检索结果-南通市图书馆

Cocrystal@protein-anchoring nanococktail for combinatorially treating multidrug-resistant cancer

Acta Pharmaceutica Sinica B 2024年第10期14卷 4509-4525页

作者： Jiahui zou Xuyang Xing chao Teng Qingling Zhao Wei He Xuri Wu Yuanzheng Xia School of Pharmacy China Pharmaceutical UniversityNanjing 211198China School of Computer Science and Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Life Science and Technology China Pharmaceutical UniversityNanjing 211198China State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product Research School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 211198China

Multidrug resistance(MDR),the major mechanism by which various cancers develop specific resistance to therapeutic agents,has set up enormous obstacles to many forms of tumor *** cocktail therapy administration,based on the combination of multiple drugs for anti-MDR chemotherapy,often suffers from inconsistent in vivo pharmacokinetic behaviors that cannot act synchronously on the lesions,leading to limited pharmacodynamic *** the emergence of nanomedicines,which has improved chemotherapeutic drugs’bioavailability and therapeutic effect on clinical application,these monotherapy-based nano-formulations still show poor progression in overcoming ***,a“one stone and three birds”nanococktail integrated by a cocrystal@protein-anchoring strategy was purposed for triple-payload delivery,which paclitaxel-disulfiram cocrystal-like nanorods(NRs)were anchored with the basic protein drug Cytochrome c(Cyt C),followed by hyaluronic-acid *** particular,NRs were utilized as carrier-like particles to synchronously deliver biomacromolecule Cyt C into tumor cells and then promote cell *** note,on A549/Taxol drug-resistant tumor-bearing mice,the system with extraordinarily high encapsulation efficiency demonstrated prolonged in vivo circulation and increased tumor-targeting accumulation,significantly reversing tumor drug resistance and improving therapeutic *** mechanistic study indicated that the system induced the apoptosis of Taxol-resistant tumor cells through the signal axis P-glycoprotein/Cyt C/caspase ***,this nanococktail strategy offers a promising approach to improve the sensitivity of tumor cells to chemotherapeutic drugs and strengthen intractable drug-resistant oncotherapy.

关键词： Cocktail Multidrug-resistant Co-delivery combined therapy Cytochrome C Nanocrystals

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Effects of Arbuscular Mycorrhizal Fungi on Reactive Oxyradical Scavenging System of Tomato Under Salt Tolerance

引用

Agricultural Sciences in China 2010年第8期9卷 1150-1159页

作者： HUANG Zhi HE chao-xing HE Zhong-qun zou Zhi-rong ZHANG Zhi-bin College of Horticulture Northwest A&F University Yangling 712100 PR. China Institute of Vegetables and Flowers Chinese Academy of Agricultural Sciences Beijing 100081 P.R.China College of Horticulture Sichuan Agricultural University Ya'an 625014 P.R.China

The effects of arbuscular mycorrhizal fungi （AMF）, Glomus mosseae, on oxygen radical scavenging system of tomato under salt stress were studied in potted culture experiments. The response of tomato （Lycopersieon eseulentum L.） cultivar Zhongza 9 seedlings with AMF inoculation and control to salt stress （0, 0.5 and 1.0% NaCl solution, respectively） was investigated. The results showed that the salt stress significantly reduced the dry matter content of roots, stems and leaves, and also the leaf area as compared with the control treatment. However, arbuscular mycorrhizal-inoculated （AM） significantly improved the dry matter and the leaf area in the salt-stressed plants. The effect of AMF on dry matter was more pronounced in aerial bromass than in root biomass which might be due to AM colonization. The activities of SOD, POD, ASA-POD, and CAT in leaves and roots of mycorrhizal and non-mycorrhizal treatment of tomato plants were increased and had different rules under different NaCl concentrations （solution of 0, 0.5 and 1% NaCl）, but all enzymes had a rise in the beginning of treatment under salt stress conditions. The AMF did not change the rule of tomato itself under salt stress, but AMF increased these enzyme activities in different levels. The AMF treatment significantly increased SOD, POD and ASA-POD activities in leaves and roots, whereas it had little effects on CAT in root. O2- production rate and MDA content in leaves increased continuously, which showed a positive line correlation with salt stress concentration. O2- production rate and MDA content in tomato plants significantly decreased by AM treatment compared with nonmycorrhizal treatment. In conclusion, AM could alleviate the growth limitations imposed by saline conditions, and thereby play a very important role in promoting plant growth under salt stress in tomato.

