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The compound(e)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one alleviates neuroinflammation and cognitive impairment in a mouse model of Alzheimer's disease

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neural Regeneration Research 2025年第11期20卷 3330-3344页

作者： Xueyan Liu Wei Wu Xuejuan Li Chengyan Wang ke Chai Fanru yuan Huijuan Zheng yuxing yao Chenlu Li Zu-Cheng ye Daijun Zha department of Medicinal Chemistry School of PharmacyFujian Medical UniversityFuzhouFujian ProvinceChina Fujian Provincial key Laboratory of Brain Aging and neurode.e.erative Diseases School of Basic Medical SciencesFujian Medical UniversityFuzhouFujian ProvinceChina Institute of Laboratory Animal Center Fujian Medical UniversityFuzhouFujian ProvinceChina department of neurosurgery Neurosurgery Research InstituteThe First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina department of Hyperbaric Oxygen National Regional Medical CenterBinhai Campus of the First Affiliated HospitalFujian Medical UniversityFuzhouFujian ProvinceChina

Previous studies have shown that the compound(e)-2-(3,4-dihydroxystyryl)-3-hydroxy-4H-pyran-4-one(D30),a pyromeconic acid derivative,possesses antioxidant and anti-inflammatory properties,inhibits amyloid-β aggregation,and alleviates scopolamine-induced cognitive impairment,similar to the phase Ⅲ clinical drug *** this study,we established a mouse model of Alzheimer's disease via intracerebroventricular injection of fibrillar amyloid-β to investigate the effect of D30 on fibrillar amyloid-β-induced *** results showed that D30 alleviated fibrillar amyloid-β-induced cognitive impairment,promoted fibrillar amyloid-β clearance from the hippocampus and cortex,suppressed oxidative stress,and inhibited activation of microglia and astrocytes.D30 also reversed the fibrillar amyloid-β-induced loss of dendritic spines and synaptic protein ***,we demonstrated that exogenous fibrillar amyloid-βintroduced by intracerebroventricular injection greatly increased galectin-3 expression levels in the brain,and this increase was blocked by *** the role of D30 in clearing amyloid-β,inhibiting neuroinflammation,protecting synapses,and improving cognition,this study highlights the potential of galectin-3 as a promising treatment target for patients with Alzheimer's disease.

关键词： Alzheimer's disease amyloid-β astrocyte cognitive impairment D30 dendritic spines galectin-3 microglia neuroinflammation neuron

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estimating costs of salvage logging for large-scale burned forest lands: A case study on Turkey's Mediterranean coast

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Journal of Forestry Research 2021年第5期32卷 1899-1909页

作者： neşe Gülci Faculty of Forestry Kahramanmaras Sutcu Imam University46100 KahramanmarasTurkey

Different forest fires causing different degrees of effects occur in fire-sensitive forests due to various reasons such as climate *** as well as harmful aspects of forest fires are a multi-disciplinary research *** information systems(GIS)and remote sensing(RS)methods offer a number of benefits for researchers and operators in the field of forest fire *** present study analyses timber pricing based on forest contractor demands of post-salvage logging *** effect of timber obtained from compartment units on producers’pricing policy was *** forest fire area(2500 ha)located in Antalya in Turkey was selected as the main study *** parameters(aspect,slope and slope position),stand types(diameter class and crown closure),and burn severity were analyzed together using GIS and R software packages.A multi-linear regression model(R^(2)=0.752)demonstrated that factors that had the most impact on pricing were slope position,aspect,stand age,crown closure and burn *** model can be used to estimate salvage logging prices in Calabrian pine(Pinus brutia Ten.)stands with similar *** administrators and contractors may readily address the unit price of timber by estimating approximate costs in a given forest area for which they are going to *** will help reduce operational planning times of harvesting procedures in burned stands.

关键词： Timber extraction Forest fires Stumpage sale Cost estimation Sustainability Crown fire

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Supramolecular Polymerization of DNA Double-Crossover-Like Motifs in Various Dimensions

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Chinese Journal of Polymer Science 2023年第10期41卷 1501-1507页

作者： Cui-Zheng Zhang Da-ke Mao Victoria e.Paluzzi Cheng-de Mao department of Chemistry Purdue UniversityWest LafayetteIN47906USA

Double-crossover-like(DXL)molecules are a series of DNA motifs containing two strands with identical or different *** homo-or hetero-dimers can further polymerize into bulk structures through specific hydrogen bonding between sticky *** molecules have high designability,predictivity and sequence robustness;and their supramolecular polymerization products would easily achieve controllable *** addition,among all available DNA nanomotifs,DXL molecules are small in size so that the cost of DXL-based nanostructures is *** properties together make DXL-based nanostructures good candidates for patterning,templating,information and matter storage,***,we will discuss DXL motifs in terms of the detailed molecular design,and their supramolecular polymerization in various dimensions,and related applications.

