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Promotion and Mechanism of Acupotomy on Chondrocyte Autophagy in Knee Osteoarthritis Rabbits

Chinese Journal of Integrative Medicine 2024年第9期30卷 809-817页

作者： LU Man MENG de-hong she Ze-yu WU Xian XIA Shuai YANG Kai-ning LIU Cun-bin LI Tao YANG Yong-hui The First Affiliated Hospital of Anhui University of Chinese Medicine Hefei230031China The Second Affiliated Hospital of Anhui University of Chinese Medicine Hefei230038China department of Acupotomy Rehabilitation Anhui Provincial Hospital of Integrated Traditional Chinese and Western MedicineHefei230031China

Objective:To explore the effect of acupotomy intervention on autophagy of chondrocytes in rabbits with knee osteoarthritis(KOA),and to determine the possible mechanisms of acupotomy to alleviate cartilage ***:The modified Videman method was used to construct a KOA rabbit *** modeling,40 rabbits were randomly divided into 4 groups by a random number table:control;KOA(model);KOA+acupotomy(acupotomy),and KOA+sham acupotomy(sham),10 in each *** a 3-week treatment course,the knee joint activity was determined by the modified Lequesne MG ***-eosin staining staining was used to examine the morphological changes of *** of chondrocytes was observed by transmission electron *** surface morphology of cartilage tissue was observed by scanning electron *** mRNA and protein levels of AMP kinase/mammalian target of rapamycin/Unc-51(AMPK/mTOR/ULK1)signal pathway key proteins,autophagy-related factor Beclin-1 and microtubule-associated protein 1A/1B light chain 3(LC3)in rabbit knee cartilage were assessed by real-time fluorescence quantitative polymerase chain reaction and Western blot,***:The modified Lequesne MG score of acupotomy group was significantly lower than that of model group(Pdecreased and cartilage surface was rough in the model group,which recovered after acupotomy *** mRNA expressions of AMPK,ULK1,Beclin-1 and the protein levels of p-AMPK,p-ULK1,Beclin-1,and LC3Ⅱ/LC3Ⅰwere decreased in the model group,while the mRNA and protein expressions of mTOR were increased(P<0.01).However,acupotomy treatment reversed these abnormal changes(P<0.05).Conclusions:Acupotomy could effectively up-regulate the expressions of AMPK,ULK1 and Beclin1,reduce the expression of mTOR,promote autophagy,and alleviate joint *** is a promising complementary and alternative therapy for KOA.

关键词： acupotomy knee asteoarthritis autophagy AMPK/mTOR/ULK1 signaling pathway rabbit

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Intracoronary thrombolysis combined with drug balloon angioplasty in a young ST-segment elevation myocardial infarction patient:A case report

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World Journal of Cardiology 2024年第9期16卷 531-541页

作者： Li-Qiong she de-Kui Gao Le Hong Yin Tian Hui-Zhen Wang sheng Huang department of Critical Care Medicine Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina department of Cardiology Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina department of Interventional Medicine Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina

BACKGROUND The combination of acute ST-segment elevation myocardial infarction(STEMI)and gastric ulcers poses a challenge to primary percutaneous coronary intervention(PPCI),particularly for young *** role of drug-coated balloons(DCBs)in the treatment of de novo coronary artery lesions in large vessels remains unclear,especially for patients with *** strategy is to implement drug balloon angioplasty following the intracoronary administration of low-dose prourokinase and adequate *** SUMMARY A 54-year-old male patient presented to the emergency department due to chest pain on June 24,*** the first 3 minutes of the initial assessment in the emergency room,the electrocardiogram(ECG)showed significant *** was atrial fibrillation with ST-segment ***,atrial fibrillation terminated spontaneously and reverted to sinus *** after,the patient experienced *** ECG revealed torsades de pointes ventricular tachycardia.A few seconds later,it returned to sinus ***-sensitivity tropon in I was *** diagnosis was acute *** coronary angiography revealed subtotal occlusion with thrombus formation in the proximal segment of the left anterior descending *** the patient's age and history of peptic ulcer disease,after the intracoronary injection of prourokinase,percutaneous transluminal coronary angioplasty and cutting balloon angioplasty were conducted for thorough preconditioning,and paclitaxel drug-eluting balloon angioplasty was performed without any stents,achieving favorable *** A PPCI without stents may be a viable treatment strategy for select patients with STEMI,and further research is warranted.

