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Extramural vascular invasion and response to neoadjuvant chemoradiotherapy in rectal cancer: influence of the CpG island methylator phenotype

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World Journal of Gastrointestinal Oncology 2017年第5期9卷 209-217页

作者： Jeremy Stuart williamson Huw Geraint Jones Namor williams Anthony Paul Griffiths Gareth Jenkins John Beynon dean Anthony Harris Department of General and Colorectal Surgery Singleton Hospital Department of Pathology Singleton Hospital Department of Life Sciences Swansea University

To identify whether CpG island methylator phenotype (CIMP) is predictive of response to neoadjuvant chemoradiotherapy (NACRT) and outcomes in rectal cancer. METHODSPatients undergoing NACRT and surgical resection for rectal cancer in a tertiary referral centre between 2002-2011 were identified. Pre-treatment tumour biopsies were analysed for CIMP status (high, intermediate or low) using methylation specific PCR. KRAS and BRAF status were also determined using pyrosequencing analysis. Clinical information was extracted from case records and cancer services databases. Response to radiotherapy was measured by tumour regression scores determined upon histological examination of the resected specimen. The relationship between these molecular features, response to NACRT and oncological outcomes were analysed. RESULTSThere were 160 patients analysed with a median follow-up time of 46.4 mo. Twenty-one (13%) patients demonstrated high levels of CIMP methylation (CIMP-H) and this was significantly associated with increased risk of extramural vascular invasion (EMVI) compared with CIMP-L [8/21 (38%) vs 15/99 (15%), P = 0.028]. CIMP status was not related to tumour regression after radiotherapy or survival, however EMVI was significantly associated with adverse survival (P < 0.001). Intermediate CIMP status was significantly associated with KRAS mutation (P = 0.01). There were 14 (9%) patients with a pathological complete response (pCR) compared to 116 (73%) patients having no or minimal regression after neoadjuvant chemoradiotherapy. Those patients with pCR had median survival of 106 mo compared to 65.8 mo with minimal regression, although this was not statistically significant (P = 0.26). Binary logistic regression analysis of the relationship between EMVI and other prognostic features revealed, EMVI positivity was associated with poor overall survival, advanced “T” stage and CIMP-H but not nodal status, age, sex, KRAS mutation status and presence of local or systemic recurre

关键词： Rectal cancer CpG islands Methylation

Global Alliance against Chronic Respiratory Diseases symposium on air pollution:overview and highlights

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Chinese Medical Journal 2020年第13期133卷 1546-1551页

作者： dean E.Schraufnagel Division of Pulmonary Critical CareSleepand AllergyDepartment of Medicine M/C 719University of Illinois at Chicago840 S.Wood St.ChicagoIL 60612USA

A 1-day symposium before the annual meeting of the Global Alliance against Chronic Respiratory Diseases,gathered authorities and researchers from around the world to discuss the impact of air pollution on human and planetary *** quality is a high priority for Global Alliance against Chronic Respiratory Diseases and China,the host *** article presents a summary,commentary,and amplification of the 17 *** pollution is closely linked with global warming and harms most body systems even at levels below international *** about the genetic,cellular,and metabolic effects of exposure to air pollution is important for better understanding of individual responses and even potential therapeutic *** air pollution at its source leads to prompt and important benefits and should be the first priority for political and public action.

关键词： Air pollution Global Alliance against Chronic Respiratory Diseases Symposium World Health Organization

Sustainability in Data and Food

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Data Intelligence 2019年第1期1卷 43-57页

作者： dean Allemang Working Ontologist LLC.55 W Livingston AvenueColumbusOH 43215USA

As the world population continues to increase,world food production is not keeping *** means that to continue to feed the world,we will need to optimize the production and utilization of food around the *** of a process on a global scale requires massive *** is no exception,but also brings its own unique issues,based on how wide spread agricultural data are,and the wide variety of data that is relevant to optimization of food production and *** suggests that we need a global data ecosystem for agriculture and *** an ecosystem already exists to some extent,made up of data sets,metadata sets and even search engines that help to locate and utilize data sets.A key concept behind this is sustainability-how do we sustain our data sets,so that we can sustain our production and distribution of food?In order to make this vision a reality,we need to navigate the challenges for sustainable data management on a global *** from the current state of practice,how do we move forward to a practice in which we make use of global data to have an impact on world hunger?In particular,how do we find,collect and manage the data?How can this be effectively deployed to improve practice in the field?And how can we make sure that these practices are leading to the global goals of improving production,distribution and sustainability of the global food supply?These questions cannot be answered yet,but they are the focus of ongoing and future research to be published in this journal and elsewhere.

