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Chinese Physics B 2022年第4期31卷 667-671页

作者： Jiao-Hong Huang ying-de zhang Nai-Kun Sun Yang zhang Xin-Guo Zhao Zhi-Dong zhang State Key Laboratory of Baiyunobo Rare Earth Resource Researches and Comprehensive Utilization Baotou Research Institute of Rare EarthsBaotou 014030China School of Science Shenyang Ligong UniversityShenyang 110159China Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China

Due to the hydrogen embrittlement effect,La(Fe,Si)_(13)-based hydrides can only exist in powder form,which limits their practical *** this work,ductile and thermally conductive Al metal was homogeneously mixed with La_(0.5)Pr_(0.5)Fe_(11.4)Si_(1.6)B_(0.2)using the ball milling *** hydrogenation and compactness shaping of the magnetocaloric composites were performed in one step via a sintering process under high hydrogen *** the Al content reached 9 wt.%,the La_(0.5)Pr_(0.5)Fe_(11.4)Si_(1.6)B_(0.2)H_(y)/Al composite showed the mechanical behavior of a ductile material with a yield strength of~44 MPa and an ultimate strength of 269 MPa accompanied by a pronounced improvement in thermal *** to the ease of formation of Fe-Al-Si phases and the several micron and submicron sizes of the composite particles caused by ball milling process,the magnetic entropy change of the composites was substantially reduced to~1.2 J/kg·K-1.5 J/kg·K at 0 T-1.5 T.

关键词： ball milling mechanical behavior room-temperature magnetic refrigeration La(Fe Si)_(13)

Diagnosis,treatment,outcome,and reasons for delayed treatment of cryptorchidism with torsion in children:a 16-year retrospective study in a large pediatric medical center

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Asian Journal of Andrology 2022年第4期24卷 386-389页

作者： Meng Yang Sheng Wen Tao Lin Xing Liu de-ying zhang Feng Liu Sheng-de Wu Guang-Hui Wei Pei-Ru He Yi Hua department of Urology Children's Hospital of Chongqing Medical UniversityChongqing 400000China Pediatrics Research Institute Children's Hospital of Chongqing Medical UniversityMinistry of Education Key Laboratory of Child Development and DisordersNational Clinical Research Center for Child Health and DisordersChina International Science and Technology Cooperation Base of Child Development and Critical DisordersChildren's Hospital of Chongqing Medical UniversityChongqing 400000China Chongqing Key Laboratory of Pediatrics Chongqing Key Laboratory of Children Urogenital Development and Tissue EngineeringChongqing 400000China.

We describe and summarize the diagnosis,treatment,and reasons for delayed treatment of children with cryptorchidism torsion in Children's Hospital of Chongqing Medical *** study included 19 cases of cryptorchidism *** age of the children ranged from 16 days to 12 years(median:6 years).The interval from diagnosis to surgery varied from 4 h to 16 days(median:3 days).Ultrasound was performed in all *** cases had cryptorchidism torsion,2 cases had a soft tissue mass in the inguinal region,and 2 cases had an inguinal/abdominal *** cases were treated with an orchidopexy,12 cases were treated with orchiectomy,and 2 cases received resection of a testicular *** 5 children with an orchidopexy were followed up from 1 month to 7 years(median:3 years),with 1 child having a testis retraction and no blood *** the 12 children who had an orchiectomy,three had delayed diagnosis due to family unawareness of the condition,while other delays were due to delayed referral from primary care *** relative rarity and insufficient awareness of cryptorchidism torsion resulted in a low rate of testicular ***,hospitals of all levels should be fully aware of cryptorchidism with torsion and ensure a male child's genital system and inguinal region are examined to improve the success rate of testicular salvage.

关键词： children cryptorchidism testicular torsion

Immunoregulative Mechanism of the Leydig Cell in the Infection by Expression of IL-1,IL-6,TGF-β,Fas and FasL mRNA

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Journal of Reproduction and Contraception 2006年第1期17卷 1-8页

作者： Ye-bin XI Bao-guo WANG ying-de zhang Guang-jie CHEN Tian-wei SHEN Wei-yi LI Shanghai Jiaotong University School of Medicine Shanghai Institute of hnmunogy Shanghai 200025 China

Objective To investigate the immune regulative mechanism of Leydig cells in the local infection of rat＇s testis.Methods Ureaplasma Urealyticum（UU） was injected into rat＇s bladder, which mimicked an ascending infectious way, and at the same time culture medium was injected into rat＇s bladder as the control. The rats were sacrificed at week 1, 2 and 3 after injection respectively. Then pathological changes in testis were analyzed by histological examination. At the same time Leydig cells were separated from rat＇s testis. The comparasion of levels of IL-1,IL-6, TGF-β, Fas and FasL mRNA expression among the three groups was made by RT-PCR.Results As compared with control group, the levels of IL-1, IL-6, TGF-fl mRNA expression for UU supernatant and living UU groups increased; and levels of Fas and FasL mRNA expression decreased and increased respectively after UU infection. Conclusion During anti-infective immunity, rat＇s Leydig cells may regulate immune function of the testis by changing the levels of IL-1, IL-6, TGF-β, Fas and FasL mRNA expression and may contribute to maintain immune privilege of the testis.

