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Heat shock pretreatment improves stem cell repair following ischemia-reperfusion injury via autophagy

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World Journal of Gastroenterology 2015年第45期21卷 12822-12834页

作者： Peng-Fei Qiao Lei Yao Xin-Chen Zhang Guo-Dong Li de-quan wu department of General Surgery the Second Affiliated Hospital of Harbin Medical University department of General Surgery the Fourth Affiliated Hospital of Harbin Medical University

AIM: To investigate whether heat shock pretreatment(HSP) improves mesenchymal stem cell(MSC) repair via autophagy following hepatic ischemia-reperfusion injury(HIRI).METHODS: Apoptosis of MSCs was induced by 250 m M hydrogen peroxide(H2O2) for 6 h. HSP was carried out using a 42 ℃ water bath for 1, 2 or 3 h. Apoptosis of MSCs was analyzed by flow cytometry, and Western blot was used to detect Bcl-2, Bax and cytochrome C expression. Autophagy of MSCs was analyzed by flow cytometry and transmission electron microscopy, and the expression of beclin Ⅰ?and LC3-Ⅱ was detected by Western blot. MSCs were labeled in vivo with the fluorescent dye, CM-Dil, and subsequently transplanted into the portal veins of rats that had undergone HIRI. Liver levels of proliferating cell nuclear antigen(PCNA) were quantified by fluorescent microscopy. Serum aminotransferase activity and the extent of HIRI were also assessed at each time ***: HSP for 2 h reduced apoptosis of MSCs induced by H2O2 as seen by a decrease in apoptotic rate, a decrease in Bax and cytochrome C expression and an increase in Bcl-2 expression(P denine attenuated HSPinduced autophagy and abolished the protective effects of HSP on the apoptosis of MSCs. Rapamycin failed to have additional effects on either autophagy or apoptosis compared with HSP alone. The phosphorylation of p38 MAPK was significantly elevated and the phosphorylation of m TOR was downregulated in heat shock pretreated MSCs. Treatment with the p38 MAPK inhibitor, SB203580, reduced HSP-induced autophagy in MSCs. In vivo studies showed that the transplantation of HSP-MSCs resulted in lower serum aminotransferase levels, lower Suzuki scores, improved histopathology and an increase in PCNA-positive cells(P < 0.

关键词： Hepatic ischemia-reperfusion injury Heat shock pre

Regulation and function of endoplasmic reticulum autophagy in neurodegenerative diseases

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Neural Regeneration Research 2025年第1期20卷 6-20页

作者： Xiu-Yun Zhao de-En Xu Ming-Lei wu Ji-Chuan Liu Zi-Ling Shi quan-Hong Ma department of Neurology and Clinical Research Center of Neurological Disease the Second Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Neuroscience&Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases Soochow UniversitySuzhouJiangsu ProvinceChina department of Neurology Jiangnan University Medical CenterWuxiJiangsu ProvinceChina

The endoplasmic reticulum,a key cellular organelle,regulates a wide variety of cellular *** reticulum autophagy,one of the quality control systems of the endoplasmic reticulum,plays a pivotal role in maintaining endoplasmic reticulum homeostasis by controlling endoplasmic reticulum turnover,remodeling,and *** this review,we briefly describe the endoplasmic reticulum quality control system,and subsequently focus on the role of endoplasmic reticulum autophagy,emphasizing the spatial and temporal mechanisms underlying the regulation of endoplasmic reticulum autophagy according to cellular *** also summarize the evidence relating to how defective or abnormal endoplasmic reticulum autophagy contributes to the pathogenesis of neurodegenerative *** summary,this review highlights the mechanisms associated with the regulation of endoplasmic reticulum autophagy and how they influence the pathophysiology of degenerative nerve *** review would help researchers to understand the roles and regulatory mechanisms of endoplasmic reticulum-phagy in neurodegenerative disorders.

关键词： autophagy endoplasmic reticulum endoplasmic reticulum autophagy endoplasmic reticulum quality control system endoplasmic reticulum receptors endoplasmic reticulum-associated degradation neurodegeneration neurodegenerative disease selective autophagy unfolded protein response

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铁路工程地质遥感图像处理系统设计与实现

铁道工程学报 2017年第8期34卷 11-15,52页

作者：刘桂卫全德武中国铁路设计集团有限公司天津300142 兰州交通大学兰州730070

研究目的:铁路行业尚缺乏专业的工程地质遥感图像处理系统,为满足铁路工程地质遥感判释工作需求,需开发具备最佳波段组合方式选择、波段运算、图像融合定量评价、图像增强运算及专题信息提取等功能的软件系统。研究结论:(1)最佳指数法... 详细信息

