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Nuclear Science and Techniques 2017年第6期28卷 133-139页

作者： Yi-Xin Liu Biao Wei Yang Xu Meng He Ren-Hong Zhuo de-Zhi Wen Da-Jie ding Ben-Jiang Mao Key Laboratory of Optoelectronics Technology and System Ministry of EducationChongqing University Institute of Nuclear Physics and Chemistry China Academy of Engineering Physics

A minitype reference radiation(MRR) with dimensions of only 1 m × 1 m × 1 m has been developed for the in situ calibration of photon *** present work conducts a feasibility study on determining the conventional true value of gamma-ray air kerma at the point of test in the *** to its smaller dimensions,the scattered gamma-rays in the MRR are expected to induce a non-negligible interference with the radiation field compared with conditions in the standard reference radiation stipulated by ISO4037-1 or GB/T12162.1.A gamma-ray spectrometer was employed to obtain the spectra of scattered gamma-rays within the MRR,and the feature components of the spectra were extracted by principal component analysis to characterize the interference of a dosimeter probe in the radiation field.A prediction model of the CAK at the point of test was built by least squares support vector machine based on the feature component data obtained from nine sample dosimeters under five different dose *** mean prediction error of the CAK prediction model was within ±4.5%,and the maximum prediction error was about ±10%.

关键词： Air kerma Reference radiation Calibration Principal component analysis Support vector machine

Biological conversion of methane to polyhydroxyalkanoates:Current advances,challenges,and perspectives

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Environmental Science and Ecotechnology 2020年第2期2卷 64-71页

作者： Lu-Yao Liu Guo-Jun Xie de-Feng Xing Bing-Feng Liu Jie ding Nan-Qi Ren State Key Laboratory of Urban Water Resource and Environment School of EnvironmentHarbin Institute of TechnologyHarbin150090China

Methane emissions and plastic pollution are critical global *** biological conversion of methane to poly-b-hydroxybutyrate(PHB)not only mitigates methane emissions but also provides biodegradable polymer substitutes for petroleum-based materials used in plastics *** work provides an early overview of the methane-based PHB advances and discusses challenges and related *** advances of PHB,including PHB biosynthetic pathways,methanotrophs,bioreactors,and the performances of PHB materials are *** challenges of methane-based PHB production are discussed in detail;these include low efficiency of methanotrophs,low gas-liquid mass transfer efficiency,and poor material *** overcome these limitations,various approaches are also explored,such as feast-famine regimes,engineered microorganisms,gas-permeable membrane bioreactors,two-phase partitioning bioreactors,poly-b-hydroxybutyrate-co-hydroxyvalerate synthesis,and molecular weight manipulation.

关键词： Polyhydroxyalkanoate Methanotrophs Methane Biodegradable plastics Greenhouse gas

Role of moxibustion in inflammatory responses during treatment of rat ulcerative colitis

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World Journal of Gastroenterology 2014年第32期20卷 11297-11304页

作者： Yang Han Tie-Ming Ma Mao-Lin Lu Lu Ren Xian-de Ma Zeng-Hua Bai department of Acupuncture and Massage Liaoning University of Traditional Chinese Medicine Center for Photochemical Sciences Department of Chemistry Bowling Green State University Bowling Green OH 43403 United States

