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Effect of Three-High Rotary Piercing Process on Microstructure,Texture and Mechanical Properties of Magnesium Alloy Seamless Tube

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Acta Metallurgica Sinica(English Letters) 2024年第6期37卷 953-968页

作者： Xiaofeng Ding Zehao Wu Tong li Jianxun Chen Yuanhua shuang Baosheng liu Heavy Machinery Engineering Research Center of Education Ministry Taiyuan University of Science and TechnologyTaiyuan030024China College of Materials Science and Engineering Taiyuan University of Science and TechnologyTaiyuan030024China

Mg alloy seamless tubes(MASTs)were prepared through three-high rotary piercing process,effect of billet temperature,feed angle and plug advance on microstructure,texture and mechanical properties of tubes were *** effect on the deformation mechanism and improving mechanical properties mechanism of this process for MASTs were *** results show that the grain size could be refined to 11.3-31.1%of the initial grain size and the microstructure was more uniform due to the accumulation of *** formation of high strain gradient at the grain boundary activated the non-basal *** piercing process could change the grain orientation of as-extruded billet and eliminate the initial basal texture to produce new favorable *** the process could accelerate the continuous dynamic recrystallization *** piercing,yield strength of pierced tubes decreased by 6.7%,ultimate tensile strength(UTS)and elongation increased by 32.4 and 45%,respectively,at optimal *** plate-shapedβ_(1)-Mg_(17)Al_(12) orientation transformed from basal plates to prismatic plates,facilitating the increase in UTS and *** decrease size of nanoscale precipitates could reduce the cracking *** critical resolved shear stress ratios of pyramidal(10−11)slip and(11−22)slip to basal slip for the sample including prismatic plates both decreased compared to that including basal *** could enhance the ductility of tube ***,grain boundary sliding could contribute to a better ductility via coordinating deformation and reducing stress concentration during piercing process.

关键词： Mg alloy tube Rotary piercing Microstructure Texture Mechanical properties

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Microneedle patch loaded with ferritin-nanocaged doxorubicin for locally targeted drug delivery and efficient skin cancer treatment

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Particuology 2024年第5期88卷 282-289页

作者： Feng li Yuan Yang Hua Yue shuang Wang Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Ferritin has emerged as a promising nanocarrier for delivering therapeutic agents to ***,the limited drug loading and the off-target impacts after systemic administration remain challenges for cancer treatment with ferritin-based ***,we develop a microneedle patch loaded with ferritin-nanocaged doxorubicin(DoxFe@Fn/MN)for skin cancer ***,doxorubicin(Dox)is encapsulated in ferritin(Fn)using an iron core-assisted strategy,which results in a 3.4-fold increase in Dox loading compared to the direct loading ***,a polyvinyl alcohol-based microneedle(MN)patch is used for the transdermal delivery of DoxFe@Fn,enabling targeted tumour accumulation of DoxFe@Fn and preventing off-target *** released DoxFe@Fn can bind to CD71 highly expressed on skin cancer cells,facilitating its *** a result,the DoxFe@Fn/MN therapy presents a robust antitumour effect in a melanoma tumour model,showing its potential as a promising therapeutic modality for skin cancer treatment.

关键词： Ferritin Microneedle Skin cancer Drug delivery

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Charge regulation by ferromagnetic metal/liF spin-polarized interface for high-performance li metal anodes

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Rare Metals 2024年第3期43卷 995-1005页

作者： Ming-Yang Feng shuang Zhou Yi-Fang Zhang Ya-Ping Wang Chun-Yan Fu Jian-Wen li Yuan-Lang Wan Zhi-Jia Zhang Yong Jiang An-Qiang Pan State Key Laboratory of Powder Metallurgy School of Materials Science and EngineeringCentral South UniversityChangsha410083China State Key Laboratory of Separation Membranes and Membrane Processes Tianjin Key Laboratory of Advanced Fibers and Energy StorageSchool of Material Science and EngineeringTiangong UniversityTianjin300387China School of Materials Science and Engineering Hebei University of TechnologyTianjin300130China

