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C-X-C chemokine receptor type 5+CD8+T cells as immune regulators in hepatitis Be antigen-positive chronic hepatitis B under interferonalpha treatment

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World Journal of Gastroenterology 2025年第3期31卷 73-83页

作者： Zhen-Yu Xu Zhong-Shang Dai Guo-Zhong gong Min Zhang department of Infectious Diseases Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina Institute of Hepatology and department of Infectious Diseases The Second Xiangya HospitalCentral South UniversityChangsha 410011Hunan ProvinceChina

BACKGROUND C-X-C chemokine receptor type 5(CXCR5)+CD8+T cells represent a unique immune subset with dual roles,functioning as cytotoxic cells in persistent viral infections while promoting B cell *** their importance,the specific role of CXCR5+CD8+T cells in chronic hepatitis B(CHB),particularly during interferon-alpha(IFN-α)treatment,is not fully *** study aims to elucidate the relationship between CXCR5+CD8+T cells and sustained serologic response(SR)in patients undergoing 48 weeks of pegylated IFN-α(peg-IFN-α)treatment for *** To elucidate the relationship between CXCR5+CD8+T cells and sustained SR in patients undergoing 48 weeks of peg-IFN-αtreatment for *** This study enrolled 60 patients with hepatitis Be antigen(HBeAg)-positive CHB undergoing 48 weeks of peg-IFN-α*** were assessed for eligibility based on criteria such as persistent HBsAg-positive status for at least six months,HBeAb-negative,hepatitis B virus DNA levels exceeding 2×104 copies/mL,and alanine aminotransferase(ALT)levels between 2 and 10 times the upper limit of *** samples were collected at baseline and at weeks 12,24,48,and a 24-week treatment-free follow-up(week 72)to measure serum interleukin(IL)-21 concentration via ELISA and to analyze CXCR5 and programmed death-ligand 1(PD-L1)expression on CD8+T cells by flow cytometry,CXCR5 is a chemokine receptor that directs immune cells to specific tissues,while PD-L1 is a protein that regulates immune responses by inhibiting T cell *** Patients with CHB exhibited significantly lower levels of circulating CXCR5+CD8+T cells compared to healthy controls(P<0.01).Notably,CXCR5+CD8+T cells were prominently expressed in patients who achieved sustained SR compared to non-SR(NSR).A significant correlation was observed between CXCR5 and PD-L1 expression(r=-0.189,P=0.002).However,there was no significant correlation between serum IL-21 levels and CXCR5+CD8+lymphocytes(r=-0.03,P=0.62

关键词： C-X-C chemokine receptor type 5 Programmed death-ligand 1 Interleukin-21 Pegylated interferon-alpha Chronic hepatitis B

Potassium and calcium channels in different nerve cells act as therapeutic targets in neurological disorders

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Neural Regeneration Research 2025年第5期20卷 1258-1276页

作者： Qing Qiu Mengting Yang Danfeng gong Haiying Liang Tingting Chen department of Pharmacology School of PharmacyNantong UniversityNantongJiangsu ProvinceChina Jiangsu Province Key Laboratory of Inflammation and Molecular Drug Target NantongJiangsu ProvinceChina department of Pharmacy Longyan First Affiliated Hospital of Fujian Medical UniversityLongyanFujian ProvinceChina

The central nervous system, information integration center of the body, is mainly composed of neurons and glial cells. The neuron is one of the most basic and important structural and functional units of the central nervous system, with sensory stimulation and excitation conduction functions. Astrocytes and microglia belong to the glial cell family, which is the main source of cytokines and represents the main defense system of the central nervous system. Nerve cells undergo neurotransmission or gliotransmission, which regulates neuronal activity via the ion channels, receptors, or transporters expressed on nerve cell membranes. Ion channels, composed of large transmembrane proteins, play crucial roles in maintaining nerve cell homeostasis. These channels are also important for control of the membrane potential and in the secretion of neurotransmitters. A variety of cellular functions and life activities, including functional regulation of the central nervous system, the generation and conduction of nerve excitation, the occurrence of receptor potential, heart pulsation, smooth muscle peristalsis, skeletal muscle contraction, and hormone secretion, are closely related to ion channels associated with passive transmembrane transport. Two types of ion channels in the central nervous system, potassium channels and calcium channels, are closely related to various neurological disorders, including Alzheimer's disease, Parkinson's disease, and epilepsy. Accordingly, various drugs that can affect these ion channels have been explored deeply to provide new directions for the treatment of these neurological disorders. In this review, we focus on the functions of potassium and calcium ion channels in different nerve cells and their involvement in neurological disorders such as Parkinson's disease, Alzheimer's disease, depression, epilepsy, autism, and rare disorders. We also describe several clinical drugs that target potassium or calcium channels in nerve cells and could be u

