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Relationship between oxidative stress and hepatic glutathione levels in ethanol-mediated apoptosis of polarized hepatic cells

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World Journal of Gastroenterology 2009年第21期15卷 2609-2616页

作者： Benita L McVicker Pamela L Tuma Kusum K Kharbanda Serene ML Lee dean J Tuma Liver Study Unit Department of Veterans Affairs Medical Center and Department of Internal Medicine and Biochemistry & Molecular Biology University of Nebraska Medical Center Department of Biology The Catholic University of America Department of Internal Medicine and Biochemistry & Molecular Biology University of Nebraska Medical Center

AIM： To investigate the role of reactive oxygen species （ROS） in ethanol-mediated cell death of polarized hepatic （WlF-B） cells.METHODS： In this work, WIF-B cultures were treated with pyrazole （inducer of cytochrome P4502E1, CYP2E1） and/or L-buthionine sulfoximine （BSO）, a known inhibitor of hepatic glutathione （GSH）, followed by evaluation of ROS production, antioxidant levels, and measures of cell injury （apoptosis and necrosis）.RESULTS： The results revealed that ethanol treatment alone caused a significant two-fold increase in the activation of caspase-3 as well as a similar doubling in ROS. When the activity of the CYP2E1 was increased by pyrazole pretreatment, an additional two-fold elevation in ROS was detected. However, the CYP2EIrelated ROS elevation was not accompanied with a correlative increase in apoptotic cell injury, but rather was found to be associated with an increase in necrotic cell death. Interestingly, when the thiol status of the cells was manipulated using BSO, the ethanol-induced activation of caspase-3 was abrogated. Additionally, ethanol-treated cells displayed enhanced susceptibility to Fas-mediated apoptosis that was blocked by GSH depletion as a result of diminished caspase-8 activity.CONCLUSION： Apoptotic cell death induced as a consequence of ethanol metabolism is not completely dependent upon ROS status but is dependent on sustained GSH levels,

关键词： WIF-B cells Alcohol Fas/CD95 Glutathi-one Caspase

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Asponchimides A−E: new enantiomeric N-acetyldopamine trimers from Aspongopus chinensis

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Chinese Journal of Natural Medicines 2023年第11期21卷 859-867页

作者： NIE Jinchun MEI Fang ZHENG Yueyuan WEN Qiuyi LI Zhenwei ZHANG Daidi LI Wei GUO dean School of Pharmaceutical Sciences Southern Medical UniversityGuangzhou 510515China Zhongshan Institute for Drug Discovery Shanghai Institute of Materia MedicaChinese Academy of SciencesZhongshan 528400China

Five new racemic N-acetyldopamine (NADA) trimers, asponchimides A−E ( 1 − 5 ), were isolated from Aspongopus chinensis, a prominent traditional Chinese medicinal insect employed for alleviating pain, treating indigestion, and addressing kidney ailments. Compounds 1 − 5 were successfully resolved by chiral high-performance liquid chromatography (HPLC), yielding five pairs of enantiomers: (+)- and (−)-asponchimides A−E ( 1a / 1b − 5a / 5b ). Their structural identities were discerned by extensive spectroscopic analyses, including high-resolution mass spectrometry (HRMS), ultraviolet-visible (UV-Vis) spectroscopy, infrared (IR) spectroscopy, and nuclear magnetic resonance (NMR), and their absolute configurations were determined by electronic circular dichroism (ECD) calculations. Compounds 1 − 5 are pioneering instances of NADA trimers featuring a Δ7 double bond. When subjected to a series of bioassays, a majority of the compounds exhibited weak inhibitory activity against nitric oxide (NO) production in LPS-induced RAW 264.7 cells.

关键词： Aspongopus chinensis N-acetyldopamine trimer ECD calculations NO inhibitory activity

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Kabuki-Syndrome and Congenital Heart Disease-A Twenty-Year Institutional Experience

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Congenital Heart Disease 2021年第2期16卷 171-181页

作者： Reghan Conrey Sebastian Tume Carlos Bonilla-Ramirez Seema Lalani dean McKenzie Marc Anders Baylor College of Medicine HoustonUSA Section of Critical Care Medicine Department of PediatricsBaylor College of MedicineTexas Children’s HospitalHoustonUSA Division of Congenital Heart Surgery Texas Children’s HospitalDepartment of SurgeryBaylor College of MedicineHoustonUSA Department of Molecular and Human Genetics Baylor College of MedicineHoustonUSA

