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A computational model to identify fertility-related proteins using sequence information

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Frontiers of Computer Science 2024年第1期18卷 229-237页

作者： Yan lin Jiashu wang Xiaowei LIU Xueqin XIE de WU Junjie ZHANG Hui DING Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China School of Life Science and Technology and Center for Informational Biology University of Electronic Science and Technology of ChinaChengdu 610054China

Fertility is the most crucial step in the development process,which is controlled by many fertility-related proteins,including spermatogenesis-,oogenesis-and embryogenesis-related *** identification of fertility-related proteins can provide important clues for studying the role of these proteins in ***,in this study,we constructed a two-layer classifier to identify fertility-related *** this classifier,we first used the composition of amino acids(AA)and their physical and chemical properties to code these three fertility-related ***,the feature set is optimized by analysis of variance(ANOVA)and incremental feature selection(IFS)to obtain the optimal feature *** five-fold cross-validation(CV)and independent data tests,the performance of models constructed by different machine learning(ML)methods is evaluated and ***,based on support vector machine(SVM),we obtained a two-layer model to classify three fertility-related *** the independent test data set,the accuracy(ACC)and the area under the receiver operating characteristic curve(AUC)of the first layer classifier are 81.95%and 0.89,respectively,and them of the second layer classifier are 84.74%and 0.90,*** results show that the proposed model has stable performance and satisfactory prediction accuracy,and can become a powerful model to identify more fertility related proteins.

关键词： sfertility-related proteins machine1 learning sequence information feature selection

NextPolish2:A Repeat-aware Polishing Tool for Genomes Assembled Using HiFi Long Reads

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Genomics, Proteomics & Bioinformatics 2024年第1期22卷 105-109页

作者： Jiang Hu Zhuo wang Fan Liang Shan-lin Liu Kai Ye de-Peng wang School of Automation Science and Engineering Faculty of Electronic and Information EngineeringXi’an Jiaotong UniversityXi’an 710049China GrandOmics Biosciences Beijing 102206China department of Entomology College of Plant ProtectionChina Agricultural UniversityBeijing 100193China

The high-fidelity(HiFi)long-read sequencing technology developed by PacBio has greatly improved the base-level accuracy of genome ***,these assemblies still contain base-level errors,particularly within the error-prone regions of HiFi long *** genome polishing tools usually introduce overcorrections and haplotype switch errors when correcting errors in genomes assembled from HiFi long ***,we describe an upgraded genome polishing tool-NextPolish2,which can fix base errors remaining in those“highly accurate”genomes assembled from HiFi long reads without introducing excessive overcorrections and haplotype switch *** believe that NextPolish2 has a great significance to further improve the accuracy of telomere-to-telomere(T2T)***2 is freely available at https://***/Nextomics/NextPolish2.

关键词： Telomere-to-telomere Genome assembly Genome polishing Error correction HiFi long read

Optimal structural design for a certain near-space composite propeller of airship using adaptive region division blending model

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Chinese Journal of Aeronautics 2024年第5期37卷 301-316页

作者： Weigang AN Tianyu lin Shigen wang School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China

Near-space airship is a frontier and hotspot in current military research and development,and the near-space composite propeller is the key technology for its *** order to obtain higher aerodynamic efficiency at an altitude of 22 km,a certain near-space composite propeller is designed as a long and slender aerodynamic shape with a 10 m diameter,which brings many challenges to the composite structure *** initial design is obtained by the composite structure variable stiffness design method using based on fixed region division blending ***,it weighs 23.142 kg,exceeding the required 20 *** order to meet the structural design requirements of the propeller,a variable stiffness design method using the adaptive region division blending model is proposed in this *** with the methods using the fixed region division blending model,this method optimizes region division,stacking thickness and stacking sequence in a single level,considering the coupling effect among *** a more refined region division,this method can provide a more optimal design for composite tapered ***,to improve the efficiency of optimization subjected to manufacturing constraints,a hierarchical penalty function is proposed to quickly filter out the solutions that do not meet manufacturing *** above methods combined with a Genetic Algorithm(GA)using specific encoding are adopted to optimize the near-space composite *** optimal design of the structure weighs 18.831 kg,with all manufacturing constraints and all structural response constraints being *** with the initial design,the optimal design has a more refined region division,and achieves a weight reduction of 18.6%.This demonstrates that a refined region division can significantly improve the mechanical performance of the composite tapered structure.