关键词： astrocytes calcium channels central nervous system extracellular ion concentration microglia neurological disorders neurons potassium channels

Correlation analyse between thyroid hormone levels and severity of schizophrenia symptoms

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World Journal of Psychiatry 2025年第1期15卷 63-71页

作者： Qi-Hui Jiang Wei-Dong gong department of Endocrinology and Metabolism Hengyang Central HospitalHengyang 421000Hunan ProvinceChina Breast Tumor Surgical Outpatient Hengyang Central HospitalHengyang 421000Hunan ProvinceChina

BACKGROUND The imbalance of hormone levels in the body is closely related to the occurrence and progression of schizophrenia,especially thyroid *** To study the relationship between triiodothyronine(T3),thyroxine(T4),free T3(FT3),free T4(FT4),thyroid stimulating hormone(TSH)and *** In this study,100 schizophrenia patients were selected from our hospital between April 2022 and April *** clinical data were analyzed *** on the Positive and Negative Syndrome Scale(PANSS)score,patients were divided into mild(1-3 points,n=39),moderate(4 points,n=45),and severe groups(5-7 points,n=16).Additionally,55 healthy individuals served as a control *** blood samples were collected to measure T3,T4,FT3,FT4,TSH,and cortisol concentrations,analyzing their relationship with PANSS *** The serum levels of T3,FT3,FT4,TSH and cortisol in the schizophrenia group were lower than those in the control group(Pdecreased,while the con-centrations of TSH and cortisol increased(Pdecreased T3 level,decreased T4 level,decreased TSH level and increased cortisol level may be independent risk factors for *** Thyroid hormone levels are associated with the severity of schizophrenia symptoms,which can provide new solutions for the diagnosis and treatment of schizophrenia.

关键词： Thyroid hormone Schizophrenia Symptom severity Positive and Negative Syndrome Scale score Cortisol

Parabose Coherent States Based on Green's Ansatz

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Communications in Theoretical Physics 2001年第7期36卷 29-32页

作者： gong ren-Shan department of Physics Nanchang University Nanchang 330047 Jiangxi Province China

The coherent states of parabose oscillator of order p based on the well-known Green's ansatz have been constructed. Furthermore, it is shown that the completeness relation for these coherent states may be expressed in... 详细信息

关键词： parabose coherent state, Green's ansatz, completeness relation

ON INTERIOR POINTS OF THE JULIA SET J(R) FOR RANDOM DYNAMICAL SYSTEM R

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Chinese Annals of Mathematics,Series B 1997年第4期18卷 503-512页

作者： gong ZHIMIN ren GUYAO Institute of Mathematics Fudan UniversityShanghai 200433China

The authors consider the random iteration of serval *** byJ(R)the Julia set for the random iteration dynamical system formed by a set of complex functionsR={R 1,R 2,…,R M}.Some sufficient conditions are given forJ(R)to have no interior *** some conditions are given forJ(R)to have interior points but fail to be the extended *** addition,J(az n,bz n)(n≥2,ab≠0)andJ(z 2+c 1,z 2+c 2)are investigated and some interesting results are obtained.

关键词： Random iteration Dynamical system Julia set

Characteristic changes in astrocyte properties during astrocyte-to-neuron conversion induced by NeuroD1/Ascl1/Dlx2

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Neural Regeneration Research 2025年第6期20卷 1801-1815页

作者： Qing He Zhen Wang Yuchen Wang Mengjie Zhu Zhile Liang Kanghong Zhang Yuge Xu gong Chen GHM Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina

Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.

