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Review of the potential value of serum interleukin levels as prognostic biomarkers of liver failure

World Journal of Clinical Cases 2024年第27期12卷 6045-6056页

作者： Yong Lin Geng-Jie Yan Mei-Yan Liu Yin Cao Kan Zhang Na Wang Fu-Li Long de-wen mao Graduate School Guangxi University of Chinese MedicineNanning 530200Guangxi Zhuang Autonomous RegionChina Guangxi School of Chinese Medicine Guangxi University of Traditional Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina department of Hepatology The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina department of Administration The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530023Guangxi Zhuang Autonomous RegionChina

Liver failure(LF)is prevalent in China and is characterized by complex path-ogenesis,challenging clinical management,poor prognosis,and rising incidence and mortality *** immune status is an important factor affecting LF ***(Ils)are a type of cytokine that act and interact with multiple cells,including immune *** signaling molecules play important roles in intercellular information transmission,including the regulation of immune cells;mediation of the activation,proliferation,and differentiation of T and B cells;and orchestration of the inflammatory *** date,many studies have explored the correlation between IL expression and liver disease prognosis,but few studies have evaluated Ils as the prognostic biomarkers of *** article reviews the potential use of Ils as the prognostic biomarkers of ***,it evaluates the predictive values of IL-21,IL-22,and IL-31,the three often overlooked yet promising prognostic biomarkers,in predicting suscept-ibility to *** biomarkers for early prognostic insights can facilitate tailored treatment strategies and enhance patient ***,this article focuses on the identification of IL-21,IL-22,and IL-33 as biomarkers in preclinical and clinical studies on LF and reviews their role as biomarkers in the pathogenesis and diagnosis of LF.

关键词： Interleukin-21 Interleukin-22 Interleukin-31 Liver failure Biological markers Potential value

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Dynamic steric confinement effect expands the frontier of Cu-catalyzed asymmetric propargylic aminations

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Science China Chemistry 2024年第10期67卷 3181-3183页

作者： Peng Chen mao-mao Zhang wen-Jing Xiao Liang-Qiu Lu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China Wuhan Institute of Photochemistry and Technology Wuhan 430082China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou 730000China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Chiralα-tertiary amines and related azacycles are commonly found in many natural products,pharmaceuticals and agrochemicals[1].Copper-catalyzed asymmetric propargylic amination(APA)reactions have been established as a reliable method to access enantio-enriched propargylic amines,largely due to the seminal contribution of Nishibayashi et al.[2]and van Maarseveen et al.[3]in 2008.

关键词： catalyzed asymmetric amines

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Rare leptin in non-alcoholic fatty liver cirrhosis:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10293-10300页

作者： Yao-Bin Nong Hong-Na Huang Jing-Jing Huang Yuan-Qin Du wen-Xuan Song de-wen mao Yue-Xue Zhong Rong-Huo Zhu Xi-Yu Xiao Rui-Xi Zhong The First Clinical Medical College Guangxi University of Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina department of Internal Medicine of Traditional Chinese Medicine The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina department of Spleen and Stomach Liver Diseases The First Affiliated Hospital of Guangxi University of Chinese MedicineNanning 530022Guangxi Zhuang Autonomous RegionChina department of Hepatology The First Affiliated Hospital of Guangxi University of Traditional Chinese MedicineNanningGuangxi Zhuang Autonomous RegionChina

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)-related cirrhosis is mainly caused by NAFLD by causing inflammation which leads to *** role of leptin in NAFLD-related cirrhosis has been rarely *** SUMMARY This study presents the case of a 65-year-old male patient who was referred to The First Affiliated Hospital of Guangxi University of Chinese Medicine,Guangxi,Chi-na,for diagnosis and treatment for liver ***,the cause of liver cirrhosis was *** radiology,laboratory examination,pathological results and analysis of the patient’s signs and symptoms,the case was finally diagnosed with final NAFLD-related *** this study reports a single case,the findings might expand the understanding of leptin’s role in NAFLD-related cirrhosis and might provide a basis for the clinical diagnostic criteria,pathological features and treatment of NAFLD-related *** Although the occurrence of marasmus NAFLD-related cirrhosis is rare,it needs to be distinguished from other liver diseases,including viral hepatitis,drug-induced liver disease,Wilson’s disease and autoimmune liver *** treatment is needed to prevent the progression of NAFLD-related cirrhosis.