AIM: To investigate the efficacy of moxibustion in ulcerative colitis (UC) rats from morphological, immunological and molecular biological perspectives. METHODS: Thirty-two Sprague-Dawley rats were randomly assigned to a blank control group (normal rats, n = 6) and a model replication (MR) group (UC rats, n = 26). A UC model was established by 2,4,6-trinitrobenzenesulfonic acid/dextran sulfate sodium enema. Rats in the MR group were further randomly assigned to a 9-min moxibustion (9M) group (9 moxa-cone, n = 6), 6-min moxibustion (6M) group (6 moxa-cone, n = 6), 3-min moxibustion (3M) group (3 moxa-cone, n = 6), and a waiting list control (WLC) group (no moxibustion treatment, n = 6). Rats in the moxibustion treatment group were treated in 14 sessions over 28 d. Disease activity, local tissue morphology, serum level of interleukin (IL)-8 and IL-10, and expression of Toll-like receptor (TLR)9 as well as nuclear factor (NF)-kappa B p65 in colonic tissue were determined by disease activity index (DAI), hematoxylin and eosin staining, electron microscopy, enzyme-linked immunosorbent assay and Western blotting, respectively. RESULTS: DAI was lowest in the 9M group and highest in the WLC group. The differences in DAI between the moxibustion treatment (3M, 6M, 9M) and no treatment groups were significant for all one-to-one comparisons (0.60 +/- 0.54 vs 1.20 +/- 0.44, 0.60 +/- 0.54 vs 1.80 +/- 0.45, 0.60 +/- 0.54 vs 3.0 +/- 0.45, respectively, P decreased while IL-10 level increased from the WLC to 3M, 6M and 9M groups. The differences among these groups were significant for all comparisons (105.46 +/- 8.75 vs 76.61 +/- 3.58, 105.46 +/- 8.75 vs 69.78 +/- 1.87, 105.46 +/- 8.75 vs 67.41 +/- 1.84, respectively, P < 0.01 for IL-8; and 30.83 +/- 1.29 vs 75.64 +/- 1.90, 30.83 +/- 1.2

关键词： Moxibustion Ulcerative colitis Disease activity index Interleukin-8 Interleukin-10 Toll-like receptor 9 Nuclear factor-kappa B p65

Absolute copy number differences of Y chromosomal genes between crossbred (Bos taurus×Bos indicus) and Indicine bulls

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Journal of Animal Science and Biotechnology 2013年第4期4卷 257-263页

作者： Ayan Mukherjee Gulshan Dass Jagan Mohanarao G Moloya Gohain Biswajit Brahma Tirtha Kumar Datta Sachinandan de Animal Genomics Lab Animal Biotechnology Centre National Dairy Research Institute department of Veterinary Biochemistry College of Veterinary Sciences & Animal Husbandry Central Agricultural University

Background： The Y chromosome in mammal is paternally inherited and harbors genes related to male fertility and spermatogenesis. The unique intra-chromosomal recombination pattern of Y chromosome and morphological difference of this chromosome between Bos taurus and Bos indicus make it an ideal model for studying structural variation, especially in crossbred （Bos taurus x Bos indicus） bulls. Copy Number Variation （CNV） is a type of genomic structural variation that gives information complementary to SNP data. The purpose of this study was to find out copy number differences of four Y chromosomal spermatogenesis-related candidate genes in genomic DNA of crossbred and purebred Indicine bulls. Result： Four Y chromosomal candidate genes of spermatogenesis namely, sex determining gene on Ychromosome （SRY）, deAD box po/ypeptide 3-Y chromosome （DDX3 Y）, Ubiquidn specific peptidase 9, Y-linked （ usPgY）, testis-specific protein on Y chromosome （TSPY） were evaluated. Absolute copy numbers of Y chromosomal genes were determined by standard curve-based quantitative real time PCR. Copy numbers of SRYand TSPYgenes per unit amount of genomic DNA are higher in crossbred than Indicine bulls. However, no difference was observed in DDX3Yand usPgYgene copy numbers between two groups. Conclusion： The present study demonstrates that the structural organization of Y chromosomes differs between crossbred and Indicine bulls which are reproductively healthy as observed from analysis of semen attributes. The absolute copy numbers of SRY and TSPY genes in unit mass of genomic DNA of crossbred bulls are significantly higher than Indicine bulls. No alteration in absolute copies ofDDX3Yand usPgYgene was found between the genome of crossbred and Indicine bulls. This study suggests that the DDX3Yand USPgYare likely to be single copy genes in the genome of crossbred and Indicine bulls and variation in Y chromosome length between crossbred and Indicine bulls may be due to the copy number variation of

关键词： Absolute copy SRY DDX3Y usPgY TSPY Crossbred

Combined use of chemotherapeutics and oncolytic adenovirus in treatment of AFP-expressing hepatocellular carcinoma