Background:Patients with genetic syndromes who undergo surgery to correct congenital heart defects can be at risk for increased morbidity or *** outcomes and postoperative courses following congenital heart surgery in patients with Kabuki-Syndrome(KS)have not been well ***:The purpose of this study was to describe the postoperative courses and associated outcomes in the largest set of KS patients undergoing congenital heart surgery to ***:Patients with a confirmed molecular diagnosis of KS and a diagnosis of a CHD admitted to Texas Children’s Hospital between January 1,2000 and January 1,2020 were included(n=20).Demographics and medical histories were collected from the hospitals’electronic health ***:Of 20 patients identified with KS and a CHD,15 required surgical correction of their congenital cardiac *** age and weight at the time of surgery was 2 months and 4.1 kg,*** duration of hospital stay was 49 days for all surgeries and 151 days for the Norwood *** infections and pleural effusions were detected and treated in 45.8%and 50%of patients,*** was no in-hospital mortality for any *** follow up time was 5.6 years;survival at 6 years was 94%.Conclusions:Although KS patients seem to be at increased risk for a more complicated,prolonged postoperative course than that of patients without a genetic syndrome,patients with a diagnosis of a CHD and KS do not appear to be at increased risk of mortality following congenital heart surgery.

关键词： Kabuki syndrome genetic disorder congenital heart disease survival outcome pediatric

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The use of animal sensor data for predicting sheep metabolisable energy intake using machine learning

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Information Processing in Agriculture 2021年第4期8卷 494-504页

作者： Hari Suparwito dean T.Thomas Kok Wai Wong Hong Xie Shri Rai Murdoch University MurdochWA 6150Australia CSIRO Agriculture and Food Private Bag 5WembleyWA 6913Australia

The use of sensors for monitoring livestock has opened up new possibilities for the management of livestock in extensive grazing *** work presented in this paper aimed to develop a model for predicting the metabolisable energy intake(MEI)of sheep by using temperature,pitch angle,roll angle,distance,speed,and grazing time data obtained directly from wearable sensors on the sheep.A Deep Belief Network(DBN)algorithm was used to predict MEI,which to our knowledge,has not been attempted *** results demonstrated that the DBN method could predict the MEI for sheep using sensor data *** mean square error(MSE)values of 4.46 and 20.65 have been achieved using the DBN model for training and testing datasets,*** also evaluated the influential sensor data variables,i.e.,distance and pitch angle,for predicting the *** study demonstrates that the application of machine learning techniques directly to on-animal sensor data presents a substantial opportunity to interpret biological interactions in grazing systems directly from sensor *** expect that further development and refinement of this technology will catalyse a step-change in extensive livestock management,as wearable sensors become widely used by livestock producers.

关键词： Energy intake Livestock behaviour Machine learning Predictions Sensor data

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The influence of chemical composition on models of Type Ia supernovae

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Frontiers of physics 2013年第2期8卷 168-188页

作者： Alan C. Calder Brendan K. Krueger Aaron P. Jackson dean M. Townsley Department of Physics Astronomy The State University of New York - Stony Brook Stony BrookUSA NY 11794 New York Center for Computational Sciences The State University of New York - Stony Brook Stony BrookUSA NY 11794 National Research Council Research Associateship Program and Laboratories for Computational Physics and Fluid Dynamics Naval Research Laboratory WashingtonUSA DC 20375 Department of Physics and Astronomy The University of Alabama TuscaloosaUSA AL 35487

Type Ia supernovae are bright stellar explosions distinguished by standardizable light curves that allow for their use as distance indicators for cosmological studies. Despite the highly successful use of these events in this capacity, many fundamental questions remain. Contemporary research inves- tigates how properties of the progenitor system that follow from the host galaxy such as composition and age influence the brightness of an event with the goal of better understanding and assessing the intrinsic scatter in the brightness. We provide an overview of these supernovae and proposed progenitor systems, all of which involve one or more compact stars known as white dwarfs. We describe contemporary research investigating how the composition and structure of the progenitor white dwarf systematically influences the explosion outcome assuming the progenitor is a single white dwarf that has gained mass from a companion. We present results illustrating some of these systematic effects from our research.