关键词： aquaporin-4 Ascl1 astrocyte cortex Dlx2 gap junction glia-to-neuron conversion neural regeneration NeuroD1 reprogramming

Composition- and oxidation-controlled magnetism ternary FeCoNi nanocrystals

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Nano Research 2016年第3期9卷 831-836页

作者： Maogang gong Ridwan Sakidja Shenqiang ren department of Mechanical Engineering Temple University Philadelphia PA 19122 USA department of Physics Astronomy and Materials Science Missouri State University Springfield MO 65897 USA

Ternary FeCoNi metallic nanostructures have attracted significant attention due to their high saturation magnetization, unique mechanical properties, and large corrosion resistance. In this study, we report a controlled synthesis of ternary FeCoNi nanocrystals using solution-based epitaxial core-shell nanotechnology. The thickness and stoichiometry of the FeCoNi nanocrystals affect their magnetic characteristics, which can be controlled by a phase transformation-induced tetragonal distortion. Furthermore, surface oxidation of the stoichiometry-controlled FeCoNi nanostructures can drastically enhance their magnetic coercivity （up to 8,881.60e for AuCu-FeCo）, and optimize the AuCu-FeCo08Ni0.2 performance corresponding to the saturated magnetization of 134.4 emu-g-1 and coercivity of 4,036.70e, which opens the possibility of developing rare-earth free high energy nanomagnets.

关键词： iron-cobalt-nickel nanomagnetism magnetocrystallineanisotropy core-shell nanocrystals

黄土高原森林林下植被物种多样性及其影响因素

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东北林业大学学报 2025年第2期53卷 66-74页

作者：宫正黄河文明与可持续发展研究中心(河南大学) 开封475001

以黄土高原不同密度刺槐(Robinia pseudoacacia)林为研究对象,通过调查样地的地形及土壤理化性质,利用方差分析、线性拟合、冗余分析等方法,分析林下植被物种多样性特征,探究影响林下植被物种多样性的因素。结果表明:不同林分密度的刺... 详细信息

以黄土高原不同密度刺槐(Robinia pseudoacacia)林为研究对象,通过调查样地的地形及土壤理化性质,利用方差分析、线性拟合、冗余分析等方法,分析林下植被物种多样性特征,探究影响林下植被物种多样性的因素。结果表明:不同林分密度的刺槐林林下植被物种多样性存在显著差异(P<0.05)。刺槐林下灌木Margalef丰富度指数随坡向的增大而减小,林下草本植物Margalef丰富度指数随坡度的增加而减小。刺槐林下灌木植物物种多样性的主要影响因素是密度、坡向、土壤全氮质量分数、土壤铵态氮质量分数,草本植物物种多样性的主要影响因素是土壤速效磷质量分数。

关键词：刺槐林物种多样性影响因素冗余分析黄土高原

Rockburst process and strength-weakening effect of the high-stress circular tunnel under internal unloading

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第4期15卷 864-885页

作者： Fengqiang gong Wuxing Wu Li ren Engineering Research Center of Safety and Protection of Explosion&Impact of Ministry of Education(ERCSPEIME) Southeast UniversityNanjing211189China School of Civil Engineering Southeast UniversityNanjing211189China Key Laboratory of deep Earth Science and Engineering Ministry of EducationSichuan UniversityChengdu610065China

To investigate the influence of unloading effect of a circular tunnel face on rockburst process,by innovatively combining rock drilling unloading devices and triaxial systems,the strain rockburst simulation under the entire stress path of“high initial stressþinternal unloadingþstress adjustment”(HUS test)was realized for the intact cubic red sandstone samples(100 mm×100 mm×100 mm).Comparative tests were conducted on cubic red sandstone samples with prefabricated circular holes(425 mm)under the stress path of“prefabricated circular hole+þhigh initial stress+stress adjustment”(PHS test),thereby highlighting the influence of internal unloading on rockburst *** test results revealed that with an increase in vertical stress,the sidewalls in both the HUS and PHS tests suffered strain rockburst *** with the PHS test,the initial failure stress in the HUS test is lower,and it is easier to induce sidewall *** indicates that the internal unloading influences the sidewall failure,causing an obvious strength-weakening effect,which becomes more significant with an increase in buried *** strain rockburst failure was more severe in the HUS test owing to the influence of internal unloading.V-shaped rockburst pits were formed in the HUS tests,whereas in the PHS test,arcshaped rockburst pits were *** was also found that strain rockburst failure may occur only when the rock has a certain degree of rockburst proneness.

关键词： Rockburst Unloading Strength-weakening effect deep rock V-shaped notch Circular tunnel