关键词： Structural optimization Composite tapered structure Genetic algorithm Adaptive region division Manufacturing constraint Near-space composite propeller

Highly Transparent Fire-resistant Coatings with Intumescent Three-source Integration

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Chinese Journal of Polymer Science 2024年第7期42卷 907-915,I0005页

作者： Xiao-Liang Zeng Xin-Sheng Lan Yan wang lin Zhang de-Ming Guo Hai-Bo Zhao State Grid Sichuan Electric Power Research Institute Chengdu610041China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(Ministry of Education) National Engineering Laboratory of Eco-Friendly Polymeric Materials(Sichuan)State Key Laboratory of Polymer Materials EngineeringCollege of ChemistrySichuan UniversityChengdu610064China

Wood,a readily available and sustainable natural resource,has found widespread use in construction and ***,its inherent flammability poses a potential fire *** intumescent fire-retardant coatings effectively mitigate this risk,achieving high transparency in such coatings presents a significant *** our approach,we employed a cross-linked network of phytic acid anion and N-[3-(trimethoxysilyl)propyl]-N,N,N-trimethylammonium cation to create a transparent"three-in-one"intumescent *** collaborative P/N/Si flame-retardant effect markedly improved the intumescent char-forming capability,preventing the wood from rapid *** resulted in a substantial reduction in heat release(13.9%decrease in THR)and an increased limiting oxygen index(LOI)value of 35.5%.Crucially,the high transparency of the coating ensured minimal impact on the wood's appearance,allowing the natural wood grains to remain clearly *** innovative approach provides a straightforward method for developing transparent intumescent flame-retardant coatings suitable for wooden *** potential applications extend to preserving ancient buildings and heritage conservation efforts.

关键词： Fire-resistant coating Flame retardancy Wood Transparency

Adaptive Robust Servo Control for Vertical Electric Stabilization System of Tank and Experimental Validation

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defence Technology（防务技术） 2024年第1期31卷 326-342页

作者： Darui lin Xiuye wang Yimin wang Guolai Yang School of Mechanical Engineering Nanjing University of Science and TechnologyNanjing210094China

A tracking stability control problem for the vertical electric stabilization system of moving tank based on adaptive robust servo control is *** paper mainly focuses on two types of possibly fast timevarying but bounded uncertainty within the vertical electric stabilization system:model parameter uncertainty and uncertain ***,the vertical electric stabilization system is constructed as an uncertain nonlinear dynamic system that can reflect the practical mechanics transfer process of the ***,the dynamical equation in the form of state space is established by designing the angular tracking ***,the comprehensive parameter of system uncertainty is designed to estimate the most conservative effects of ***,an adaptive robust servo control which can effectively handle the combined effects of complex nonlinearity and uncertainty is *** feasibility of the proposed control strategy under the practical physical condition is validated through the tests on the experimental *** paper pioneers the introduction of the internal nonlinearity and uncertainty of the vertical electric stabilization system into the settlement of the tracking stability control problem,and validates the advanced servo control strategy through experiment for the first time.

关键词： Adaptive robust servo control Experimental validation Nonlinearity compensation System uncertainty Vertical electric stabilization system

Dynamics modeling and optimal control for multi-information diffusion in Social Internet of Things

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Digital Communications and Networks 2024年第3期10卷 655-665页

作者： Yaguang lin Xiaoming wang Liang wang Pengfei Wan School of Computer Science Shaanxi Normal UniversityXi'an710119China

As an ingenious convergence between the Internet of Things and social networks,the Social Internet of Things(SIoT)can provide effective and intelligent information services and has become one of the main platforms for people to spread and share ***,SIoT is characterized by high openness and autonomy,multiple kinds of information can spread rapidly,freely and cooperatively in SIoT,which makes it challenging to accurately reveal the characteristics of the information diffusion process and effectively control its *** this end,with the aim of exploring multi-information cooperative diffusion processes in SIoT,we first develop a dynamics model for multi-information cooperative diffusion based on the system dynamics theory in this ***,the characteristics and laws of the dynamical evolution process of multi-information cooperative diffusion are theoretically investigated,and the diffusion trend is *** this basis,to further control the multi-information cooperative diffusion process efficiently,we propose two control strategies for information diffusion with control objectives,develop an optimal control system for the multi-information cooperative diffusion process,and propose the corresponding optimal control *** optimal solution distribution of the control strategy satisfying the control system constraints and the control budget constraints is solved using the optimal control ***,extensive simulation experiments based on real dataset from Twitter validate the correctness and effectiveness of the proposed model,strategy and method.