The interfacial characteristics of the li metal anode(LMA)play a crucial role in its overall *** various materials being applied to modify the interface,a comprehensive understanding of their specific mechanisms remains to be ***,we have prepared carbon cloth(CC)frameworks with their surfaces modified using ferromagnetic metal/liF heterogeneous films(T^(M)-liF-CC)as the substrate for LMA,which exhibit superior electrochemical *** ferromagnetic Co as a representative example,our study demonstrates that the enhanced performance of Co-liF-CC,compared to bare CC,is attributed to the spinpolarized interface contributed by the Co/liF *** and liF play individual roles in redistributing electrons and li^(+)to promote homogeneous li *** nanoparticles play a crucial role in generating strong surface capacitance by storing electrons in spin-split bands,while liF,with low surface diffusion barriers,ensures fast transportation of li^(+).The Co-liF-CC@li electrodes deliver long lives of 7400 and 3600 h at 1 and 2 mA·cm^(-2)in symmetric cells,respectively;moreover,they enable full batteries with high and durable capacities,particularly when the N/P ratios are low(3.3 or even 1.7).

关键词： lithium metal anode Interfacial charge Ferromagnetic metal lithium fluoride Spin polarization

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PEGylated graphene oxide-mediated stimulation of vascular endothelial cells and responsive release of PD-1/PD-L1 inhibitor for efficient chemo-immunotherapy against cancer Author links open overlay panel

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Particuology 2024年第8期91卷 280-290页

作者： Yan Wang Feng li shuang Wang Jiaqi Meng Xiao Zhang Wei Wei State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing100190China Key Laboratory of Biopharmaceutical Preparation and delivery Chinese Academy of SciencesBeijing100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing100049China

Immune checkpoint blockade(ICB)has emerged as a promising immunotherapeutic modality against cancer in the ***,only 10-30%of patients respond to ICB,primarily due to poor immunogenicity and insufficient T cell infiltration in solid ***,we presented an approach for high-performance cancer treatment using the programmed cell death protein-1 and programmed cell death ligand-1(PD-1/PD-L1)inhibitor(BMS-202)-loaded PEGylated graphene oxide(GPi).On the one hand,GPi dissociated tight junctions of vascular endothelial cells(VECs)in tumor,thus promoting the extravasation and intratumoral accumulation of liposomal doxorubicin(lipDox),which then effectively induced immunogenic cell death of tumor *** the other hand,GPi also stimulated VECs to upregulate the expression of cell-cell interaction molecules,such as intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1,which facilitated the infiltration of T cells in *** acting as a stimulator of VECs,GPi could exert responsive release of BMS-202 under the acidic tumor microenvironment and blockade PD-1/PD-L1 axis in ***,the alternating administration of GPi and lipDox effectively inhibited tumor growth in a 4T1 tumor model,providing a novel treatment mode for chemo-immunotherapy.

关键词： PEGylated graphene oxide Vascular endothelial cells Immune checkpoint blockade Immunogenic cell death Chemo-immunotherapy

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Construction of multifunctional lanthanum manganese mixed nanoparticles mediated by ionic liquids for selective aerobic oxidation of cyclohexane

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Rare Metals 2024年第5期43卷 2205-2221页

作者： Hao li Rui-Rui Zhang Ke-Xin li shuang Wei Yu-Mei liu Rui-Xia liu Beijing Key Laboratory of Ionic liquids Clean Process CAS Key Laboratory of Green Process and EngineeringState Key Laboratory of Multiphase Complex SystemsInstitute of Process EngineeringChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Selective oxidation of alkanes to produce highvalue chemicals is an essential strategy and means to realize efficient utilization of *** this work,a strategy of lanthanum manganese mixed metal oxides(LMMO)regulated via a facile ionic liquid(IL)-assisted hydrothermal method was proposed to construct the multifunctional catalysts,which exhibited excellent catalytic performance in the selective aerobic oxidation of *** 8.9%cyclohexane conversion with 90%KA oi(cyclohexanol and cyclohexanone)selectivity was achieved over the optimal LMMO catalyst under mild *** effects of anion type,carbon chain length and concentration of ILs on the structure and properties of catalysts were investigated through various characterizations,indicating the structure-directing and template effect of ILs on the multifunctional *** formation of self-assembled spherical nanoparticles followed the"dissolution-nucleation-proliferation"mechanism with the introduction of 1-butyl-3-methylimidazolium hydrogen sulfate,ascribing the synergistic effect between the microenvironment of ILs and the hydrothermal ***,the high reactive oxygen concentration redox capacity,and suitable basic sites of LMMO catalysts mediated by ILs enhance the activation of C-H bonds and molecular oxygen,simultaneously influencing the adsorption and desorption of the substrate.A comprehensive understanding of the high KA oil selectivity and radical reaction mechanism was elucidated based on in situ diffuse reflectance infrared Fourier transform spectroscopy(DRIFTS)and radical trapping *** recycling and regeneration experiments further illuminated that the removal of adsorbed cyclohexanone acting on the LMMO catalyst was the key to achieve high KA oil selectivity.