关键词： arbuscular mycorrhizal fungi (AMF) osmoregulation salt stress tomato

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Extractable Fractions of Metals in Sewage Sludges from Five Typical Urban Wastewater Treatment Plants of China

引用

Pedosphere 2006年第6期16卷 756-761页

作者： WANG chao LI Xiao-Chen WANG Pei-Fang zou Li-Min MA Hai-Tao Key Laboratory of Integrated Regulation and Resource department on Shallow Lakes Ministry of Education Nanjing 210098 China School of Environmental Science and Engineering Hohai University Nanjing 210098 China

Metal content and bioavailability are often the limiting factors for application of sewage sludge in agricultural fields. Sewage sludge samples were collected from five typical urban wastewater treatment plants in China to investigate their contents and distribution of various chemical fractions of Cu, Zn, Ni, Cr, Pb and Mo by using the BCR （Community Bureau of Reference） sequential extraction procedure. The sludges contained considerable amounts of organic matter （31.8%- 48.0%）, total N （16.3-26.4 g kg^-1） and total P （15.1-23.9 g kg^-1）, indicating high potential agricultural benefits of their practical applications. However, total Zn and Ni contents in the sludge exceeded the values permitted in China＇s control standards for pollutants in sludges from agricultural use （GB 4284-1984）. The residual fraction was the predominant fraction for Mo, Ni and Cr, the oxidizable fraction was the primary fraction for Cu and Pb, and the exchangeable and reducible fractions were principal for Zn. The distribution of different chemical fractions among the sludge samples refiected differences in their physicochemical properties, especially pH. The sludge pH was negatively correlated with the percentages of reducible fraction of Cu and exchangeable fraction of Zn. The sludges from these plants might not be suitable for agricultural applications due to their high contents of Zn, Ni and Cr, as well as high potential of mobility and bioavailability of Zn.

关键词： fractions heavy metals sequential extraction sewage sludge

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Revisiting gamma-ray burst afterglows with time-dependent parameters

引用

Research in Astronomy and Astrophysics 2018年第2期18卷 53-72页

作者： chao Yang Yuan-Chuan zou Wei Chen Bin Liao Wei-Hua Lei Yu Liu School of Physics Huazhong University of Science and Technology

The relativistic external shock model of gamma-ray burst （GRB） afterglows has been estab- lished with five free parameters, i.e., the total kinetic energy E, the equipartition parameters for electrons ee and for the magnetic field eB, the number density of the environment n and the index of the power- law distribution of shocked electrons p. A lot of modified models have been constructed to consider the variety of GRB afterglows, such as： the wind medium environment by letting n change with radius, the energy injection model by letting kinetic energy change with time and so on. In this paper, by as- suming all four parameters （except p） change with time, we obtain a set of formulas for the dynamics and radiation, which can be used as a reference for modeling GRB afterglows. Some interesting results are obtained. For example, in some spectral segments, the radiated flux density does not depend on the number density or the profile of the environment. As an application, through modeling the afterglow of GRB 060607A, we find that it can be interpreted in the framework of the time dependent parameter model within a reasonable range.

