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Nonlinear inversion of ultrasonic guided waves for in vivo evaluation of cortical bone properties

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Chinese Physics B 2022年第7期31卷 371-378页

作者： Xiaojun Song tii Fan Jundong Zeng Qin-Zhen Shi Qiong Huang Meilin Gu Petro Moilanen Yi-Fang Li dean ta Center for Biomedical Engineering Fudan UniversityShanghai 200433China College of Electronics and Information engineering Shanghai University of Electric PowerShanghai 200090China Department of Physics University of HelsinkiHelsinkiFinland Academy for Engineering and technology Fudan UniversityShanghai 200433China

Ultrasonic guided waves(UGWs),which propagate throughout the entire thickness of cortical bone,are attractive for the early diagnosis of ***,this is challenging due to the impact of soft tissue and the inherent difficulties related to multiparametric inversion of cortical bone quality factors,such as cortical thickness and bulk wave ***,in this research,a UGW-based multi-parameter inversion algorithm is developed to predict strength-related *** simulation,a free plate(cortical bone)and a bilayer plate(soft tissue and cortical bone)are used to validate the proposed *** inversed cortical thickness(Cth),longitudinal velocity(V_(L))and transverse velocity(V_(t))are in accordance with the true *** four bovine cortical bone plates were used in in vitro *** with the reference values,the relative errors for cortical thickness were 3.96%,0.83%,2.87%,and 4.25%,*** the in vivo measurements,UGWs are collected from the tibias of 10 *** theoretical dispersion curves depicted by the estimated parameters(V_(t),V_(L),Cth)match well with the extracted experimental *** comparison with dual-energy x-ray absorptiometry,our results show that the estimated transverse velocity and cortical thickness are highly sensitive to ***,these two parameters(Cth and V_(t))of long bones have potential to be used for diagnosis of bone status in clinical applications.

关键词： ultrasonic guided waves inversion algorithm transverse velocity bone evaluation

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伪随机扫描在可控震源探测中的应用

世界地震译丛 2016年第1期47卷 64-90页

作者： t. dean 朱维(译) 吴何珍(校) 不详中国地震局地球物理研究所

伪随机可控震源扫描一直被认为是一种可替代标准线性扫描的方法,因为其有以下潜能:优越的正交性、对基础设施破坏的可能性较小以及可增强低频成分。尽管这一特性现在已不是十分重要,但它们因以前具有良好的自相关形状而备受青睐。虽然... 详细信息

伪随机可控震源扫描一直被认为是一种可替代标准线性扫描的方法,因为其有以下潜能:优越的正交性、对基础设施破坏的可能性较小以及可增强低频成分。尽管这一特性现在已不是十分重要,但它们因以前具有良好的自相关形状而备受青睐。虽然它们的应用受到了限制,但是由于它们能够降低干扰噪声,且同步采集技术越来越受欢迎,所以重新激发了人们的兴趣。过去45年间发展了各种各样的伪随机扫描方法。本文在对各类扫描进行分类和描述前先将其应用机能进行阐述。最后将依据扫描的主要性质,包括对同步探测的适用性,对它们进行比较。

关键词：伪随机扫描可控震源同步

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让援助更为明智

金融与发展 2005年第2期42卷 42-46页

作者： dean t.Jamison Steven Radelet 洛杉矶加利福尼亚大学教育与公共健康教授全球发展中心的高级研究员

为全世界儿童提供初等学校教育将是一项漫长而且耗费甚大的工程。幸好，自1990年以来，主要的捐助者极大地增加了他们对于总体教育，特别是初等教育的官方发展援助（ODA）。2003年对所有教育目标的捐赠承诺额达到了67亿美元，是6年前承... 详细信息

为全世界儿童提供初等学校教育将是一项漫长而且耗费甚大的工程。幸好，自1990年以来，主要的捐助者极大地增加了他们对于总体教育，特别是初等教育的官方发展援助（ODA）。2003年对所有教育目标的捐赠承诺额达到了67亿美元，是6年前承诺额真实数量的两倍以上。对于初等教育的承诺额增加得甚至更快，在1990—2003年间增长了四倍，达到19亿美元。对于初等教育的援助比总体ODA增长的更快，其在承诺额中的份额从1990年的0．4％增长到2003年的1．9％（见图1和图2）。

关键词： 2003年 1990年明智官方发展援助初等教育学校教育承诺全世界 ODA

Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients

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World Journal of Gastroenterology 2006年第33期12卷 5352-5356页

