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Regulations of m^(6)A and other RNA modifications and their roles in cancer

Frontiers of Medicine 2024年第4期18卷 622-648页

作者： Xin-Hui chen Kun-Xiong Guo Jing Li Shu-Hui Xu Huifang Zhu Guang-Rong Yan Biomedicine Research Center Guangdong Provincial Key Laboratory of Major Obstetric DiseaseGuangdong Provincial Clinical Research Center for Obstetrics and GynecologyState Key Laboratory of Respiratory Diseasethe Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510150China

RNA modification is an essential component of the epitranscriptome,regulating RNA metabolism and cellular *** types of RNA modifications have been identified to date;they include N^(6)-methyladenosine(m^(6)A),N^(1)-methyladenosine(m1A),5-methylcytosine(m5C),N^(7)-methylguanosine(m^(7)G),N^(6),2′-O-dimethyladenosine(m^(6)Am),N4-acetylcytidine(ac^(4)C),*** modifications,mediated by regulators including writers,erasers,and readers,are associated with carcinogenesis,tumor microenvironment,metabolic reprogramming,immunosuppression,immunotherapy,chemotherapy,etc.A novel perspective indicates that regulatory subunits and post-translational modifications(PTMs)are involved in the regulation of writer,eraser,and reader functions in mediating RNA modifications,tumorigenesis,and anticancer *** this review,we summarize the advances made in the knowledge of different RNA modifications(especially m^(6)A)and focus on RNA modification regulators with functions modulated by a series of factors in cancer,including regulatory subunits(proteins,noncoding RNA or peptides encoded by long noncoding RNA)and PTMs(acetylation,SUMOylation,lactylation,phosphorylation,etc.).We also delineate the relationship between RNA modification regulator functions and carcinogenesis or cancer ***,inhibitors that target RNA modification regulators for anticancer therapy and their synergistic effect combined with immunotherapy or chemotherapy are discussed.

关键词： RNA modification writers erasers readers regulatory subunits PTMs cancer

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A novel flow electrode capacitive deionization device with spindle-shaped desalting chamber

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 1-4页

作者： Yunke Li Junjun Ma chenxu Yang Jianrui Niu Yonghuan Bian Ruicheng chen Puming Zhang Jing Zhang Chun Liu College of Environmental Science and Engineering Hebei University of Science and TechnologyShijiazhuang 050018China Pollution Prevention Biotechnology Laboratory of Hebei Province Shijiazhuang 050018China

Flow-electrode capacitive deionization(FCDI)is an innovative technology in which an intermediate chamber plays an important role in the desalination ***,relatively few studies have been conducted on the structures of these intermediate *** this study,we propose a novel flow-electrode capacitive deionization device with a spindle-shaped inlet chamber(S-FCDI).The desalination rate of the S-FCDI under optimal operating conditions was 36%higher than that of the FCDI device with a conventional rectangular chamber(R-FCDI).The spindle-shaped chamber transferred 1.2μmol more ions than the rectangular chamber,based on energy per ***,we performed a detailed analysis of different inlet chamber shapes using computational fluid dynamics *** concluded that S-FCDI has a relatively low flow resistance and almost no stagnation *** provides unique insights into the development of intermediate *** study may contribute to the improvement of the desalination performance in industrial applications of FCDI.

关键词： Spindle-shaped chamber desalination performance Flow electrode capacitive deionization

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Clathrate structure of YB_(3)C_(3) for high-performance thermoelectrics with superior mechanical properties

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Journal of Materiomics 2024年第4期10卷 783-791页

作者： Yangfan Cui Shuai Duan Xiaojun Wang Qinghang Tang Jinyang Xi Xiaobing Liu Yongsheng Zhang Xin chen Laboratory of High Pressure Physics and Material Science(HPPMS) School of Physics and Physical EngineeringQufu Normal UniversityQufuShandong273165China Materials Genome Institute Shanghai UniversityShanghai200444China Advanced Research Institute of Multidisciplinary Science Qufu Normal UniversityQufuShandong273165China

