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System control-mediated drug delivery towards complex systems via nanodiamond carriers

International Journal of Smart and Nano Materials 2010年第1期1卷 69-81页

作者： dean Ho Chih-Ming Ho Department of Biomedical Engineering Department of Mechanical Engineering Northwestern UniversityEvanstonIL 60208USA Robert H.Lurie Comprehensive Cancer Center Northwestern UniversityChicagoIL 60611USA Department of Mechanical and Aerospace Engineering University of CaliforniaLos AngelesLACA 90095USA Center for Cell Control A NIH Nanomedicine Development CenterLos AngelesCA 90095USA

Cells represent the basic units of life and contain an intertwined network of signaling and regulatory circuitries that drive the processes of *** processes include the mediation of mechano-sensation,onset of and protection against disease,inflammation,and *** the network of bio-complex systems,each pathway interacts nonlinearly with others through different molecular *** a result,specific functionalities can not be simply linked to the cellular molecules in isolation.A complex system generally possesses very rich information content that can be characterized by the following features:(i)they contain a large number of building blocks;(ii)their interactions among building blocks and with their environment;(iii)they display organization without an external organizing principle being applied;and(iv)they exhibit adaptability and *** properties account for the innate intelligence of biology and its ability to regulate its homeostatic ***,this same complexity underlies,in cancer for example,challenges towards disease management,as the addressing of singular pathways with therapeutic compounds is not ***,combinatorial therapy often serves as a key strategy towards tumor *** iterative searching for optimized therapeutic combinations is indeed a daunting,if not preclusive task,we introduce the feedback system control(FSC)scheme,which may serve as a clinically relevant approach,provided a translational approach towards drug delivery is *** to their innate biocompatibility,which has been comprehensively observed,as well as their ability to delivery virtually any type of therapeutic in a sustained fashion due to their unique surface properties,nanodiamonds may serve as a foundation for nanoenabled combinatorial therapy.

关键词： bio-complex system feedback system control drug delivery,nanodiamond combinatorial medicine signaling network nanomedicine

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Adding fifth dimension to optoacoustic imaging: volumetric time-resolved spectrally enriched tomography

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Light(Science & Applications) 2014年第1期3卷 330-334页

作者： Xose Luis dean-Ben Daniel Razansky Institute for Biological and Medical Imaging(IBMI) Technical University of Munich and Helmholtz Center Munich85764 NeuherbergGermany

Optoacoustics provides a unique set of capabilities for bioimaging,associated with the intrinsic combination of ultrasound-and light-related advantages,such as high spatial and temporal resolution as well as powerful spectrally enriched imaging contrast in biological *** demonstrate here,for the first time,the acquisition,processing and visualization of five-dimensional optoacoustic data,thus offering unparallel imaging capacities among the current bioimaging *** newly discovered performance is enabled by simultaneous volumetric detection and processing of multispectral data and is further showcased here by attaining time-resolved volumetric blood oxygenation maps in deep human vessels and real-time tracking of contrast agent distribution in a murine model in vivo.

关键词： biophotonics multispectral optoacoustic imaging photoacoustic tomography

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Curbing the burden of lung cancer

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Frontiers of Medicine 2016年第2期10卷 228-232页

作者： Alexandra Urman H. dean Hosgood Department of Oncology Montefiore Medical Center Bronx NY 10461 USA Department of Epidemiology and Population Health AlbertEinstein College of Medicine Bronx NY 10461 USA

Lung cancer contributes substantially to the global burden of disease and healthcare costs. New screening modalities using low-dose computerized tomography are promising tools for early detection leading to curative surgery. However, the screening and follow-up diagnostic procedures of these techniques may be costly. Focusing on prevention is an important factor to reduce the burden of screening, treatment, and lung cancer deaths. The International Agency for Research on Cancer has identified several lung carcinogens, which we believe can be considered actionable when developing prevention strategies. To curb the societal burden of lung cancer, healthcare resources need to be focused on early detection and screening and on mitigating exposure（s） of a person to known lung carcinogens, such as active tobacco smoking, household air pollution （HAP）, and outdoor air pollution. Evidence has also suggested that these known lung carcinogens may be associated with genetic predispositions, supporting the hypothesis that lung cancers attributed to differing exposures may have developed from unique underlying genetic mechanisms attributed to the exposure of interest. For instance, smoking- attributed lung cancer involves novel genetic markers of risk compared with HAP-attributed lung cancer. Therefore, genetic risk markers may be used in risk stratification to identify subpopulations that are at a higher risk for developing lung cancer attributed to a given exposure. Such targeted prevention strategies suggest that precision prevention strategies may be possible in the future; however, much work is needed to determine whether these strategies will be viable.