作者： Viacheslav N Kalinin Jussuf t Kaifi Heidi Schwarzenbach Anatoly S Sergeyev Bjoern C Link dean Bogoevski Yogesh Vashist Jakob R Izbicki Emre F Yekebas Department of General Visceral and Thoracic Surgery University Medical Center Hamburg-Eppendorf Hamburg Germany Institute for tumor Biology University Medical Center Hamburg-Eppendorf Hamburg Germany Research Centre for Medical Genetics Moscow Russia

AIM: to verify and expand the known spectrum of serine protease inhibitor Kazal type 1 (SPINK1) gene mutations in chronic pancreatitis. MEtHODS: DNA extracted from 172 chronic pancreatitis patients was assayed for SPINK1 gene mutations by PCR and DNA sequencing. A control cohort of 90 unrelated healthy individuals was analysed by the same methods for presence of common populational polymorphisms, and frequency of five-loci haplotypes was calculated. Linkages of gene aberrations in single SPINK1 gene copies were analysed by long-distance PCR followed by allele-specifi c PCR and DNA sequencing. RESULtS: the most frequent SPINK1 gene mutation N34S was found at a frequency of 6%. Furthermore, we detected the heterozygous intervening sequence (IVS) 3 + 2 t > C mutated gene in 2 German patients and 1 Macedonian chronic pancreatitis patient. In all three SPINK1 gene copies an additional rare base substitution was found: 5’untranslated region (UtR)-215 G > A. Poly-morphism analysis revealed that all three affected genes carried the same fi ve-loci haplotype. DNA sequencing of another chronic pancreatitis-related gene PRSS1 (cationic trypsinogen) did not reveal any mutations in these 3 ***: We found in 3 (2%) of 172 chronic pancreatitis patients an IVS3 + 2 t > C SPINK1 gene mutation and a base substitution 5’UtR-215 G > A inthe same gene copy. Most probably the 5’UtR-215 G >A represents a rare polymorphism and not a mutationas previously concluded. Haplotype analysis suggests acommon origin of the IVS3 + 2 t > C mutation in thesepatients.

关键词： Chronic pancreatitis Serine protease inhibitor Kazal type 1 Gene mutations

OsRLR4 binds to the OsAUX1 promoter to negatively regulate primary root development in rice

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Journal of Integrative Plant Biology 2022年第1期64卷 118-134页

作者： Chendong Sun Dongming Li Zhenyu Gao Lei Gao Lianguang Shang Mei Wang Jiyue Qiao Shilin Ding Chuanyou Li Markus Geisler dean Jiang Yanhua Qi Qian Qian Key Laboratory of Herbage&Endemic Crop Biology of Ministry of Education Inner Mongolia Key Laboratory of Herbage&Endemic Crop BiotechnologySchool of Life SciencesInner Mongolia UniversityHohhot 010000China State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejiang UniversityHangzhou 310058China the Key Laboratory for Quality Improvement of Agricultural Products of Zhejiang Province College of Advanced Agricultural SciencesZhejiang Agriculture and Forestry UniversityLin'an Hangzhou 311300China State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 310006China College of Life Sciences and Oceanography Guangdong Provincial Key Laboratory for Plant EpigeneticsShenzhen UniversityShenzhenChina Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural SciencesShenzhen 518120China State Key Laboratory of Plant Genomics National Center for Plant Gene ResearchInstitute of Genetics and Developmental BiologyThe Chinese Academy of SciencesBeijing 100101China Department of Biology University of FribourgFribourg CH-1700Switzerland

Root architecture is one of the most important agronomic traits that determines rice crop yield. the primary root(PR) absorbs mineral nutrients and provides mechanical support;however, the molecular mechanisms of PR elongation remain unclear in rice. Here, the two loss-of-function t-DNA insertion mutants of root length regulator 4(Os RLR4), osrlr4-1 and osrlr4-2 with longer PR, and three Os RLR4 overexpression lines, OE-Os RLR4-1/-2/-3 with shorter PR compared to the wild type/Hwayoung(Wt/HY), were identified. Os RLR4 isone of five members of the PRAF subfamily of the regulator chromosome condensation1(RCC1) family. Phylogenetic analysis of Os RLR4 from wild and cultivated rice indicated that it is under selective sweeps, suggesting its potential role in domestication. Os RLR4 controls PR development by regulating auxin accumulation in the PR tip and thus the root apical meristem activity. A series of biochemical and genetic analyses demonstrated that Os RLR4 functions directly upstream of the auxin transporter Os AUX1. Moreover, Os RLR4 interacts with the tRItHORAX-like protein Os trx1 to promote H3 K4 me3 deposition at the Os AUX1 promoter, thus altering its transcription level. this work provides insight into the cooperation of auxin and epigenetic modifications in regulating root architecture and provides a genetic resource for plant architecture breeding.