关键词： STsegment elevation myocardial infarction Recombinant human prourokinase de novo coronary lesion Large vessels Drug-eluting balloon angioplasty Case report

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Analysis on Band Gaps of MCM-41 Type of Materials

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Chemical Research in Chinese Universities 2004年第1期20卷 108-110页

作者： HANPei-de LIANGJian XUBing-she LIUXu-guang PENGLian-mao CollegeofMaterialsScienceandengineering TaiyuanUniversityofTechnologyTaiyuan030024P.R.China BeifingLaboratoryofElectronMicroscopy InstituteofPhysicsChineseAcademyofSciencesBeijing100080P.R.China

The concept and analysis method of photonic crystals and band gaps are introduced into one-dimensional(1D) ordered mesoporous materials. MCM-41 type of materials are treated theoretically as photonic crystals. The formation of band gaps is exhibited and confirmed by a calculation of transfer matrix technique. PBG was found around 9-42 nm in soft X-ray region. The photonic band-gap was predicted to be dependent on incident direction, pore size and lattice constant. The mesoporous materials with different pore sizes and different lattice constants have different band-gap widths.

关键词： Mesoporous material Photonic crystal Photonic band-gap

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壳聚糖-柑橘精油复合处理对蓝莓果实采后贮藏保鲜效果的影响

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保鲜与加工 2024年第1期24卷 1-7页

作者：郁欣然付思怡佘文琴福建农林大学园艺学院福建福州350002 福建农林大学园艺产品贮运保鲜研究所福建福州350002

以鲜食蓝莓为试材,采用浸泡方法研究了不同浓度壳聚糖与柑橘精油复合保鲜剂处理对蓝莓果实采后4℃贮藏过程中腐烂率、呼吸强度、可滴定酸含量、丙二醛含量、谷胱甘肽含量以及过氧化物酶活性、抗坏血酸过氧化物酶活性的影响,筛选壳聚糖... 详细信息

以鲜食蓝莓为试材,采用浸泡方法研究了不同浓度壳聚糖与柑橘精油复合保鲜剂处理对蓝莓果实采后4℃贮藏过程中腐烂率、呼吸强度、可滴定酸含量、丙二醛含量、谷胱甘肽含量以及过氧化物酶活性、抗坏血酸过氧化物酶活性的影响,筛选壳聚糖与柑橘精油的最佳浓度组合。结果表明:与对照(蒸馏水浸泡)相比,壳聚糖与柑橘精油复合保鲜剂处理可有效降低蓝莓果实在贮藏期间的腐烂率和呼吸强度峰值,抑制呼吸作用和丙二醛的积累,减缓果实可滴定酸含量的下降,保持较高的谷胱甘肽含量,提高过氧化物酶和抗坏血酸过氧化物酶的活性。其中15 g/L壳聚糖和1.0%柑橘精油复合处理的保鲜效果最佳。该研究可为绿色、健康的天然防腐剂在蓝莓保鲜上的应用提供了参考。

关键词：蓝莓壳聚糖柑橘精油采后贮藏保鲜效果

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Aspirin inhibits tumor necrosis factor-a-stimulated fractalkine expression in human umbilical vein endothelial cells

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Chinese Medical Journal 2009年第10期122卷 1147-1153页

作者： JIANG de-qian LIU Hong ZHANG she-bing ZHANG Xiao-lian department of Cardiology Second Xiangya Hospital of Central Southern University Changsha Hunan 410011 China department of Geriatrics Second Xiangya Hospital of Central Southern University Changsha Hunan 410011 China