关键词： Non-alcoholic fatty cirrhosis Leptin type Nonalcoholic fatty liver disease Case report

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A chitosan-based antibacterial hydrogel with injectable and self-healing capabilities

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Marine Life Science & Technology 2024年第1期6卷 115-125页

作者： Rui Chen Yanan Hao Secundo Francesco Xiangzhao mao wen-Can Huang State Key Laboratory of Marine Food Processing and Safety Control College of Food Science and EngineeringOcean University of ChinaQingdao 266404China Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology Qingdao 266237China Qingdao Key Laboratory of Food Biotechnology Qingdao 266404China Key Laboratory of Biological Processing of Aquatic Products China National Light IndustryQingdao 266404China Istituto di Scienze e Tecnologie Chimiche“Giulio Natta” Consiglio Nazionale delle Ricerche via Mario Bianco 920131 MilanItaly

The presence of bacteria directly affects wound ***-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial ***,a double-cross-linking chitosanbased hydrogel with antibacterial,self-healing,and injectable properties is *** chitosan was successfully prepared,and the thiolated chitosan molecules were cross-linked by Ag-S coordination to form a supramolecular ***,the amine groups in the thiolated chitosan covalently cross-linked with genipin to further promote hydrogel *** vitro experimental results indicate that hydrogel can release Ag^(+)over an extended time,achieving an antibacterial rate of over 99% against Escherichia coli and Staphylococcus *** to the reversible and dynamic feature of Ag-S coordination,an antibacterial hydrogel exhibited injectable and self-healing ***,the hydrogel showed excellent biocompatibility and biodegradability.

关键词： Hydrogel Chitosan Silver ion Cross-linking Antibacterial

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Experimental Study on Mixed-Mode(Ⅰ–Ⅱ)Fracture Toughness of Freshwater Ice

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Acta Mechanica Solida Sinica 2024年第2期37卷 252-264页

作者： Yaozhong Xu mao Zhou Xian Yi wen Hua Jiuzhou Huang wenyu Zhang Shiming Dong Key Laboratory of deep Underground Science and Engineering Ministry of EducationCollege of Architecture and EnvironmentSichuan UniversityChengdu610065China Failure Mechanics and Engineering Disaster Prevention Key Laboratory of Sichuan Province Sichuan UniversityChengdu610065China China Aerodynamics Research and development Center/Low Speed Aerodynamics Research Institute Mianyang621000China College of Mechanical and Electrical Engineering Xichang UniversityXichang615000China

In recent years,the issue of aircraft icing has gained widespread *** breaking and detachment of dynamic ice can pose a threat to flight ***,the shedding and fracture mechanisms of dynamic ice are unclear and cannot meet the engineering needs of ice-shedding hazard ***,studying the fracture toughness of ice bodies has extremely important practical *** address this issue,this article uses a centrally cracked Brazilian disk(CCBD)specimen to measure the pure modeⅠtoughness and pure modeⅡfracture toughness of freshwater ice at different loading *** mixed-mode(Ⅰ–Ⅱ)fracture characteristics of ice are discussed,and the experimental results are compared and analyzed with the theoretical values of the generalized maximum tangential stress(GMTS)criterion considering the influence of *** results indicated that as the loading rate increases,the pure modeⅠtoughness and pure modeⅡfracture toughness of freshwater ice decrease,and the fracture toughness of freshwater ice is more sensitive to the loading rate.Ⅰn terms of fracture criteria,the theoretical value of the ratio of pure modeⅡfracture toughness to pure modeⅠfracture toughness based on the GMTS criterion is in good agreement with the experimental value,while the theoretical value based on the maximum tangential stress(MTS)criterion deviates significantly from the experimental value,indicating that the GMTS criterion considering the influence of T-stress can better predict the experimental results.

关键词： Freshwater ice Fracture criteria Centrally cracked Brazilian disk(CCBD) Mixed-mode(Ⅰ-Ⅱ) Loading rate

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Correlation and Pathway Analysis of the Carbon,Nitrogen,and Phosphorus in Soil-Microorganism-Plant with Main Quality Components of Tea(Camellia sinensis)

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 487-502页

作者： Chun mao Ji He Xuefeng wen Yangzhou Xiang Jihong Feng Yingge Shu College of Agriculture Guizhou UniversityGuiyangChina School of Geography and Resources Guizhou Education UniversityGuiyangChina

