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Synthesis of 1, 4-Bis[3-N-propionyl-2-aryl-1, 3, 4- oxadiazoline-5-yl]phenylenes

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Chinese Chemical Letters 2006年第5期17卷 625-627页

作者： de jiang li He Qing FU departrnent of Chemistry Yunyang Teachers College Hubei 442700 Institute of Chemical Engineering South China University of Technology Guangzhou 510640

1, 4-Bis[3-N-propionyl-2-aryl-1, 3, 4-oxadiazoline-5-yl]phenylenes 4 were synthesized by cyclization of corresponding hydrazones 3 with propionic anhydride.

关键词： 1,4-Bis[3-N-propionyl-2-aryl-1,3,4-oxadiazoline-5-yl]phenylenes hydrazones terephthaloyldihydrazine synthesis.

Synthesis and Fungicidal Activities of 2-Alkylthio-5-(3,4,5-tribenzyloxyphenyl)-1,3,4-oxadiazoles

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Chinese Chemical Letters 2006年第11期17卷 1427-1430页

作者： de Qing LONG de jiang li Wei Quan CAI Sheng Sheng CHEN department of Chemistry Yunyang Teachers College Hubei 442700 College of Chemical Engineering Wuhan University of Technology Wuhan 430070

Abstract： Ten novel 2-alkylthio-5-（3, 4, 5-tribenzyloxyphenyl）-1, 3, 4-oxadiazole derivatives （5a-j） were synthesized from methyl 3, 4, 5-trihydroxybenzoate by ethedfication, hydrazidation, cyclization and thioetherification reactions. The structures of 5a-j were confirmed by 1HNMR, MS spectra and elemental analysis. The results indicated that most of the compounds 5 exhibited good fungicidal activities. The activity of 5h is higher than 90% against Fusarium oxysporum and Botrytis cinereapers in 50 mg/L.

关键词： 1,3,4-Oxadiazole derivatives synthesis fungicidal activity.

Clodronate-containing liposomes attenuate lung injury in rats with severe acute pancreatitis

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2010年第11期11卷 828-835页

作者： Sheng-chun DANG de-li jiang Min CHEN Di li Jian-xin ZHANG department of General Surgery the Affiliated Hospital of Jiangsu University Zhenjiang 212001 China School of Chemistry and Chemical Engineering Jiangsu University Zhenj iang 212013 China

Objectives： Severe acute pancreatitis （SAP） can lead to acute lung injury （ALl）. The purpose of this paper is to investigate the protective effect of clodronate-containing liposomes on ALl in rats with SAP. Methods： The thin film method was used to prepare liposomes. Sprague-Dawley rats were randomly divided into three groups. After the SAP model was established by injecting 5% （w/v） sodium taurocholate （2 ml/kg body weight） into the subcapsular space of the pancreata, normal saline was administered to the control （C） group, phosphate buffer solution （PBS）-containing liposome to the P group, and clodronate-containing liposome to the T group through tail veins. Blood samples were obtained from the superior mesenteric vein at 2 and 6 h to measure the levels of amylase, interleukin-6 （IL-6）, and tumor necrosis factor-a （TNF-α）. Morphological changes in the pancreata and lung were observed using hematoxylin and eosin （H＆E） staining, while cell apoptosis was detected using terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling （TUNEL）. In addition, the macrophage marker cluster of differentiation 68 （CD68） in lung tissue was detected with immunohistochemistry. Results： Blood levels of amylase, IL-6, and TNF-α were significantly increased in the P group compared to those in the T group （P〈0.05）. In the T group, large numbers of TUNEL-positive cells were observed, but no or few in the C and P groups. Gross inspection and H＆E staining of pancreata and lung showed dramatic tissue damage, including inflammation and necrosis in the P group. Less remarkable changes were noted in the T group, and the C group exhibited normal histology. The histological scores according to Kaiser＇s criteria were consistent with H＆E findings. The number of CD68-positive macrophages decreased in the T group. Conclusions CIodronate-containing liposomes have a protective effect against ALl in rats with SAP. Blockade of macrophages may represent a novel therapeutic strategy in SAP.

关键词： Pancreatitis Clodronate disodium Macrophage Lung injury

To improve robustness of mechanical properties of semi-solid cast A356 alloy using taguchi design method

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China Foundry 2024年第2期21卷 175-184页

作者： Yi-wu Xu Hong-yi Zhan Wei Tong Jin-ping li Le-peng Zhang de-jiang li Xiao-qin Zeng School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China China Science Lab General Motors Global Research&DevelopmentShanghai 201206China General Motors(China)Investment Co. Ltd.Shanghai 201206China China International Intellectech Corporation(CIIC) Beijing 100004China

Mechanical properties of semi-solid casting are dependent on multiple processing parameters,and improper processing parameters will not only reduce mean data but also increase *** present study investigated the impact of parameters in slurry preparation and heat treatment on the yield strength and ductility of T6 heat-treated A356 Al-Si alloy using rapid slurry forming(RSF)semi-solid *** focus was primarily on the robustness of mechanical properties based on Taguchi design *** analyzing signal-to-noise ratio and minimum value calculated from-3S,the optimum slurry preparation parameters and heat treatment parameters were determined to be no quench,enthalpy exchange material(EEM)temperature of 140℃,EEM-to-melt ratio of 6mass%,stirring time of 18 s,solution heat treated at 520℃ for 2 h,and ageing heat treated at 190℃ for 6 *** a small batch validation,the-3S yield strength and-3S elongation reach 256.1 MPa and 5.03% respectively,showing a satisfactory *** hardness and microstructure of heat-treated samples with the best and worst properties were characterized to gain insight into the underlying mechanisms affecting the mean value and variations of mechanical properties.

