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Gene knockout or inhibition of macrophage migration inhibitory factor alleviates lipopolysaccharide-induced liver injury via inhibiting inflammatory response

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Hepatobiliary & Pancreatic Diseases International 2021年第5期20卷 469-477页

作者： Yu-Lei Gu li-li Xiao de-jian li Yan-Na liu Chang-Ju Zhu Shui-Jun Zhang Emergency department the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of Cardiology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of Hepatobiliary and Pancreatic Surgery the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Open and Key Laboratory of Hepatobiliary&Pancreatic Surgery and Digestive Organ Transplantation at Henan Province Zhengzhou 450052China Zhengzhou Engineering Laboratory of Organ Transplantation Technique and Application Zhengzhou 450052China

Background:liver injury is one of the most common complications during *** migration inhibitory factor(MIF)is an important proinflammatory *** study explored the role of MIF in the lipopolysaccharide(LPS)-induced liver injury through genetically manipulated mouse ***:The model of LPS-induced liver injury was established in wild-type and Mif-knockout C57/BL6 *** levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),and total bilirubin(TBil)were detected,and the expressions of MIF,tumor necrosis factor-α(TNF-α)and interleukin-1β(IL-1β)were *** histopathology was conducted to assess liver ***,the inhibitions of MIF with(S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid methyl ester(ISO-1)and 4-iodo-6-phenylpyrimidine(4-IPP)were used to evaluate their therapeutic potential of liver ***:Compared with wild-type mice,the liver function indices and inflammation factors presented no significant difference in the Mif-/-*** 72 h of the LPS-induced liver injury,serum levels of ALT,AST,and TBil as well as TNF-αand IL-1βwere significantly increased,but the knockout of Mif attenuated liver injury and inflammatory *** liver tissue,m RNA levels of TNF-α,IL-1βand NF-κB p65 were remarkably elevated in LPS-induced liver injury,while the knockout of Mif reduced these ***,in LPS-induced liver injury,the inhibitions of MIF with ISO-1 and 4-IPP alleviated liver injury and slightly attenuated inflammatory ***,compared to mice with LPS-induced liver injury,Mif knockout or MIF inhibitions significantly prolonged the survival of the ***:In LPS-induced liver injury,the knockout of Mif or MIF inhibitions alleviated liver injury and slightly attenuated inflammatory response,thereby prolonged the survival of the *** MIF may be an important strategy to protect the liver from injury during sepsis.

关键词： Sepsis liver injury Migration inhibitory factor Gene knockout Inflammation

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development in oxide metallurgy for improving the weldability of high -strength low-alloy steel-Combined deoxidizers and microalloying elements

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International Journal of Minerals,Metallurgy and Materials 2024年第6期31卷 1263-1284页

作者： Tingting li jian Yang State Key Laboratory of Advanced Special Steel School of Materials Science and EngineeringShanghai UniversityShanghai 200444China

The mechanisms of oxide metallurgy include inducing the formation of intragranular acicular ferrite(IAF)using micron-sized inclusions and restricting the growth of prior austenite grains(PAGs)by nanosized particles during *** chaotically oriented IAF and refined PAGs inhibit crack initiation and propagation in the steel,resulting in high impact *** work summarizes the com-bined effect of deoxidizers and alloying elements,with the aim to provide a new perspective for the research and practice related to im-proving the impact toughness of the heat affected zone(HAZ)during the high heat input *** complex deoxidation with other strong deoxidants,such as Mg,Ca,Zr,and rare earth metals(REMs),can improve the toughness of the heat-affected zone(HAZ)by re-fining PAGs or increasing IAF ***,it is difficult to identify the specific phase responsible for IAF nucleation because ef-fective inclusions formed by complex deoxidation are usually *** alloying elements,such as C,Si,Al,Nb,or Cr,con-tents can impair HAZ toughness.A high C content typically increases the number of coarse carbides and decreases the potency of IAF ***,Cr,or Al addition leads to the formation of undesirable *** reduces the high-temperature stability of the ***,V,and B can enhance HAZ ***-containing precipitates present good thermal *** or V(C,N)is ef-fective in promoting IAF nucleation due to its good coherent crystallographic relationship with *** formation of the B-depleted zone around the inclusion promotes IAF *** interactions between alloying elements are complex,and the effect of adding dif-ferent alloying elements remains to be *** the future,the interactions between various alloying elements and their effects on ox-ide metallurgy,as well as the calculation of the nucleation effects of effective inclusions using first principles calculations will become the focus of

关键词： oxide metallurgy technology heat affected zone high-strength low-alloy steel intragranular acicular ferrite microalloying element

