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Chinese Medical Journal 2021年第22期134卷 2647-2655页

作者： Pan Li Xiao-Rong Dong Bei Zhang Xin-Tong Zhang Jing-Zhuo Liu de-sheng ma Li ma department of Emergency Hong Hui HospitalXi’an Jiaotong UniversityXi’anShaanxi 710054China department of Emergency Intensive Care Unit Lanzhou University of Second HospitalLanzhouGansu 730030China

Cell death occurs in various tissues and organs in the *** is a physiological or pathological process that has different *** is of great significance in maintaining the morphological function of cells and clearing abnormal ***,apoptosis,and necrosis are all modes of cell death that have been studied extensively by many experts and scholars,including studies on their effects on the liver,kidney,the heart,other organs,and even the whole *** heart,as the most important organ of the body,should be a particular *** review summarizes the mechanisms underlying the various cell death modes and the relationship between the various mechanisms and heart *** current research status for heart therapy is discussed from the perspective of pathogenesis.

关键词： Cell death Apoptosis Necrosis Pyroptosis Autophagy Pathogenesis Treatment

Vector meson's spin alignments in high energy reactions

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 5-20页

作者： Jin-Hui Chen Zuo-Tang Liang Yu-Gang ma Xin-Li sheng Qun Wang Key Laboratory of Nuclear Physics and Ion-beam Application (MoE) Institute of Modern PhysicsFudan University Institute of Frontier and Interdisciplinary Science Key Laboratory of Particle Physics and Particle Irradiation (MOE)Shandong University INFN-Firenze department of Modern Physics University of Science and Technology of China School of Mechanics and Physics Anhui University of Science and Technology

The global spin alignment of vector mesons has been observed by the STAR collaboration at the Relativistic Heavy Ion Collider （RHIC） at Brookhaven National Laboratory （BNL）.It provides a unique opportunity to probe the correlation between the polarized quark and antiquark in the strongly coupled quark-gluon plasma （sQGP） produced in relativistic heavy ion collisions,opening a new window to explore the properties of s *** addition,spin alignments of vector mesons have also been observed in other high-energy particle collisions such as e+e-annihilations at high energies where hadron production is dominated by quark fragmentation *** results obtained are quite different from those obtained in heavy ion collisions where quark coalescence/combination mechanism dominates suggesting strong dependence on hadronization *** comprehensive studies in different hadronization processes are *** this article,we present a brief review of theoretical and experimental advances in the study of vector meson’s spin alignments in a variety of high-energy particle collisions,with emphasis on hadronization mechanisms.

关键词： vector meson spin alignment global polarization relativistic heavy ion collisions fragmentation

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao sheng-Lan Xu Hua ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Effect of Aging on the Microstructure and Mechanical Properties of 1460 Alloy

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Acta Metallurgica Sinica(English Letters) 2015年第4期28卷 454-459页

作者： Juan ma de-sheng Yan Li-Jian Rong Yi-Yi Li Institute of Metal Research Chinese Academy of Sciences

Effects of the aging temperature on the hardening response, the tensile properties and the precipitate micro- structure evolution of 1460 alloy were studied in this work. It was found that Al3 （Sc, Zr） and δ′ （Al3Li） phases were precipitated from the matrix at the very early aging stage, while the precipitation of T1 （Al2CuLi） and θ′ （Al2Cu） was much slower than that of the δ′ phase. When aging at higher temperature （160 and 190 ℃）, the δ′, T1 and θ′ phases tended to form simultaneously and grow up very quickly. Conversely, the δ′ and θ″ （Al2Cu） phases were precipitated separately and more dispersive at lower aging temperature （130 ℃）. Taken together, the alloy aged at 160 ℃ exhibited improved mechanical properties owing to the uniform dispersion of the fine T1 precipitates.

关键词： Al-Li alloy Precipitate Precipitation hardening process Mechanical property

Low Electrical Resistance Properties of Acupoints:Roles of NOergic Signaling Molecules and Neuropeptides in Skin Electrical Conductance

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Chinese Journal of Integrative Medicine 2021年第8期27卷 563-569页

作者： ma sheng-xing Lundquist Institute for Biomedical Innovation at Harbor University of California at Los Angeles(UCLA)Medical Center and department of Obstetrics and Gynecology David Geffen School of Medicine at UCLA and Harbor-UCLA Medical CenterTorranceCA 90502United States