关键词： (stars:) gamma.ray burst: general -- methods: analytical

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Phase Transformation and Its Effects on Mechanical Properties and Pitting Corrosion Resistance of 2205 Duplex Stainless Steel

引用

Journal of Iron and Steel Research International 2010年第11期17卷 67-72页

作者： zou de-ning HAN Ying ZHANG Wei FAN Guang-wei School of Metallurgy and Engineering Xi'an University of Architecture and Technology Xi'an 710055 Sbaanxi China State Key Laboratory for Mechanical Behavior of Metal Materials Xi'an Jiaotong University Xi'an 710049 Shaanxi China State Key Laboratory of Advanced Stainless Steel Materials Taigang Stainless Steel Co Ltd Taiyuan 030003 Shanxi China

The effects of phase transformation on mechanical properties and pitting corrosion of 2205 duplex stainless steel were investigated. The amount of a phase in the test specimen varied up to a maximum of 6 % by thermal treatment at 850 ℃ for up to 60 min. The results showed that ~ phase markedly increased the hardness and decreased the impact toughness of the test steel. But the increasing tendency of the ultimate tensile strength and the yield strength was not obvious, while the total elongation abruptly decreased with the aging time from 5 to 60 min. SEM impact microfractograph analysis revealed that the types of impact fracture changed from ductile mode to transcrystalline mode when the specimens were aged for 5-60 min. Furthermore, the extent of pitting potential reducing was found to be strongly temperature dependent, more pronounced at the higher temperature. During the incubation period of σ phase nucleation, the pitting corrosion test temperature and the aging time had collaborative effects on evidently displacing the pitting potential towards less noble values. After 15 min, the higher temperature contributed more to decreasing the pitting potential than the aging time.

关键词： duplex stainless steel phase transformation mechanical property pitting corrosion

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mapping and compositional analysis of mare basalts in the Aristarchus region of the Moon using Clementine data

引用

Research in Astronomy and Astrophysics 2014年第1期14卷 113-128页

作者： Feng Zhang Yong-Liao zou Yong-Chun Zheng Xiao-Hui Fu Yong-chao Zhu National Astronomical Observatories Chinese Academy of Sciences University of Chinese Academy of Sciences Space Science Institute Macao University of Science and Technology Center for Space Science Research and department of Mathematics The Hong Kong University of Science and Technology

The process of accurately defining and outlining mare basalt units is nec- essary for constraining the stratigraphy and ages of basalt units, which are used to determine the duration and the flux of lunar volcanism. We use a combination of Clementine＇s five-band ultraviolet/visible data and Ti02 and FeO abundance distri- bution maps to define homogenous mare basalt units and characterize their composi- tional variations （with maturity） in the Aristarchus region. With 20 groups of distinct mare basaltic soils identified using the method in this paper, six additional spectrally defined areas and five basaltic units are constructed, and their mineralogic quanfiza- tion values provide new constraints on their temporal and spatial evolution. Our results indicate that the Aristarchus region has diverse basalt units and a complex history of volcanic evolution. We also demonstrate that the techniques, from which spectrally distinct mare basalts can be mapped, performed well in this study and can be confi- dently expanded to other mare regions of the Moon.

关键词： spectroscopic -- image processing -- data analysis -- Moon

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Primary squamous cell carcinoma with sarcomatoid differentiation of the kidney associated with ureteral stone obstruction: A case report

引用

World Journal of Clinical Cases 2022年第32期10卷 11942-11948页

作者： Xue-Hua Liu Qian-Ming zou Jia-Dong Cao Zhi-chao Wang department of Urology Surgery Fangcun Hospital of Guangdong Provincial Hospital of traditional Chinese MedicineGuangzhou 510120Guangdong ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)with sarcomatoid differentiation of the kidney was rarely *** disease is usually related to renal stones,and due to a lack of symptoms and radiological features,patients usually attend the hospital with late stage *** SUMMARY A 54-years-old female presented with left flank pain and an abdominal mass for 6 *** studies revealed that the left kidney was enlarged and massive hydronephrosis was present.A stone was seen in the ureteropelvic *** patient subsequently underwent left radical nephrectomy,and histopathological examination of the mass revealed a poorly differentiated renal SCC with sarcomatoid *** primary surgery,the patient received four cycles of *** months later,the patient developed adrenal,lymph,and uterine appendage *** SCC of the kidney has a poor prognosis,and should be considered in patients with a renal mass,long-standing urinary calculi and massive hydronephrosis.