关键词： semi-solid casting taguchi design method signal-to-noise ratio mechanical property microstructure

Effects of Ce content on the modification of Mg_(2)Si phase in Mg-5Al-2Si alloy

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Journal of Magnesium and Alloys 2023年第7期11卷 2299-2311页

作者： Bo Hu Wen-Jie Zhu Zi-Xin li Seul Bi Lee de-jiang li Xiao-Qin Zeng Yoon Suk Choi National Engineering Research Center of light Alloy Net Forming School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China School of Materials Science and Engineering Pusan National UniversityBusan 46241Republic of Korea The State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University800 Dongchuan RoadShanghai 200240China

The effect of Ce content(0–1.6 wt.%)on the modification of Mg_(2)Si phase in the as-cast Mg-5Al-2Si alloy was *** original Chinese script type Mg_(2)Si phase was refined distinctly and transformed to dispersive block shape gradually by adding Ce *** length of Chinese script type Mg_(2)Si phase was reduced from 110 to 50μm with increasing Ce content to 1.6 wt.%.The results calculated by Pandat software indicated that the added Ce element first combined with Si to form CeSi_(2)phase,which could serve as the heterogeneous nucleation of Mg_(2)Si phase due to the small lattice mismatch of 7.97%.The modification of Mg_(2)Si phase was mainly attributed to the facts that Ce changed the growth steps of Mg_(2)Si phase and CeSi_(2)promoted the nucleation of Mg_(2)Si *** increasing Ce content from 0 wt.%to 1.6 wt.%,the YS,UTS and EL at 150℃were improved from 67.7 MPa,91.2 MPa and 1.6%to 84.2 MPa,128 MPa and 7.5%,respectively.

关键词： Mg-Al-Si alloys Mg_(2)Si modification Heterogeneous nucleation Mechanical properties

First-principles Calculations of Strengthening Compounds in Magnesium Alloy： A General Review

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Journal of Materials Science & Technology 2016年第12期32卷 1222-1231页

作者： Yong liu Hui Ren Wen-Cheng Hu de-jiang li Xiao-Oin Zeng Ke-Gang Wang Jian Lu Key Laboratory of Near Net Forming of jiangxi Province. Nanchang University Nanchang 330031 China National Engineering Research Center of light Alloys Net Forming Shanghai Jiao Tong University Shanghai 200240 China State Key Laboratories of Metal Matrix Composite Shanghai Jiao Tong University Shanghai 200240 China Mechanical and Aerospace Engineering department Florida Institute of Technology Melbourne FL 32901 USA department of Mechanical and Biomedical Engineering City University of Hong Kong Kowloon Hong Kong China Centre for Advanced Structural Materials City University of Hong Kong Shenzhen Research Institute 8 Yuexing 1st Road Shenzhen Hi-Tech Industrial Park Nanshon District Shenzhen China

First-principles computation methods play an important role in developing and designing new magnesium *** this article,we present an overview of the first-principles modeling techniques used in recent years to simulate ideal models of the structure of strengthening compounds in Mg *** typical Mg compounds,structural stability,mechanical properties,electronic structure and thermodynamic properties have been ***,the elastic anisotropies of these compounds are examined,which is highly correlated with the possibility of inducing ***,some heterogeneous nucleation interfaces investigated by first-principles method are *** of the theoretical results are compared with available experimental *** hope to illustrate that the first-principles computation can help to accelerate the design of new Mg-based materials and the development of materials genome *** problems and future directions in this research field are considered.

关键词： Magnesium alloy Strengthening compounds First-principles calculation Mechanical properties Thermodynamic properties

MRI shows clodronate-liposomes attenuating liver injury in rats with severe acute pancreatitis

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Hepatobiliary & Pancreatic Diseases International 2010年第2期9卷 192-200页

作者： Zhang, Jian-Xin Dang, Sheng-Chun Zhang, Yong Sha, Xin Zhang, li-Rong Wei, Chuan-She Chen, Min jiang, de-li jiangsu Univ Affiliated Hosp Dept Gen Surg Zhenjiang 212001 Peoples R China jiangsu Univ Affiliated Hosp Dept MRI Zhenjiang 212001 Peoples R China jiangsu Univ Sch Chem & Chem Engn Zhenjiang 212013 Peoples R China