Background Fractalkine is an important chemokine mediating local monocyte accumulation and inflammatory reactions in the vascular wall. Aspirin inhibits inflammatory cytokine expression closely related to atherosclerosis through the way independent of platelet and cyclooxygenase （COX）. There has been no report about the effect of aspirin on fractalkine expression. We aimed to determine the fractalkine expression in human umbilical vein endothelial cell （HUVEC） stimulated by tumor necrosis factor （TNF）-α and the effect of aspirin intervention. Methods Six of 8 HUVEC groups received either different concentrations of aspirin （0.02, 0.2, 1.0, 5.0 mmol/L） or 40 μmol/L pyrrolidinecarbodithioc acid （PDTC） or 0.5 μmol/L NS-398. The other two groups were negative control and positive control （TNF-α-stimulated）. After being incubated for 24 hours, cells of the 8 groups except the negative control one were stimulated with TNF-α （4 ng/ml） for another 24 hours. After that, the cells were collected for RNA isolation and protein extraction. Results Both mRNA and protein expressions of fractalkine in HUVEC were upregulated by 4 ng/ml TNF-α stimulation. Aspirin inhibited fractalkine expression in a dose-dependent manner at mRNA and protein levels. Nuclear factor-kappa B inhibitor, PDTC, effectively decreased the fractalkine expression. Fractalkine expression was not influenced by COX-2 selective inhibitor NS-398. COX-1 protein expression was not changed by either TNF-α stimulation or aspirin, PDTC, NS-398 intervention. Both mRNA and protein expression of COX-2 in HUVEC were upregulated by 4 ng/ml TNF-α stimulation. Aspirin decreased COX-2 expression in a dose-dependent manner at mRNA and protein levels. Conclusions TNF-α-stimulated fractalkine expression is suppressed by aspirin in a dose-dependent manner through the nuclear factor-kappa B p65 pathway.

关键词： aspirin fractalkine tumor necrosis factor-alpha nuclear factor-kappa B

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锚索抗滑桩在边坡治理工程中的应用

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江西建材 2024年第6期 203-204,209页

作者：佘雪伟中建材(河南)勘测设计有限公司河南信阳464000

为了优选合理的锚索抗滑桩施工方案,文中依托某路堑边坡项目,建立锚索抗滑桩的仿真模型,利用MIDAS软件模拟分析预应力锚索抗滑桩的稳定性及力学变形特性。结果表明,未设置支护的边坡工程稳定性系数为1.03,边坡稳定性系数随着抗滑桩截面... 详细信息

为了优选合理的锚索抗滑桩施工方案,文中依托某路堑边坡项目,建立锚索抗滑桩的仿真模型,利用MIDAS软件模拟分析预应力锚索抗滑桩的稳定性及力学变形特性。结果表明,未设置支护的边坡工程稳定性系数为1.03,边坡稳定性系数随着抗滑桩截面尺寸的增加以及预应力的增加而逐渐增加;随着桩深的增加,抗滑桩的水平位移初期不断增加,工况3条件下抗滑桩的桩底水平位移最低,即工况3支护方案的边坡抗变形能力最强。随着桩深的增加,抗滑桩的剪力表现为先负向降低、后正向增加、后降低、再次反向增加的变化规律,抗滑桩的弯矩表现为先降低、后增加、再降低的变化规律。

关键词：边坡工程锚索抗滑桩数值模拟水平位移剪力弯矩

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Coinfection with hepatic cystic and alveolar echinococcosis with abdominal wall abscess and sinus tract formation:A case report

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World Journal of Hepatology 2024年第2期16卷 279-285页

作者： Miao-Miao Wang Xiu-Qing An Jin-Ping Chai Jin-Yu Yang Ji-de A Xiang-Ren A School of Continuing Education Qinghai UniversityXining 810000Qinghai ProvinceChina department of Internal Medicine-Cardiovascular Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina department of General Surgery Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina department of Hepatic Hydatidosis Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina department of Medical Laboratory Medicine Qinghai Provincial People's HospitalXining 810007Qinghai ProvinceChina

BACKGROUND Hepatic cystic and alveolar echinococcosis coinfections,particularly with concurrent abscesses and sinus tract formation,are extremely *** article presents a case of a patient diagnosed with this unique presentation,discussing the typical imaging manifestations of both echinococcosis types and detailing the diagnosis and surgical treatment experience *** SUMMARY A 39-year-old Tibetan woman presented with concurrent hepatic cystic and alveolar echinococcosis,accompanied by abdominal wall abscesses and sinus tract *** conventional imaging examinations suggested only hepatic cystic echinococcosis,but intraoperative and postoperative pathological examination revealed the *** radical resection of the lesions,the patient’s condition improved,and she was discharged soon *** outpatient follow-ups confirmed no recurrence of the hydatid lesion and normal surgical wound *** mixed hepatic cystic and alveolar echinococcosis with abdominal wall abscesses and sinus tract formations are rare,the general treatment approach remains consistent with that of simpler infections of alveolar *** Lesions involving the abdominal wall and sinus tract formation,may require radical ***-term prognosis includes albendazole and follow-up examinations.

