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Poorly controlled type II diabetes mellitus significantly enhances postoperative chemoresistance in patients with stage III colon cancer

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World Journal of Gastroenterology 2025年第3期31卷 29-41页

作者： Ruo-Yu Guan Jia-Wei Wu Zi-Yun yuan zhi-yuan Liu Zi-Zhu Liu zhi-Cong Xiao Jing-Hui Li Cheng-zhi Huang Jun-Jiang Wang Xue-Qing Yao Guangdong Cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesSouthern Medical UniversityGuangzhou 510080Guangdong ProvinceChina department of Gastrointestinal Surgery Department of General SurgeryGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080Guangdong ProvinceChina department of General Surgery Guangdong Provincial People’s Hospital Ganzhou Hospital(Ganzhou Municipal Hospital)Ganzhou 341000Jiangxi ProvinceChina Shantou University Medical College Shantou 515041Guangdong ProvinceChina School of Medicine South China University of TechnologyGuangzhou 510006Guangdong ProvinceChina Gannan Medical University Ganzhou 341000Jiangxi ProvinceChina

BACKGROUND Type II diabetes mellitus(T2DM)has been associated with increased risk of colon cancer(CC)and worse prognosis in patients with *** effects of T2DM on postoperative chemoresistance rate(CRR)and long-term disease-free survival(DFS)and overall survival(OS)in patients with stage III CC who receive curative resection remain *** To investigate whether T2DM or glycemic control is associated with worse postoperative survival outcomes in stage III *** This retrospective cohort study included 278 patients aged 40-75 years who underwent surgery for stage III CC from 2018 to *** on preoperative T2DM history,the patients were categorized into non-DM(n=160)and DM groups(n=118).The latter was further divided into well-controlled(n=73)and poorly controlled(n=45)groups depending on the status of glycemic ***,OS,and CRR were compared between the groups and Cox regression analysis was used to identify risk *** Patients in the DM and non-DM groups demonstrated similar DFS,OS,and CRR(DFS:72.03%vs 78.75%,P=0.178;OS:81.36%vs 83.12%,P=0.638;CRR:14.41%vs 7.5%,P=0.063).Poorly controlled DM was associated with a significantly worse prognosis and higher CRR than well-controlled DM(DFS:62.22%vs 78.07%,P=0.021;OS:71.11%vs 87.67%,P=0.011;CRR:24.40%vs 8.22%,P=0.015).High preoperative fasting plasma glucose[DFS:Hazard ratio(HR)=2.684,Pdentified as risk factors associated with poor postoperative outcomes and high CRR in patients with stage III CC.

关键词： Colon cancer Chemoresistance Diabetes mellitus Prognosis Type II diabetes mellitus

Thrombolysis and extracorporeal cardiopulmonary resuscitation for cardiac arrest due to pulmonary embolism:A case report

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World Journal of Critical Care Medicine 2025年第1期14卷 111-117页

作者： Guan-Xing yuan zhi-Ping Zhang Jia Zhou department of Emergency Wuhan Asia General HospitalWuhan 430056Hubei ProvinceChina department of Neurosurgery Central Theater Command General HospitalWuhan 430000Hubei ProvinceChina

BACKGROUND Cardiac arrest caused by acute pulmonary embolism(PE)is the most serious clinical circumstance,necessitating rapid identification,immediate cardiopulmonary resuscitation(CPR),and systemic thrombolytic *** CPR(ECPR)is typically employed as a rescue therapy for selected patients when conventional CPR is failing in settings where it can be *** SUMMARY We present a case of a 69-year-old male who experienced a prolonged cardiac arrest in an ambulance with pulseless electrical *** arrival at the emergency department with ongoing manual chest compressions,bedside pointof-care ultrasound revealed an enlarged right ventricle without *** PE was suspected as the cause of cardiac arrest,and intravenous thrombolytic therapy with 50 mg tissue plasminogen activator was administered during mechanical chest *** 31 minutes of CPR,return of spontaneous circulation was not achieved until 8 minutes after initiation of Veno-arterial extracorporeal membrane oxygenation(ECMO)*** ECMO support,the hemodynamic status and myocardial contractility significantly ***,the patient ultimately did not survive due to intracerebral hemorrhagic complications,leading to death a few days later in the *** This case illustrates the potential of combining systemic thrombolysis with ECPR for refractory cardiac arrest caused by acute PE,but it also highlights the increased risk of significant bleeding complications,including fatal intracranial hemorrhage.