BACKGROUND: Studies have revealed that macrophages play an important role in the development of severe acute pancreatitis (SAP). Activated macrophages can lead to a systemic inflammatory response, induce lipid peroxidation, impair membrane structure, result in injury to the liver and the other extrahepatic organs, and eventually result in multiple organ dysfunction syndrome by promoting excessive secretion of cytokines. liver injury can further aggravate the systemic inflammatory response and increase mortality by affecting the metabolism of toxins and the release of excessive inflammatory mediators. Clodronate is a synthetic bisphosphonate, which is often used for treating bone changes caused by osteoporosis and other factors. In the current study, we created liposomes containing superparamagnetic iron oxide particles (SPIOs) for macrophage labeling and magnetic resonance imaging, using a novel method that can bind the clodronate to induce apoptosis and deplete macrophages. METHODS: Superparamagnetic Fe(3)O(4) nanoparticles were prepared by chemical coprecipitation. SPIO-containing liposomes and SPIO-clodronate-containing liposomes were prepared by the thin film method. SAP models were prepared by injection of sodium taurocholate (2 ml/kg body weight) into the subcapsular space of the pancreas. Sprague-Dawley rats were randomly divided into a control group, a SAP plus SPIO-liposome group, and a SAP plus SPIO-clodronate-containing group. Two and six hours after SAP models were available, T2-weighted MRI scans (in the same plane) of the livers of rats in each group were performed. At the end of the scans, 2 ml of blood was taken from the superior mesenteric vein to measure the levels of serum amylase, ALT, AST, TNF-alpha, and IL-6. Pathological changes in the liver and pancreas were assessed. RESULTS: Transmission electron microscopy showed that the liposomes had a uniform size. No pathological changes in the pancreata of rats in the control group were noted. The pat

关键词： pancreatitis, acute clodronate disodium liver injury MR imaging macrophage

Population pharmacokinetic model of valproate and prediction of valproate serum concentrations in children with epilepsy

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Acta Pharmacologica Sinica 2004年第12期25卷 10-17页

作者： de-chun jiang, li WANG2 department of Pediatrics, Peking University First Hospital, TherapeuticDrug Monitoring and Clinical Toxicology, Center of Peking University, Beijing 100034, China department of Pediatrics Peking University First Hospital Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University Beijing 100034 China

AIM: Using sparse data of valproate (VPA) serum concentrations to build a population pharmacokinetic (PPK) model of VPA in Chinese children with epilepsy and to predict serum concentrations for new patients using a Bayesian approach. METHODS: Two hundred epileptic children, whose VPA serum concentrations were collected, were divided randomly into two groups (A and B, n=100 each). The PPK parameter values of group A were calculated to establish a PPK Model by using the NPEM Program of USC*PACK software. Based on it, VPA serum concentrations of group B were predicted with the Bayesian Fitting Program of the USC*PACK software. To assess the accuracy and precision of prediction, a paired-comparisons t-test was run between predicted and ob- served concentrations, and then the mean prediction error (MPE), mean square prediction error (MSPE), root mean square prediction error (RMSPE), and coincidence rates for different percentages of prediction error were all calculated. RESULTS: Optimum PPK parameters were: Ka, 2.522±2.743 h-1; Vs, 0.329±0.496 L/kg; and Kel, 0.0438±0.0384 h-1. For group B, there was no significant difference between predicted and observed concentrations. MPE was -0.43 mg/L, MSPE was 115.40 (mg/L)2, and RMSPE was 5.47 mg/L. The coincidence rates for percent- ages of prediction error, which were less than 5 %, 10 %, 15 %, 20 %, 25 %, and 30 %, were 62 %, 74 %, 82 %, 85 %, 89 %, and 93 %, respectively. CONCLUSION: A PPK model of VPA in epileptic children was successfully established. Based on it, VPA serum concentrations can be predicted accurately with a Bayesian approach.

关键词： pharmacokinetics valproic acid epilepsy Bayes theorem USC*PACK software

Atomic relaxation,stability and electronic properties of Mg2Sn(100)surfaces from ab-initio calculations

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Journal of Magnesium and Alloys 2016年第1期4卷 62-67页

作者： Hui Ren Wen-Cheng Hu de-jiang li Xiao-Qin Zeng Xue Yang Xiao-Shu Zeng Xiang-Jie Yang Bolong Huang Yong liu Key Laboratory of Near Net Forming of jiangxi Province Nanchang UniversityNanchang 330031China National Engineering Research Center of light Alloys Net Forming Shanghai Jiao Tong UniversityShanghai 200240China State Key Laboratories of Metal Matrix Composite Shanghai Jiao Tong UniversityShanghai 200240China department of Physics and Materials Science City University of Hong KongKowloonHong Kong

Mg2Sn(100)surfaces were investigated using ab-initio method based on density functional theory in order to explore the surface *** is found that both the eleven-layers for Mg-termination surfaces and the nine-layers for Sn-termination surfaces are all converged very *** effects of relaxation mainly occurred within the three outermost atomic layers for both Mg and Sn terminations during the surface ***-termination surfaces are more stable than Sn-termination surfaces according to the analysis of surface *** density of states reveals the metallic property of both Mg-termination and Sn-termination *** bonding exists in Mg2Sn(100)surfaces according to the analysis of partial density of states.

关键词： Magnesium alloy Ab-initio calculation Surface energy Surface stability Electronic properties