关键词： auxin transporter primary root development regulator chromosome condensation 1 rice root length regulator

Assessment of Biological Reaction to Whole Body Vibration training by Evaluating Changes in Salivary Components and Cutaneous Blood Flow

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Health 2014年第10期6卷 1049-1056页

作者： Seiko yamaguchi Yousuke Morita takehiko Yukishita Keiko K. Lee takuji yamaguchi Naoko Koga Hiroyuki Kobayashi Center for Advanced Kampo Medicine and Clinical Research Juntendo University Graduate School of Medicine Tokyo Japan Department of Hospital Administration Juntendo University Graduate School of Medicine Tokyo Japan

Aim: Whole body vibration (WBV) is thought to improve blood flow and autonomic balance and thereby induce a relaxation effect, which suggests its use for stress management. However, the relaxation effect of WBV training has not been objectively evaluated thus far. the purpose of this study was to determine the biological response to WBV training by measuring peripheral blood flow and salivary components using non-invasive techniques. Methods: Participants included 10 healthy volunteers (7 men, 3 women;mean age 33.8 ± 2.3) who provided oral consent and served as their own control. Each participant performed 15 types of stretching exercises for 10.5 min on the Power Plate? and cutaneous blood flow and salivary components were measured before and after the exercise. One week later, all participants performed the same exercise regimen for 10.5 min on a non-vibratory plate, and blood flow measurement and salivary tests were performed in a similar manner. Cutaneous blood flow was measured in the 4th digit for 1 min using the laser speckle flowgraphy. Saliva samples were evaluated for cortisol levels and α-amylase activity. to determine the effects of stretching exercises on the Power Plate? vs a non-vibratory plate, the differences in pre- and post-exercise peripheral blood flow, salivary cortisol levels, and salivary α-amylase activity were statistically evaluated by the t-test. Results: Mean blood flow before and after the exercise on the Power Plate? was 122.0 ± 54.2 and 156.7 ± 51.2, respectively;on a non-vibratory plate, blood flow was 136.6 ± 47.9 and 146.3 ± 38.3, respectively. the differences in pre-exercise and post-exercise values of the two training methods were not significant (p = 0.215). Mean cortisol levels before and after the exercise on the Power Plate? were 266.6 ± 125 and 204.9 ± 61.6, respectively;on a non-vibratory plate, the levels were 439.0 ± 121.7 and 425.8 ± 118.8, respectively. the differences in pre-exercise and post-exercise values of the two

关键词： Whole Body Vibration Cutaneous Blood Flow Salivary Cortisol Salivary α-Amylase Activity Relaxation Effect

the Protocol of Ultrasonic Backscatter Measurements of Musculoskeletal Properties

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Phenomics 2024年第1期4卷 72-80页

作者： Dongsheng Bi Lingwei Shi Boyi Li Ying Li Chengcheng Liu Lawrence HLe Jingchun Luo Sijia Wang dean ta Center for Biomedical Engineering School of InformationScience and TechnologyFudan University2005 SonghuRoadYangpu DistrictShanghai 200438China Academy for Engineering and technology Fudan UniversityShanghai 200433China Department of Radiology and Diagnostic Imaging University of AlbertaEdmonton T6G2B7Canada Human Phenome Institute Fudan UniversityShanghai 201203China Shanghai Institute of Nutrition and Health Chinese Academyof SciencesShanghai 200031China

this study aims to introduce the protocol for ultrasonic backscatter measurements of musculoskeletal properties based on a novel ultrasonic backscatter bone diagnostic(UBBD)***-energy X-ray absorptiometry(DXA)can be adopted to measure bone mineral density(BMD)in the hip,spine,legs and the whole *** muscle and fat mass in the legs and the whole body can be also calculated by DXA body composition *** on the proposed protocol for backscatter measurements by UBBD,ultrasonic backscatter signals can be measured in vivo,deriving three backscatter parameters[apparent integral backscatter(AIB),backscatter signal peak amplitude(BSPA)and the corresponding arrival time(BSPt)].AIB may provide important diagnostic information about bone *** and BSPt may be important indicators of muscle and fat *** standardized backscatter measurement protocol of the UBBD instrument may have the potential to evaluate musculoskeletal characteristics,providing help for promoting the application of the backscatter technique in the clinical diagnosis of musculoskeletal disorders(MSDs),such as osteoporosis and muscular atrophy.