关键词： Agriculture Data science Data sharing Sustainability Vocabulary management

超高强耐磨钢NM500多层多道对接接头残余应力的研究

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机械工程学报 2024年第4期60卷 335-344页

作者：胡龙刘红艳成慧梅陈维奇冯广杰叶延洪邓德安重庆大学材料科学与工程学院重庆400044 河钢集团邯钢公司邯郸056003

基于SYSWELD软件平台,以新型NM500钢的多层多道对接接头为研究对象,开发一种考虑固态相变的“热-冶金-力学”耦合计算方法来模拟对接接头的温度场、组织体积百分数以及焊接残余应力。同时,采用光学显微镜观察对接接头的显微组织,采用显... 详细信息

基于SYSWELD软件平台,以新型NM500钢的多层多道对接接头为研究对象,开发一种考虑固态相变的“热-冶金-力学”耦合计算方法来模拟对接接头的温度场、组织体积百分数以及焊接残余应力。同时,采用光学显微镜观察对接接头的显微组织,采用显微硬度计测量接头硬度分布,以及采用小孔法测量对接接头表面残余应力。数值模拟结果与试验测量结果的比较表明:使用实际焊接热输入模拟得到的对接接头超过冶金熔点以上的温度区域与实际焊接接头熔化区吻合较好;纵向残余应力峰值位于紧邻热影响区的母材上,其值约为1600 MPa,与母材的常温屈服极限相当;横向残余应力在焊缝厚度方向呈现“拉-压-拉”的分布形态。总体而言,数值模拟得到纵向及横向残余应力的大小及分布与试验测量结果吻合较好,验证了“热-冶金-力学”耦合计算方法的有效性。基于数值模拟结果,探讨了NM500钢多层多道对接接头焊接残余应力的形成机理。

关键词：耐磨钢焊接固态相变残余应力数值模拟

丹江口水库特大桥钢-混凝土组合围堰施工技术

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桥梁建设 2024年第3期54卷 135-141页

作者：于得安姜永生周范武高海涛中交第二航务工程局有限公司湖北武汉430040

丹江口水库特大桥为主跨760 m双塔双索面部分地锚式混合梁斜拉桥,主墩采用整体式承台+大直径群桩基础,主墩承台平面为八边形,尺寸为48 m(横桥向)×26 m(顺桥向)×6.5 m(高),承台底部设置26根直径2.8 m钻孔灌注桩。为适应库区倾斜裸岩地... 详细信息

丹江口水库特大桥为主跨760 m双塔双索面部分地锚式混合梁斜拉桥,主墩采用整体式承台+大直径群桩基础,主墩承台平面为八边形,尺寸为48 m(横桥向)×26 m(顺桥向)×6.5 m(高),承台底部设置26根直径2.8 m钻孔灌注桩。为适应库区倾斜裸岩地形,降低施工难度及施工费用,主墩围堰采用下部混凝土挡墙围堰+上部单壁钢围堰的钢-混凝土组合围堰方案。下部混凝土挡墙围堰采用衡重式挡墙围堰及抗滑桩挡墙围堰,高3~11 m;上部单壁钢围堰分块设置,其长度与下部挡墙围堰匹配,高8 m。钢-混凝土组合围堰施工时,首先根据地形条件进行挡墙围堰分段,之后采用破碎锤开挖混凝土挡墙围堰基础;混凝土挡墙围堰采用分层、分块施工,顶部圈梁与挡墙围堰同步浇筑;上部单壁钢围堰采用加工厂预制+现场分块安装,并预留竖向型钢接长部分;最后进行单壁钢围堰底部及组合围堰山体连接处止水混凝土施工,完成钢-混凝土组合围堰施工。钢-混凝土组合围堰的应用,有效缩短了基础施工周期,降低了围堰施工难度及施工费用,经济合理,满足现场施工各项要求。

关键词：部分地锚式斜拉桥倾斜裸岩钢-混凝土组合围堰混凝土挡墙围堰单壁钢围堰施工技术

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中学物理实验改进的问题与策略探析

物理教学 2024年第4期46卷 22-25,28页

作者：郑柔纯麦宜平李德安华南师范大学物理与电信工程学院广东510006

基于目前实验改进中存在的问题,提出实验改进与创新的四个策略:生活化实验可作为专业常规实验的拓展与补充;数字化实验应发挥其在实验改进中的辅助作用;集成化实验可朝着积件式方向发展;直观化实验应重视学生概念、规律建构的过程。

关键词：实验改进存在问题改进与创新策略探析

基于图像三维重建的隧道喷射混凝土回弹率测定方法研究

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建筑科学与工程学报 2024年第2期41卷 106-114页

作者：阳军生王子建汤宇梁雄刘德安中南大学土木工程学院湖南长沙410075 湖南航天建筑工程有限公司湖南长沙410205 中铁五局集团第一工程有限责任公司长沙湖南410021