Exploring high-performance thermoelectric materials with improved mechanical properties is important for broadening the application scope and the assembly requirement of stable *** work presents an effective strategy to discover hard thermoelectric material by inserting foreign atoms in the rigid covalent *** demonstrate this in boron-carbon clathrate VII structure,showing a promising candidate for highly efficient thermoelectric energy conversion,especially with Y atom filled in the cage,with a peak zT of 0.73 at 1,000 *** ab initio calculations indicate that YB_(3)C_(3) system has low lattice thermal conductivity of 4.5 W/(m·K)at 1,000 K due to the strong rattling of encaged Y *** strongly covalent framework provides highly degenerate band structures consisting of heavy and light electron pockets,which can maintain high carrier mobility arising from small effective mass and thus large group ***,high power factor can be achieved in YB_(3)C_(3) for both electron and hole *** addition,it exhibits well mechanical properties and a Vickers hardness of 23.7 GPa because of the strong covalent boron-carbon *** work provides a novel avenue for the search of high-performance thermoelectric materials with excellent mechanical properties,based on boron-carbon clathrate structure.

关键词： Clathrate structure Thermoelectric performance First-principles calculations Mechanical properties Thermal conductivity

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Species composition and distribution of common Crassostrea and Saccostrea oysters along the coast of Hainan Island

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Journal of Oceanology and Limnology 2024年第5期42卷 1609-1620页

作者： Ruijing LU Ya chen Peizhen MA Cui LI Zhen ZHANG Guochen ZANG Zhenqiang LIU Haiyan WANG Qingdao Agricultural University Qingdao 266109China Institute of Oceanology Chinese Academy of SciencesQingdao 266071China University of Chinese Academy of Sciences Beijing 100049China

Oyster cultivation is a pivotal economic industry in Hainan Island,South China,where a high oyster species diversity is ***,the specific distribution and biodiversity of oyster resources in the island have remained *** elucidate the diversity of oyster species and their distribution there,307 oyster samples were collected from 29 sites in the intertidal zone around the island,and were identified using both morphological and molecular approaches.A minimum of 12 oyster species were identified in taxonomy,including Crassostrea species(*** angulata,***,***,***,***,***,and ***),and Saccostrea species(***,***,***,***,and ***).The results revealed a remarkable diversity of oyster species along the coast of the *** noteworthy are that *** and *** constituted 36%and 22%of the collected specimens,*** study provided a comprehensive overview on current state of oyster biodiversity in Hainan,serving as a valuable reference for conservation and research on species distribution and resource dynamics in oyster populations.

关键词： distribution of oysters Crassostrea Saccostrea oyster resource

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Multi-modal knowledge graph inference via media convergence and logic rule

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CAAI Transactions on Intelligence Technology 2024年第1期9卷 211-221页

作者： Feng Lin Dongmei Li Wenbin Zhang Dongsheng Shi Yuanzhou Jiao Qianzhong chen Yiying Lin Wentao Zhu School of Information Science and Technology Beijing Forestry UniversityBeijingChina Engineering Research Center for Forestry-oriented Intelligent Information Processing National Forestry and Grassland AdministrationBeijingChina Michigan Technological University HoughtonMichiganUSA

Media convergence works by processing information from different modalities and applying them to different *** is difficult for the conventional knowledge graph to utilise multi-media features because the introduction of a large amount of information from other modalities reduces the effectiveness of representation learning and makes knowledge graph inference less *** address the issue,an inference method based on Media Convergence and Rule-guided Joint Inference model(MCRJI)has been *** authors not only converge multi-media features of entities but also introduce logic rules to improve the accuracy and interpretability of link ***,a multi-headed self-attention approach is used to obtain the attention of different media features of entities during semantic ***,logic rules of different lengths are mined from knowledge graph to learn new entity ***,knowledge graph inference is performed based on representing entities that converge multi-media *** experimental results show that MCRJI outperforms other advanced baselines in using multi-media features and knowledge graph inference,demonstrating that MCRJI provides an excellent approach for knowledge graph inference with converged multi-media features.