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Hepatobiliary & Pancreatic Diseases International 2009年第3期8卷 282-287页

作者： Mao, Chen-Yu Hua, Han-Ju Chen, Ping Yu, de-Chao Cao, Jiang Teng, Li-Song Zhejiang Univ Sch Med Dept Surg Oncol Affiliated Hosp 1 Hangzhou 310003 Peoples R China Zhejiang Univ Sch Med Sir Run Run Shaw Inst Clin Med Key Lab Biotherapy Zhejiang Prov Hangzhou 310016 Peoples R China

BACKGROUND: Hepatocellular carcinoma (HCC) which is always refractory to most chemotherapeutic agents may result in poor survival of patients with advanced HCC. Oncolytic adenovirus is a new form for cancer gene therapy via its ability to replicate and kill tumor cells in a tumor-specific manner. In order to eradicate tumors effectively, the combination of chemotherapeutic agents and oncolytic adenovirus has been considered. This study aimed to systematically analyze the possibility of synergistic cytotoxicity of oncolytic adenoviruses in combination with chemotherapeutic agents. METHODS: Several types of human HCC cell lines were used to determine the specificity and cytotoxicity of oncolytic adenovirus Ad5-HC and Ad5-AFP (IRES) by measuring cell viability in vitro and antitumor efficiency in vivo. The cytotoxicity of Ad5-HC and Ad5-AFP (IRES) combined with chemotherapeutic agents were also assessed by the methyl thiazolyl tetrazolium assay. RESULTS: Both Ad5-HC and Ad5-AFP (IRES) were significantly cytotoxic to HCC cells with great specificity in vitro and in vivo. The combination of oncolytic adenovirus with 5-FU, doxorubicin, and paclitaxel was synergistically effective for the killing of HCC cells. CONCLUSIONS: These data suggest that oncolytic adenovirus sensitize tumors to chemotherapy and the combination therapy of chemotherapeutic agents and oncolytic adenovirus has an enhanced antitumor effect on HCC cells. (Hepatobiliary Pancreat Dis Int 2009; 8: 282-287)

关键词： hepatocellular carcinoma drug resistance oncolytic adenovirus chemotherapy

Effect of CD74 on the prognosis of patients with resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2014年第1期13卷 81-86页

作者： Jun-Feng Zhang Rong Hua de-Jun Liu Wei Liu Yan-Miao Huo Yong-Wei Sun department of General Surgery Renji Hospital School of Medicine Shanghai Jiaotong University

BACKGROUND: CD74 is known as a type II transmembrane glycoprotein that is associated with the major histocompatibility complex class II α and β chains. Recent studies have demonstrated that the expression of CD74 is also linked to some forms of tumors. The present study was to assess the effect of CD74 expression on the prognosis of resectable pancreatic ductal adenocarcinoma(PDAC). METHODS: Forty-six patients who had received a curative resection of primary PDAC and postoperative chemotherapy were included in this study. Immunohistochemical staining was conducted of CD74 on paraffin-embedded tumor sample slices. The patients were grouped according to CD74 staining: CD74(-): CD74 positive tumor cells dependent prognostic indicators. CONCLUSIONS: The overexpression of CD74 is a key factor associated with perineural invasion. Lower-stage(I and II) PDAC patients with CD74 overexpression have a poor prognosis even if they receive a curative resection. CD74 can be used as a prognostic indicator for resectable PDAC.