关键词： hydrodynamics nuclear reactions nucleosynthesis abundances stars: supernovae:general stars: white dwarfs

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Typical Refractory Wear Phenomena in Copper Vessels and Novel Monitoring Technologies

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China's Refractories 2021年第2期30卷 16-21页

作者： dean GREGUREK Katja REINHARTER Juergen SCHMIDL Christine WENZL Alfred SPANRING RHI Magnesita Leoben 8700Austria RHI Magnesita Wien 1120Austria

Copper smelting furnaces are typically lined with magnesia-chromite refractories,which are exposed to multiple and complex *** selection of the processing route,furnace type,and slag system is dictated by the specific ore type available;which will determine the individual refractory *** paper evaluates the common refractory wear mechanisms as observed in the copper Peirce-Smith converter and in the copper anode *** chemical factors include corrosion caused by fayalite type slag and sulphur supply,as well as by Cu-oxide *** in the temperature during the furnace operation(thermal shock)create stresses in the brick lining which can only be absorbed to a limited *** factors include erosion,caused primarily by the movement of the metal bath,slag and charging material,as well as stresses in the brickwork due to ***,improper lining procedures can also affect the service *** these wear parameters lead to severe degeneration of the brick microstructure and a decreased lining life,and in the worst case overheated furnace structures and possibly dangerous hot spots or even ***,a detailed investigation and understanding of the wear mechanisms through“post-mortem studies”together with thermochemical calculations by FactSageTM software is an important prerequisite for the refractory *** on these research results,combined with specific process knowledge,appropriate brick lining solutions for copper processing furnaces can be *** addition to the described efforts to investigate refractory wear and optimise lining qualities,it is also essential to monitor the process and the effect on the refractories to further improve both safety and *** this purpose,technologies using sensors and novel digital solutions can be applied.

关键词： wear phenomena copper vessel monitoring technologies

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Oral immune regulation using colitis extracted proteins for treatment of Crohn's disease: Results of a phase Ⅰ clinical trial

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World Journal of Gastroenterology 2005年第20期11卷 3105-3111页

作者： Eran Israeli Eran Goldin Oren Shibolet Athalia Klein Nilla Hemed dean Engelhardt Elazar Rabbani Yaron Ilan Gastroenterology and Liver Units Department of Medicine Hebrew University-Hadassah Medical Center Jerusalem Israel Enzo Biochem New York NY USA

AIM: To evaluate safety and possible efficacy of induction of oral immune regulation using colitis extracted proteins (CEP) in Crohn's disease (CD) subjects. METHODS: Ten CDs were treated orally with autologous CEP thrice weekly for 16 wk. Subjects were monitored for CDAI and IBDQ. Immune modulatory effect was assessed by T-lymphocyte FACS analysis, CEP-specific IFNγ ELISPOT assay and cytokine levels. RESULTS: Induction of oral immune regulation significantly ameliorated disease activity. All (10/10) subjects had clinical response (CDAI≤70) and 7/10 achieved clinical remission (CDAI≤150). Significant increase in mean IBDQ score was noted (134±9 vs 164±12). No treatment-related adverse events were noted. High levels of CEP-specific IFNγ spot forming colonies were detected in five subjects prior to treatment and in all five, a marked decrease was observed. The CD4+/CD8+ lymphocyte ratio and peripheral NKT cell numbers increased significantly, in 7/10 and in 5/10 subjects, respectively. Significant increase in serum IL-10 and IL-4 levels was observed in 7/10 subjects during treatment period. CONCLUSION: Immune regulation via oral administration of CEP is a safe and possibly effective treatment for subjects with moderate CD and may provide means of antigen-specific immune modulation.

关键词： Crohn's disease Colitis extracted proteins

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A Longitudinal Study of Human Exposure to Potential Nuclear Power Plant Risk

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International Journal of Disaster Risk Science 2015年第4期6卷 399-414页

作者： dean Kyne Jason T.Harris Department of Sociology and Anthropology The University of Texas Rio Grande Valley School of Health Sciences Purdue University

This study constructs a potential risk index(PRI) for the 65 U.S.-based commercial nuclear power plant(NPP) sites in relation to their surrounding populations. Four risk levels are defined: low risk, moderate risk,high risk, and very high risk. Discrepancies that exist in the sociodemographic characteristics of the host communities’ populations are examined as sorted by risk-level *** is found that a greater percentage of minority groups are exposed to the highest levels of risk. In addition, percent 'Hispanic' and percent 'Other,'a grouping that includes multiracial, mixed, interracial, as well as Hispanic and Latino groups(for example, Mexican, Puerto Rican,Cuban, or Spanish) are categories that show the greatest percent change in both the period 1990–2000 and2000–2010.