关键词： Pulmonary embolism Cardiac arrest Thrombolytic therapy Cardiopulmonary resuscitation Extracorporeal membrane oxygenation Intracranial hemorrhage Case report

Mizagliflozin ameliorates diabetes induced kidney injury by inhibitor inhibit inflammation and oxidative stress

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World Journal of Diabetes 2025年第1期16卷 91-103页

作者： zhi-Min Lin Han-yuan Gao Shu-Han Shi Yue-Ting Li department of Nephrology The Second Affiliated Hospital of Fujian Medical UniversityQuanzhou 362000Fujian ProvinceChina

BACKGROUND Mizagliflozin(MIZ)is a specific inhibitor of sodium-glucose cotransport protein 1(SGLT1)originally developed as a medication for *** To explore the impact of MIZ on diabetic nephropathy(DN).METHODS Diabetic mice were created using db/db *** were administered either a low dose(0.5 mg/kg)or a high dose(1.0 mg/kg)of the SGLT1 inhibitor MIZ via stomach gavage for 8 ***,mesangial cells(MCs)were isolated and subjected to high glucose conditions in culture to assess the effects of MIZ on *** The results showed that low doses of MIZ significantly reduced albuminuria to a level comparable to that achieved with high doses in db/db *** doses of MIZ led to a substantial increase in body weight in mice,along with decreased blood glucose levels and food ***,the intervention with high-dose MIZ notably decreased the expression of extracellular matrix genes,such as collagen type 1 alpha 1 mRNA *** the expression of SGLT1 increased after exposure to high glucose,it decreased following treatment with ***,MIZ intervention was more effective in improving lactate dehydrogenase levels in MCs induced by high glucose compared to *** also significantly elevated levels of antioxidant enzymes superoxide dismutase,catalase,and glutathione,while reducing malondialdehyde *** These findings indicate that MIZ can ameliorate DN by inhibiting SGLT1,inflammation,and oxidative stress.

关键词： Mizagliflozin Sodium-glucose cotransport protein 1 Diabetic nephropathy Mesangial cells

Unlocking the future:Mitochondrial genes and neural networks in predicting ovarian cancer prognosis and immunotherapy response

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World Journal of Clinical Oncology 2025年第1期16卷 43-52页

作者： zhi-Jian Tang yuan-Ming Pan Wei Li Rui-Qiong Ma Jian-Liu Wang department of Obstetrics and Gynecology Peking University People’s HospitalBeijing 100044China Cancer Research Center Beijing Chest HospitalBeijing 101149China department of Thoracic Surgery Sichuan Provincial People's HospitalChengdu 610072Sichuan ProvinceChina

BACKGROUND Mitochondrial genes are involved in tumor metabolism in ovarian cancer(OC)and affect immune cell infiltration and treatment *** To predict prognosis and immunotherapy response in patients diagnosed with OC using mitochondrial genes and neural *** Prognosis,immunotherapy efficacy,and next-generation sequencing data of patients with OC were downloaded from The Cancer Genome Atlas and Gene Expression *** genes were sourced from the MitoCarta3.0 *** discovery cohort for model construction was created from 70% of the patients,whereas the remaining 30% constituted the validation *** the expression of mitochondrial genes as the predictor variable and based on neural network algorithm,the overall survival time and immunotherapy efficacy(complete or partial response)of patients were *** In total,375 patients with OC were included to construct the prognostic model,and 26 patients were included to construct the immune efficacy *** average area under the receiver operating characteristic curve of the prognostic model was 0.7268[95% confidence interval(CI):0.7258-0.7278]in the discovery cohort and 0.6475(95%CI:0.6466-0.6484)in the validation *** average area under the receiver operating characteristic curve of the immunotherapy efficacy model was 0.9444(95%CI:0.8333-1.0000)in the discovery cohort and 0.9167(95%CI:0.6667-1.0000)in the validation *** The application of mitochondrial genes and neural networks has the potential to predict prognosis and immunotherapy response in patients with OC,providing valuable insights into personalized treatment strategies.

