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Resolving the developmental mechanisms of cardiac microthrombosis of SARS-CoV-2 based on single-cell transcriptome analysis

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Science China Life Sciences 2025年第1期 103-115页

作者： Xizi luo Nan Zhang Yuntao Liu Beibei Du Xuan Wang Tianxu Zhao Bingqiang Liu Shishun Zhao Jiazhang Qiu Guoqing Wang State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Basic MedicineJilin University State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases Key Laboratory for Zoonosis Research of the Ministry of EducationCollege of Veterinary MedicineJilin University College of Mathematics Jilin University Bioinformatic Lab School of MathematicsShandong University department of Cardiology China-Japan Union HospitalJilin University

The coronavirus disease 2019（COVID-19） outbreak caused by the severe acute respiratory syndrome coronavirus-2（SARS-CoV-2） developed into a global health emergency. Systemic microthrombus caused by SARS-CoV-2 infection is a common complication in patients with COVID-19. Cardiac microthrombosis as a complication of SARS-CoV-2 infection is the primary cause of cardiac injury and death in patietns with severe COVID-19. In this study, we performed single-cell sequencing analysis of the right ventricular free wall tissue from healthy donors,patients who died during the hypercoagulable period of characteristic coagulation abnormality（CAC）, and patients who died during the fibrinolytic period of CAC. We collected 61,187 cells enriched in 24 immune cell subsets and 13 cardiac-resident cell subsets. We found that in the course of SARS-CoV-2 infected heart microthrombus, MYO1EhighRASGEF1Bhighmonocyte-derived macrophages promoted hyperactivation of the immune system and initiated the extrinsic coagulation pathway by activating chemokines CCL3, CCL5. This series of events is the main cause of cardiac microthrombi following SARS-CoV-2 infection. In a SARS-CoV-2 infected heart microthrombus, excessive immune activation is accompanied by an increase in cellular iron content, which in turn promotes oxidative stress and intensifies intercellular competition. This induces cells to alter their metabolic environment, resulting in increased sugar uptake via the glycosaminoglycan synthesis pathway. In addition, high levels of reactive oxygen species generated by elevated iron levels promote increased endogenous malondialdehyde synthesis in a subpopulation of cardiac endothelial cells. This exacerbates endothelial cell dysfunction and exacerbates the coagulopathy process.

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Hamiltonian System and Infinite Conservation Laws Associated with a New Discrete Spectral Problem

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Communications in Theoretical Physics 2008年第6期49卷 1399-1402页

作者： luo lin FAN En-Gui department of Mathematics Xiaogan University Xiaogan 432100 China School of Mathematics Fudan University Shanghai 200433 China

Starting from a new discrete spectral problem, the corresponding hierarchy of nonlinear lattice equations is proposed. It is shown that the lattice soliton hierarchy possesses the bi-Hamiltonian structures and infinit... 详细信息

关键词： Hamiltonian system infinite conservation laws discrete spectral problem

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Engineering high-performance chemiluminescent probes via enzymatic pocket targeting: high-throughput screening for ultralong afterglow imaging of orthotopic hepatocellular carcinoma

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Science China Chemistry 2025年

作者： Shuai Huang Shuaige Bai Ting luo Bin Feng Min Liu Fan Zheng Shuang Huang Yanpeng Fang Dan Ding Wenbin Zeng Xiangya School of Pharmaceutical Sciences Central South University College of Life Sciences Nankai University

Hepatocellular carcinoma （HCC） is a highly aggressive liver malignancy and the main form of liver cancer. Early diagnosis and treatment of HCC can effectively reduce mortality. Carboxylesterase （CE）-specific detection and imaging can be used for early diagnosis and image-guided surgical of HCC. However, traditional optical probes suffer from poor selectivity and low imaging signal-to-noise ratio. Here, we have constructed a series of chemiluminescent probes for carboxylesterase detection based on the strategy of enzymatic pocket-oriented steric tailoring techniques. The probes with different unique and excellent properties have been obtained through the structure-based steric hindrance adjustment on the recognition site. Here, CE-2 has been successfully used for high-throughput screening of rapid carboxylesterase inhibitors due to its extremely low detection limit (2.5×10-4U mL-1) and fast recognition ability. CE-3 has been successfully used for image-guided surgery of orthotopic hepatocellular carcinoma due to its ultra-long chemiluminescence imaging （over 12 h） of hepatocellular carcinoma. This study may promote advances in the rapid detection and screening of inhibitory drugs for CE and the field of surgical navigation in HCC.