关键词： Social Internet of Things Information diffusion Dynamics modeling Trend prediction Optimal control

Granular collapse in fluids:Dynamics and flow regime identification

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Particuology 2024年第9期92卷 30-41页

作者： Hu Tang Bisong lin dengming wang department of Mechanics and Engineering Science School of Civil Engineering and MechanicsKey Laboratory of Mechanics on Disaster and Environment in Western China of Ministry of EducationLanzhou UniversityLanzhou730000China

The collapse of granular material in fluids is a prevalent phenomenon in both natural and industrial processes,displaying a notable sensitivity to initial configuration of the *** study is specifically oriented towards falling process of collapsing material under various fluid conditions,employing the computational fluid dynamics-discrete element method(CFD-deM)to primarily investigate the dynamics and scaling laws of deposit morphology of collapsed *** a comprehensive analysis of particle sedimentation in fluids,we introduce a refined inertial characteristic time for granular collapse within the inertial ***,we propose modifications to conventional fluid-particle density ratio and Reynolds number,aiming to enhance the accuracy of depicting collapse dynamics and identifying flow regimes across diverse column heights and fluid ***,we construct a phase diagram of flow regimes using modified dimensionless numbers,emphasizing the role of column height in transition between viscous and inertial *** parameters demonstrate enhanced relevance in governing the collapse of immersed granular columns,thereby contributing to a more nuanced understanding of fluid-particle interations in dense granular flows under different regimes.

关键词： Immersed granular material Collapse Dynamic Flow regime Computational fluid dynamics-discrete element method

Aubry-Mather theory for contact Hamiltonian systems Ⅲ

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Science China Mathematics 2024年第11期67卷 2541-2570页

作者： Panrui Ni lin wang Shanghai Center for Mathematical Sciences Fudan University School of Mathematics and Statistics Beijing Institute of Technology

By exploiting the contact Hamiltonian dynamics（T*M × R,Φ_t） around the Aubry set of contact Hamiltonian systems,we provide a relation among the Mather set,the Φ_t-recurrent set,the strongly static set,the Aubry set,the Ma?é set,and the Φ_t-non-wandering ***,we consider the strongly static set,as a new flow-invariant set between the Mather set and the Aubry set in the strictly increasing *** show that this set plays an essential role in the representation of certain minimal forward weak Kolmogorov-Arnold-Moser（KAM） solutions and the existence of transitive orbits around the Aubry set.

关键词： Aubry-Mather theory weak KAM theory contact Hamiltonian systems Hamilton-Jacobi equations

Construction of algal-bacterial consortia using green microalgae Chlorella vulgaris and As(Ⅲ)-oxidizing bacteria:As tolerance and metabolomic profiling

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Journal of Environmental Sciences 2024年第5期139卷 258-266页

作者： Xiaoman He Guobing lin Jiayuan Zeng Zhaoguang Yang lin wang College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China Key Laboratory of Hunan Province for Water Environment and Agriculture Product Safety Central South UniversityChangsha 410083China

Bioremediation became a promising technology to resolve arsenic(As)contamination in aquatic *** monoculture such as microalgae or bacteria was sensitive to environmental disturbance and vulnerable to contamination,green microalgae Chlorella vulgaris and arsenite(As(Ⅲ))-oxidizing bacteria Pseudomonas ***11 were co-cultured to construct algal-bacterial consortia in the current *** effects of algae-bacteria(A:B)ratio and exposure As(Ⅲ)concentration on algal growth,As speciation and metabolomic profile were *** growth arrested when treated with 100 mg/L As(Ⅲ)without the co-cultured *** contrast,co-cultured with strain SMS11 significantly enhanced As tolerance in *** especially with A:B ratio of 1:*** the As(Ⅲ)in culture media of the consortia were oxidized into As(Ⅴ)on day *** of As was observed on day *** 1% and 0.5% of total As were converted into dimethylarsinic acid(DMA)after 21days cultivation when the initial concentrations of As(Ⅲ)were 1 and 10 mg/L,*** analysis was further performed to reveal the response of consortia metabolites to external As(Ⅲ).The enriched metabolomic pathways were associated with carbohydrate,amino acid and energy *** acid cycle and glyoxylate and dicarboxylate metabolism were upregulated under As stress due to their biological functions on alleviating oxidative stress and protecting *** carbohydrate and amino acid metabolisms provided precursors and potential substrates for energy production and cell protection under abiotic *** of the pathways relevant to carbohydrate or amino acid metabolism were triggered by energy requirement.

关键词： Microalgae Algal-bacterial consortia As(Ⅲ)-oxidizing bacteria Metabolomics Energy metabolism