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Inhibiting SHP2 reduces glycolysis, promotes microglial M1 polarization, and alleviates secondary inflammation following spinal cord injury in a mouse model

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Neural Regeneration Research 2025年第3期20卷 858-872页

作者： Xintian Ding Chun Chen Heng Zhao Bin Dai lei Ye Tao Song Shuai Huang Jia Wang Tao You department of Orthopedics The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina department of Orthopedics Provincial Hospital Affiliated to Anhui Medical UniversityHefeiAnhui ProvinceChina

Reducing the secondary inflammatory response, which is partly mediated by microglia, is a key focus in the treatment of spinal cord injury. Src homology 2-containing protein tyrosine phosphatase 2(SHP2), encoded by PTPN11, is widely expressed in the human body and plays a role in inflammation through various mechanisms. Therefore, SHP2 is considered a potential target for the treatment of inflammation-related diseases. However, its role in secondary inflammation after spinal cord injury remains unclear. In this study, SHP2 was found to be abundantly expressed in microglia at the site of spinal cord injury. Inhibition of SHP2 expression using siRNA and SHP2 inhibitors attenuated the microglial inflammatory response in an in vitro lipopolysaccharide-induced model of inflammation. Notably, after treatment with SHP2 inhibitors, mice with spinal cord injury exhibited significantly improved hind limb locomotor function and reduced residual urine volume in the bladder. Subsequent in vitro experiments showed that, in microglia stimulated with lipopolysaccharide, inhibiting SHP2 expression promoted M2 polarization and inhibited M1 polarization. Finally, a co-culture experiment was conducted to assess the effect of microglia treated with SHP2 inhibitors on neuronal cells. The results demonstrated that inflammatory factors produced by microglia promoted neuronal apoptosis, while inhibiting SHP2 expression mitigated these effects. Collectively, our findings suggest that SHP2 enhances secondary inflammation and neuronal damage subsequent to spinal cord injury by modulating microglial phenotype. Therefore, inhibiting SHP2 alleviates the inflammatory response in mice with spinal cord injury and promotes functional recovery postinjury.

关键词： apoptosis glycolysis inflammatory response microglia neurons polarization spinal cord injury Src homology 2-containing protein tyrosine phosphatase 2

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ON CONTROL OF STRONG CONSENSUS FOR NETWORKED AGENTS WITH NOISY OBSERVATIONS

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Journal of Systems Science & Complexity 2012年第1期25卷 1-12页

作者： Haitao FANG Han-Fu CHEN lei wen Key Laboratory of Systems and Control Institute of Systems ScienceAcademy of Mathematics and Systems ScienceChinese Academy of Sciences

The discrete-time first-order multi-agent networks with communication noises are under consideration. Based on the noisy observations, the consensus control is given for networks with both fixed and time-varying topologies. The states of agents in the resulting closed-loop network are updated by a stochastic approximation （SA） algorithm, and the consensus analysis for networks turns to be the convergence analysis for SA. For networks with fixed topologies, the proposed consensus control leads to consensus of agents with probability one if the graph associated with the network is connected. In the case of time-varying topologies, the similar results are derived if the graph is jointly connected in a fixed time period. Compared with existing results, the networks considered here are in a more general setting under weaker assumptions and the strong consensus is established by a simpler proof.

关键词： Consensus control multi-agent networks stochastic approximation strong consensus.

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Urban rail departure capacity analysis based on a cellular automaton model

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Chinese Physics B 2018年第7期27卷 196-202页

作者： wen-Jun Li lei Nie School of Traffic and Transportation Beijing Jiaotong UniversityBeijing 100044China

As an important traffic mode, urban rail transit is constantly developing toward improvement in service capacity and quality. When an urban rail transit system is evaluated in terms of its service capacity, the train departure capacity is an important index that can objectively reflect the service level of an urban rail transit facility. In light of the existing cellular automaton models, this paper proposes a suitable cellular automaton model to analyze the train departure capacity of urban rail transit under different variable factors and conditions. The established model can demonstrate the train operating processes by implementing the proposed sound rules, including the rules of train departure at the origin and intermediate stations, and the velocity and position updating rules. The properties of train traffic are analyzed via numerical experiments. The numerical results show that the departure capacity is negatively affected by the train departure control manner. In addition, （i） the real-time signal control can offer a higher train service frequency; （ii） the departure capacity gradually rises with the decrease in the line design speed to a limited extent; （iii） the departure capacity decreases with extension in the train length; （iv） the number of departed trains decreases as the train stop time increases; （v） the departure capacity is not affected by the section length. However, the longer the length, the worse the service quality of the urban rail transit line. The experiments show that the proposed cellular automaton model can be used to analyze the train service capacity of an urban rail transit system by performing quantitative analysis under various considered factors, conditions, and management modes.