关键词： CD74 pancreatic ductal adenocarcinoma perineural invasion cumulative survival rate prognosis

Cow-YOLO:Automatic cow mounting detection based on non-local CSPDarknet53 and multiscale neck

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 193-202页

作者： de Li Junhao Wang Zhe Zhang Baisheng Dai Kaixuan Zhao Weizheng Shen Yanling Yin Yang Li College of Electrical Engineering and Information Northeast Agricultural UniversityHarbin 150030China College of Agricultural Equipment Engineering Henan University of Science and TechnologyLuoyang 471023HenanChina College of Animal Sciences and Technology Northeast Agriculture UniversityHarbin 150030China Key Laboratory of Northeast Smart Agricultural Technology of Ministry of Agriculture and Rural Affairs Northeast Agricultural UniversityHarbin 150030China

Cows mounting behavior is a significant manifestation of estrus in *** timely detection of cows mounting behavior can make cows conceive in time,thereby improving milk production of cows and economic benefits of the *** methods of mounting behavior detection are difficult to achieve precise detection under occlusion and severe scale change environments and meet real-time ***,this study proposed a Cow-YOLO model to detect cows mounting *** meet the needs of real-time performance,YOLOv5s model is used as the baseline *** order to solve the problem of difficult detection of cows mounting behavior in an occluded environment,the CSPDarknet53 of YOLOv5s is replaced with Non-local CSPDarknet53,which enables the network to obtain global information and improves the model’s ability to detect the mounting ***,the neck of YOLOv5s is redesigned to Multiscale Neck,reinforcing the multi-scale feature fusion capability of model to solve difficulty detection under dramatic scale ***,to further increase the detection accuracy,the Coordinate Attention Head is integrated into ***,these improvements form a novel cow mounting detection model called Cow-YOLO and make Cow-YOLO more suitable for cows mounting behavior detection in occluded and drastic scale changes ***-YOLO achieved a precision of 99.7%,a recall of 99.5%,a mean average precision of 99.5%,and a detection speed of 156.3 f/s on the test *** with existing detection methods of cows mounting behavior,Cow-YOLO achieved higher detection accuracy and faster detection speed in an occluded and drastic scale-change ***-YOLO can assist ranch breeders in achieving real-time monitoring of cows estrus,enhancing ranch economic efficiency.

关键词： cows mounting automatic detection Cow-YOLO computer vision CSPDarknet53 multiscale neck

Early Predictors of Acute Pancreatitis Related In-Hospital Mortality: How Practical Are They?

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Open Journal of Gastroenterology 2018年第3期8卷 67-78页

作者： Elham Ahmed Hassan Abeer Sharaf El-din Abdel Rehim Mohammad Alyamany Kobeisy Ahmed Mohammed Ashmawy Zain El-Abdeen Ahmed Sayed Raed Salah Ameen department of Tropical Medicine and Gastroenterology Faculty of Medicine Assiut University Assiut Egypt department of Internal Medicine Faculty of Medicine Assiut University Assiut Egypt

Background/Purpose: Early assessment of the severity of acute pancreatitis (AP) is a highly challenge for a physicians’ practice to improve the management and decrease the mortality. We aimed to determine early prognostic factors for AP related in-hospital mortality. Methods: Upon hospital admission, predictors of AP related in-hospital mortality were prospectively assessed using regression analysis over 129 consecutive AP patients. Predictive abilities of these prognostic factors were compared using the area under receiver operating characteristic curve (AUC). Results: AP related in-hospital mortality was 10.9%. Red cell distribution (RDW), serum creatinine, glucose and albumin were associated with AP mortality. RDW had the highest AUC followed by serum creatinine and albumin (AUC: 914, 95% CI: 0.797 - 0.975;0.797, 95% CI: 0.695 - 0.878;0.798, 95% CI: 0.677 - 0.865 respectively). The cut-off with the best ability to predict in-hospital mortality was 14.2 for RDW. By coupling RDW and serum creatinine, AUC was improved to 0.940, 95% CI: 0.839 - 0.986. Conclusion: RDW, serum creatinine, albumin, and glucose even with borderline level changes may predict AP related in-hospital mortality, where, RDW has the highest prognostic accuracy. Coupling RDW and serum creatinine model significantly improves their predictive accuracy that may aid in further improvement of the quality of care of AP patients.

