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Study on pharmacodynamic mechanism of compound Shuanghuanglian in prevention and treatment of pneumonia based on network pharmacology and association analysis

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Medical Data Mining 2021年第3期4卷 37-46页

作者： Xiao-Lin zhang Cao Di Long zhang Chao-Chao Hua de-Hui Ma Hui-Hui Liu ming-Jun Liu Changchun University of Chinese Medicine Changchun 130117China Changchun Hospital of Chinese Medicine Changchun 130000China Chifeng University School of Basic Medical Sciences Chifeng 024000China

Background:Platform for prediction and analysis of Chinese medicine against coronavirus disease 2019(TCMAntiCOVID-19 V1.0)was used to explore the active ingredients,key targets and mechanisms of the compound coronavirus disease 2019(COVID-19),It will provide a reference for the clinical application of this prescription as a broad-spectrum agent in the prevention and treatment of *** will also win valuable time for finding symptomatic Chinese medicine prescriptions and vaccine research and ***:Set Banxia Tianma Baizhu decoction as the negative *** Paidu decoction as the positive control,and use TCMAntiCOVID-19 V1.0 platform to predict the potential efficacy of compound *** used the quantitative evaluation algorithm of multi-target drugs for the network disturbance of disease,by comparing the changes of network topological characteristics before and after drug intervention,and using the disturbance rate to evaluate the drug’s dryness for disease *** batman-TCM,the credibility card value of the target sets 20,then the target of traditional Chinese medicine composition is predicted,the heterogeneous network of traditional Chinese medicine composition-drug target-disease target is *** interaction of related network is realized by JavaScript Visualization is realized,and cycloscape is *** average connectivity,the average shortest path length,the centrality of connectivity and the centrality of network compactness are calculated by using R’s iGraph package,and nulldistribution is used as the overall distribution to correct the disturbance rate of drugs to the real network,so as to evaluate the stability of network topology and explore its ***:The key targets of COVID-19 were Aif1,Ccl2,Cdc20,Cxcl13,Fcer1g,Ido1,Ifng,Il10,Il1rnIl6,Ncf4,Ptger4,Spi1,Tnf,Xcl1;after the intervention,the average connectivity,the average shortest path length,the network connectivity centrality and the

关键词： Compound Shuanghuanglian Coronavirus disease 2019 TCMAntiCOVID-19 Network pharmacology Pharmacodynamic mechanism

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Novel phase difference extraction method of FPP system based on DWT and OMP algorithm

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Optoelectronics Letters 2020年第2期16卷 131-136页

作者： Lü Shan-shan JIANG ming-shun SU Chen-hui zhang Lei zhang Fa-ye SUI Qing-mei JIA Lei Institute of Marine Science and Technology Shandong UniversityQingdao 266237China School of Control Science and Engineering Shandong UniversityJinan 250061China

In this paper, to reduce the non-linear phase error caused by gamma effect of the digital projector, a novel phase difference extraction method is proposed. First, through multi-layer discrete wavelet decomposition(DWT), the components of the original phase difference at different frequencies are extracted. Subsequently, the effective components are taken by the orthogonal matching pursuit(OMP) algorithm, and the phase difference is reconstructed. According to the upper and lower envelopes of the original phase difference extracted by cubic spline interpolation, the residual threshold of OMP is set. According to the results of three-dimensional(3-D) reconstruction experiment on a standard sphere, the proposed method is capable of reducing the errors in the original phase difference and achieving a better imaging result.

关键词： difference phase algorithm

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Evolution of Morphology and Properties of Sulfonated Poly(ether ether ketone ketone) Membranes Fabricated via Electrospinning

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Chemical Research in Chinese Universities 2010年第1期26卷 157-160页

作者： MA Hai-song HAO Xiu-feng LI Xian-feng ZHAO Cheng-ji FU Tie-zhu NA Hui zhang ming-lei Alan G. MacDiarmid Institute College of Chemistry Jilin University Changchun 130012 P. R. China Prosthetic department of the Hospital of Stomatology Jilin University Changchun 130021 P. R. China

Sulfonated poly（ether ether ketone kctone）（SPEEKK） membranes with different degrees of sulfonation（DS） were successfully prepared via electrospinning method. The morphology of the resulted membranes varies from nanospheres to nanofibers with increasing the concentration of SPEEKK. The conductivities of the membranes prepared under the same condition increase with the DS increasing. The spherical morphological membranes with a DS of 1.2 show the highest proton conductivity, 0.55 S/cm, which is much higher than those of the membranes prepared via normal solution evaporation method. The results show that electrospinning is an efficient method to prepare high performance SPEEKK membranes with different morphologies.

关键词： Proton conductivity Electrospinning Membrane

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A new sulfated triterpenoid from the bark of Zygophyllum fabago L.