关键词： DNA nanotechnology Palindromic sequence Helical twisting Supramolecular polymerization Controllable morphology

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Hydrothermal Synthesis and Structure of a Novel Binuclear Molybdenum Complex with Oxalate Ligand, (enH_2){NH_4[Co(en)_3][Mo_2O_7(C_2O_4)] }_2·2H_2O

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Chinese Journal of Structural Chemistry 2004年第1期23卷 57-61页

作者： LIUPei-de PeIXiao-ke LINBi-Zhou InstituteofMaterialsPhysicalChemistry HuaqiaoUniversityQuanzhouFujian362011China. InstituteofMaterialsPhysicalChemistry HuaqiaoUniversityQuanzhouFujian362011ChinaTel：0595-2691569E-mail：bzlin@hqu.e***

The title complex (enH2){NH4[Co(en)3][Mo2O7(C2O4)]}22H2O (C18H70Co2Mo4- N16O24, Mr = 1396.52) was obtained under hydrothermal conditions and its crystal structure has been de.e.mined by single-crystal X-ray diffraction. It crystallizes in the monoclinic system, space group P21/c with a = 17.8023(8), b = 7.7527(4), c = 16.9781(4) ? b = 103.878(7), V = 2274.8(2) 3, Dc = 2.039 g/cm3, Z = 2, m(MoKa) = 1.878 mm-1 and F(000) = 1408. The final R = 0.0410 and wR = 0.1070 for 4065 observed reflections with I≥2s(I). The crystal structure is composed of bi- nuclear [Mo2O7(C2O4)]4- anions, complex [Co(en)3]2+ cations, protonated ethylenediamine cations, ammonium cations and crystal water molecules, which are held together into a three-dimensional network via hydrogen-bonding interactions. The binuclear structure of [Mo2O7(C2O4)]4- consist of one MoO4 and one MoO6 octahedra through sharing a bridging oxygen atom, where the oxalate ligand acts as a bidentate ligand coordinating to the octahedral molybdenum atom though two deprotonated corboxylate groups.

关键词： hydrothermal synthesis crystal structure molybdenum complexes cobalt complexes oxalate complexes

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Cytotoxicity of Ti–6Al–4V–5Cu Alloy to MC3T3-e1 Cells

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Acta Metallurgica Sinica(english Letters) 2021年第5期34卷 694-700页

作者： Ji Zhang Ling Ren ke yang Institute of Metal Research Chinese Academy of SciencesShenyang110016China

The aim of this work was to study the cytotoxicity of Ti–6 Al–4 V–5 Cu(TC4–Cu)alloy for dental applications and evaluate the cell viability of diff erent fabricated TC4–Cu alloys in contact with MC3 T3-e1 cells in ***–6 Al–4 V(TC4)alloy was used as a negative control to evaluate the cytotoxicity level of TC4–Cu alloy so as to provide basic support for the dental clinical *** group TC4 and experimental group TC4–Cu with diff erent fabrications were incubated in the cell culture *** absorbance value of mouse osteoblast MC3 T3-e1 cells was de.e.ted by CCK-8 assay after 1,3 and 7 days,*** relative proliferation rate of cells was calculated,and then the toxicity level was valued for each *** morphology on the surface was also studied by observing the cytoskeleton through F-actin filament *** experimental results showed that the absorbance values for the experimental and the negative control groups were not same at diff erent time *** with diff erent fabricated TC4–Cu alloys,the annealing-TC4–Cu alloy showed much better *** mouse osteoblast MC3 T3-e1 cells cultured with annealing-TC4–Cu,rolling-TC4–Cu and solution+aging-TC4–Cu have no toxic eff ects,and these alloys could promote the proliferation of mouse osteoblasts.

关键词： Cytotoxicity Ti–6Al–4V–5Cu alloy Fabrication Biocompatibility

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The Strategy of Third-Party Mediation Based on the Option Prioritization in the Graph Model

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Journal of Systems Science and Systems engineering 2019年第4期28卷 399-414页

作者： Zhenggao Wu Haiyan Xu Ginger y. ke College of economics and Management Nanjing University of Aeronautics and Astronautics Nanjing 211106 China Faculty of Business Administration Memorial University of Newfoundland St. John's Newfoundland and Labrador A1B 3X5 Canada

The resolution of real-world conflicts is often supported by third-party intervention (i.e., media? tion). This paper proposes a possible mediation support in the form of a reverse optimization procedure under the framework of the Graph Model for Conflict Resolution (GMCR). The approach computes minimal priority adjustments of preference statements that are necessary to achieve a desired agreement. A mathematical model, based on the matrix form of GMCR, is de.e.oped to analyze this third-party mediation problem. Thereby;this study makes a first attempt to obtain option-based mediation strategies, which add comprehensiveness to the traditional state-based strategies, yet are easier to understand and hence more acceptable to the conflict participants. To illustrate the practicality;the proposed procedure is applied to a medical dispute between a patient and a hospital, with the aim to suggest changes in the ordering of preference statements that lead to a desired outcome.

