS和nap CMS的保持系和恢复系的测交结果表明,“浠水白”雄性不育与nap CMS具有相同的恢保关系,与pol CMS具有完全不同的恢保关系。EcoR I、HindⅢ、Pst I和Sal I四种限制性内切酶的线粒体DNA酶切图谱及以atp6和orf222作探针的RFLP分析结果显示,“浠水白”的细胞质与nap CMS相同,而与pol CMS不同。

关键词：白菜型油菜细胞质雄性不育遗传