The contents of carbon(C),nitrogen(N),and phosphorus(P)in soil-microorganisms-plant signiﬁcantly affect tea quality by altering the main quality components of tea,such as tea polyphenols,amino acids,and ***,few studies have quantiﬁed the effects of these factors on the main quality components of *** study aimed to explore the interactions of C,N,and P in soil-microorganisms-plants and the effects of these factors on the main quality components of tea by using the path analysis *** results indicated that(1)The contents of C,N,and P in soil,microorganisms,and tea plants were highly correlated and collinear,and showed signiﬁcant correlations with the main quality components of tea.(2)Optimal regression equations were established to esti-mate tea polyphenol,amino acid,catechin,caffeine,and water extract content based on C,N,and P contents in soil,microorganisms,and tea plants(R^(2)=0.923,0.726,0.954,0.848,and 0.883,respectively).(3)Pathway analysis showed that microbial biomass phosphorus(MBP),root phosphorus,branch nitrogen,and microbial biomass carbon(MBC)were the largest direct impact factors on tea polyphenol,catechin,water extracts,amino acid,and caffeine content,*** carbon,root phosphorus,and leaf nitrogen were the largest indirect impact factors on tea polyphenol,catechin,and water extract content,*** carbon indirectly affected tea polyphenol content mainly by altering MBP *** phosphorus indirectly affected catechin content mainly by altering soil organic carbon *** nitrogen indirectly affected water extract content mainly by altering branch nitrogen *** research results provide the scientiﬁc basis for reasonable fertilization in tea gardens and tea quality improvement.

关键词： Soil-microorganisms-plant system carbon nitrogen phosphorus tea quality path analysis

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Optimization design of the hydro-pneumatic suspension system for high clearance self-propelled sprayer using improved MOPSO algorithm

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International Journal of Agricultural and Biological Engineering 2024年第2期17卷 109-122页

作者： Fan Yang Yuefeng Du Changkai wen Zhen Li Enrong mao Zhongxiang Zhu College of Engineering China Agricultural UniversityBeijing 100083China Beijing Key Laboratory of Optimized design for Modern Agricultural Equipment China Agricultural UniversityBeijing 100083China

Large high clearance self-propelled sprayers were widely used in field plant protection due to their high-efficiency operation *** by the characteristics of field operations such as high power,heavy weight,high ground clearance,and fast operation speed,the comprehensive requirements for the ride comfort,handling stability and road friendliness of the sprayer were increasingly *** the present stage,the chassis structure of the high clearance selfpropelled sprayer that attaches great importance to the improvement of comprehensive performance still has the problems of severe bumps,weak handling performance and serious road damage in complex field ***,this paper proposes an optimization design method for hydro-pneumatic suspension system of a high clearance self-propelled sprayer based on the improved MOPSO(Multi-Objective Particle Swarm Optimization)algorithm,covering the entire process of configuration design,parameter intelligent optimization,and system verification of the high clearance self-propelled sprayer ***,chassis structure of the hydro-pneumatic suspension suitable for the high clearance self-propelled sprayer was designed,and a design method combining the improved MOPSO algorithm based on time-varying fusion strategy and adaptive update with the parameter optimization of hydro-pneumatic suspension based on this algorithm was proposed,and finally the software simulation and bench performance verification were carried *** results show that the optimized hydropneumatic suspension has excellent vibration reduction effect,and the body acceleration,suspension dynamic deflection and tire deflection were increased by 16.5%,9.9%and 0.9%respectively,compared with those before *** comprehensive performance of the hydro-pneumatic suspension designed in this study is better than that of the traditional suspension.

关键词： high clearance self-propelled sprayer vibration reduction hydro-pneumatic suspension MOPSO multi-objective optimization

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Effect of Rheum palmatum *** NF-κ B signaling pathway of mice with acute liver failure

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Asian Pacific Journal of Tropical Medicine 2015年第10期8卷 823-829页

作者： Rong-Zhen Zhang Hua Qiu Na Wang Fu-Li Long de-wen mao First Affiliated Hospital of Guangxi University of TCM

Objective:To explore the regulation effect of Rheum palmatum(***) *** NF-κ.B signaling pathway of ALF ***:The intraperitoneal injection of D-GalN/LPS was employed for the model *** in the treatment group and positive control group were given the R,palmatum *** bifendate before the model *** in the normal group were given the intraperitoneal injection of equivalent normal saline for continuously *** 16 h of model building,the blood was collected from eyeballs of mice and then mice were *** measurement was performed on the content of ALT,AST,NO and 11-1βin the serum of mice in eaeh group,as well as the activity of Caspase 3 and Caspase 8 in the liver *** staining was employed to detect the pathological morphology of liver;and the western blot was used to detect the expression of iNOS,COX-2,Bax,Bcl-2,PCNA,NF-κ B p65 and I κ.***:The content of ALT,AST,NO and I1-1β in the serum and the activity of Caspase 3 and Caspase 8 in the liver tissue were increased in the mice of ALF model ***,the expression of iNOS,COX-2 and Bax was increased,the expression of Bcl-2 and PCNA was decreased,the phosphorylation of NF-κ B p65 and 1κ B was significant and the treatment group of *** *** inhibit such ***:Through NF-κB signaling pathway,the *** *** reduce the content of enzyme of liver function and inflammation factor in the serum of ALF mice,regulate the expression of cell apoptosisrelated protein and improve the symptoms of ALF mice.