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DYNAMICS OF MEDDIES INTERACTED WITH A SEAMOUNT IN A 1.5 LAYER MOdeL

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Journal of Hydrodynamics 2001年第3期13卷 93-99页

作者： luo, de-Hai Lu, Yan dept. of Atmosph. and Oceanic Sci. Ocean Univ. of Qingdao Qingdao 266003 China

A simplified model is proposed to describe the interaction of meddies with a seamount. In the absence of topography, the meddy obtained in this model moves very slowly to the west. However, in the presence of Gaussian-shaped topography (seamount) the movement of the meddy is strongly controlled by its site. As the seamount is located in the southwest side of a meddy, this meddy will be induced to move southward. But if the seamount is located in the west side of the meddy, the seamount forcing will cause a southwest movement of such a meddy. For two meddies in the absence of seamount, the two meddies will be located on the northwest-southeast axis due to their interaction, which is the natural evolution of two anticyclonic eddies. However, the presence of a seamount will cause the meddies to merge rapidly. This merging is also influenced by the site of the seamount, the closer the seamount is to the two meddies, the faster the two meddies merge. In addition, the direction of the corotating two meddies in the northwest-southeast axis is also influenced by the site of the seamount.

关键词： Equations of motion Hydrodynamics Hydrographic surveys Multilayers Numerical analysis Ocean currents

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Investigation of saltwater intrusion and salinity stratification in winter of 2007/2008 in the Zhujiang River Estuary in China

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Acta Oceanologica Sinica 2012年第3期31卷 31-46页

作者： ZHOU Wei WANG Dongxiao luo lin Key Laboratory of Tropical Marine Environmental Dynamics South China Sea Institute of OceanologyChinese Academy of ScienceGuangzhou 510301China Graduate School Chinese Academy of SciencesBeijing 100049China

Saltwater intrusion is a serious environmental problem in the Zhujiang River Estuary (ZRE),which threatens the water supply of fifteen million people. The hydrological observations as well as meteorological and tidal forcing in the winter of 2007/2008 were analyzed to examine the saltwater intrusion in the *** observational results suggest that the maximum vertical difference of salinity can reach 10 in the Humen Channel during neap tide,but is very small in the Hengmen Channel. The vertically averaged salinity from time series stations during spring tide is higher than that during neap tide.A three-dimensional finite difference model was developed based on the environmental fluid dynamic code (EFDC) to study the mechanism of saltwater intrusion and salinity stratification in the *** analyzing the salt transport and the temporal variation of saltwater intrusion,the authors found that the net salt transport due to the estuarine circulation during neap tide was more than that during spring *** caused salt to advance more into the estuary during neap ***,saltwater intrusion was stronger during spring tide than that during neap tide because the spring-neap variation in salt transport was small relative to the total length of the saltwater *** physical mechanism causing this saltwater intrusion was investigated by a series of sensitivity experiments,in order to examine saltwater intrusion in response to river discharge and *** freshwater source was a dominant influencing factor to the saltwater intrusion and controlled salinity structure,vertical stratification and length of the saltwater *** prevailing northeast monsoon during winter could increase the saltwater intrusion in the *** the southwest wind was uufavorable to saltwater intrusion during spring tide,it could increase stratification and saltwater intrusion during neap tide.

关键词： saltwater intrusion spring tide neap tide salt transport

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Investigating the seasonal dynamics of surface water over the Qinghai-Tibet Plateau using Sentinel-1 imagery and a novel gated multiscale ConvNet

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International Journal of Digital Earth 2023年第1期16卷 1372-1394页

作者： Xin luo Zhongwen Hu lin Liu School of Earth Sciences Yunnan UniversityKunmingPeople’s Republic of China School of Architecture and Urban Planning Shenzhen UniversityShenzhenPeople’s Republic of China Earth System Science Programme Faculty of ScienceThe Chinese University of Hong KongHong Kong

The surface water in the Qinghai–Tibet Plateau(QTP)region has undergone dramatic changes in recent *** capture dynamic surface water information,many satellite imagery-based methods have been ***,these methods are still limited in terms of automation and accuracy and thus prevent surface water dynamic studies in large-scale QTP *** this study,we developed a new fully automatic method for accurate surface water mapping by using Sentinel-1 synthetic aperture radar(SAR)imagery and convolutional networks(ConvNets).Specifically,we built a new multiscale ConvNet structure to improve the model capability in surface water body ***,a gating mechanism is introduced to promote the efficient use of multiscale *** to the accuracy assessment,the proposed gated multiscale ConvNet(GMNet)achieved the highest overall accuracy of 98.07%.We applied our GMNet for monthly surface water mapping on the QTP;accordingly,we found that the QTP region experienced significant surface waterfluctuations over one *** surface water also showed distinct spatial heterogeneity on the QTP;that is,the surface water fraction of the Inner Tibetan Basin was significantly higher than that of the Mekong Basin in both the wet and dry seasons.

