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Recent advances in morphology control of platinum catalysts toward oxygen reduction reaction

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Frontiers in Energy 2024年第3期18卷 330-355页

作者： shun CHEN Yanru liu Xiaogang FU Wanglei WANG State Key Laboratory of Solidification Processing Atomic Control and Catalysis Engineering LaboratorySchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China

Exploring advanced platinum (Pt)-based electrocatalysts is vital for the widespread implementation of proton exchange membrane fuel cells (PEMFCs). Morphology control represents an effective strategy to optimize the behavior of Pt catalysts. In this work, an attempt is made to comprehensively review the effect of morphology control on the catalytic behavior of catalysts in the oxygen reduction reaction (ORR). First, the fundamental physicochemical changes behind morphology control, including exposing more active sites, generating appropriate lattice strains, and forming different crystalline surfaces, are highlighted. Then, recently developed strategies for tuning the morphologies of electrocatalysts, including core-shell structures, hollow structures, nanocages, nanowires, and nanosheets, are comprehensively summarized. Finally, an outlook on the future development of morphology control of Pt catalysts is presented, including rational design strategies, advanced in situ characterization techniques, novel artificial intelligence, and mechanical learning. This work is intended to provide valuable insights into designing the morphology and technological innovation of efficient redox electrocatalysts in fuel cells.

关键词： morphology platinum catalysts electrocatalysis ORR PEMFC

PTEN-induced kinase 1-induced dynamin-related protein 1 Ser637 phosphorylation reduces mitochondrial fission and protects against intestinal ischemia reperfusion injury

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World Journal of Gastroenterology 2020年第15期26卷 1758-1774页

作者： Wasim Qasim Yang Li Rui-Min Sun Dong-Cheng Feng Zhan-Yu Wang de-shun liu Ji-Hong Yao Xiao-Feng Tian department of General Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina department of Gastrointestinal Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003Zhejiang ProvinceChina department of Pharmacology Dalian Medical UniversityDalian 116044Liaoning ProvinceChina

BACKGROUND Intestinal ischemia reperfusion(I/R)occurs in various diseases,such as trauma and intestinal *** reactive oxygen species(ROS)accumulation and subsequent apoptotic cell death in intestinal epithelia are important causes of I/R ***-induced putative kinase 1(PINK1)and phosphorylation of dynamin-related protein 1(DRP1)are critical regulators of ROS and ***,the correlation of PINK1 and DRP1 and their function in intestinal I/R injury have not been ***,examining the PINK1/DRP1 pathway may help to identify a protective strategy and improve the patient *** To clarify the mechanism of the PINK1/DRP1 pathway in intestinal I/R *** Male C57BL/6 mice were used to generate an intestinal I/R model via superior mesenteric artery occlusion followed by ***’s score was used to evaluate intestinal mucosa *** mitochondrial fission inhibitor mdivi-1 was administered by intraperitoneal ***-2 cells were incubated in vitro in hypoxia/reoxygenation *** interfering RNAs and overexpression plasmids were transfected to regulate PINK1 *** protein expression levels of PINK1,DRP1,p-DRP1 and cleaved caspase 3 were measured by Western *** viability was evaluated using a Cell Counting Kit-8 assay and cell apoptosis was analyzed by TUNEL *** fission and ROS were tested by MitoTracker and MitoSOX *** Intestinal I/R and Caco-2 cell hypoxia/reoxygenation decreased the expression of PINK1 and p-DRP1 *** with mdivi-1 inhibited mitochondrial fission,ROS generation,and apoptosis and ameliorated cell injury in intestinal I/*** PINK1 knockdown or overexpression in vitro,we found that p-DRP1 Ser637 expression and DRP1 recruitment to the mitochondria were associated with ***,we verified the physical combination of PINK1 and p-DRP1 *** PINK1 is correlated with mitochondrial fissi

关键词： Intestinal ischemia reperfusion injury Mitochondrial fission PTEN-induced putative kinase 1 Dynamin-related protein 1 ser637 Phosphorylation Apoptosis

Fluorescence analysis of antibiotics and antibiotic-resistance genes in the environment: A mini review