关键词： Ovarian cancer Mitochondria Prognosis Immunotherapy Neural network

Based on non-targeted metabolomics for differential components screening of Rosae Chinensis Flos and Rosae Rugosae Flos and their quality evaluation

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Traditional Medicine Research 2025年第2期10卷 1-15页

作者： Xu Liang Ni-Hui Zhang zhi-Lai Zhan Guang-Lu Chang Yan Gao Xia Li Wen-yuan Gao School of Pharmaceutical Science and Technology Faculty of MedicineTianjin UniversityTianjin 300193China State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs China Academy of Chinese Medical SciencesBeijing 100700China Key Laboratory of Modern Chinese Medicine Resources Research Enterprises Tianjin 300402China

Background:Rosa chinensis *** Rosa rugosa *** not only of ornamental value,but also edible flowers and the flower buds have been listed in the Chinese Pharmacopoeia as traditional *** two plants have some differences in efficacy,but the flower buds are easily confused for similar *** addition,large-scale cultivation of ornamental rose flowers may lead to a decrease in the effective components of medicinal ***,it is necessary to study the chemical composition and make quality evaluation of Rosae Chinensis Flos(Yueji)and Rosae Rugosae Flos(Meigui).Methods:In this study,40 batches of samples including Meigui and Yueji from different regions in China were collected to establish high-performance liquid chromatography ***,the fingerprints data was analyzed using principal component analysis,hierarchical cluster analysis,and partial least squares discriminant analysis analysis chemometrics to obtain information on intergroup differences,and non-targeted metabolomic techniques were applied to identify and compare chemical compositions of samples which were chosen from groups with large *** compounds were screened by orthogonal partial least-squares discriminant analysis and S-plot,and finally multi-component quantification was performed to comprehensively evaluate the quality of Yueji and ***:The similarity between the fingerprints of 40 batches roses and the reference print R was 0.73 to 0.93,indicating that there were similarities and differences between the *** principal component analysis and hierarchical cluster analysis of fingerprints data,the samples from different origins and varieties were intuitively divided into four *** least-squares discriminant analysis analysis showed that Meigui and Yueji cluster into two categories and the model was reliable.A total of 89 compounds were identified by high resolution mass spectrometry,mainly were flavonoids and flavon

关键词： Rosa chinensis Jacq. Rosa rugosa Thunb. metabolomics chemometrics multiple component quantification quality evaluation

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脓毒性休克并发急性肾损伤的危险因素研究

临床和实验医学杂志 2020年第20期19卷 2196-2199页

作者：支德源林瑾张萌段美丽首都医科大学附属北京友谊医院重症医学科北京100050

目的探讨脓毒性休克并发急性肾损伤(AKI)的危险因素。方法回顾性分析2016年1月至2019年12月在首都医科大学附属北京友谊医院就诊的108例脓毒症患者的临床资料,按有无AKI损伤将其均分为两组:AKI组为脓毒性休克并发急性肾损伤的患者,非AK... 详细信息

目的探讨脓毒性休克并发急性肾损伤(AKI)的危险因素。方法回顾性分析2016年1月至2019年12月在首都医科大学附属北京友谊医院就诊的108例脓毒症患者的临床资料,按有无AKI损伤将其均分为两组:AKI组为脓毒性休克并发急性肾损伤的患者,非AKI组为脓毒性休克未并发AKI的患者,每组各54例。比较两组患者的临床资料,包括平均动脉压(MAP)、氧合指数、血清肌酐(SCR)、乳酸、血尿素氮(BUN)、24 h液体净入量等指标。比较两组患者的白蛋白、血小板、血钾、血钠、C反应蛋白(CRP)等相关实验室指标。采用多因素logistic回归分析确定脓毒性休克并发AKI的危险因素。结果AKI组氧合指数均显著低于非AKI组,差异有统计学意义(P0.05)。将单因素分析中有统计学意义的6个影响脓毒性患者并发AKI的危险因素,包括MAP、氧合指数、血BUN、动脉血乳酸、SCR、24 h液体净入量作为协变量后进入logistic回归模型,得出SCR、24 h液体净入量、MAP及动脉血乳酸是脓毒性休克患者并发AKI的危险因素。结论SCR、24 h液体净入量、MAP及动脉血乳酸是脓毒性休克患者并发急性肾损伤的危险因素,有助于临床医生诊断早期脓毒性休克并发急性肾损伤。

关键词：脓毒性休克急性肾损伤危险因素

临床诊疗路径在上消化道出血患者医疗质量同质化中的效果研究

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临床和实验医学杂志 2021年第5期20卷 546-549页

作者：徐芳支德源王慧英首都医科大学附属北京友谊医院医务处北京100050

目的探讨临床诊疗路径在上消化道出血患者医疗质量同质化中的应用效果。方法采用回顾性研究,选取首都医科大学附属北京友谊医院2018年8~12月收治的120例上消化道出血的患者为对照组,采用常规诊疗方法。选取首都医科大学附属北京友谊医院... 详细信息

