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design,synthesis and biological evaluation of acylhydrazone derivatives as PI3K inhibitors

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Chinese Chemical Letters 2015年第1期26卷 118-120页

作者： Guo-Rui Gao Jia-Li Liu de-sheng mei Jian Ding Ling-Hua Meng Wen-Hu Duan School of Pharmacy East China University of Science & Technology Division of Anti-tumor Pharmacology State Key Laboratory of Drug ResearchShanghai Institute of Materia MedicaChinese Academy of Sciences department of Medicinal Chemistry Shanghai Institute of Materia MedicaChinese Academy of Sciences

Since the PI3K signaling pathway is the most commonly activated in human cancers,inhibition of PI3K is a promising approach to cancer *** this study,a series of 2-methyl-5-nitrobenzeneacylhydrazones were designed and *** the new derivatives were tested by p110α enzymatic and Rh30 cellular *** enzyme selectivity profiling proved that 6e and 7 were potential selective PI3K inhibitors.

关键词： PI3K Inhibitor Aclhydrazone

Accurate Period Approximation for Any Simple Pendulum Amplitude

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Chinese Physics Letters 2012年第4期29卷 129-132页

作者： XUE de-sheng ZHOU Zhao GAO mei-Zhen Key Lab for Magnetism and Magnetic Materials of the Ministry of Education Lanzhou UniversityLanzhou 730000

Accurate approximate analytical formulae of the pendulum period composed of a few elementary functions for any amplitude are *** on an approximation of the elliptic integral,two new logarithmic formulae for large amplitude close to 180° are *** the trigonometric function modulation results from the dependence of relative error on the amplitude,we realize accurate approximation period expressions for any amplitude between 0 and 180°.A relative error less than 0.02% is achieved for any *** kind of modulation is also effective for other large-amplitude logarithmic approximation expressions.

关键词： approximation formulae logarithmic

Boundary element method of hydrodynamic characteristics of lubricant in three-leaf dislocated floating-ring bearing

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航空动力学报 2014年第5期29卷 1211-1215页

作者： HUANG Ming-han ZHANG Wen-zhong TONG de-sheng PENG Hong-mei YANG de-quan CCCC-Key Hydrodynamic Laboratory for Coastal Engineering Tianjin Port Engineering Institute Limited of China Communications Construction Company Limited Tianjin 300222 China School of Civil Engineering Tianjin University Tianjin 300072 China Institute of Physics and Electronic Information Inner Mongolia University for the NationalitiesTongliao Inner Mongolia 028043 China

The problem of hydrodynamics of the three-leaf dislocated floating-ring bearing was studied by means of boundary element *** law including the distribution of pressure on boundary surface(axial,bearing and floating-ring)and its friction loss in different eccentricities was *** results show that the inner friction of three-leaf dislocated bearing increases from 390.875to 1 091.65,and the inner friction of three-leaf dislocated floating-ring bearing increases from 94.2523to 114.5069with eccentricity varying from 0to 0.075in *** changing the pressure and flow field of bearing by adding floating-ring is more stability and less wasted work of friction than three-leaf dislocated bearing.

关键词：三叶错位浮环轴承流体力学边界元法稳定性内摩擦

Absorption and Recurrence Spectra of Li Rydberg Atom in Perpendicular Electric and Magnetic Fields

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Communications in Theoretical Physics 2006年第3X期46卷 545-552页

作者： WANG de-Hua LIN sheng-Lu WANG mei-Shan YANG Chuan-Lu College of Physics and Electronic Engineering Ludong University Yantai 264025 China School of Physics and Microelectronics Shandong University Jinan 250100 China department of Physics Shandong Normal University Jinan 250014 China

We develop the semi-closed orbit theory from two degrees of freedom to three non-separable degrees of freedom and put forward a new model potential for the Li Rydberg atom, which reduces the study of the system to an effective one-particle problem. Using this model potential and the closed orbit theory for three degrees of freedom, we caiculate the recurrence spectra of Li Rydberg atom in perpendicular electric and magnetic fields. The closed orbits in the corresponding classicai system have also been obtained. The Fourier transformed spectra of Li atom have ailowed direct comparison between the resonance peaks and the scaied action values of closed orbits, whereas the nonhydrogenic resonance can be explained in terms of the new orbits created by the core scattering. Our result is in good agreement with the quantum spectra, which suggests that our calculation is correct.

关键词： closed orbit theory model potential recurrence spectra core scattering

design and flow field analysis for visualization experiment facility of pebble bed based on molten salt reactor

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Nuclear Science and Techniques 2019年第3期30卷 139-148页

作者： Mu-Dan mei Xing-Wei Chen sheng-de Sun Rui Yan Yang Zou Shanghai Institute of Applied Physics Chinese Academy of Sciences University of Chinese Academy of Sciences

Molten salt pebble bed reactor is one of the sixth-generation Ⅳ reactor types. To investigate the mechanical behavior of the fuel pebbles in the core, a visualization experiment facility of pebble bed(VEFPB) is designed. To obtain a uniform flow field of the core and analyze the influence of the flow field on the structure of the pebble bed, computational fluid dynamics software Fluent is used to simulate the flow field distribution of the core of VEFPB. The simulation results show that the disturbance at the bottom of the pebble bed is proportional to the flow velocity of the inlet pipe, and the flow velocity close to the inlet side is more significant than that in other parts; the design of the cylinder bottom plate with holes of different sizes can effectively reduce the flow velocity and the disturbance at the bottom of the pebble bed. In addition,according to the velocity contours of the core of VEFPB, it is observed that the flow field distribution of the core is considerably uniform except at the bottom of the pebble bed. This ensures the stability of the pebble bed and verifies the rationality of the design of VEFPB. This study provides the technical support and reference for the flow field analysis of the core of molten salt pebble bed reactor.