关键词： lung cancer screening risk factors environmental

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Advances in alimentary tract imaging

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World Journal of Gastroenterology 2006年第20期12卷 3139-3145页

作者： dean DT Maglinte Kumaresan Sandrasegaran Mark Tann Department of Radiology Indiana University School of Medicine IndianapolisUnited States

in imaging techniques are changing the way radiologists undertake imaging of the gastrointestinal tract and their ability to answer questions posed by surgeons. In this paper we discuss the technological improvements of imaging studies that have occurred in the last few years and how these help to better diagnosing alimentary tract disease.

关键词： Imaging Alimentary tract

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In-office balloon dilation of the Eustachian tube under local anesthesia: A retrospective review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2019年第3期5卷 143-147页

作者： Marc dean Texas Tech University Health Science Center LubbockTXUSA Vitruvio Institute of Medical Advancement DallasTXUSA

Objective:To study the effectiveness and feasibility of in office balloon dilation of the Eustachian tube(BDET)utilizing a novel anesthetic *** design:retrospective ***:Retrospective chart review looking at the tolerability and effectiveness of standalone BDET in an office setting utilizing a novel topical anesthesia protocol in 33 patients with Eustachian tube dysfunction as defined by an ETDQ-7 score greater than 2.2 and type B or C tympanograms for greater than 3 months despite maximal medical management,including at least 4 weeks of nasal ***:BDET in the office was well tolerated with 94%(31/33)of patients completing the procedure as *** adverse effects or complications were reported;however,the planned dilation time was cut short in one case due to significant discomfort and aborted prior to dilation in another due significant *** normalized at six weeks in 87.1%(27/31)of patients who underwent ***:This study demonstrates that performing BDET in an office setting utilizing a local anesthesia protocol is feasible and effective when the unique barometric considerations of BDET are addressed.

关键词： Balloon dilatation Eustachian tube Local anesthesia In office Topical

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Pseudo feature point registration of pavement images

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Journal of Traffic and Transportation Engineering(English Edition) 2018年第4期5卷 254-267页

作者： dean Wright Ginger Lehmann UK Leamington Spa CV31 1PR UK

Over the last 20 years road pavement imaging has become a routine output from annual pavement assessment survey regimes across the world. Hitherto the traditional use of road pavement images in road condition assessment has been crack detection, rather than direct analysis of image features such as aggregate loss, changes in surface texture or deterioration of road markings. Any attempt to assess pavement condition change from features in a sequence of such images captured months or years apart requires image registration. A method for registering road pavement images is presented that makes use of an affine transformation based on pseudo-features within images. An affine trans- formation is considered suitable for registering road pavement images because of the linear way in which pavements are surveyed. Pseudo feature points are found using a modified corner detector, and then matching points between reference and template im- ages established via a correlation analysis of pavement image texture. With 4 such points it is possible to establish an affine transformation between the images. The method is tested on pavement images captured on three UK sites between winter 2014/15 and 2015/16. The method successfully registered 98% of images captured on sites typical of the UK＇s strategic road network, and 65% of images captured on a site typical of the UK＇s minor road network.

关键词： Pavement engineering Pavement texture Image registration Pseudo feature point

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ＯＰＥＲＡＴＯＲ－ＳＰＬＩＴＴＩＮＧＭＥＴＨＯＤＳＦＯＲＴＨＥＳＩＭＵＬＡＴＩＯＮＯＦＢＩＮＧＨＡＭＶＩＳＣＯ－ＰＬＡＳＴＩＣＦＬＯＷ

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Chinese Annals of Mathematics,Series B 2002年第2期23卷 187-204页

作者： E.J.dean R.GLOWINSKI DepartmentofMathematicsUniversitofHouston Departmentof MathematicsUniversity of Houston 651 P.G.HoffmanHallHoustonTX 77204-3008US

This article discusses computational methods for the numerical simulation of unsteady Bingham visco-plastic flow. These methods are based on time-discretization by operator-splitting and take advantage of a characterization of the solutions involving some kind of Lagrange multipliers. The full discretization is achieved by combining the above operator-splitting methods with finite element approximations, the advection being treated by a wave-like equation 'equivalent' formulation easier to implement than the method of characteristics or high order upwinding methods. The authors illustrate the methodology discussed in this article with the results of numerical experiments concerning the simulation of wall driven cavity Bingham flow in two dimensions.

关键词： Bingham visco-plastic flow Operator-splitting methods Finite element

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超声背散射法在孕妇松质骨骨密度测量中的应用价值

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医学临床研究 2024年第2期41卷 185-187,191页

作者：白博周毓青他得安上海市长宁区妇幼保健院超声医学科上海200040 华东师范大学附属妇幼保健院超声医学科上海200040 复旦大学电子工程系上海200433

【目的】探讨超声背散射法在孕妇松质骨骨密度(BMD)测量中的应用价值。【方法】选取2017年6月至2018年7月在上海市长宁区妇幼保健院进行常规产检的235例孕妇,所有孕妇同时采用超声背散射法与超声透射法测量松质骨的BMD与超声传导速度(SO... 详细信息