关键词： Graph Model for Conflict Resolution third party mediation option prioritization minimal adjustment

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Current Zoology 2019年第5期65卷 527-534页

作者： ke deNG Wei LIU de-Hua WANG State key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina Chengdu Institute of Biology Chinese Academy of SciencesChengduSichuanChina University of Chinese Academy of Sciences BeijingChina

Kin selection theory predicts that individuals should generally behave less aggressively or more amicably towards relatives than ***,how individuals treat conspecifics de.e.ds on genetic relatedness but also on the ecological context,which influences the benefits and costs of their *** this study,we used microsatellite DNA markers and behavioral tests to examine the influence of kinship and proximity on the social behavior of Mongolian gerbils Meriones unguiculatus living in different social groups,and whether these effects varied with sex and *** recorded the duration of 4 behavioral categories(investigative,neutral,amicable,and agonistic)during a 10-min pairwise *** found that genetic relatedness had significant effects on the duration of investigative,neutral,and amicable behavior,but not on agonistic *** also found significant interaction effects of relatedness and distance between burrow systems(i.e.,spatial distance)on investigative,neutral,and amicable behavior,which suggests that the effects of kinship on social behavior were restricted by spatial *** interaction effect between sex and relatedness on amicable behavior showed that male gerbils became more intimate with individuals of the same sex that had higher pairwise relatedness than ***,both male and female gerbils enhanced their aggression during the food-hoarding season,but the intensity of these changes was significantly higher in ***,our results suggest that the effects of kinship and spatial proximity on social behavior exhibit sexual or seasonal patterns,thereby implying ecological context-de.e.dent responses to out-group individuals in Mongolian gerbils.

关键词： familiarity kinship Meriones unguiculatus seasonality social behavior

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Stress Corrosion Cracking of X80 Pipeline Steel in near-neutral pH environment under Constant Load Tests with and without Preload

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Journal of Materials Science & Technology 2011年第11期27卷 1039-1046页

作者： y.Z. Jia J.Q. Wang e.H. Han W. ke1 State key Laboratory for Corrosion and Protection Institute of Metal Research Chinese Academy of Sciences Shenyang 110016 China department of electromeehanical engineering Siehuan College of Architectural Technology Deyang 318000 China

Constant load tests in NS4 solution purged with N2-5%CO2 gas mixture were conducted on American Petroleum Institute （API） X80 pipeline steel applied in the 2nd West-east （;as Pipeline project with and without preload. The results show that cracks could initiate and propagate in X80 pipeline steel in near-neutral pH environment under a constant load condition. The life of crack initiation and propagation increased with decreasing applied stress. Preload did not change its corrosion behavior obviously. However, preload reduced the time for crack initiation.

关键词： Stress corrosion cracking X80 pipeline steel near-neutral pH solution Preload

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THe ALTeRNATING DIReCTION MeTHODS FOR SOLVING THe SyLVeSTeR-TyPe MATRIX eQUATION AXB ＋ CXTD = e

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Journal of Computational Mathematics 2017年第5期35卷 620-641页

作者： yifen ke Changfeng Ma School of Mathematics and Computer Science & FJKLMAA Fujian Normal University Fuzhou 350117 China

In this paper, we present two alternating direction methods for the solution and best approximate solution of the Sylvester-type matrix equation AXB ＋ CXTD = e arising in the control theory, where A, B, C, D and e are given matrices of suitable sizes. If the matrix equation is consistent （inconsistent）, then the solution （the least squares solution） can be obtained. Preliminary convergence properties of the proposed algorithms are presented. Numerical experiments show that the proposed algorithms tend to deliver higher quality solutions with less iteration steps and CPU time than some existing algorithms on the tested problems.

关键词： Sylvester-type matrix equation Alternating direction method The least squares solution Best approximate solution.

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Atom probe tomographic observation of hydrogen trapping at carbides/ferrite interfaces for a high strength steel

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Journal of Materials Science & Technology 2018年第8期34卷 1344-1348页

作者： y.F.Jiang B.Zhang y.Zhou J.Q.Wang e.-H.Han W.ke CAS key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and engineering University of Science and Technology of ChinaShenyang 110016China

A three-dimensional atom probe （3DAP） technique has been used to characterize the hydrogen dis- tribution on carbides for a high strength AISI 4140 steel. Direct evidence of H atoms trapped at the carbide/ferrite interfaces has been revealed by 3DAP mapping. Hydrogen is mainly trapped on car- bide/ferrite interfaces along the grain boundaries. Slow strain rate tensile （SSRT） testing shows that the AIS14140 steel is highly sensitive to hydrogen embrittlement. The corresponding ffactographic mor- phologies of hydrogen charged specimen exhibit brittle fracture feature. Combined with these results, it is proposed that the hydrogen trapping sites present in the grain boundaries are responsible for the hydrogen-induced intergranular fracture of AISI 4140. The direct observation of hydrogen distribution contributes to a better understanding of the mechanism of hydrogen embrittlement.

关键词： Low alloy steel TeM Interfaces Hydrogen embrittlement

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