关键词： Leydig cell immune regulation cytokines Fas FasL

应用离子选择性电极进行溶液热力学研究——Ⅳ.氯化钠在5—45℃间九个温度下由水至二甲基甲酰胺-水混合溶剂的标准转移Gibbs自由能及转移熵的测定

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化学学报 1988年第9期46卷 848-853页

作者：褚德萤张颖衣影刘瑞麟北京大学化学系北京贵州师范大学化学系

本文应用钠离子玻璃电极及氯离子选择性电极组成无液界可逆电池,即Cl选择电极|NaCl(m),w或s|Na+玻璃电极测定电池的标准电动势.

关键词：混合溶剂自由能 DMF 热力学性质甲酰胺 Gibbs 离子选择性电极

Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali Liu Shanshan Qi Biao Shi ying Zhao Xiaodan zhang Institute of Photoelectronic Thin Film devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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海拉尔盆地介形类化石的发现及其地层意义

微体古生物学报 1989年第1期6卷 17-30,115-116页

作者：叶得泉张莹大庆石油管理局勘探开发研究院

海拉尔盆地发现了较丰富的介形类化石,主要分布在青元岗组和大磨拐河组。建立了2个介形类化石组合,Talicypridea组合和Limnocypridea组合。描记了3个新种Talicypridea hailarensis ***.,*** ***.,T.,subranaformis ***.。对盆地中白垩... 详细信息

海拉尔盆地发现了较丰富的介形类化石,主要分布在青元岗组和大磨拐河组。建立了2个介形类化石组合,Talicypridea组合和Limnocypridea组合。描记了3个新种Talicypridea hailarensis ***.,*** ***.,T.,subranaformis ***.。对盆地中白垩纪沉积进行了元素含量分析,根据元素分析结果,讨论了各组地层的沉积环境。

关键词：海拉尔盆地介形类地层沉积环境白垩纪化石组合发现新种

NOX4 exacerbates Parkinson's disease pathology by promoting neuronal ferroptosis and neuroinflammation

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Neural Regeneration Research 2025年第7期20卷 2038-2052页

作者： Zhihao Lin Changzhou ying Xiaoli Si Naijia Xue Yi Liu Ran Zheng ying Chen Jiali Pu Baorong zhang department of Neurology The Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang ProvinceChina

Parkinson's disease is primarily caused by the loss of dopaminergic neurons in the substantia nigra ***,a novel form of regulated cell death characterized by iron accumulation and lipid peroxidation,plays a vital role in the death of dopaminergic ***,the molecular mechanisms underlying ferroptosis in dopaminergic neurons have not yet been completely *** oxidase 4 is related to oxidative stress,however,whether it regulates dopaminergic neuronal ferroptosis remains *** aim of this study was to determine whether NADPH oxidase 4 is involved in dopaminergic neuronal ferroptosis,and if so,by what *** found that the transcriptional regulator activating transcription factor 3 increased NADPH oxidase 4 expression in dopaminergic neurons and astrocytes in an 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced Parkinson's disease *** oxidase 4 inhibition improved the behavioral impairments observed in the Parkinson's disease model animals and reduced the death of dopaminergic ***,NADPH oxidase 4 inhibition reduced lipid peroxidation and iron accumulation in the substantia nigra of the Parkinson's disease model ***,we found that NADPH oxidase 4 interacted with activated protein kinase Cαto prevent ferroptosis of dopaminergic ***,by lowering the astrocytic lipocalin-2 expression,NADPH oxidase 4 inhibition reduced 1-methyl-4-phenyl-1,2,3,6 tetrahydropyridine-induced *** findings demonstrate that NADPH oxidase 4 promotes ferroptosis of dopaminergic neurons and neuroinflammation,which contribute to dopaminergic neuron death,suggesting that NADPH oxidase 4 is a possible therapeutic target for Parkinson's disease.