关键词： train departure capacity urban rail transit cellular automaton model

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THE EFFECT OF SILICA MORPHOLOGY ON PROPERTIES OF PVA/SILICA NANO-COMPOSITES

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Chinese Journal of Polymer Science 2013年第11期31卷 1546-1553页

作者： lei Bi Jin-wen Wang 陈枫傅强 College of Polymer Science and Engineering State Key Laboratory of Polymer Materials EngineeringSichuan University

Two kinds of poly（vinyl alcohol）（PVA）-silica composites were prepared with different methods. One composite was prepared by directly mixing PVA with 80 nm silica nano-particles which were made from tetraethoxysilane （TEOS）. The another was obtained by the mixing PVA and hydrolyzed TEOS in the presence of acid-catalyst. The properties of the two PVA/silica hybrids were characterized by means of scanning electron microscopy （SEM）, UV-Visible spectroscopy, solubility tests, limiting oxygen index （LOI） test, tensile test and dynamical mechanical analysis （DMA）, respectively. The results indicate that PVA-TEOS composites （PT for short） display more transparency than PVA-silica nano-particles hybrids （PS for short）. At the same time, The PT composites presented more excellent performance than PS in water resistance, fire resistance and mechanical properties. Moreover, the Tg of PT increased with increasing TEOS content, while that of PS decreased.

关键词： Silica Poly(vinyl alcohol) TEOS Network Nano-composite.

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Quantum to classical transition induced by a classically small influence

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Chinese Physics B 2020年第8期29卷 151-156页

作者： wen-lei Zhao Quanlin Jie School of Science Jiangxi University of Science and TechnologyGanzhou 341000China department of Physics Wuhan UniversityWuhan 430072China

We investigate the quantum to classical transition induced by two-particle interaction via a system of periodically kicked *** classical dynamics of particle 1 is almost unaffected in condition that its mass is much larger than that of particle ***,such classically weak influence leads to the quantum to classical transition of the dynamical behavior of particle ***,the quantum diffusion of this particle undergoes the transition from dynamical localization to the classically chaotic diffusion with the decrease of the effective Planck constantħ*** behind physics is due to the growth of entanglement in the *** classically very weak interaction leads to the exponential decay of purity in condition that the classical dynamics of external degrees freedom is strongly chaotic.

关键词： quantum to classical transition quantum decoherence quantum chaos

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Analysis of Crystallization Behavior of Mold Fluxes Containing TiO_2 Using Single Hot Thermocouple Technique

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Journal of Iron and Steel Research International 2016年第4期23卷 322-328页

作者： Yun lei Bing XIE wen-hui MA State Key Laboratory of Complex Nonferrous Metal Resources Clean Utilization Kunming University of Science and Technology College of Materials Science and Engineering Chongqing University

The crystallization behavior of mold fluxes containing 0-8 mass% TiO2 was investigated using the single hot therrnocouple technique （SHTT） and X ray diffraction （XRD） to study the possible effects on the coordination of heat transfer control and strand lubrication for casting crack sensitive peritectic steels. Time-temperature-transforma tion （TTT） and continuous-cooling transformation （CCT） curves were plotted using the data obtained from SHTT to characterize the crystallization of the mold fluxes. The results showed that crystallization of the mold fluxes during isothermal and non-isothermal processes was suppressed with TiO2 addition. From the TTT curves, it could be seen that the incubation and growth time of crystallization increased significantly with TiO2 addition. The CCT curves showed that the crystallization temperature initially decreased, and then suddenly increased with increasing the TiO2 content. XRD analysis suggested the presence of cuspidine in the mold fluxes with lower TiO2 content （〈4 mass%） , while both perovskite and cuspidine were detected in the mold fluxes when the TiO2 content was increased to 8 mass%. In addition, the growth mechanisms of the crystals changed during the isothermal crystallization process from interface controlled growth to diffusion-controlled growth with increasing the TiO2 content.