目的探讨临床诊疗路径在上消化道出血患者医疗质量同质化中的应用效果。方法采用回顾性研究,选取首都医科大学附属北京友谊医院2018年8~12月收治的120例上消化道出血的患者为对照组,采用常规诊疗方法。选取首都医科大学附属北京友谊医院2019年1~5月收治的130例上消化道出血患者为观察组,采用临床诊疗路径。比较2组患者的诊疗效果、病例质量、住院时间以及医疗费用等指标。结果观察组患者的次均医嘱修改次数明显少于对照组[(0.57±0.21)次vs.(1.12±0.45)次],差异有统计学意义(P <0.05)。观察组患者的总有效率高于对照组(97.69%vs. 91.67%),卧床时间、进食时间和住院时间均短于对照组[(20.12±2.59) h vs.(24.53±3.05) h、(22.45±2.87) h vs.(27.24±3.12) h、(5.87±1.72) d vs.(7.03±2.01) d],差异有统计学意义(P <0.05)。观察组患者的药费、检查费、住院费用均少于对照组[(2 294.4±185.7)元vs.(2 395.6±205.3元)、(2 834.2±362.4)元vs.(3 078.4±383.6)元、(5 865.5±721.6)元vs.(6 260.4±864.5)元],差异有统计学意义(P <0.05)。结论临床诊疗路径在上消化道出血中的应用不仅能提高治疗效果,减少患者的治疗费用,还能提高医师的工作效率。

关键词：上消化道出血临床诊疗路径医疗质量效果

Numerical investigation on the effects of current headings on vortex induced motions of a semi-submersible

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Journal of Hydrodynamics 2022年第3期34卷 382-394页

作者： Wei-wen Zhao zhi-yuan Wei de-cheng Wa Computational Marine Hydrodynamics Lab(CMHL) School of Naval ArchitectureOcean and Civil EngineeringShanghai Jiao Tong UniversityShanghai200240China Marine design&Research Institute of China Shanghai200011China Ocean College Zhejiang UniversityZhoushan316021China

In this paper,numerical simulations on vortex-induced motions(VIM)of a semi-submersible at two different current headings are conducted over a wide range of current *** simulations are performed with the computational fluid dynamics(CFD)solver VIM-FOAM-SJTU which is an in-house solver developed based on the OpenFOAM *** turbulent flows are resolved with a shear stress transport-delayed detached eddy simulation(SST-DdeS)*** decay tests for transverse and yaw motion are performed in calm still water to make sure the equivalent stiffness is setup *** the results of VIM,including motion response,forces and moments,and flow patterns are presented and analyzed *** including transverse,in-line and yaw motion at different current headings and velocities are *** vorticity in the wake regions at different time stamps are also illustrated for different current headings and velocities.

关键词： Vortex-induced motions(VIM) vortex-induced yaw vim-FOAM-SJTU solver Reynolds stress

Influence of hot rolling on the microstructure of lean duplex stainless steel 2101

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International Journal of Minerals,Metallurgy and Materials 2019年第10期26卷 1266-1273页

作者： zhi-jun Gao Jing-yuan Li zhi-hui Feng Yi-de Wang School of material science and engineering University of Science and Technology BeijingBeijing100083China Institute of Engineering Technology University of Science and Technology BeijingBeijing100083China

In this work, the microstructure and the strain partitioning of lean duplex stainless steel 2101 (LDX 2101) during different hot-rolling processes are investigated by optical microscopy and electron-backscattered diffraction (EBSD). The results show that the LDX 2101 exhibits poor thermoplasticity at high temperature. The four-pass hot-rolled plates show fewer edge-cracking defects and superior thermoplasticity compared with the two-pass hot-rolled plates prepared at different temperature. The phase boundary is the weakest site in the LDX 2101. The cracks are initiated and propagated along the phase boundaries during the hot-rolling process. According to the EBSD analysis, the increase of the hot-rolling pass can dramatically improve the strain distribution in ferrite and austenite phases and promote the strain transmission in the constituent phases, thereby improving the coordinated deformation ability of the two phases. This effect further in- creases the thermoplasticity and reduces the formation of edge cracks in LDX 2101.

关键词： lean duplex stainless steel hot-rolling process thermoplasticity strain distribution