关键词： dopaminergic neuron ferroptosis NADPH oxidase 4(NOX4) neuroinflammation Parkinson's disease

Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases

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Neural Regeneration Research 2025年第8期20卷 2373-2381页

作者： Lifang Zhao Mingkai zhang Qimeng Li Xuemin Wang Jie Lu ying Han Yanning Cai department of Clinical Biobank Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Geriatric Medical Research Center BeijingChina department of Neurology Xuanwu HospitalCapital Medical UniversityBeijingChina department of Radiology and Nuclear Medicine Xuanwu HospitalCapital Medical UniversityBeijingChina Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics BeijingChina Key Laboratory of Neurodegenerative diseases Ministry of EducationBeijingChina School of Biomedical Engineering Hainan UniversityHaikouHainan ProvinceChina Center of Alzheimer’s Disease Beijing Institute for Brain DisordersBeijingChina National Clinical Research Center for Geriatric Diseases BeijingChina Institute of Biomedical Engineering Shenzhen Bay LaboratoryGaoke Innovation CenterShenzhenGuangdong ProvinceChina department of Neurobiology Xuanwu HospitalCapital Medical UniversityBeijingChina

Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative ***,little is known about the long-term stability of these biomarker proteins in plasma samples stored at-80°*** aimed to explore how storage time would affect the diagnostic accuracy of these biomarkers using a large *** samples from 229 cognitively unimpaired individuals,encompassing healthy controls and those experiencing subjective cognitive decline,as well as 99 patients with cognitive impairment,comprising those with mild cognitive impairment and dementia,were acquired from the Sino Longitudinal Study on Cognitive decline *** samples were stored at-80°C for up to 6 years before being used in this *** results showed that plasma levels of Aβ42,Aβ40,neurofilament light chain,and glial fibrillary acidic protein were not significantly correlated with sample storage ***,the level of total tau showed a negative correlation with sample storage ***,in individuals without cognitive impairment,plasma levels of total protein and tau phosphorylated protein threonine 181(p-tau181)also showed a negative correlation with sample storage *** was not observed in individuals with cognitive ***,we speculate that the diagnostic accuracy of plasma p-tau181 and the p-tau181 to total tau ratio may be influenced by sample storage ***,caution is advised when using these plasma biomarkers for the identification of neurodegenerative diseases,such as Alzheimer's ***,in cohort studies,it is important to consider the impact of storage time on the overall results.

关键词： Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein neurodegeneration neurofilament light chain plasma biomarkers single molecule array storage time tau

增设喷雾降温系统的家用空调器性能与特性的试验研究

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流体机械 2017年第5期45卷 58-61,25页

作者：胡文举张帅李德英张啊文北京建筑大学北京市供热、供燃气、通风及空调重点实验室北京100044 天津大学天津300072

针对家用空调器夏季运行室外热环境差的问题,提出在其室外机增设喷雾加湿装置以降低冷凝温度进而达到提高空调器性能和制冷量的目的。本文对增设喷雾降温系统地空调器进行了试验研究,分析了增设喷雾降温系统对空调器冷凝器出口空气温度... 详细信息

针对家用空调器夏季运行室外热环境差的问题,提出在其室外机增设喷雾加湿装置以降低冷凝温度进而达到提高空调器性能和制冷量的目的。本文对增设喷雾降温系统地空调器进行了试验研究,分析了增设喷雾降温系统对空调器冷凝器出口空气温度和制冷系统性能的影响。实测研究发现,增设喷雾加湿系统后,冷凝器出口制冷剂压力有所降低,制冷系统性能系数EER可提高2%~7%,效果显著。

关键词：喷雾降温冷凝压力性能系数

Unraveling the mechanism of action of Shangxia Liangji formula for treating insomnia:a metabolomics and network pharmacology approach

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Traditional Medicine Research 2025年第2期10卷 16-29页

作者： Xia-Jie Quan Hao Liang Yong-Hong Tang Li Jiang Xiong-ying Ji Feng-ying zhang Ping zhang Bo Ouyang department of Information The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China department of Neurology The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China department of Gastroscopy The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China department of Traditional Chinese Medicine The Affiliated Nanhua HospitalHengyang Medical SchoolUniversity of South ChinaHengyang 421002China

Background:Insomnia is a prevalent clinical condition and Shangxia Liangji formula(SXLJF)is a well-established method of ***,the specific mechanism of action of SXLJF remains ***:The mouse model of insomnia was established by intraperitoneal injection of ***-two mice were randomly divided into a negative control group,model group,SXLJF group(18.72 g/kg/day),and positive control group(diazepam,2 mg/kg)and treated with the corresponding drugs for 7 consecutive *** open field test and pentobarbital-induced sleeping test were ***-MS-based untargeted metabolomics and network pharmacology were applied to explore the potential targets of SXLJF for treating ***,key targets were validated using ***:Behavioral tests demonstrated that SXLJF reduced the total distance,average velocity,central distance,and sleep latency,and prolonged sleep *** and network pharmacology revealed potential targets,signaling pathways,metabolic pathways,and metabolites associated with the anti-insomnia effects of ***,tyrosine hydroxylase(TH)and tyrosine metabolism emerged as crucial metabolic pathways and targets,***-qPCR results supported the role of TH in the mechanism of SXLJF in treating ***:In conclusion,TH and tyrosine metabolism may represent significant targets and pathways for SXLJF in treating insomnia.

关键词： Shangxia Liangji formula insomnia metabolomics network pharmacology tyrosine hydroxylase tyrosine metabolism