研究目的:铁路行业尚缺乏专业的工程地质遥感图像处理系统,为满足铁路工程地质遥感判释工作需求,需开发具备最佳波段组合方式选择、波段运算、图像融合定量评价、图像增强运算及专题信息提取等功能的软件系统。研究结论:(1)最佳指数法能够辅助波段组合方式的选择;(2)基于光谱逼真度和纹理清晰度指标对图像融合结果进行定量评价,能够优选出最佳融合算法,提高了影像的可判释能力;(3)去条纹功能消除了传感器标定差异,增强了影像清晰度;(4)水体指数法适用于提取平坦区域水体信息,在细节反映上较谱间信息法更好;谱间信息法能将水体与阴影区分开来,适合陡峻山区水体的提取;(5)该软件系统能为铁路工程地质遥感图像处理提供基础支持,可广泛应用于工程地质遥感判释前期数据处理工作。

关键词：地质遥感融合评价图像增强专题信息提取软件系统

Bending Stiffness of Concrete-Filled Steel Tube and Its Influence on Concrete Placement Timing of Composite Beam-String Structure

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Structural Durability & Health Monitoring 2025年第1期19卷 55-75页

作者： Zhenyu Zhang quan Jin Haitao Zhang Zhao Liu Yuyang wu Longfei Zhang Renzhang Yan CCCC Third Highway Engineering Co. Ltd.Beijing101300China School of Civil Engineering Chongqing Jiaotong UniversityChongqing400074China

When the upper chord beam of the beam-string structure(BSS)is made of concrete-filled steel tube(CFST),its overall stiffness will change greatly with the construction of concrete placement,which will have an impact on the design of the tensioning plans and selection of control measures for the *** order to accurately obtain the bending stiffness of CFST beam and clarify its impact on the mechanical properties of composite BSS during construction,the influence of some factors such as height-width ratio,wall thickness of steel tube,elasticity modulus of concrete,and friction coefficient on the bending stiffness are analyzed parametrically by the numerical simulation technology based on an actual *** calculation formula of the equivalent bending stiffness of CFST is also established through mathematical statistical ***,the equivalent bending stiffness is introduced into the construction and use stages of the composite BSS,respectively,and the mechanical properties such as prestress-tensioning control value,structural deformation,and internal force of key members are comparatively analyzed when adopting two different construction ***,the optimal construction plan of concrete placement first and then prestress-tensioning is proposed.

关键词： Concrete panels freeze-thaw damage compression-shear crack tension-shear crack

高铁滨海北站路基段环境振动试验研究与数值分析

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铁道标准设计 2017年第12期61卷 131-136页

作者：陈洪运全德武中国铁路设计集团有限公司天津300251 中国铁路设计集团有限公司轨道交通勘察设计工程实验室天津300251 兰州交通大学交通运输学院兰州730070

为了研究高速铁路列车在路基段运行时引起的周边环境地面上的竖向振动特性和传播规律,进行现场试验和数值分析。实测结果表明:高速铁路路基段周边环境地面不同距离测点的Z振级均小于78 d B,振动并没有随距离衰减,只是在距离外轨30~60 m... 详细信息

为了研究高速铁路列车在路基段运行时引起的周边环境地面上的竖向振动特性和传播规律,进行现场试验和数值分析。实测结果表明:高速铁路路基段周边环境地面不同距离测点的Z振级均小于78 d B,振动并没有随距离衰减,只是在距离外轨30~60 m范围内有减弱;距离线路外轨30 m外的环境振动的频谱主峰频率以小于10 Hz的低频为主;振动频谱中并没有显现出高频振动衰减快、低频振动衰减慢的规律。基于FLAC3D的数值分析结果与实测值吻合良好,验证了模型的合理性,并分析群桩加固区对振动的影响,结果表明:在路基段采用群桩基础对地基进行加固,可有效降低高速铁路列车运行对路基段周边环境振动的影响。

关键词：高速铁路路基振动现场试验数值分析

The cGAS-STING-interferon regulatory factor 7 pathway regulates neuroinflammation in Parkinson's disease

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Neural Regeneration Research 2025年第8期20卷 2361-2372页

作者： Shengyang Zhou Ting Li Wei Zhang Jian wu Hui Hong Wei quan Xinyu Qiao Chun Cui Chenmeng Qiao Weijiang Zhao Yanqin Shen Laboratory of Neurodegenerative and Neuroinjury Diseases Wuxi Medicine SchoolJiangnan UniversityWuxiJiangsu ProvinceChina