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Chinese Chemical Letters 2024年第10期35卷 82-91页

作者： Yuxin Li Chengbin liu Qiuju Li shun Mao College of Environmental Science and Engineering State Key Laboratory of Pollution Control and Resource ReuseTongji UniversityShanghai 200092China Institute for Agri-food Standards and Testing Technology Shanghai Academy of Agricultural SciencesShanghai 201403China

Antibiotics,as widely used antibacterial drug,exist in various environmental *** residues can affect biological metabolism and lead to bacterial resistance and the formation of antibiotic-resistance genes,posing a threat to human health and ecological *** efficient detection methods for antibiotics and antibiotic-resistance genes has great environmental *** detection methods,due to their fast response,high sensitivity and specificity,and low-cost,are widely used in chemical and biological *** review first summarizes the pre-treatment methods for different types of environmental samples,and then focuses on the recent advances of fluorescence methods for the detection of antibiotics and antibiotic-resistance ***,main challenges and future research directions of fluorescence methods for antibiotic and antibiotic-resistance genes detection are *** review highlights the promising prospect of fluorescence methods in-situ detection and monitoring of antibiotics and antibiotic-resistance genes,and provides guidance for the construction of overall risk assessment system of environmental media.

关键词： Antibiotics Antibiotic-resistancegenes Fluorescence detection Environmental samples In-situdetection

Immediate implantation of ultrafine fiber slow-release system based on cell electrospinning to induce osteogenesis of mesenchymal stem cells

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Regenerative Biomaterials 2024年第2期3卷 76-87页

作者： Tao Lu Long Yang Zhuoyang Li Yin liu shun'en Xu Chuan Ye department of Orthopaedics The Affliated Hospital of Guizhou Medical UniversityGuiyang 550004China department of Orthopaedics The First People's Hospital of GuiyangGuiyang 550004China Center for Tissue Engineering and Stem Cell Research Guizhou Medical UniversityGuiyang 550004China department of Otolaryngology Head and Neck Surgery Xinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing 400037China department of dental implant Stomatological Hospital of GuiyangGuiyang 550000China

This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(deX)within the'fbers,ensuring sustained osteogenic *** scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were *** subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction *** fabricated P34HB ultrafine fiber slow-release *** ization *** distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active *** vitro tests showcased a prolonged release of deX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular *** Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on ***,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 *** findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.

关键词： bone tissue engineering cell electrospinning in vivo induction immediate implantation biomaterials

Isocyanide-Based One-Pot Cascade Synthesis of 3-Acyl Isoindolinones

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Chinese Journal of Chemistry 2024年第3期42卷 259-263页

作者： Jia liu Yi-Ming Zhu Xiao-Ping Xu shun-Jun Ji Key Laboratory of Organic Synthesis of Jiangsu Province College of ChemistryChemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and TechnologySoochow UniversitySuzhouJiangsu215123 China Suzhou Baolidi Functional Materials Research Institute SuzhouJiangsu215144 China

A series of 3-acyl-substituted isoindolinone derivatives were synthesized in a one-pot manner via the reaction of o-bromobenzaldehydes,isocyanides,and carboxylic acids in the presence of palladium catalyst and base. The reaction employing easily available starting materials features simple operation and high efficiency. The mechanistic study showed that the reaction might undergo 1) Pd-catalyzed [3+2] cyclization of o-bromobenzaldehyde with isocyanide and the re-insertion of another molecule of isocyanide,2) addition of carboxylic acid to in situ formed ketenimine followed by a rearrangement relay to give 3,3-diacyl-substituted isoindolinone derivative. Further transformations of the obtained products through decarbonylation could also be realized.