关键词： Ionic liquids Nanoparticle Multifunctional catalyst Cyclohexane oxidation

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Interplay of RNA-binding proteins controls germ cell development in zebrafish

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Journal of Genetics and Genomics 2024年第9期51卷 889-899页

作者： de-li Shi Laboratory of developmental Biology CNRS-UMR7622Institut de Biologie Paris-Seine(IBPS)Sorbonne University75005 ParisFrance

The specification of germ cells in zebrafish mostly relies on an inherited mechanism by which localized maternal determinants,called germ plasm,confer germline fate in the early *** studies have partially allowed the identification of key regulators governing germ plasm formation and subsequent germ cell ***-binding proteins,acting in concert with other germ plasm components,play essential roles in the organization of the germ plasm and the specification,migration,maintenance,and differentiation of primordial germ *** loss of their functions impairs germ cell formation and causes sterility or sexual *** is emerging that they instruct germline development through differential regulation of mRNA fates in somatic and germ ***,the challenge remains to decipher the complex interplay of maternal germ plasm components in germ plasm compartmentalization and germ cell *** failure to control the developmental outcome of germ cells disrupts the formation of gametes,it is important to gain a complete picture of regulatory mechanisms operating in the germ cell *** review sheds light on the contributions of RNA-binding proteins to germ cell development in zebrafish and highlights intriguing questions that remain open for future investigation.

关键词： Germplasm Primordialgerm cell Germlinestem cell Gametogenesis Zebrafish RNA-binding protein Posttranscriptional gene expression Translational activation and repression

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Integrating Shipborne Images with Multichannel deep Learning for Landslide detection

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Journal of Earth Science 2024年第1期35卷 296-300页

作者： Pengfei Feng Changdong li shuang Zhang Jie Meng Jingjing Long School of Mechanical Engineering and Electronic Information China University of GeosciencesWuhan 430074China Faculty of Engineering China University of GeosciencesWuhan 430074China department of Civil Badong National Observation and Research Station of Geohazards China University of GeosciencesWuhan 430074China College of Geology Engineering and Geomatics Changan UniversityXi'an 710054China department of Geosciences University of OsloOslo 0316Norway

0 *** disasters in recession zones along riverbanks impose significant global social,economic,and ecological *** areas are particularly susceptible to *** inflict significant harm due to fluctuating water levels(Meng et al.,2023;Dai et al.,2021;li et al.,2021).This,in turn,endangers the safety and accessibility of roads and waterways adjacent to rivers,and hydropower station and reservoir security(Yan et al.,2022;Guo et al.,2020;Tang et al.,2017).