关键词： Environmental justice Nuclear power induced disaster Nuclear power plant Potential risk index

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Myokine Response to Blood-Flow Restricted Resistance Exercise in Younger and Older Males in an Untrained and Resistance-Trained State:A Pilot Study

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Journal of Science in Sport and Exercise 2023年第3期5卷 203-217页

作者： dean M.Cordingley Judy E.Anderson Stephen M.Cornish Applied Health Sciences University of ManitobaWinnipegMB R3T 2N2Canada Pan Am Clinic Foundation 75 Poseidon BayWinnipegMB R3M 3E4Canada Faculty of Science University of ManitobaWinnipegMBCanada Faculty of Kinesiology and Recreation Management University of Manitoba110 Frank Kennedy CentreWinnipegMB R3T 2N2Canada Centre for Aging University of ManitobaWinnipegMB R3T 2N2Canada

Purpose The purpose of this study was to examine the response of myokines to blood-flow restricted resistance-exercise(BFR-RE)in younger and older males before and after completing a 12-week resistance-training *** There were 8 younger(24.8±3.9 yrs)and 7 older(68.3±5.0 yrs)untrained male participants completed this *** and maximal strength(1RM)measurements were collected before and after a 12-week,supervised,progres-sive full-body resistance-training *** well,an acute bout of full-body BFR-RE was performed with venipuncture blood samples collected before and immediately following the BFR-RE,followed by sampling at 3,6,24 and 48 *** The 12-week training program stimulated a 32.2%increase in average strength and 30%increase in strength per kg of fat free *** response of particular myokines to the acute bout of BFR-RE was influenced training status(IL-4,untrained=78.1±133.2 pg/mL ***=59.8±121.6 pg/mL,P=0.019;IL-7,untrained=3.46±1.8 pg/mL ***=2.66±1.3 pg/mL,P=0.047)or both training and age(irisin,P=0.04;leukemia inhibitory factor,P<0.001).As well,changes in strength per kg of fat free mass were correlated with area under the curve for IL-4(r=0.537;P=0.039),IL-6(r=0.525;P=0.044)and LIF(r=−0.548;P=0.035)in the untrained *** This study identified that both age and training status influence the myokine response to an acute bout of BFR-RE with the release of IL-4,IL-6 and LIF in the untrained state being associated with changes in strength per kg of fat free mass.

关键词： Hypertrophy Myokine Exercise immunology BFR Aging

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合成MRI定量参数在PI-RADS评分3~4分前列腺病变诊断中的应用

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中国中西医结合影像学杂志 2024年第4期22卷 445-448,479页

作者：桑节峰韩磊李大鹏祁德安孟钢张虎江苏省连云港市赣榆区人民医院影像科江苏连云港222100 南京医科大学第二附属医院影像科江苏南京210038 江苏省连云港市赣榆区人民医院泌尿外科江苏连云港222100

目的:分析合成MRI定量参数对前列腺成像报告和数据系统(PI-RADS)评分3~4分前列腺病变的评估价值,为临床鉴别诊断前列腺癌提供参考。方法:收集60例PI-RADS评分3~4分前列腺病变患者作为研究对象,其中前列腺癌38例(前列腺癌组),前列腺炎10... 详细信息

目的:分析合成MRI定量参数对前列腺成像报告和数据系统(PI-RADS)评分3~4分前列腺病变的评估价值,为临床鉴别诊断前列腺癌提供参考。方法:收集60例PI-RADS评分3~4分前列腺病变患者作为研究对象,其中前列腺癌38例(前列腺癌组),前列腺炎10例(前列腺炎组)和前列腺增生12例(前列腺增生组)。3组均行合成MRI检查并获得相关参数[T_(1)、T_(2)、质子密度(PD)、ADC值]。以术后病理检查结果为金标准,分析合成MRI定量参数对PI-RADS评分3~4分前列腺病变的诊断价值。结果:3组的T_(1)、T_(2)、PD及ADC值比较差异均有统计学意义(均P0.7,评估价值中等;T_(1)、T_(2)、PD值鉴别诊断前列腺癌与前列腺增生的AUC>0.7,评估价值中等;ADC值鉴别诊断前列腺癌与前列腺增生的AUC>0.9,评估价值较高。结论:合成MRI定量参数对PI-RADS评分3~4分前列腺病变评估价值较高,能为临床鉴别诊断前列腺癌提供一定依据。

关键词：前列腺肿瘤前列腺增生前列腺炎合成磁共振成像前列腺成像报告和数据系统

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