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Prolonged dual antiplatelet therapy after drug-eluting stent implantation improves long-term prognosis for acute coronary syndrome:five-year results from a large cohort study

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World Journal of Emergency Medicine 2023年第1期14卷 25-30页

作者： Jing-jing Xu Si-da Jia Lin Jiang Ying Song Pei Zhu de-shan yuan Yi Yao Xue-yan Zhao Jian-xin Li Yue-jin Yang Shu-bin Qiao Bo Xu Run-lin Gao Jin-qing yuan department of Cardiology Fuwai Hospital and Cardiovascular InstituteNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100037China

BACKGROUND:To investigate the most appropriate dual antiplatelet therapy(DAPT)duration for patients with acute coronary syndrome(ACS)after drug-eluting stent(deS)implantation in the largest cardiovascular center of ***:We enrolled 5,187 consecutive patients with ACS who received deS from January to december *** were divided into four groups based on DAPT duration:standard DAPT group(11-13 months,n=1,568)and prolonged DAPT groups(13-18 months[n=308],18-24 months[n=2,125],and>24 months[n=1,186]).Baseline characteristics and 5-year clinical outcomes were ***:Baseline characteristics were similar across the four *** the four groups,those with prolonged DAPT(18-24 months)had the lowest incidence of major adverse cardiovascular and cerebrovascular events(MACCEs)(14.1%vs.11.7%vs.9.6%vs.24.2%,Pdeath(4.8%vs.3.9%vs.2.1%vs.2.6%,Pdeath(3.1%vs.2.6%vs.1.4%vs.1.9%,P=0.004),and myocardial infarction(MI)(3.8%vs.4.2%vs.2.5%vs.5.8%,Pdence of bleeding was not different among the four groups(9.9%vs.9.4%vs.11.0%vs.9.4%,P=0.449).Cox multivariable analysis showed that prolonged DAPT(18-24 months)was an independent protective factor for MACCEs(hazard ratio[HR]0.802,95%confidence interval[CI]0.729-0.882,Pdeath(HR 0.660,95%CI 0.547-0.795,Pdeath(HR 0.663,95%CI 0.526-0.835,Pdependent protective factor for all-cause death and ***:For patients with ACS after deS,appropriately prolonging the DAPT duration may be associated with a reduced risk of adverse ischemic events without increasing the bleeding risk.

关键词： Dual antiplatelet therapy Acute coronary syndrome Drug-eluting stent implantation

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Prolonging dual antiplatelet therapy improves the long-term prognosis in patients with diabetes mellitus undergoing complex percutaneous coronary intervention

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Journal of Geriatric Cardiology 2023年第8期20卷 586-595页

作者： Jing-Jing XU Si-Da JIA Pei ZHU Ying SONG de-shan yuan Xue-Yan ZHAO Yi YAO Lin JIANG Jian-Xin LI Yin ZHANG Lei SONG Run-Lin GAO Ya-Ling HAN Jin-Qing yuan department of Cardiology National Clinical Research Center for Cardiovascular DiseasesNational Center for Cardiovascular DiseasesState Key Laboratory of Cardiovascular DiseaseFuwai HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina department of Cardiology General Hospital of Northern Theater CommandShenyangChina

OBJECTIVE To investigate the optimal duration of dual antiplatelet therapy(DAPT)in patients with diabetes mellitus(DM)requiring complex percutaneous coronary intervention(PCI).METHODS A total of 2403 patients with DM who underwent complex PCI from January to december 2013 were consecutively enrolled in this observational cohort study and divided according to DAPT duration into a standard group(11-13 months,n=689)and two prolonged groups(13-24 months,n=1133;>24 months,n=581).RESULTS Baseline characteristics,angiographic findings,and complexity of PCI were comparable regardless of DAPT *** incidence of major adverse cardiac and cerebrovascular event was lower when DAPT was 13-24 months than when it was 11-13 months or>24 months(4.6%vs.8.1%vs.6.0%,P=0.008),as was the incidence of all-cause death(1.9%vs.4.6%vs.2.2%,P=0.002)and cardiac death(1.0%vs.3.0%vs.1.2%,P=0.002).After adjustment for confounders,DAPT for 13-24 months was associated with a lower risk of major adverse cardiac and cerebrovascular event[hazard ratio(HR)=0.544,95%CI:0.373-0.795]and all-cause death(HR=0.605,95%CI:0.387-0.944).DAPT for>24 months was associated with a lower risk of all-cause death(HR=0.681,95%CI:0.493-0.942)and cardiac death(HR=0.620,95%CI:0.403-0.952).The risk of major bleeding was not increased by prolonging DAPT to 13-24 months(HR=1.356,95%CI:0.766-2.401)or>24 months(HR=0.967,95%CI:0.682-1.371).CONCLUSIONS For patients with DM undergoing complex PCI,prolonging DAPT might improve the long-term prognosis by reducing the risk of adverse ischemic events without increasing the bleeding risk.