关键词： Cystic echinococcosis Alveolar echinococcosis Abdominal wall abscess Surgical treatment Sinus tract Case report

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Cardiac remodeling in patients with atrial fibrillation reversing bradycardia-induced cardiomyopathy:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1339-1345页

作者： de-Kui Gao Xiang-Lin Ye Zhen Duan Hong-Yang Zhang Tao Xiong Zheng-Hong Li Hai-Feng Pei department of Cardiology Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina department of Cardiology The General Hospital of Western Theater CommandChengdu 610083Sichuan ProvinceChina department of Clinical Medicine Southwest Medical UniversityLuzhou 646000Sichuan ProvinceChina department of Special Inspection Jiangyou Second People's HospitalJiangyou 621701Sichuan ProvinceChina

BACKGROUND Bradycardia-induced cardiomyopathy(BIC),which is a disease resulting from bradycardia,is characterized by cardiac chamber enlargement and diminished cardiac *** correction of bradycardia can allow for significant improvements in both cardiac function and structure;however,this disease has been infrequently *** this case,we conducted a longitudinal followup of a patient who had been enduring BIC for more than 40 years to heighten awareness and prompt timely diagnosis and rational *** SUMMARY A woman who presented with postactivity fatigue and dyspnea was diagnosed with bradycardia at the age of *** she had no obvious symptoms,she did not receive any treatment to improve her bradycardia during the 42-year follow-up,except for the implantation of a temporary pacemaker during labor induction *** time progressed,the patient's heart gradually expanded due to her low ventricular rate,and she was diagnosed with *** 2014,the patient developed atrial fibrillation,her ventricular rate gradually increased,and her heart shape gradually returned to *** report describes the cardiac morphological changes caused by the heart rate changes in BIC patients older than 40 years,introduces another possible outcome of BIC,and emphasizes the importance of early intervention in treating *** BIC can induce atrial fibrillation,causing an increased ventricular rate and leading to positive cardiac remodeling.

关键词： Bradycardia cardiomyopathy Heart rate Atrial fibrillation Cardiac dilatation Case report

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Chiral magnetic effect for chiral fermion system

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Chinese Physics C 2020年第7期44卷 126-134页

作者： Ren-Da Dong Ren-Hong Fang de-Fu Hou Duan she Institute of Particle Physics and Key Laboratory of Quark and Lepton Physics(MOS) Central China Normal UniversityWuhan 430079China

The chiral magnetic effect is concisely derived by employing the Wigner function approach in the chiral fermion ***,the chiral magnetic effect is derived by solving the Landau levels of chiral fermions in *** second quantization and ensemble average leads to the equation of the chiral magnetic effect for righthand and lefthand fermion *** chiral magnetic effect arises uniquely from the contribution of the lowest Landau *** carefully analyze the lowest Landau level and find that all righthand(chirality is+1)fermions move along the direction of the magnetic field,whereas all lefthand(chirality is-1)fermions move in the opposite direction of the magnetic ***,the chiral magnetic effect can be explained clearly using a microscopic approach.

关键词： CME Landau levels chiral fermions

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Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

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World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang Zheng-de Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie Zheng Yun-Xiao Shang Bao-Ping Xu Zhi-sheng Liu Gen Lu Ji-Kui deng Guang-Hua Liu Xiao-Chuan Wang Jian-she Wang Lu-Zhao Feng Wei Liu Yi Zheng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong shen Gang Liu Li-Wei Gao Li-Juan Xiong Yan Bai Li-Kai Lin Zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi Zhao Jian-Bo Shao Daniel Kwok-keung Ng Gary Wing-kin Wong Zheng-Yan Zhao Xing-Wang Li Yong-Hong Yang Kun-Ling shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China department of Respiratory Shenzhen Children's HospitalShenzhen 518038China department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

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