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Effects of cooling rate on microstructure and microhardness of directionally solidified Galvalume alloy

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China Foundry 2024年第3期21卷 213-220页

作者： Ji-peng li de-gao Qiao jian li Xiao-yang Luo Peng Peng Xian-tao Yan Xu-dong Zhang Gansu Jiu Steel Group Hongxing Iron and Steel Co. Ltd.Jiayuguan 735111GansuChina School of Materials and Energy Lanzhou UniversityLanzhou 730000China

The influences of cooling rate on the phase constitution,microstructural length scale,and microhardness of directionally solidified Galvalume(Zn-55Al-1.6Si)alloy were investigated by directional solidification experiments at different withdrawal speeds(5,10,20,50,100,200,and 400μm·s^(-1)).The results show that the microstructure of directionally solidified Galvalume alloys is composed of primary Al dendrites,Si-rich phase and(Zn-Al-Si)ternary eutectics at the withdrawal speed ranging from 5 to 400μm·s^(-1).As the withdrawal speed increases,the segregation of Si element intensifies,resulting in an increase in the area fraction of the Si-rich *** addition,the primary Al dendrites show significant refinement with an increase in the withdrawal *** relationship between the primary dendrite arm spacing(λ_(1))and the thermal parameters of solidification is obtained:λ_(1)=127.3V^(-0.31).Moreover,as the withdrawal speed increases from 5 to 400μm·s^(-1),the microhardness of the alloy increases from 90 HV to 151 *** is a combined effect of grain refinement and second-phase strengthening.

关键词： Galvalume alloy directional solidification microstructure length scale microhardness

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Evidence-based practices in sustainable travel behavior intervention: A knowledge graph-based systematic review

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第2期11卷 293-311页

作者： jian li Chenjie Xu Key Laboratory of Road and Traffic Engineering of the Ministry of Education College of Transportation EngineeringTongji UniversityShanghai 201804China

Sustainable travel behavior intervention is an essential strategy to promote the development of urban *** interventions offer personalized strategies based on certain scenario and participants to promote its effectiveness over hard travel ***,personalized strategies may also bring about difficulties to identify the actual effect of the ***,based on current practice,to make full use of travel behavior interventions,it is necessary to construct a unified methodological evidencebased framework to assess the reliability and effectiveness of travel behavior intervention *** response to these issues,we applied evidence-based knowledge graph to the field of sustainable travel behavior interventions to help decision supporters design sustainable travel behavior interventions wisely and in turn avoid excessive use of hard travel *** introduced concept of evidence-based practice to conduct a systematic analysis concerning reliability and validity of current full volume empirical studies by dimensions of scenarios,types of interventions and *** addition,we took advantage of high extensivity and integrability of knowledge graph to organize evidence-based related *** of the systematic analysis shows that in terms of reliability of evidence,school intervention is the best scenario,knowledge incentive is the best intervention type and promoting public transit and walking proportion are the best ***,the reliability of interventions in workplace,belonging to reward and threat along with aiming at changing travel patterns generally and lowering travel carbon emission need to be *** the study,various research prospects are raised to promote evidence quality in the field of travel behavior intervention *** a pioneer study,our research contributes to the field of urban transportation in introducing concepts of evidence-based practice and enabling optimization and

关键词： Evidence-based decision-making Evidence assessment Knowledge graph Travel behavior intervention Sustainable travel

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Research on the solid particle erosion wear of pipe steel for hydraulic fracturing based on experiments and numerical simulations

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Petroleum Science 2024年第4期21卷 2779-2792页

作者： Si-Qi Yang jian-Chun Fan Ming-Tao liu de-Ning li Jun-liang li li-Hong Han jian-Jun Wang Shang-Yu Yang Si-Wei Dai Lai-Bin Zhang State Key Laboratory of Oil and Gas Equipment CNPC Tubular Goods Research Institute Key Laboratory of Oil and Gas Safety and Emergency Technology China University of Petroleum Oil Production Technology Research Institute of liaohe Oilfield Company Tianjin Gas Storage Branch PetroChina Dagang Oilfield Company Petroleum Production Engineering Research Institute Daqing Oilfield Company