关键词： patients coronary mellitus

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南丹瑶鸡产业现状及发展对策

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广西农学报 2013年第2期28卷 59-61页

作者：单德源南丹县水产畜牧兽医局广西河池市547200

发展南丹瑶鸡这一特色产业是南丹县农业产业结构全面调整的一项重大举措。本文结合南丹县"五大工程"的实施及南丹瑶鸡特色养殖业的发展,提出相应的对策,对指导南丹瑶鸡项目的发展具有重要的现实意义。

关键词：南丹瑶鸡产业现状对策

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有机磷酸酯成核剂在聚丙烯中成核的有效性

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石油化工 2003年第9期32卷 771-774页

作者：张广平俞建勇辛忠桂全德王善元东华大学纺织学院上海200051 华东理工大学聚合物加工研究室上海200237

采用差示扫描量热计考察了 2 ,2′-亚甲基 -双 (4 ,6-二叔丁基苯基 )磷酸及其衍生物在聚丙烯中成核的有效性 ,并研究了成核剂对力学性能的影响。结果表明 :在聚丙烯中添加 0 4% (质量分数 )的磷酸酯的钠盐或甘油酯 ,使聚丙烯的结晶温... 详细信息

采用差示扫描量热计考察了 2 ,2′-亚甲基 -双 (4 ,6-二叔丁基苯基 )磷酸及其衍生物在聚丙烯中成核的有效性 ,并研究了成核剂对力学性能的影响。结果表明 :在聚丙烯中添加 0 4% (质量分数 )的磷酸酯的钠盐或甘油酯 ,使聚丙烯的结晶温度提高了 15℃或 11℃ ,结晶度增加 3 %～ 6% ,结晶速率显著增加 ;在反复熔融、结晶过程中 ,其成核效应没有发生改变 ;材料的模量提高了 2 0 %～ 3 0 % ,弯曲强度也提高了 10 %～ 2 0 %。

关键词：成核效应热稳定性结晶速率有机磷酸酯聚丙烯成核有效性

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Multiscale simulation and nanoindentation experimental study of initial plasticity of Fe single crystal

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Transactions of Nonferrous Metals Society of China 2009年第S2期19卷 458-462页

作者： yuan Lin shan de-bin GUO Bin School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China Key Laboratory of Micro-Systems and Micro-Structures Manufacturing Ministry of EducationHarbin Institute of TechnologyHarbin 150001China

It is very important to understand the initial plastic behavior of metals at *** order to research the initial plasticity of body centered cubic metals in micro-/nano-scale,the multiscale simulation method and experimental study were used to study the nanoindentation process of Fe single *** results show that the first abruption of load-displacement curve in nanoindentation of Fe single crystal can be attributed to the first transition from elastic to plastic deformation characterized by the dislocation emission.

关键词： initial plasticity nanoindentation multiscale simulation dislocation

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Existence and multiplicity results for nonlinear Schrodinger-Poisson equation with general potential

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Frontiers of Mathematics in China 2020年第6期15卷 1189-1200页

作者： yuan shan School of Statistics and Mathematics Nanjing Audit UniversityNanjing 210029China

This paper is concerned with the Schrodinger-Poisson equation -△u+V(x)u+Ф(x)u=f(x,u),x∈R^(3),-△Ф=u^(2),lim|x|→+∞Ф(x)=*** certain hypotheses on V and a general spectral assumption,the existence and multiplicity... 详细信息

关键词： Schrodinger-Poisson equation Morse index variational method

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Homoclinic Orbits for First Order Hamiltonian Systems with Some Twist Conditions

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Acta Mathematica Sinica,English Series 2015年第11期31卷 1725-1738页

作者： yuan shan School of Mathematics and Statistics Nanjing Audit University

In this paper, we study the nonperiodic first-order Hamiltonian system u = JL（t）u ＋ JH＇（t,u）, where HεCl（RxR2n）. With some assumptions on L, the corresponding Hamiltonianoperator has only discrete spectrum. By using the index theory for self-adjoint operator equation, we establish the existence of multiple homoclinic orbits for the asymptotically quadratic nonlinearty satisfying some twist conditions between infinity and origin.