关键词： Thorium molten salt reactor (TMSR) Particle image velocimetry (PIV) Computational fluid dynamics (CFD) Experiment facility

Soliton Solutions of Discrete Complex Ginzburg-Landau Equation via Extended Hyperbolic Function Approach

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Communications in Theoretical Physics 2005年第1X期44卷 79-84页

作者： LIHua-mei LINJi XUYou-sheng departmentofPhysics ZhejiangNormalUniversityJinhua321004China

In this paper, we extend the hyperbolic function approach for constructing the exact solutions of nonlinear differential-difference equation (NDde) in a unified way. Applying the extended approach and with the aid of Maple,we have studied the discrete complex Ginzburg-Landau equation (dCGLE). As a result, we find a set of exact solutions which include bright and dark soliton solutions.

关键词：孤波解 Ginzburg-Landau离散方程双曲线方程非线性微分方程

Performance evaluation of ultra-long lithium heat pipe using an improved lumped parameter model

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Nuclear Science and Techniques 2021年第12期32卷 89-102页

作者： Chong-Ju Hu Da-Li Yu mei-sheng He Hua-Ping mei Jie Yu Tao-sheng Li Institute of Nuclear Energy Safety Technology Hefei Institutes of Physical ScienceChinese Academy of SciencesHefei 230031China University of Science and Technology of China Hefei 230026China Suzhou University Suzhou 234000China

Lithium heat pipes have broad applications in heat pipe cooling reactors and hypersonic vehicles owing to their ultra-high working *** particular,when the length of the lithium heat pipe is ultra-long,the flow and heat transfer characteristics are more *** this study,an improved lumped parameter model that considers the Marangoni effect,bending effect,and different vapor flow patterns and Mach numbers was ***after,the proposed model was verified using the University of New Mexico’s Heat Pipe and HTPIPE ***,the verified model was applied to simulate the steady-state operation of an ultra-long lithium heat pipe in a Heat PipeSegmented Thermoelectric Module Converters space *** on the results:(1)Vapor thermal resistance was dominant at low heating power and decreased with increasing heating *** vapor flow inside the heat pipe developed from the laminar to the turbulent phase,whereas the liquid phase in the heat pipe was always laminar.(2)The vapor pressure drop caused by bending was approximately 22–23%of the total,and the bending effect on the liquid pressure drop could be ignored.(3)The Marangoni effect reduced the capillary limit by hindering the liquid reflux,especially at low vapor *** considering the Marangoni effect,the capillary limit of the lithium heat pipe was overestimated by 9%when the vapor temperature was 1400 K.(4)The total thermal resistance of the heat pipe significantly increased with increasing adiabatic length when the vapor temperature was ***,the wick dryness increased with increasing adiabatic length at any vapor *** findings improve on current knowledge for the optimal design and safety analysis of a heat pipe reactor,which adopts ultra-long lithium heat pipes.

关键词： Lithium heat pipe Bending effect Marangoni effect Capillary limit Heat Pipe-Segmented Thermoelectric Module Converters(HP-STMC)

Thermal oxidation of SiAlON powders synthesized from coal gangue

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International Journal of Minerals,Metallurgy and Materials 2011年第1期18卷 77-82页

作者： Xin-mei Hou Chang-sheng Yue mei Zhang Kuo-chih Chou School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing 100083 China The Key Laboratory of Ecological ＆ Recycle Metallurgy Ministry of Education of China Beijing 100083 China

The oxidation behavior of different SiAlON phases（β-SiAlON,X-phase SiAlON and 12H powders） synthesized from coal gangue in air atmosphere was investigated using isothermal thermogravimetry（TG） and field-emission scanning electron microscopy（FE-SEM）.The effect of ferric oxide impurities in coal gangue was *** results show that ferric oxide contributes to the growth of SiAlON crystalline during the synthesis *** the oxidation experiment,the existence of ferric oxide decreases the oxidation resistance of *** reason is that the impurity causes the formation of a liquid phase at a higher *** 1423-1623 K,the oxidation of SiAlON powders is diffusion controlled and it can be described by Chou＇s model.A fair agreement is found between theoretical calculations and the experimental data.

关键词： oxidation kinetics silicon compounds powders coal

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一种编码式光纤光栅温度传感检测系统的研制

武汉理工大学学报 2004年第10期26卷 21-23,27页

作者：姜德生梅加纯陈宏波范典武汉理工大学光纤传感技术研究中心武汉430070

介绍了一种新的大容量编码式光纤光栅传感测量技术 ,引入了一种由编码式光纤光栅作为传感探头的温度传感检测系统。该系统采用双波长编码技术 ,对检测点的位置和温度同时进行编码测量 ,系统具有精确度高、稳定性好、信息量大等特点。特... 详细信息

介绍了一种新的大容量编码式光纤光栅传感测量技术 ,引入了一种由编码式光纤光栅作为传感探头的温度传感检测系统。该系统采用双波长编码技术 ,对检测点的位置和温度同时进行编码测量 ,系统具有精确度高、稳定性好、信息量大等特点。特别是双波长编码测量技术的采用 ,系统由一维编码增进到二维编码 ,极大地提高了系统的检测容量 ,克服了传统的一维编码系统由于光源有限带宽导致的信息容量限制。由于在光纤的同一位置集成多个传感探头 ,降低了成本。

关键词：编码式光纤光栅温度传感集成