Interferon regulatory factor 7 plays a crucial role in the innate immune ***,whether interferon regulatory factor 7-mediated signaling contributes to Parkinson's disease remains *** we report that interferon regulatory factor 7 is markedly up-regulated in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced mouse model of Parkinson's disease and co-localizes with microglial *** the selective cyclic guanosine monophosphate adenosine monophosphate synthase inhibitor RU.521 and the stimulator of interferon genes inhibitor H151 effectively suppressed interferon regulatory factor 7 activation in BV2 microglia exposed to 1-methyl-4-phenylpyridinium and inhibited transformation of mouse BV2 microglia into the neurotoxic M1 *** addition,si RNA-mediated knockdown of interferon regulatory factor 7 expression in BV2 microglia reduced the expression of inducible nitric oxide synthase,tumor necrosis factorα,CD16,CD32,and CD86 and increased the expression of the anti-inflammatory markers ARG1 and *** together,our findings indicate that the cyclic guanosine monophosphate adenosine monophosphate synthase-stimulator of interferon genes-interferon regulatory factor 7 pathway plays a crucial role in the pathogenesis of Parkinson's disease.

关键词： cyclic guanosine monophosphate adenosine monophosphate synthase H151 interferon regulatory factor 7 M1 phenotype neurodegenerative disease neuroinflammation Parkinson’s disease RU521 STING type I interferon

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细胞自噬在肿瘤中作用的研究进展

癌症 2009年第4期28卷 445-448页

作者：李国东吴德全李本义哈尔滨医科大学附属第二临床医学院普外科黑龙江哈尔滨150086 美国堪萨斯大学医学院泌尿外科堪萨斯美国66160

自噬(autophagy)是广泛存在于真核细胞中的基本生命现象,是程序性细胞死亡形式之一,近年来备受关注。自噬活性的变化与人类肿瘤的发生、发展密切相关,并可从多个层面影响肿瘤进程,包括肿瘤细胞凋亡、血管生成及抗肿瘤治疗等。本文就自... 详细信息

自噬(autophagy)是广泛存在于真核细胞中的基本生命现象,是程序性细胞死亡形式之一,近年来备受关注。自噬活性的变化与人类肿瘤的发生、发展密切相关,并可从多个层面影响肿瘤进程,包括肿瘤细胞凋亡、血管生成及抗肿瘤治疗等。本文就自噬及其在肿瘤中作用的研究进展进行简要综述。

关键词：自噬肿瘤信号调控肿瘤治疗

太湖中大银鱼、太湖新银鱼和寡齿新银鱼群体的遗传结构

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水产学报 1999年第3期22卷 254-260页

作者：夏德全曹萤吴婷婷杨弘中国水产科学研究院淡水渔业研究中心!无锡214081

利用ＲＡＰＤ技术对太湖中的大银鱼、太湖新银鱼、寡齿新银鱼的遗传结构进行了研究。共在太湖中的６个采样片采到大银鱼和太湖新银鱼样品，在两个采样片得到了寡齿新银鱼的样品。结果表明，太湖中不同水域的三种银鱼没有明显的遗传差... 详细信息

利用ＲＡＰＤ技术对太湖中的大银鱼、太湖新银鱼、寡齿新银鱼的遗传结构进行了研究。共在太湖中的６个采样片采到大银鱼和太湖新银鱼样品，在两个采样片得到了寡齿新银鱼的样品。结果表明，太湖中不同水域的三种银鱼没有明显的遗传差异。三种银鱼中，大银鱼的遗传相似性指数显示最大，太湖新银鱼的次之，寡齿新银鱼的最小，说明大银鱼的遗传变异性最小，寡齿新银鱼的最大，太湖新银鱼的遗传变异性界于两者之间。

关键词：大银鱼太湖新银鱼寡齿新银鱼遗传结构太湖

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基于ILP的综合接入系统I/O调度方案

通信学报 2003年第6期24卷 99-105页

作者：韩国栋杭德全邬江兴解放军信息工程大学国家数字交换系统工程技术研究中心河南郑州450002

在综合业务接入系统中引入了自治系统内部标签(ILP)信令格式,提出了一种新的基于优先级的参数自适应轮询调度(priority-based parameter auto-adaptive round-robin scheduling)方案,给出了该方案在综合接入系统I/O调度中的实现方法,并... 详细信息

在综合业务接入系统中引入了自治系统内部标签(ILP)信令格式,提出了一种新的基于优先级的参数自适应轮询调度(priority-based parameter auto-adaptive round-robin scheduling)方案,给出了该方案在综合接入系统I/O调度中的实现方法,并对调度方案的性能进行了实验分析。

关键词：综合接入系统内部标签参数自适应 I/O调度