关键词： Acute Pancreatitis In-Hospital Mortality Red Cell Distribution Width

Differential tectonic evolution and formation mechanism of three subsags in Wenchang Sag of Pearl River Mouth Basin,South China Sea

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Petroleum Science 2023年第3期20卷 1379-1394页

作者： Qiu-Gen Zheng Jun-Liang Li Bao-Hua Lei Peng Song Qi Li de-Feng Shi Hao Liu Chang-Song Lin School of Ocean Sciences China University of Geosciences(Beijing)Beijing100083China Hainan Branch of the China National Ofshore Oil Corporation HaikouHainan570311China Qingdao Institute of Marine Geology QingdaoShandong266237China Laboratory for Marine Mineral Resources Pilot National Laboratory for Marine Scence and Technoogy(Qingdao)QingdaoShandong26637China

Notable differences in the structural characteristics and evolution of three adjacent sub-sags,i.e.,the Wenchang sub-sags A,B,and C,on the downthrown side of the Zhu IlI South Fault in the Wenchang Sag,are significant as they affect the formation and distribution of the oil and gas in these three ***,the differences in their tectonic evolutions and formation mechanisms have not yet been adequately *** this paper,stress analysis,equilibrium profiles,and paleogeomorphic restora-tion,are used to investigate the dynamic settings,formation mechanisms,and influencing factors of the structural deformation related to the formation of the Wenchang Sag based on interpretation of seismic *** results of the stress analysis suggest clockwise deflection of the regional tensile stress direction from a WNW-ESE trend during the Early Paleocene to NW-SE and NNW-SSE trends during the Eocene,to a nearly N-S trend during the Oligocene,and finally to a NNE-SSW trend during the *** clockwise rotation of the regional tensile stress direction led to the formation of a dextral strike-slip stress component parallel to the NE-trending Zhu I South *** strike-slip stress component formed a releasing bend in sub-sag A,and may be associated with the continuous subsidence of a thick sedimentary layer in sub-sag *** also created a restraining bend in sub-sag B,which underwent multiple structural inversions during its extension and subsidence and has a relatively s mall sedimentary *** double restraining bend in sub-sag C is considered to have been strongly uplifted and eroded in response to this strike-slip stress *** obvious structural inversions in sub-sag B are iden-tified in this *** structural inversions correspond to the last four regional tectonic *** interpretation suggests that the formation of the structural inversions was likely related to the strong tensile stress and the small intersection angle between

关键词： Strike-slip stress Releasing bend Restraining bend Double restraining bend Structura linversion ZhuⅢSouthfault Wenchang sag Northern South China Sea

Triiodothyronine and breast cancer

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World Journal of Clinical Oncology 2014年第3期5卷 503-508页

作者： Maria Teresa de Sibio Miriane de Oliveira Fernanda Cristina Fontes Moretto Regiane Marques Castro Olimpio Sandro José Conde Aline Carbonera Luvizon Célia Regina Nogueira department of Internal Medicine Botucatu Medical SchoolUniv Estadual PaulistaUNESPBotucatuSP 18618-970Brazil department of Pathology Botucatu Medical School Univ Estadual Paulista-UNESP Botucatu SP 18618-970Brazil

The thyroid hormones(THs), triiodothyronine(T3) and thyroxine(T4), are essential for survival; they are involved in the processes of development, growth, and metabolism. In addition to hyperthyroidism or hypothyroidism, THs are involved in other diseases. The role of THs in the development and differentiation of mammary epithelium is well established; however, their specific role in the pathogenesis of breast cancer(BC) is controversial. Steroid hormones affect many human cancers and the abnormal responsiveness of the mammary epithelial cells to estradiol(E2) in particular is known to be an important cause for the development and progression of BC. The proliferative effect of T3 has been demonstrated in various types of cancer. In BC cell lines, T3 may foster the conditions for tumor proliferation and increase the effect of cell proliferation by E2; thus, T3 may play a role in the developmentand progression of BC. Studies show that T3 has effects similar to E2 in BC cell lines. despite controversy regarding the relationship between thyroid disturbances and the incidence of BC, studies show that thyroid status may influence the development of tumor, proliferation and metastasis.

关键词： Thyroid hormone Triiodothyronine Breast cancer Mammary gland and metabolism