关键词： logic rule media convergence multi-modal knowledge graph inference representation learning

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建筑装饰材料智能修复涂层制备方法探析

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表面技术 2024年第6期53卷 45-54,89页

作者：陈惠江西科技学院南昌330098

随着社会经济的发展,建筑装饰材料的使用不可或缺,其长久性和稳定性受自然环境腐蚀的考验。施加涂层是有效的防腐手段,解决自修复涂层稳定性和长久性的问题也是防腐科学研究和实际应用的前沿。综述了几种常见的自修复涂层的制备及防腐机... 详细信息

随着社会经济的发展,建筑装饰材料的使用不可或缺,其长久性和稳定性受自然环境腐蚀的考验。施加涂层是有效的防腐手段,解决自修复涂层稳定性和长久性的问题也是防腐科学研究和实际应用的前沿。综述了几种常见的自修复涂层的制备及防腐机制:外援型自修复涂层,在涂料中添加含成膜物质/缓蚀剂的微胶囊,当涂层受到机械冲击后胶囊随之破裂并释放成膜物质/缓蚀剂,形成保护膜或抑制电化学反应保护金属基底;本征型自修复涂层,其涂层基质对环境因素敏感,在环境刺激下通过恢复涂层基质聚合物网络中内在化学键和/或物理构象而修复涂层,其主要包括动态键型和形状记忆型自修复涂层;多重自修复涂层,通过将含有成膜剂/缓蚀剂的微胶囊掺进可恢复涂层基质聚合物中,使其兼顾外援型和本征型自修复涂层的性能。总的来说,自修复涂层的防腐机制主要是通过在涂层中添加缓蚀剂/成膜物质或使涂层恢复活性来抑制涂层下的金属电化学腐蚀,目前建筑装饰用的自修复防腐涂层已逐步应用到建筑防腐工程中,但仍需要在多个方面进行更加深入的研究,多重自修复涂层是未来自修复涂层研究和应用发展的方向,其长效稳定性及制备工艺是主要的科学问题。

关键词：自修复防腐涂层外援型自修复本征型自修复多重自修复建筑装饰材料

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Aparecium:understanding and detecting scam behaviors on Ethereum via biased random Walk

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Cybersecurity 2024年第3期7卷 16-31页

作者： Chuyi Yan chen Zhang Meng Shen Ning Li Jinhao Liu Yinhao Qi Zhigang Lu Yuling Liu Institute of Information Engineering Chinese Academy of SciencesBeijing 100093China School of Cyber Security University of Chinese Academy of SciencesBeijing 100049China School of Cyberspace Science and Technology Bejing Institute of TechnologyBeijing 100081China

Ethereum's high attention,rich business,certain anonymity,and untraceability have attracted a group of *** on it has become increasingly rampant,among which scam behavior is convenient,cryptic,antagonistic and resulting in large economic *** we consider the scam behavior on Ethereum and investigate it at the node interaction *** on the life cycle and risk identification points we found,we propose an automatic detection model named ***,a graph generation method which focus on the scam life cycle is adopted to mitigate the sparsity of the scam ***,the life cycle patterns are delicate modeled because of the crypticity and antagonism of Ethereum scam *** experiments in the wild Ethereum datasets,we prove Aparecium is effective which the precision,recall and F1-score achieve at 0.977,0.957 and 0.967 respectively.

关键词： Blockchain Network security Ethereum Scam detection Behavior understanding

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Combined intestinal microbiota and transcriptomic analysis to investigate the effect of different stocking densities on the ability of Pacific white shrimp(Litopenaeus vannamei)to utilize Chlorella sorokiniana

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Animal Nutrition 2024年第3期18卷 203-219页

作者： Hang Yuan Minghua Xie Jian chen Naijie Hu Honming Wang Beiping Tan Lili Shi Shuang Zhang College of Fisheries Guangdong Ocean UniversityZhanjiangChina College of Fisheries and Life Science Dalian Ocean UniversityDalianChina Zhanjiang Experimental Station Chinese Academy of Tropical Agricultural SciencesZhanjiangChina