关键词： reservoir Landslide Ship

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The guest CH_(3)CN molecule triggers solid-state photochromism in a Cu_(2)I_(2)-based MOF for advanced time-dependent encryption and inkless erasable printing

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Chinese Chemical Letters 2024年第3期35卷 532-537页

作者： Meng-Juan Wang Bo li Yong-li Wei Shu-Na Zhao shuang-Quan Zang Henan Key Laboratory of Crystalline Molecular Functional Materials Henan International Joint Laboratory of Tumor Theranostical Cluster MaterialsGreen Catalysis Centerand College of ChemistryZhengzhou UniversityZhengzhou 450001China College of Chemistry and Pharmaceutical Engineering Nanyang Normal UniversityNanyang 473061China

It remains a big challenge to develop solid-state stimuli-responsive materials for time-dependent information encryption and inkless erasable printing with long retention ***,a 2D Cu_(2)I_(2)-based MOF with photoresponsive spiropyran(SP)groups orderly installed on its skeleton is *** structural isomerization from SP to colored merocyanine(MC)form can be triggered by removing the CH_(3)CN ***,the degree of structural isomerization and the retention time can be adjusted by controlling the amount of CH_(3)CN guests,exhibiting dynamic photochromic behavior with multicolor states and tunable retention *** on these advantages,time-dependent information encryption is successfully ***,the long retention time(>72 h)of the MC form under daylight conditions in the CH_(3)CN-removed Cu_(2)I_(2)-based MOF and good repeatability make it promising in various applications,such as temporary calendars,price-cards,billboards,and reusable identity *** work provides a novel design strategy to fabricate multi-functional MOF-based smart materials for challenging applications of time-dependent information encryption and inkless erasable printing.

关键词： Stimuli-responsive materials Spiropyran Solid-state photochromism Time-dependent encryption Inkless erasable printing

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Dynamic shielding of bacterial outer membrane vesicles for safe and efficient chemo-immunotherapy against tumors

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Nano Research 2024年第2期17卷 836-847页

作者： Shuping li Xin li Jiaqi Meng Weier Bao shuang Wang Peng Ye Xiao-Dong Gao Wei Wei Key Laboratory of Carbohydrate Chemistry and Biotechnology Ministry of Education School of BiotechnologyJiangnan UniversityWuxi 214122China State Key Laboratory of Biochemical Engineering Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China School of Chemical Engineering University of Chinese Academy of SciencesBeijing 100049China

Bacterial outer membrane vesicles(OMVs)are potent immunostimulants of regulating the tumor microenvironment(TME)for immunotherapy,and can be used to deliver ***,the severe systemic inflammatory response triggered by OMVs upon intravenous(i.v.)injection has limited their ***,we developed a safe and effective strategy by conjugating doxorubicin-loaded serum albumin(SA-DOX,AD)onto the surface of OMVs using a matrix metalloproteinase(MMP)-cleavable peptide linker(cL).This approach enabled the dynamic shielding of OMVs to reduce the systemic side effects while simultaneously enhancing the anti-tumor effects through ***,the resulting OMV-cL-AD formulation exhibited significantly enhanced accumulation at the tumor site after ***,facilitated by the SA decoration on the OMVs ***,the shield on the OMV-cL-AD was cleaved by the over-expressed MMP in the TME,leading to the release of both OMVs and *** process provided OMV-induced immunotherapy and DOX-induced chemotherapy,resulting in synergistic tumor *** conclusion,our work demonstrated the potential of OMV-cL-AD as an effective immunochemotherapy strategy that can prolong the survival time of mice without inducing side effects.

关键词： outer membrane vesicles doxorubicin tumor microenvironment immunotherapy chemotherapy

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Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes

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Science China(life Sciences) 2024年第5期67卷 1051-1060页

作者： Yaomeng Yuan Xihao liao shuang li Xin-Hui Xing Chong Zhang MOE Key Laboratory for Industrial Biocatalysis Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Base editing,the targeted introduction of point mutations into cellular DNA,holds promise for improving genome-scale functional genome screening to single-nucleotide *** efforts in prokaryotes,however,remain confined to loss-of-function screens using the premature stop codons-mediated gene inactivation library,which falls far short of fully releasing the potential of base ***,we developed a base editor-mediated functional single nucleotide variant screening pipeline in Escherichia *** constructed a library with 31,123 sgRNAs targeting 462 stress response-related genes in ***,and screened for adaptive mutations under isobutanol and furfural selective *** by the screening results,we successfully identified several known and novel functional *** pipeline might be expanded to the optimization of other phenotypes or the strain engineering in other microorganisms.

关键词： base editor high-throughput large-scale screening Escherichia coli functional mutation

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