Erosion wear is a common failure mode in the oil and gas industry. In the hydraulic fracturing, the fracturing pipes are not only in high-pressure working environment, but also suffer from the impact of the high-speed solid particles in the fracturing fluid. Beneath such complex conditions, the vulnerable components of the pipe system are prone to perforation or even burst accidents, which has become one of the most serious risks at the fracturing site. Unfortunately, it is not yet fully understood the erosion mechanism of pipe steel for hydraulic fracturing. Therefore, this article provides a detailed analysis of the erosion behavior of fracturing pipes under complex working conditions based on experiments and numerical simulations. Firstly, we conducted erosion experiments on AISI 4135 steel for fracturing pipes to investigate the erosion characteristics of the material. The effects of impact angle, flow velocity and applied stress on erosion wear were comprehensively considered. Then a particle impact dynamic model of erosion wear was developed based on the experimental parameters, and the evolution process of particle erosion under different impact angles, impact velocities and applied stress was analyzed. By combining the erosion characteristics, the micro-structure of the eroded area, and the micro-mechanics of erosion damage, the erosion mechanism of pipe steel under fracturing conditions was studied in detail for the first time. Under high-pressure operating conditions, it was demonstrated through experiments and numerical simulations that the size of the micro-defects in the eroded area increased as the applied stress increased, resulting in more severe erosion wear of fracturing pipes.

关键词： Erosion wear Applied stress Particle impact dynamics Erosion mechanism

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Accelerating Data Transfer in Dataflow Architectures Through a Look-Ahead Acknowledgment Mechanism

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Journal of Computer Science & Technology 2022年第4期37卷 942-959页

作者： Yu-Jing Feng de-jian li Xu Tan Xiao-Chun Ye Dong-Rui Fan Wen-Ming li Da Wang Hao Zhang Zhi-Min Tang State Key Laboratory of Computer Architecture Institute of Computing TechnologyChinese Academy of SciencesBeijing 100190China Beijing Smartchip Microelectronics Technology Company limited Beijing 100000China School of Computer and Control Engineering University of Chinese Academy of SciencesBeijing 100190China

The dataflow architecture,which is characterized by a lack of a redundant unified control logic,has been shown to have an advantage over the control-flow architecture as it improves the computational performance and power efficiency,especially of applications used in high-performance computing(HPC).Importantly,the high computational efficiency of systems using the dataflow architecture is achieved by allowing program kernels to be activated in a simultaneous ***,a proper acknowledgment mechanism is required to distinguish the data that logically belongs to different *** solutions include the tagged-token matching mechanism in which the data is sent before acknowledgments are received but retried after rejection,or a handshake mechanism in which the data is only sent after acknowledgments are ***,these mechanisms are characterized by both inefficient data transfer and increased area *** performance of the dataflow architecture depends on the efficiency of data *** order to optimize the efficiency of data transfer in existing dataflow architectures with a minimal increase in area and power cost,we propose a Look-Ahead Acknowledgment(LAA)*** accelerates the execution flow by speculatively acknowledging ahead without *** simulation analysis based on a handshake mechanism shows that our LAA increases the average utilization of computational units by 23.9%,with a reduction in the average execution time by 17.4%and an increase in the average power efficiency of dataflow processors by 22.4%.Crucially,our novel approach results in a relatively small increase in the area and power consumption of the on-chip logic of less than 0.9%.In conclusion,the evaluation results suggest that Look-Ahead Acknowledgment is an effective improvement for data transfer in existing dataflow architectures.

关键词： dataflow model control-flow model high-performance computing application data transfer power efficiency

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Effect of Cr_(2)O_(3) on properties of CaO-SiO_(2)-Fe_(t)O-MgO system and dissolution behavior of lime

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Journal of Iron and Steel Research International 2024年第4期31卷 870-881页

作者： Shan-nan li jian-li li Yue Yu Hang-yu Zhu The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The productivity of the chrome-containing semi-steel converter smelting process is directly affected by the slag-forming speed during the converter preliminary *** effects of Cr_(2)O_(3) content on the physicochemical properties of the CaO-SiO_(2)-Fe_(t)O-MgO system,such as melting temperature,solidification behavior,mineral composition,and lime dissolution rate,were *** results showed that the slag was an amorphous phase at 1500℃.When Cr_(2)O_(3) was added,Ca(Fe,Mg)Si_(2)O_(6) and spinel were formed in the *** the increase in Cr_(2)O_(3) content,the amount of spinel precipitation increased,and the dendritic FegO_(4) crystal gradually changed into the granular(Fe,Mg)(Fe,Cr)2O_(4) *** the Cr_(2)O_(3) content increased from O to 2.91 wt.%,the melting temperature of the slag rose,and the melting range of the slag expanded slightly,but the lime dissolution rate did not *** the Cr_(2)O_(3) content further increased to 9.09 wt.%,the melting temperature continued to rise,the melting range rapidly expanded,and the lime dissolution rate decreased.