关键词： Squamous cell carcinoma Sarcomatoid differentiation Kidney Ureteral stone Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

清至民国时期贵州野菜的辨别、加工与价值探析※

引用

四川旅游学院学报 2025年第1期 24-29页

作者：邹潇逸贵州师范大学贵州贵阳550025

贵州地处云贵高原,地理环境的复杂多变造就了丰富多样的野菜种类。各族人民常根据野菜的外形、生长季节等因素来辨别其可食用性。因野菜中多年生植物较多,且季节性强,一年中大部分时间都有不同类型的野菜可供采摘,即使是在出产量少的季... 详细信息

贵州地处云贵高原,地理环境的复杂多变造就了丰富多样的野菜种类。各族人民常根据野菜的外形、生长季节等因素来辨别其可食用性。因野菜中多年生植物较多,且季节性强,一年中大部分时间都有不同类型的野菜可供采摘,即使是在出产量少的季节,亦有加工储存之野菜可供食用,以至于在20世纪80年代前,贵州黔东南、黔南部分少数民族地区仍常年不种家蔬,专以野菜为食。野菜除充饥外,还具有药用、营养、饲用、观赏等价值。因此,充分认识贵州野菜的资源优势,对贵州山区经济的发展有着重要意义。

关键词：清至民国时期贵州野菜辨别加工价值

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

P-V Criticality of Born-Infeld AdS Black Holes Surrounded by Quintessence

引用

Communications in Theoretical Physics 2018年第10期70卷 459-464页

作者： Chen-Hao Wu de-Cheng zou Yue Wang Center for Gravitation and Cosmology College of Physical Science and TechnologyYangzhou UniversityYangzhou 225009China Institute of Basic Sciences and department of Computer Simulation Inje UniversityGimhae 50834Korea

We discuss the P-V criticality and phase transition in the extended phase space of Born-Infeld AdS(BIAdS) black hole surrounded by quintessence dark energy, where the cosmological constant Λ is identified with the thermodynamical pressure P. Comparing with Van der Waals(VdW)-like SBH/LBH phase transition of Born-Infeld AdS(BI-AdS) black hole, we find that the BI-AdS black hole surrounded by quintessence dark energy possesses lower critical temperature because of parameter a > 0, even disappears since the parameter a taking enough large values leads to Tc ≤ 0. Moreover, the interesting thermodynamic phenomenon of reentrant phase transition(RPT) are also observed,and the quintessence dark energy plays a similar role in this RPT.

关键词： general relativity quintessence black hole thermodynamics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influences of ^7Li enrichment on Th-U fuel breeding for an Improved Molten Salt Fast Reactor(IMSFR)

引用

Nuclear Science and Techniques 2017年第7期28卷 105-113页

作者： Guang-chao Li Yang zou Cheng-Gang Yu Jian-Long Han Jin-Gen Chen Hong-Jie Xu Shanghai Institute of Applied Physics Chinese Academy of Sciences Shanghai 201800 China CAS Innovative Academies in TMSR Energy System Shanghai 201800 China University of Chinese Academy of Sciences Beijing 100049China

The molten salt fast reactor(MSFR) shows great promise with high breeding ratio(BR),large negative temperature coefficient of reactivity,high thermal-electric conversion efficiency,inherent safety,and online *** on an improved MSFR optimized by adding axial fertile salt and a graphite reflector,the influences of ~7Li enrichment on Th-U breeding are investigated,aiming to provide a feasible selection for the molten salt with high fissile breeding and a relatively low technology requirement for ~7Li *** the self-developed molten salt reactor reprocessing sequence based on SCALE6.1,the burn-up calculations with online reprocessing are carried *** are explored including BR,^(233)U production,double time(DT),spectrum,~6Li inventory,neutron absorption,and the tritium *** results show that the Li enrichment of 99.95% is appropriate in the fast fission *** this case,BR above 1.10 can be achieved for a long time,corresponding to the ^(233)U production of130 kg per year and DT of 36 *** 80 years' operation,the tritium production for 99.5% is only about 7kg,and there is no obvious increase compared to that for 99.9995%.

关键词：繁殖率熔盐富集铀燃料裂变反应堆快堆在线处理负温度系数

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：