关键词： Homoclinic solutions first order Hamiltonian system index theory twist conditions

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Large Time Behavior of Solutions to a 3D Keller-Segel-Stokes System Involving a Tensor-valued Sensitivity with Saturation

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Acta Mathematicae Applicatae Sinica 2023年第4期39卷 1032-1064页

作者： yuan-yuan KE Jia-shan ZHENG School of Mathematics Renmin University of ChinaBeijing 100872China School of Mathematics and Statistics Science Yantai UniversityYantai 264005China

In this paper we deal with the initial-boundary value problem for the coupled Keller-Segel-Stokes system with rotational flux, which is corresponding to the case that the chemical is produced instead of consumed,■subject to the boundary conditions( n-n S(x, n, c) c) · ν = c · ν = 0 and u = 0, and suitably regular initial data(n0(x), c0(x), u0(x)), where ? ? R3is a bounded domain with smooth boundary ??. Here S is a chemotactic sensitivity satisfying |S(x, n, c)| ≤ CS(1 + n)-αwith some CS> 0 and α > 0. The greatest contribution of this paper is to consider the large time behavior of solutions for the system(KSS), which is still open even in the 2D case. We can prove that the corresponding solution of the system(KSS) decays to(■) exponentially, if the coefficient of chemotactic sensitivity is appropriately small. As a precondition to consider the asymptotic behavior, we also show the global existence and boundedness of the corresponding initial-boundary problem KSS with a simplified method. We find a new phenomenon that the suitably small coefficient CSof chemotactic sensitivity could benefit the global existence and boundedness of solutions to the model KSS.

关键词： Large time behavior Global existence Boundedness Keller-Segel-Stokes system

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New Proposals for Application of Terahertz Imaging Technique in Chinese Medicine

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Chinese Journal of Integrative Medicine 2022年第4期28卷 366-373页

作者： BAI shan-shan YANG Hua-yuan School of Acupuncture Moxibustion and Tuina Shanghai University of Traditional Chinese MedicineShanghai201203China

The rapid development of terahertz technology promotes the realization of various terahertz imaging *** technology features terahertz waves as good non-invasive illumination sources due to their high spectral resolution,penetration and *** terahertz imaging technique(TIT)has gradually been extended from the biomedical field to the field of Chinese medicine(CM),and it has become a powerful tool for seeking scientific evidence for CM theories with the use of modern science and *** paper reviews the current application of TITs in the field of CM research,and most importantly offers novel proposals for the application of TITs in CM research from the perspective of CM syndrome objectification and acupuncture research and cites existing reports as reference to the feasibility of these new proposals.

关键词： terahertz Chinese medicine syndrome objectification meridians acupuncture moxibustion new proposals

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发芽糙米特征营养、食味品质提升及功能性评价研究进展

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食品科学 2025年第1期46卷 284-292页

作者：任传英洪滨张珊袁迪冯俊然山珊张竞一管立军李波黄文功卢淑雯黑龙江省农业科学院食品加工研究所黑龙江省食品加工重点实验室黑龙江省全谷物营养食品工程技术研究中心黑龙江哈尔滨150086 黑龙江省农业科学院农产品质量安全研究所黑龙江哈尔滨150086

发芽糙米作为一种全谷物,保留了完整的皮层和胚,集中了大部分营养素和功能性活性物质,但由于皮层纤维结构致密,蒸饭过程中阻碍了吸水速率、吸水量和淀粉糊化,与大米相比,其蒸煮性和食用品质较差,且难以同煮同熟,因此一直以来未被广大消... 详细信息

发芽糙米作为一种全谷物,保留了完整的皮层和胚,集中了大部分营养素和功能性活性物质,但由于皮层纤维结构致密,蒸饭过程中阻碍了吸水速率、吸水量和淀粉糊化,与大米相比,其蒸煮性和食用品质较差,且难以同煮同熟,因此一直以来未被广大消费者接受。本文综述糙米发芽的生理代谢反应及发芽过程中营养成分、活性成分和食味品质的变化,总结发芽糙米胁迫富集γ-氨基丁酸(γ-aminobutyric acid,GABA)技术和发芽糙米的功能特性研究现状。糙米发芽过程中,多种生物活性物质在酶促反应下富集,尤其是特征成分GABA含量显著提升。多种逆境胁迫均可通过改变Ca^(2+)、H^(+)或底物水平促进GABA富集,一些预处理技术可进一步提升发芽糙米的食味品质。GABA与其他营养成分和活性成分发挥协同作用,赋予发芽糙米抗高血脂、抗高血糖、保护心脏、改善睡眠、抗炎和抗氧化等一系列功效与作用。

关键词：发芽糙米特征营养食味品质功能性

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