关键词： Cr_(2)O_(3) Vanadium-titanium magnetite Converter Slag lime dissolution

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Janus mesoporous nanoparticles enable building biological logic systems

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Science China Chemistry 2024年第1期67卷 316-318页

作者： Haitao li jian liu State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China College of Chemistry and Chemical Engineering Inner Mongolia UniversityHohhot 010021China

This highlight is inspired by a recent article in Nature Chemistry[1],in which Zhao and co-workers from Fudan University developed an innovative emulsion-orientated anisotropic assembly method for the controllable fabrication of MSN&mPDA(mesoporous silica nanoparticles=MSN,mesoporous polydopamine=mPDA)Janus mesoporous nanoparticles and used them to build biological logic *** reported Janus mesoporous nanoparticles have delicate structures and are well-controlled,and the authors also demonstrated the unique performance of this material at the application end.

关键词： enable emulsion silica

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Exploring changes of precipitation extremes under climate change through global variable-resolution modeling

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Science Bulletin 2024年第2期69卷 237-247页

作者： Wei Sun jian li Rucong Yu Nina li Yi Zhang State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Institute of Tibetan Plateau Meteorology China Meteorological AdministrationChengdu 610072China department of Atmospheric Science Yunnan UniversityKunming 650091China National Meteorological Center China Meteorological AdministrationBeijing 100081China 2035 Future Laboratory PIESAT Information Technology Co.Ltd.Beijing 100105China

Understanding the responses of precipitation extremes to global climate change remains limited owing to their poor representations in models and complicated interactions with multi-scale *** we take the record-breaking precipitation over China in 2021 as an example,and study its changes under three different climate scenarios through a developed pseudo-global-warming(PGW)experimental framework with 60-3 km variable-resolution global ensemble *** to the present climate,the precipitation extreme under a warmer(cooler)climate increased(decreased)in intensity,coverage,and total amount at a range of 24.3%-37.8%(18.7%-56.1%).With the help of the proposed PGW experimental framework,we further reveal the impacts of the multi-scale system interactions in climate change on the precipitation *** the warmer climate,large-scale water vapor transport converged from double typhoons and the subtropical high marched into central China,enhancing the convective energy and instability on the leading edge of the transport *** a result,the mesoscale convective system(Mcs)that directly contributed to the precipitation extreme became stronger than that in the present *** the contrary,the cooler climate displayed opposite changing characteristics relative to the warmer climate,ranging from the large-scale systems to local environments and to the *** summary,our study provides a promising approach to scientifically assess the response of precipitation extremes to climate change,making it feasible to perform ensemble simulations while investigating the multi-scale system interactions over the globe.

关键词： Precipitation extreme Climate change Pseudo-global-warming experiment Variable-resolution modeling Multi-scale system interaction

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Alignment efficient image-sentence retrieval considering transferable cross-modal representation learning

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Frontiers of Computer Science 2024年第1期18卷 77-91页

作者： Yang YANG Jinyi GUO Guangyu li Lanyu li Wenjie li jian YANG School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China department of Computing Hong Kong Polytechnic UniversityHong Kong 100872China State Key Lab.for Novel Software Technology Nanjing UniversityNanjing 210094China 14th Research Institute of China Electronics Technology Group Corporation Nanjing 210094China guangyu.li2017@***

Traditional image-sentence cross-modal retrieval methods usually aim to learn consistent representations of heterogeneous modalities,thereby to search similar instances in one modality according to the query from another modality in *** basic assumption behind these methods is that parallel multi-modal data(i.e.,different modalities of the same example are aligned)can be obtained in *** other words,the image-sentence cross-modal retrieval task is a supervised task with the alignments as ***,in many real-world applications,it is difficult to realign a large amount of parallel data for new scenarios due to the substantial labor costs,leading the non-parallel multi-modal data and existing methods cannot be used *** the other hand,there actually exists auxiliary parallel multi-modal data with similar semantics,which can assist the non-parallel data to learn the consistent ***,in this paper,we aim at“Alignment Efficient Image-Sentence Retrieval”(AEIR),which recurs to the auxiliary parallel image-sentence data as the source domain data,and takes the non-parallel data as the target domain *** single-modal transfer learning,AEIR learns consistent image-sentence cross-modal representations of target domain by transferring the alignments of existing parallel ***,AEIR learns the image-sentence consistent representations in source domain with parallel data,while transferring the alignment knowledge across domains by jointly optimizing a novel designed cross-domain cross-modal metric learning based constraint with intra-modal domain adversarial ***,we can effectively learn the consistent representations for target domain considering both the structure and semantic ***,extensive experiments on different transfer scenarios validate that AEIR can achieve better retrieval results comparing with the baselines.

关键词： image-sentence retrieval transfer learning semantic transfer structure transfer

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