关键词： Ultrasonic backscatter Musculoskeletal disorders Bone mineral density Muscle mass Fat mass

transmembrane serine protease 4 expression in the prognosis of radical resection for biliary tract cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2555-2564页

作者： Yoshiyuki Shibata takeshi Sudo Sho tazuma Naoki tanimine takashi Onoe Yosuke Shimizu Atsushi yamaguchi Kazuya Kuraoka Shinya takahashi Hirotaka tashiro Department of Surgery National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Gastroenterology National Hospital Organization Kure Medical Center and Chugoku Cancer CenterHiroshima 737-0023Japan Department of Diagnostic Pathology National Hospital Organization Kure Medical Centerand Chugoku Cancer CenterHiroshima 737-0023Japan Department of Surgery Graduate School of Biochemical and Health ScienceHiroshima UniversityHiroshima 734-8551Japan

BACKGROUND Recent advancements in biliary tract cancer(BtC)treatment have expanded beyond surgery to include adjuvant therapy,yet the prognosis remains *** prognostic biomarkers could enhance the assessment of patients who have undergone radical resection for *** to determine transmembrane serine protease 4(tMPRSS4)utility as a prognostic biomarker of radical resection for *** Medical records of patients who underwent radical resection for BtC,excluding intrahepatic cholangiocarcinoma,were retrospectively *** associations between tMPRSS4 expression and clinicopathological factors,overall survival,and recurrence-free survival were *** Among the 85 patients undergoing radical resection for BtC,46(54%)were *** tMPRSS4-positive group exhibited significantly higher preoperative carbohydrate antigen 19-9(CA19-9)values and greater lymphatic invasion than the tMPRSS4-negative group(P=0.019 and 0.039,respectively).Postoperative overall survival and recurrence-free survival were significantly worse in the tMPRSS4-positive group(median survival time:25.3 months vs not reached,Ptime:28.7 months vs not reached,P=0.043,respectively).Multivariate overall survival analysis indicated tMPRSS4 positivity,pt3/t4,and resection status R1 were independently associated with poor prognosis(P=0.032,0.035 and 0.030,respectively).tMPRSS4 positivity correlated with preoperative CA19-9 values≥37 U/mL and pathological tumor size≥30 mm(P=0.016 and 0.038,respectively).CONCLUSION tMPRSS4 is a potential prognostic biomarker of radical resection for BtC.

关键词： Biliary tract cancer Biomarker Prognosis Radical resection transmembrane serine protease 4

Hybrid magnetic resonance and optoacoustic tomography(MROt) for preclinical neuroimaging

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Light(Science & Applications) 2022年第12期11卷 2961-2971页

作者： Zhenyue Chen Irmak Gezginer Mark-Aurel Augath Wuwei Ren Yu-Hang Liu Ruiqing Ni Xose Luis dean-Ben Daniel Razansky Institute for Biomedical Engineering and Institute of Pharmacology and toxicology Faculty of MedicineUniversity of ZurichZurichSwitzerland Institute for Biomedical Engineering Department of Information Technology and Electrical EngineeringETH ZurichZurichSwitzerland Zurich Neuroscience Center(ZNZ) ZurichSwitzerland

Multi-modal imaging is essential for advancing our understanding of brain function and unraveling pathophysiological processes underlying neurological and psychiatric *** resonance(MR)and optoacoustic(OA)imaging have been shown to provide highly complementary contrasts and capabilities for preclinical *** integration between these modalities can thus offer unprecedented capabilities for studying the rodent brain in *** report on a hybrid magnetic resonance and optoacoustic tomography(MROt)system for concurrent noninvasive structural and functional imaging of the mouse *** OA tomography was designed as an insert into a high-field MR scanner by integrating a customized MR-compatible spherical transducer array,an illumination module,and a dedicated radiofrequency coil.A tailored data processing pipeline has been developed to mitigate signal crosstalk and accurately register image volumes acquired with t1-weighted,angiography,and blood oxygenation level-dependent(BOLD)sequences onto the corresponding vascular and oxygenation data recorded with the OA *** demonstrate the concurrent acquisition of dual-mode anatomical and angiographic brain images with the scanner,as well as real-time functional readings of multiple hemodynamic parameters from animals subjected to oxygenation *** approach combines the functional and molecular imaging advantages of OA with the superb soft-tissue contrast of MR,further providing an excellent platform for cross-validation of functional readings by the two modalities.

关键词： scanner resonance illumination