Aiming to investigate the impact of different stocking densities on the ability of Pacific white shrimp(Litopenaeus vannamei)to utilize Chlorella sorokiniana(CHL),a 3×2 factorial design stocking experiment was used in this ***,shrimp was fed with two dietary protein sources(fishmeal[FM]and CHL)at low(LSD;100 per m^(3)),medium(MSD;200 per m^(3))and high(HSD;300 per m^(3))stocking densities for 8 *** growth performance and resistance to Vibrio parahaemolyticus(1.0×10^(7) CFU/mL)of shrimp decreased with the increase of stocking density,but dietary CHL improved this *** between the CHL and FM groups for *** resistance were significant only under high-density conditions(Pdensity and protein source were found on the activities of catalase(CAT),superoxide dismutase(SOD)and phenol oxidase(PO),and the contents of malondialdehyde(MDA)in the hepatopancreas and the activities of intestinal amylase,most of which were significantly different between CHL and FM groups only at high stocking density(Pdensities,differentially expressed genes(deGs)in the FM vs CHL group were mostly upregulated and primarily enriched in immune and metabolic related pathways including Toll,immune deficiency(Imd)and glycolysis–gluconeogenesis *** correlation analysis revealed significant correlation between the top ten intestinal bacteria at the genus level and markedly enriched deGs,also more were detected under high density *** conclusion,CHL has great potential as a novel protein source in the intensive farming of shrimp.

关键词： Chlorella sorokiniana Stocking density Microbiota structure Transcriptomic profile Litopenaeus vannamei

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基于改进凸包缺陷算法的扎带定位方法

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纺织学报 2024年第9期45卷 212-219页

作者：周其洪陈唱任佳伟洪巍岑均豪东华大学机械工程学院上海201620 广州盛原成自动化科技有限公司广东广州511400

针对传统视觉在检测捆扎带时存在难检、漏检、定位扎带位置困难和速度慢等问题,提出一种基于改进凸包缺陷算法的扎带定位方法。采用自适应直方图均衡化图像增强算法,以增强编织袋区域与背景的对比度;利用快速凸包算法获得编织袋轮廓的凸... 详细信息

针对传统视觉在检测捆扎带时存在难检、漏检、定位扎带位置困难和速度慢等问题,提出一种基于改进凸包缺陷算法的扎带定位方法。采用自适应直方图均衡化图像增强算法,以增强编织袋区域与背景的对比度;利用快速凸包算法获得编织袋轮廓的凸包,减少获取凸包的时间;最后,通过改进凸包缺陷算法对编织袋轮廓凸包进行缺陷检测,根据检测结果中凸包缺陷点的位置和缺陷深度进行筛选得到扎带定位点。同时为验证该算法的准确性与鲁棒性,在具有复杂背景干扰的环境下进行实验,将传统凸包缺陷算法与改进后的凸包缺陷算法进行对比分析。实验结果表明:相比于传统凸包缺陷算法无法检测出编织袋轮廓的全部缺陷从而存在漏检,改进后的凸包缺陷算法漏检率为0,定位误差小于4 mm,可有效定位扎带位置并具有较高的鲁棒性。

关键词：扎带定位凸包算法缺陷检测图像增强直方图均衡化筒子纱包装

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Cooperative localization methods of autonomous underwater vehicle swarm integrated with inverted ultrashort baseline

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Chinese Journal of Acoustics 2024年第1期43卷 1-22页

作者： LIU Feng WANG Yuxiong chen Huifang XIE Lei College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027 Zhejiang Provincial Laboratory of Information Processing Communication and NetworkingHangzhou 310027 Zhoushan Ocean Research Center Zhejiang UniversityZhoushan 316021

A cooperative localization factor graph for the autonomous underwater vehicle(AUV) swarm integrated with inverted ultrashort baseline(iUSBL) is constructed. Two cooperative localization methods of slave AUV in an AUV swarm are proposed, namely the extended Kalman filter(EKF)-based cooperative localization method and particle belief propagation(BP)-based cooperative localization method, where the effect of the positioning error of leader AUV is mitigated. For the EKF-based cooperative localization method, the state of the slave AUV is reconstructed with the positioning information of leader AUV to achieve cooperative localization. In the particle-BP-based cooperative localization method,the measurement particles are generated to realize cooperative localization. The proposed methods can solve the poor real-time problem of traditional methods, and only require oneway acoustic positioning transmission measurement to realize the localization of the slave AUV. Simulation results show that the two proposed cooperative localization methods work well for slave AUVs with different localization abilities. Compared with the dead-reckoning method, the localization errors of two proposed methods are reduced by more than 80%,and the positioning error accumulation is effectively suppressed. Furthermore, the proposed cooperative localization methods can operate normally under a high packet loss rate of the underwater acoustic channel, and the localization performance is not significantly degraded.

关键词： underwater autonomous cooperative

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