关键词： Rheum officinale Acute liver failure Inflammation

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A semi-analytical model for coupled flow in stress-sensitive multi-scale shale reservoirs with fractal characteristics

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Petroleum Science 2024年第1期21卷 327-342页

作者： Qian Zhang wen-Dong Wang Yu-Liang Su Wei Chen Zheng-Dong Lei Lei Li Yong-mao Hao Key Laboratory of Unconventional Oil&Gas development(China University of Petroleum(East China)) Ministry of EducationQingdao266580ShandongChina School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongChina Shale Oil development Branch Changqing Oilfield CompanyPetroChinaQingyang745708GansuChina PetroChina Research Institute of Petroleum Exploration&development Beijing100083China

A large number of nanopores and complex fracture structures in shale reservoirs results in multi-scale flow of oil. With the development of shale oil reservoirs, the permeability of multi-scale media undergoes changes due to stress sensitivity, which plays a crucial role in controlling pressure propagation and oil flow. This paper proposes a multi-scale coupled flow mathematical model of matrix nanopores, induced fractures, and hydraulic fractures. In this model, the micro-scale effects of shale oil flow in fractal nanopores, fractal induced fracture network, and stress sensitivity of multi-scale media are considered. We solved the model iteratively using Pedrosa transform, semi-analytic Segmented Bessel function, Laplace transform. The results of this model exhibit good agreement with the numerical solution and field production data, confirming the high accuracy of the model. As well, the influence of stress sensitivity on permeability, pressure and production is analyzed. It is shown that the permeability and production decrease significantly when induced fractures are weakly supported. Closed induced fractures can inhibit interporosity flow in the stimulated reservoir volume (SRV). It has been shown in sensitivity analysis that hydraulic fractures are beneficial to early production, and induced fractures in SRV are beneficial to middle production. The model can characterize multi-scale flow characteristics of shale oil, providing theoretical guidance for rapid productivity evaluation.

关键词： Multi-scale coupled flow Stress sensitivity Shale oil Micro-scale effect Fractal theory

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The source of lithium in Lakkor Co Salt Lake on Qinghai-Tibet Plateau,China:evidence from hydrochemical characteristics and boron isotope

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Acta Geochimica 2024年第5期43卷 933-946页

作者： Zheng Yan Li Bin Kai Li mao-Yong He Xue Qin wen Jiang Di Zhou department of Geoscience and Technology Taiyuan University of TechnologyYingzexi StreetTaiyuan 030024Shanxi ProvinceChina State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy of SciencesXi’an 710061China Qinghai Provincial Key Laboratory of Geology and Environment of Salt Lakes Qinghai Institute of Salt LakesChinese Academy of SciencesXining 810008QinghaiChina School of Earth Science and Resources Chang’an UniversityXi’an 710000ShaanxiChina Qinghai Normal University Academy of Plateau Science and SustainabilityXining 810016China

The availability of lithium resources is of great significance for the development of modern technologies,as well as for civil and military *** Qinghai-Tibet Plateau is a region known for its abundance of lithium-rich salt ***,the specific origin of lithium in these lakes is still unknown,which hinders the advancement of the lithium resource business in this *** research this issue,this study involved the collection of 20 samples from Lakkor Co Salt Lake on Qinghai-Tibet Plateau,encompassing samples of surface brine,cold springs,fresh lakes,and recharge *** composition of anions and cations in these samples was ***,the analysis extensivelyutilizedthePiperthree-linediagram,Gibbs model,and ion proportion *** findings of this study indicate that as the moves from the recharge water system to salt lake,there is a transition in water type from strong carbonate to moderate carbonate and weak carbonate,as well as Na *** research based on a similar source of both lithium and boron,utilized ion correlation analysis and boron isotope study in the Lakkor Co area,and analyzed the source and transporting process of *** main origin of lithium in Lakkor Co is the dissolution of lithiumrich rocks,recharge water systems,and deep hydrothermal *** findings are highly significant in enhancing the foundational data of lithium-rich brine resources in the Qinghai-Tibet Plateau and are beneficial for assessing the future development of such deposits.

关键词： Lithium Hydrochemical Li-rich Salt lake Boron isotope

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