关键词： mold flux single hot thermocouple technique kinetics crystallization TTT curve CCT curve

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Recent advances of long noncoding RNAs involved in the development of multiple sclerosis

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Chinese Journal of Natural Medicines 2020年第1期18卷 36-46页

作者： LI Qian-wen lei wen CHEN Cong GUO Wei School of Life Science and Technology China Pharmaceutical UniversityJiangsu Key Laboratory of Druggability of BiopharmaceuticalsNanjing 210009China Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China

Given the rapid increase of patients with autoimmune diseases and the lack of satisfactory therapies,the discovery of novel and effective therapeutic targets have been in an urgent *** studies have revealed that long noncoding RNAs(lncRNAs)play crucial roles in the development of multiple sclerosis(MS),which provides a new opportunity of uncovering novel mechanism associated with the progression of *** review highlights the dysregulation of lncRNAs in the development of MS in patients and animal ***,the potential clinical relevance of lncRNAs severed as therapeutic targets and diagnostic markers are discussed.

关键词： Multiple sclerosis Long noncoding RNA Experimental autoimmune encephalomyelitis Clinical relevance Dysregulation

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A comparative study on corrosion kinetic parameter estimation methods for the early stage corrosion of Q345B steel in 3.5wt% NaCl solution

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International Journal of Minerals,Metallurgy and Materials 2017年第10期24卷 1112-1124页

作者： Shuang-yu Cai lei wen Ying Jin National Center for Materials Service Safety University of Science and Technology Beijing Beijing 100083 China

Corrosion kinetic parameters play an important role in researchers' ability to understand and predict corrosion behavior. The corrosion kinetic parameters of structural steel Q345B specimens immersed in 3.5wt% NaCl solution for 1–2 h were determined using linear polarization resistance(LPR), Tafel-curve multiparameter fitting, electrochemical impedance spectroscopy(EIS), and electrochemical frequency modulation(EFM) methods. The advantages and disadvantages of each method were investigated and discussed through comparative investigation. Meanwhile, the average corrosion rate was examined using traditional coupon tests. The results showed that the corrosion current density values estimated by EFM at a base frequency of 0.001 Hz and those obtained by Tafel-curve four-parameter fitting(TC4) are similar and consistent with the results of coupon tests. Because of their slight perturbation of the corrosion system, EIS and EFM/TC4 in collaborative application are the recommended techniques for determining the kinetics and the corresponding parameters for the homogeneous corrosion of the naked metal. In our study of the electrochemical kinetics, we obtained much more abundant and accurate electrochemical kinetic parameters through the combined use of different electrochemical methods.

关键词： structural steel corrosion kinetics Tafel curve electrochemical impedance spectroscopy

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Construction of biomimetic smart nanochannels for confined water

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National Science Review 2014年第1期1卷 144-156页

作者： Liping wen lei Jiang Beijing National Laboratory for Molecular Sciences (BNLMS) Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education School of Chemistry & Environment Beihang University

In this review,we focus on the conined water that exists in one-dimensional micro/nano composite structures,particularly inside biological *** these nanochannels as inspiration,we discuss a strategy for the design and construction of biomimetic smart *** features of the inner surfaces of a nanochannel’s wall have similar properties to living ***,the abiotic analogs have potential applications in,for example,sensing,energy conversion and iltering.

关键词： conined water micro/nano structures nanochannel

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Automatic radar antenna scan type recognition based on limited penetrable visibility graph

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Journal of Systems Engineering and Electronics 2021年第2期32卷 437-446页

作者： LIU Songtao lei Zhenshuo GE Yang wen Zhenming department of Information System Dalian Naval AcademyDalian 116018China

To address the problem of the weak anti-noise and macro-trend extraction abilities of the current methods for identifying radar antenna scan type,a recognition method for radar antenna scan types based on limited penetrable visibility graph(LPVG)is ***,seven types of radar antenna scans are analyzed,which include the circular scan,sector scan,helical scan,raster scan,conical scan,electromechanical hybrid scan and two-dimensional electronic ***,the time series of the pulse amplitude in the radar reconnaissance receiver is converted into an LPVG network,and the feature parameters are ***,the recognition result is obtained by using a support vector machine(SVM)*** experimental results show that the recognition accuracy and noise resistance of this new method are improved,where the average recognition accuracy for radar antenna type is at least 90%when the signalto-noise ratio(SNR)is 5 dB and above.

关键词： antenna scan type limited penetrable visibility graph(LPVG) support vector machine(SVM) cognitive electronic warfare

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