关键词： One-pot reaction Isocyanide Pd catalysis Rearrangement reaction Isoindolinone

Strain engineering of Pt-based electrocatalysts for oxygen reaction reduction

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Frontiers in Energy 2024年第2期18卷 241-262页

作者： Zeyu WANG Yanru liu shun CHEN Yun ZHENG Xiaogang FU Yan ZHANG Wanglei WANG State Key Laboratory of Solidification Processing Atomic Control and Catalysis Engineering LaboratorySchool of Materials Science and EngineeringNorthwestern Polytechnical UniversityXi’an 710072China State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration National Clinical Research Center for Oral DiseasesShaanxi Key Laboratory of StomatologyDepartment of Dental MaterialsSchool of StomatologyThe Fourth Military Medical UniversityXi’an 710032China Institute of New Energy Materials and Engineering School of Materials Science and EngineeringFuzhou UniversityFuzhou 350108China Key Laboratory of Marine Chemistry Theory and Technology(Ministry of Education) College of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China

Proton exchange membrane fuel cells(PEMFCs)are playing irreplaceable roles in the construction of the future sustainable energy ***,the insufficient performance of platinum(Pt)-based electrocatalysts for oxygen reduction reaction(ORR)hinders the overall efficiency of *** the surface strain of catalysts is considered an effective way to tune their electronic structures and therefore optimize catalytic *** this paper,insights into strain engineering for improving Pt-based catalysts toward ORR are elaborated in ***,recent advances in understanding the strain effects on ORR catalysts are comprehensively ***,strain engineering methodologies for adjusting Ptbased catalysts are comprehensively ***,further information on the various challenges and potential prospects for strain modulation of Pt-based catalysts is provided.

关键词： strain engineering Pt-based catalysts oxygen reduction reaction(ORR) catalytic performance proton exchange membrane fuel cells(PEMFCs)

ZnS-embedded porous carbon for peroxydisulfate activation:Enhanced electron transfer for bisphenol A degradation

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Environmental Science and Ecotechnology 2024年第3期19卷 161-169页

作者： Ying liu Ningjie Du Xinru liu Ducheng Yao deli Wu Zhuo Li shun Mao College of Environmental Science and Engineering Biomedical Multidisciplinary Innovation Research InstituteShanghai East HospitalState Key Laboratory of Pollution Control and Resource ReuseTongji University1239 Siping RoadShanghai200092China Shanghai Institute of Pollution Control and Ecological Security Shanghai200092China

Transition metal sulfides have garnered increasing attention for their role in persulfate activation,a crucial process in environmental ***,the function of metal sulfides without reversible valence changes,such as ZnS,remains largely unexplored in this *** we report ZnS-embedded porous carbon(ZnS-C),synthesized through the pyrolysis of Zn-MOF-74 and dibenzyl ***-C demonstrates remarkable activity in activating peroxydisulfate(PDS)across a wide pH range,enabling the efficient mineralization removal of bisphenol A(BPA).Through electrochemical investigation and theoretical simulations of charge density distributions,we unveil that the electron transfer from BPA to PDS mediated by the ZnS-C catalyst governs the *** study,both in theory and experiment,demonstrates metal sulfide as electron pump that enhances electron transfer efficiency in PDS *** findings redefine the role of metal sulfide catalysts,shedding new light on their potential for regulating reaction pathways in PDS activation processes.

关键词： Peroxydisulfate activation Reaction pathway regulation Electron transfer ZnS Bisphenol A

Recombinant angiopoietin-like protein 4 attenuates intestinal barrier structure and function injury after ischemia/reperfusion

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World Journal of Gastroenterology 2021年第32期27卷 5404-5423页

作者： Zi-Yi Wang Jian-Yu Lin Yang-Rong Feng de-shun liu Xu-Zi Zhao Tong Li Si-Yuan Li Jing-Chao Sun Shu-Feng Li Wen-Yan Jia Hui-Rong Jing Emergent Intensive Care Unit The Second Affiliated Hospital of Dalian Medical UniversityDalian 116023Liaoning ProvinceChina department of Gastrointestinal Surgery Weihai Central HospitalWeihai 264200Shandong ProvinceChina Graduate College Shandong First Medical UniversityJinan 271000Shandong ProvinceChina department of General Surgery The Second Affiliated Hospital of Dalian Medical UniversityDalian 116027Liaoning ProvinceChina department of Pharmacology Dalian Medical UniversityDalian 116044Liaoning ProvinceChina department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100000China department of General Surgery Qingdao Municipal HospitalQingdao UniversityQingdao 266071Shandong ProvinceChina Physiological Examination Center The Affiliated Hospital of Qingdao UniversityQingdao 266000Shandong ProvinceChina