【目的】探讨超声背散射法在孕妇松质骨骨密度(BMD)测量中的应用价值。【方法】选取2017年6月至2018年7月在上海市长宁区妇幼保健院进行常规产检的235例孕妇,所有孕妇同时采用超声背散射法与超声透射法测量松质骨的BMD与超声传导速度(SOS),比较两种方法测量结果的差异;根据孕周不同将所有孕妇分为早孕组(28周)三组,比较不同孕周孕妇超声背散射法测量的BMD与SOS。【结果】超声背散射法、超声透射法测量的孕妇BMD与SOS比较,差异无统计学意义(P>0.05)。早孕组超声背散射法所测BMD与SOS值明显高于中孕组与晚孕组(P<0.05),且中孕组明显高于晚孕组(P<0.05)。【结论】超声背散射法测量的BMD、SOS与超声透射法测量值比较,差异无统计学意义,可反映孕妇BMD随孕周的变化,可用于临床监测孕妇BMD。

关键词：孕妇松质骨/影像诊断骨密度

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Preparation of porous polyamide 6(PA6)membrane with copper oxide(CuO)nanoparticles selectively localized at the wall of the pores via reactive extrusion

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Nano Materials Science 2022年第2期4卷 169-177页

作者： Tianqi Liang Jie Liu Zhaoyang Wei dean Shi Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional MaterialsHubei Key Laboratory of Polymer MaterialsSchool of Materials Science and EngineeringHubei UniversityWuhan430062PR China

In this study,CuO nanoparticles are pre-modified with styrene-maleic anhydride copolymers(SMAs)of different molecular weights and MAH *** the pre-modified CuO nanoparticles(CuO-SMAs)are added to the PA6/SEBS(Styrene Ethylene Butylene Styrene copolymer)(40/60 wt/wt)polymer blends with a co-continuous *** SMA3(MAH=8 wt%,M_(n)=250000 g/mol)is used to modify CuO nanoparticles,and the grafting degree of SMA3 on the surface of CuO reaches 2.74 wt%,90.71%of the added mCuO-SMA3 nanoparticles can be located at the interface of PA6 and SEBS.A porous PA6 membrane with CuO nanoparticles located at the pore walls can be obtained after the SEBS phase is etched with *** catalytic reaction velocity constant(k)for the reduction of p-nitrophenol in NaBH_(4)solutions with the PA6/mCuO-SMA3 porous membrane can reach 1.0040 min^(-1).This work provides a feasible and straightforward method for the preparation of porous polymer membranes with functional nanoparticles located at the wall of the pores.

关键词： Co-continuous CuO nanoparticles Selective distribution Porous PA6 membrane Catalytic performance

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Evaluation of hydro-mechano-chemical behaviour of bentonite-sand mixtures

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第2期14卷 637-652页

作者： Wenjing Sun Cheng Liu Diansen Yang dean Sun Department of Civil and Energy Engineering College of Environmental Science and EngineeringDonghua UniversityShanghai201620China Institute for the Conservation of Cultural Heritage Shanghai UniversityShanghai200444China State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China Shanghai Construction Group Co. Ltd.Shanghai200080China Department of Civil Engineering School of Mechanics and Engineering ScienceShanghai UniversityShanghai200444China

Bentonite-sand mixtures are widely used in engineering barrier of deep geological disposal of high-level radioactive nuclear waste and anti-seepage barrier of civil geotechnical *** the action of groundwater solution infiltration and external stress,the hydro-mechanical(HM)behaviour of bentonitesand mixtures,*** swelling characteristics and permeability,will *** the anti-seepage and filtration effect is weakened or lost,the pollutants will spread to the ***,it is necessary to study the swelling characteristics and permeability of bentonite-sand mixtures under coupled mechanochemical(MC)effect and to establish corresponding prediction *** this reason,swelling tests under salt solution with different concentrations are conducted on pure bentonite and its mixtures with 30%,70%and 90%sand contents,the compression tests are carried out on saturated samples,and the saturated permeability coefficient k of the sample under each load is calculated by Terzaghi’s one-dimensional consolidation *** concepts of true effective stress pe,montmorillonite void ratio em and critical sand content as are introduced to determine the em-pe relationship and finally the k-em relationship of bentonite-sand *** is found that when the sand content aas,the em-pe relationship of the mixture is linear and independent of the salt solution concentration,and when a>as,the em-pe relationship of bentonite-sand mixture is bi-linear with the true effective deviatoric stress pesa as the *** addition,the em-k relationship also shows the linear trend when aas,and the slope of the line increases with the increase of the salt solution *** a>as,the k-em relationship will deviate from the linear ***,the larger the sand content is,the farther the deviation *** the basis of summing the regularity,a model for predicting the HM behaviour of bentonite-sand mixture under the coupled MC effect is proposed.B

关键词： Bentonite-sand mixture Hydro-mechano-chemical(HMC)behaviour Salt solution True effective stress

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