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Chinese Chemical Letters 2010年第9期21卷 1100-1102页

作者： Yu Lin Feng Bin Xie He Ran Li Qiong ming Xu Xiao Juan zhang Yue Sheng Wang Shi Lin Yang National Pharmaceutical Engineering Centre for Solid Preparation in Chinese Herbal Medicine Nanchang 330006 China Jiangxi University of Traditional Chinese Medicine Nanchang 330006 China College of Pharmacy. Soochow University. Suzhou 215123. China

A new sulfated triterpenoid,3β,24-dihydroxyurs-20-ene-24-O-sulphonyl-28-oic acid（fabagoin.1） was isolated from the barks of Zygophyllum fabago *** structure was elucidated on the basis of spectroscopic data.

关键词： Zygophyllum fabago L. Sulfated triterpenoid Fabagoin

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Irisin attenuates intestinal injury,oxidative and endoplasmic reticulum stress in mice with L-arginine-induced acute pancreatitis

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World Journal of Gastroenterology 2019年第45期25卷 6653-6667页

作者： Yi-Fan Ren Meng-Zhou Wang Jian-Bin Bi Jia zhang Lin zhang Wu-ming Liu Sha-Sha Wei Yi Lv Zheng Wu Rong-Qian Wu National Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical EngineeringFirst Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina department of Hepatobiliary Surgery First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061Shaanxi ProvinceChina

BACKGROUND Acute pancreatitis(AP)is often associated with intestinal injury,which in turn exaggerates the progression of *** recent study has shown that a low level of serum irisin,a novel exercise-induced hormone,is associated with poor outcomes in patients with AP and irisin administration protects against experimental ***,the role of irisin in intestinal injury in AP has not been *** To investigate the effect of irisin administration on intestinal injury in experimental *** AP was induced in male adult mice by two hourly intraperitoneal injections of *** 2 h after the last injection of L-arginine,irisin(50 or 250μg/kg body weight)or 1 mL normal saline(vehicle)was administered through intraperitoneal *** animals were sacrificed at 72 h after the induction of *** injury,apoptosis,oxidative and endoplasmic reticulum(ER)stress were *** Administration of irisin significantly mitigated intestinal damage,reduced apoptosis,and attenuated oxidative and ER stress in AP *** addition,irisin treatment also effectively downregulated serum tumor necrosis factor-alpha and interleukin-6 levels and alleviated injury in the pancreas,liver and lung of AP *** Irisin-mediated multiple physiological events attenuate intestinal injury following an episode of *** has a great potential to be further developed as an effective treatment for patients with AP.

关键词： Irisin Intestinal injury Oxidative stress Endoplasmic reticulum stress Acute pancreatitis Mouse model

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BASIC THEORY AND MATHEMATICAL MOdeLING OF URBAN RAINSTORM WATER LOGGING

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Journal of Hydrodynamics 2004年第1期16卷 17-27页

作者： LIDa-ming zhangHong-ping LIBing-fei XIEYi-yang SchoolofCivilEngineering TianjinUinversityTianjin300072.China TianjinInstituteofMeteorologicalSciences Tianjin300074China

In this paper, a mathematical model for the urban rainstorm water logging wasestablished on the basis of one- and two-dimensional unsteady flow theory and the technique ofnon-structural irregular grid division. The continuity equation was discretized with the finitevolume method. And the momentum equations were differently simplified and discretized for differentcases. A method of ''special passage'' was proposed to deal with small-scale rivers and open *** urban drainage system was simplified and simulated in the model. The method of ''open slot'' wasapplied to coordinate the alternate calculation of open channel flow and pressure flow in drainagepipes. The model has been applied in Tianjin City and the verification is quite satisfactory.

关键词： urban rainstorm water logging urban drainage system mathematical model unsteady flow theory non-structural irregular grids finite volume method

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Regulation of Content of Malondialdehyde by Siqi decoction via Increasing Activity of Superoxide Dismutase in Blood Serum of Rats with Myocardial Ischemia

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Chemical Research in Chinese Universities 2009年第5期25卷 686-689页

作者： SU Yan-bin JIANG Yi-zhong LU ming CHENG Ying-kun SU Yan-wen zhang Fen-rong LI Zheng-qiang Key Laboratory for Molecular Enzymology and Engineering the Ministry of Education Jilin University Changehun 130021 P. R. China School of Chemical and Pharmaceutical Engineering Jilin Institute of Chemical Technology JiIin 132022 P. R. China Jilin Provincial Institute for Drug and Food Control Changchun 130033 P. R. China Cardiovascular Surgery department of China-Japan Union Hospital Jilin University Changchun 130033 P R. China