BACKGROUND Intestinal barrier breakdown,a frequent complication of intestinal ischemiareperfusion(I/R)including dysfunction and the structure changes of the intestine,is characterized by a loss of tight junction and enhanced permeability of the intestinal barrier and increased *** develop effective and novel therapeutics is important for the improvement of outcome of patients with intestinal barrier *** human angiopoietin-like protein 4(rhANGPTL4)is reported to protect the blood-brain barrier when administered exogenously,and endogenous ANGPTL4 deficiency deteriorates radiationinduced intestinal *** To identify whether rhANGPTL4 may protect intestinal barrier breakdown induced by I/*** Intestinal I/R injury was elicited through clamping the superior mesenteric artery for 60 min followed by 240 min *** epithelial(Caco-2)cells and human umbilical vein endothelial cells were challenged by hypoxia/reoxygenation to mimic I/R in *** Indicators including fluorescein isothiocyanate-conjugated dextran(4 kilodaltons;FD-4)clearance,ratio of phosphorylated myosin light chain/total myosin light chain,myosin light chain kinase and loss of zonula occludens-1,claudin-2 and VE-cadherin were significantly increased after intestinal I/R or cell hypoxia/***4 treatment significantly reversed these indicators,which were associated with inhibiting the inflammatory and oxidative cascade,excessive activation of cellular autophagy and apoptosis and improvement of survival *** results were observed in vitro when cells were challenged by hypoxia/reoxygenation,whereas rhANGPTL4 reversed the indicators close to normal level in Caco-2 cells and human umbilical vein endothelial cells *** rhANGPTL4 can function as a protective agent against intestinal injury induced by intestinal I/R and improve survival via maintenance of intestinal barrier structure and functions.

关键词： Angiopoietin-like protein 4 Intestinal ischemia/reperfusion COVID-19 Myosin light chain kinase Intestinal barrier breakdown

Tumor microenvironment-responsive arsenic-loaded layered double hydroxides film with synergistic anticancer and bactericidal activity

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Rare Metals 2024年第3期43卷 1207-1221页

作者： shun Xing Dong-Hui Wang Hai-Feng Zhang Li-Dan liu Cheng-Ce Li Chao Wei Jun-Yu liu Nai-Jian Ge Xuan-Yong liu State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of CeramicsChinese Academy of SciencesShanghai200050China Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of SciencesBeijing100049China Intervention Center Eastern Hepatobiliary Surgery HospitalThe Third Affiliated Hospital of Naval Medical UniversityShanghai200438China School of Health Sciences and Biomedical Engineering Hebei University of TechnologyTianjin300130China

Malignant obstruction makes gallbladder cancer have a high mortality ***-titanium alloy(nitinol)stents are commonly used as a local intervention to maximize patient survival time,but the stents lack antitumor and antibacterial capacity and are vulnerable to secondary ***-based drugs show good therapeutic promise against gallbladder *** meet clinical *** layered double hydroxides(LDHs)film is constructed on the nitinol,whose arsenite loading amounts rose by 60%after simple heat treatment compared with the conventional anion-exchange *** addition,calcination promotes the dissolution of nickel ions from the LDHs lattice,resulting in a powerful synergistic killing effect on tumor cells together with the released *** importantly,the calcined arsenic-loaded LDHs are sensitive to the acidic microenvironment of tumor tissues,which presents a much lower arsenic and nickel release amount in the normal tissues,guaranteeing its ***,the vertically sharp LDHs nanosheets can synergize with arsenic to achieve effective physical cleavage and chemical killing of adherent and planktonic *** short,we attempt to use arsenic drugs for local interventions and reasonably avoid their toxic side effects,which provides a new design idea for nitinol stents applied in the treatment of gallbladder cancer.

关键词： Nitinol Layered double hydroxides Arsenic Gallbladder cancer