针对复杂隧道施工环境下如何快速、准确测量喷射混凝土回弹率的问题,基于机器视觉三维重建技术中的主要理论和算法,提出了一种新的隧道喷射混凝土回弹率测定方法。该方法通过坐标标记版和手持相机快速采集图像,基于运动恢复结构(SFM)算... 详细信息

针对复杂隧道施工环境下如何快速、准确测量喷射混凝土回弹率的问题,基于机器视觉三维重建技术中的主要理论和算法,提出了一种新的隧道喷射混凝土回弹率测定方法。该方法通过坐标标记版和手持相机快速采集图像,基于运动恢复结构(SFM)算法、基于面片的密集匹配(PMVS)算法与三角剖分原则实现隧道实际开挖轮廓及初支内轮廓的三维曲面网格模型的建立;通过网格射线法,将隧道实际开挖轮廓与初支内轮廓三维网格模型进行空间差值求解,获得初支实际有效的喷射混凝土体积;最后,结合实际喷射混凝土总用量,完成喷射混凝土回弹量的测定,并以郑万高铁巴东隧道为依托进行现场试验与应用。结果表明:所提方法测得的喷射混凝土回弹率比传统现场称重法测试结果更为合理,准确性更高,说明该方法能够较好地实现喷射混凝土回弹率的测试;在现场应用中,结合喷射混凝土回弹率的测试结果提出的降低回弹率的施工质量控制建议,现场采用后施工良好,保证了隧道施工质量;该测定方法简便高效、成本低、不干扰施工,具有较好的工程应用价值。

关键词：隧道喷射混凝土回弹率三维图像点云图像三维重建

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疗愈创伤:残疾人社会创业的实践路径

残疾人研究 2024年第1期 45-54页

作者：杜德安余艳萍吉林大学哲学社会学院长春130000 武汉理工大学法学与人文社会学院武汉430070 武汉理工大学中国残疾人事业发展研究中心武汉430070

引入创伤视角,通过对两个社会创业实践的案例研究发现,残疾人社会创业的实践路径可以用疗愈创伤来概括,即治疗创伤促进创伤愈合的过程。首先,治疗创伤是残疾人社会创业的动机,残疾人社会创业缘起于治疗个体、群体与社会创伤的动机;其次... 详细信息

引入创伤视角,通过对两个社会创业实践的案例研究发现,残疾人社会创业的实践路径可以用疗愈创伤来概括,即治疗创伤促进创伤愈合的过程。首先,治疗创伤是残疾人社会创业的动机,残疾人社会创业缘起于治疗个体、群体与社会创伤的动机;其次,残疾人社会创业的过程包括机会识别、资源整合与合法性获取三个方面,残疾社会企业家通过考量创伤与优势匹配识别创业机会,通过链接社会支持网络与吸纳残疾人群体整合资源,通过满足外部需求与激发积极情绪获取合法性;最后,创伤愈合是残疾人社会创业的效应,残疾人的社会创业实践最终实现了个体、群体与社会创伤愈合的多元价值。

关键词：社会创业残疾人创伤视角疗愈

Genetics and genomics of prostate cancer

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Asian Journal of Andrology 2013年第3期15卷 309-313页

作者： Michael dean Hong LOU Cancer and Inflammation Program National Cancer Institute National Institutes of Health Frederick MD 21702 USA Basic Science Program SAIC-Frederick Nationa Cancer Institute National Institutes of Health Frederick MD 21702 USA

Prostate cancer （PCa） is one of the most common malignancies in the world with over 890 000 cases and over 258 000 deaths worldwide each year. Nearly all mortalities from PCa are due to metastatic disease, typically through tumors that evolve to be hormone-refractory or castrate-resistant. Despite intensive epidemiological study, there are few known environmental risk factors, and age and family history are the major determinants. However, there is extreme heterogeneity in PCa incidence worldwide, suggesting that major determining factors have not been described. Genome-wide association studies have been performed and a considerable number of significant, but low-risk loci have been identified. In addition, several groups have analyzed PCa by determination of genomic copy number, fusion gene generation and targeted resequencing of candidate genes, as well as exome and whole genome sequencing. These initial studies have examined both primary and metastatic tumors as well as murine xenografts and identified somatic alterations in TP53and other potential driver genes, and the disturbance of androgen response and cell cycle pathways. It is hoped that continued characterization of risk factors as well as gene mutation and misregulation in tumors will aid in understanding, diagnosing and better treating PCa.

关键词： androgen receptor cancer progression chromatin remodeling metastasis prostate cancer (PCa) risk factor somaticmutation tumor heterogeneity