Effect of Siqi decoction on myocardial ischemia is to prevent cardiac myocyte membrane from damage associated with oxygen free radicals related to NO. To research the regulatoin of the content of malondialdehyde by Siqi decoction, an index of lipid peroxidation, via increasing activity of superoxide dismutase in blood serum of rats with Myocardial Ischemia, the model of myocardium ischemia was made in Wistar rats with posterior pituitary injection through vein in tail. Siqi decoction, Diaoxinxuekang（DK） and Fufangdanshenpian（FD）, the latter two drugs of which are effective TCM drugs of anti-myocardial ischemia at present, were administrated to the rats with myocardium ischemia for 5 days to compare the effect of them on myocardium ischemia as reference drugs via measuring the changes of the content of malondialdehyde and the activity of superoxide dismutase in the rat blood serum with myocardial ischemia. There were a remarkable increase in the activity of superoxide dismutase and a decrease in the content of malondialdehyde in the serum of the rats administered Siqi decoction compared with those of the rats in control group, p〈0.05. The contents of MDA in the serum of the prevention group rats in the experiments are lower than those of the cure group rats. Anti-Myocardium Ischemia mechanism of Siqi decoction is the regulation of the content of malondialdehyde via increasing activity of superoxide dismutase in the serum of Rats with myocardial ischemia and stimulating the activity of NOS in serum so as to increase NO concentration.

关键词： Siqi decoction Myocardial ischemia Posterior pituitary Malondialdehyde Superoxide dismutase

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Leak-off behavior and water shut-off performance of a polymer/chromium(Cr^(3+)) gel in fractured media

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Journal of Central South University 2017年第6期24卷 1418-1429页

作者： LI Jun-jian XIONG Chun-ming BAI Ying-rui JIANG Ru-yi WEI Fa-lin zhang Miao College of Petroleum Engineering China University of Petroleum(Beijing) Research Institute of Petroleum Exploration & development PetroChina department of Science and Technology Management China National Petroleum Corporation

During gel treatments for fractures, the leak-off behavior of gelant has a great effect on the water shut-off performance of gel. Experiments were carried out using a polymer/chromium(Cr^(3+)) gel system to explore the leak-off behavior and the water shut-off performance of gel in fractured media. Results of the gelant leak-off study show that the gelant leak-off from fracture into matrix contributes to the formation of the gelant leak-off layer during the gelant injection. Moreover, because of the gradual formation of the gelant leak-off layer along fracture, the initial leak-off ratio of gelant is relatively high, but it declines and finally levels off with the increase of the injection volume. The polymer concentration of gelant has a great effect on the chromium output in fluids produced from fractures. With the increase of the polymer concentration, the chromium concentration first decreases and then increases, and the leak-off depth of gelant into matrix is gradually reduced. Results of the water shut-off study present that the decrease of the chromium concentration inside the fracture greatly reduces the water shut-off performance after the gel formation. Therefore, because of the relatively high degree of chromium leak-off, enough injection volume of gelant is essential to ensure the sufficient chromium concentration inside the fracture and to further achieve a favorable water shut-off performance. On the premise of gel strength assurance inside the fracture, the water shut-off performance of gel gradually declines with the extension of the distance from the fracture inlet, and different leak-off degrees of gelant along the fracture are responsible for this phenomenon. Therefore, a proper degree of gelant leak-off contributes to enhancing the water shut-off performance of gel for fractures.

关键词： polymer gelant gel leak-off water shut-off fracture

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一种新颖的WDM网波长转换器

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电子学报 2001年第3期29卷 414-416页

作者：刘雪明甘朝钦孙小菡张明德东南大学电子工程系南京210096

本文首次提出了利用周期性热及电场诱导的D型光纤的波长转换器 .推导了转换效率 η和转换带宽Δλ的表达式 ,该式与数值计算一致 .结果表明 ,η与二次非线性系数和泵浦光功率成对数关系 ,但它们对Δλ的影响不大 .适当增加D型光纤的长... 详细信息

本文首次提出了利用周期性热及电场诱导的D型光纤的波长转换器 .推导了转换效率 η和转换带宽Δλ的表达式 ,该式与数值计算一致 .结果表明 ,η与二次非线性系数和泵浦光功率成对数关系 ,但它们对Δλ的影响不大 .适当增加D型光纤的长度能有效提高 η,但却降低了Δλ .一般情况下 ,η >- 15dB ,Δλ >10 0nm .模拟了WDM网中

关键词：波分复用波长转换器全光通信网

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中国家族教育的特点

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齐鲁学刊 2007年第6期 47-50页

作者：党明德张婷济南大学山东济南250022

家族制度是中国两千多年来社会构造的基础,传统家族教育作为一种特殊的教育形式,在整个教育事业中占重要地位。对家族教育进行历史的考察,研究其特点,在促进学术繁荣和培养人才等方面都具有不容忽视的价值。

关键词：家族家族教育特点

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