关键词： Qinghai–Tibet Plateau surface water mapping deep learning convolutional neural network SAR image

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EXPERIMENTAL STUDY ON ABSORPTION OF OIL BY SEDIMENT IN WATER

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Journal of Hydrodynamics 1997年第2期9卷 24-30页

作者： Zhao, Wenqian Li, Chongming luo, lin Sichuan Univ Chengdu China

The absorption behaviour of emulsified oil by sediment (include loess) is studied by experiment. The absorption equation and the relations of absorption capacity with sediment concentration, grain size, salt concentration and temperature are analyzed. The absorbing reaction kinetics process is also studied. The absorption of emulsified oil by sediment in rivers is agreed with the Langmuir-Freundlich absorption equation. Experimental data shows that the larger the equilibrium oil concentration and the salt concentration , the more the absorption capacity. The absorption capacity increases immensely with grain size and temperature reduction.

关键词： absorption emulsified oil oil pollution

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A critical transition rule for broadening exponent of fluctuation and its effect on dissipation in chemical reaction-heat conduction coupling systems

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Science China Chemistry 2011年第5期54卷 774-781页

作者： lin Feng ZHAO NanRong luo JiuLi Institute of Chemical Physics College of ChemistrySichuan UniversityChengdu 610064China

A stochastic model of chemical reaction-heat conduction-diffusion for a one-dimensional gaseous system under Dirichlet or zero-fluxes boundary conditions is proposed in this paper. Based on this model,we extend the theory of the broadening exponent of critical fluctuations to cover the chemical reaction-heat conduction coupling systems as an asymptotic property of the corresponding Markovian master equation (ME),and establish a valid stochastic thermodynamics for such systems. As an illustration,the non-isothermal and inhomogeneous Schl-gl model is explicitly studied. Through an order analysis of the contributions from both the drift and diffusion to the evolution of the probability distribution in the corresponding Fokker-Planck equation(FPE) in the approach to bifurcation,we have identified the critical transition rule for the broadening exponent of the fluctuations due to the coupling between chemical reaction and heat conduction. It turns out that the dissipation induced by the critical fluctuations reaches a deterministic level,leading to a thermodynamic effect on the nonequilibrium physico-chemical processes.

关键词： stochastic model of chemical reaction–heat conduction–diffusion systems stochastic thermodynamics of chemical reaction–heat conduction coupling processes broadening exponent of critical fluctuation entropy production of fluctuations fluctuation–dissipation effect

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SOLVING TEMPERATURE FIELD DUE TO DISCHARGED HOT WATER BY THE CUBIC SPlinE METHOD

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Journal of Hydrodynamics 1992年第2期4卷 104-110页

作者： luo, lin Zhao, Wenqian Li, Jia Chengdu Univ of Science and Technology Chengdu China

To predict the temperature field due to heated water discharge, experiment and numerical methods are both usually used. A cubic spline method introduced by Rubin et al. has higher accuracy, but can not be used in non-linear equations like turbulent model. Authors have built a new scheme of cubic spline for non-linear partial differential equation and presented a SIMPLE-like algorithm for solving k-Ε model. Numerical results were compared with the experimental results. The results compared show that the new cubic spline scheme can be successfully used to nonlinear and strong coupling partial differential equations. The differences between experimental data and numerical results may be resulted from the turbulent model itself, therefore, further investigation is needed for these problems.

关键词： Temperature Distribution Computer Simulation

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Baseflow Characteristics in Alpine Rivers-a Multicatchment Analysis in Northwest China

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Journal of Mountain Science 2015年第3期12卷 614-625页

作者： GAN Rong SUN lin luo Yi Key Laboratory of Ecosystem Network Observation and Modeling Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of Sciences University of Chinese Academy of Sciences

As a component of streamflow, baseflow is critical for regulating seasonal distribution of river fows and stabilizing water supplies. Water resources in the arid area of Northwest China are mainly from multiple catchments in the alpine that could be influenced by varieties of climatic, land cover, soil and geological factors. While numerous studies have been done on streamflow, systematic analysis of baseflow in the alpine river systems is scare. Based on historical daily streamflow data and the automated digital filter method of baseflow separation, this study investigated characteristics of hydrographs of overland flow, streamflow and baseflowof river systems fed by rainfall, snowmelt, glacier melt or mixtures of these. This study also calculated the recession constants and baseflow indices of 65 river systems. While the recession constant was ***34- o.o728 with a mean of o.o18, the baseflow index was 0.27-0.79 with a mean of 0.57. Further, Spearman＇s correlation analysis showed that the baseflow index was significantly correlated with catchment climatic factors （e.g., precipitation and temperature）, topographic factors （e.g., elevation and slope） and aquifer properties represented by the recession constant. Multiple regression analysis indicated that the factors explained 65% of the variability of baseflow index in the studv area.

关键词： Baseflow index Recession constant Snowmelt Glacier melt Streamflow

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