Early studies from several independent laboratories demonstrated that acupoints possess the characteristics of low electrical *** devices are developing to increase the reliability of electrical skin impedance measurements for counteracting the factors including skin dryness,skin thickness,size of the sensing electrode,pressure applied on the electrode,interelectrode distance,room temperature,and *** studies have identified that blood vessels,hair follicles,and nervous components are enhanced in the meridians/acupoints,which represent areas of potentially high neuronal *** evidence shows that nitric oxide(NO)concentrations are enhanced in skin acupoints/meridians.L-arginine-derived NO synthesis modifies skin norepinephrine(NE)synthesis/release in acupoints/meridians,and NO-NE activations play an important role in mediating the skin conductance responses to electrical *** signaling molecules interact with gap junction and transient receptor potential vanilloid *** studies reported that the high conductance at acupoints is a result of the release of the neuropeptides substance P and calcitonin gene-related peptide during neurogenic inflammation in the referred pain *** body conditions caused considerable changes in skin conductance or impedance at *** systematic research with an improved equipment and research design to avoid the influencing factors are requested for a definite answer in this field,the results from anatomical and biochemical studies consistently show that acupoints exist higher levels of nervous components,and NOergic signaling molecules and neuropeptides involved in the skin low resistance at *** increased interest in the acupoints/meridians has led to an open-minded attitude towards understanding this system,which is fundamental important to establish the valid aspects of scientific basis of Chinese medicine mechanisms and therapies.

关键词： acupuncture points skin electric resistance nitric oxide norepinephrine transient receptor potential vanilloid type-1 neuropeptides

Improved Hrmander’s Theorem and New Methods for Oscillatory Integral Operators

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Acta mathematica Sinica,English Series 2009年第11期25卷 1865-1874页

作者： sheng-Ming ma LMIB and School of mathematics and System Sciences Beihang University Beijing 100083 P. R. China

This paper proves a theorem on the decay rate of the oscillatory integral operator with a degenerate C^∞ phase function, thus improving a classical theorem of HSrmander. The proof invokes two new methods to resolve the singularity of such kind of operators： a delicate method to decompose the operator and balance the L^2 norm estimates; and a method for resolution of singularity of the convolution type. The operator is decomposed into four major pieces instead of infinite dyadic pieces, which reveals that Cotlar＇s Lemma is not essential for the L^2 estimate of the operator. In the end the conclusion is further improved from the degenerate C^∞ phase function to the degenerate C^4 phase function.

关键词： oscillatory integral operators decay rate Fourier integral operators degenerate phase resolution of singularity

Stimuli-evoked NOergic molecules and neuropeptides at acupuncture points and the gracile nucleus contribute to signal transduction of propagated sensation along the meridian through the dorsal medulla-thalamic pathways

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Journal of Integrative Medicine 2024年第5期22卷 515-522页

作者： sheng-xing ma Lundquist Institute for Biomedical Innovation Harbor-University of California at Los Angeles(UCLA)Medical CenterTorranceCA 90502USA department of Obstetrics and Gynecology David Geffen School of Medicine at UCLA and Harbor-UCLA Medical CenterTorranceCA 90502USA

Numerous studies from different international groups have demonstrated that sensations can be propagated along acupuncture channel *** propagated sensation along the channel pathway(PSCP)can be elicited by electroacupuncture(EA),transcutaneous electrical nerve stimulation(TENS),manual acupuncture(ma),and heat applied to distal acupuncture points(acupoints).Nitric oxide(NO)levels were reported to be elevated in the gracile nucleus and skin regions near to the EA sites,with higher levels at acupoints associated with an enhanced expression of NO synthase and transient receptor potential vanilloid type *** stimuli,EA,ma,TENS,and heat,have been used to elicit axonal reflexes,which increase local release of NO and neuropeptides such as calcitonin gene related ***,the sensation of PSCP along the body surface occurs only ipsilaterally to the stimulated acupoints in various human studies,which does not support the involvement of the spinal-thalamic pathway,which would involve cross over transmission of the *** gracile nucleus receives ascending input from the sciatic nerve and responds to somatosensory stimulation mainly on the ipsilateral side via the dorsal column *** at Zusanli(ST36)increases NO release and expression of NO synthase mainly in the ipsilateral side of the gracile nucleus,while the cardiovascular effects and analgesic responses to EA at ST36 are changed by influences of l-arginine-derived NO synthesis in the ipsilateral gracile nucleus in *** stimuli-induced release of NOergic molecules and neuropeptides exist high levels in the acupoints,which contain rich neuronal components and blood *** NOergic molecules at acupoints cause axon reflexes during the stimuli,which elevate cutaneous blood *** NOergic molecules and local blood flow may spread over acupoints one after another along the meridian lines differing from nerve pathways following the stimuli to induce *** same types of stimula

关键词： Axon reflex Nitric oxide Biophysical approaches Calcitonin related polypeptide Dorsal funiculus tract Meridian system

In silico optimization of actuation performance in dielectric elastomercomposites via integrated finite element modeling and deep learning

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Theoretical & Applied Mechanics Letters 2024年第1期14卷 48-56页

作者： Jiaxuan ma sheng Sun materials Genome Institute Shanghai UniversityShanghai 200444China Zhejiang Laboratory Hangzhou 311100China Shanghai Frontier Science Center of Mechanoinformatics Shanghai UniversityShanghai 200444China

Dielectric elastomers(des)require balanced electric actuation performance and mechanical integrity under applied *** high dielectric particles as fillers provides extensive design space to optimize concentration,morphology,and distribution for improved actuation performance and material *** study presents an integrated framework combining finite element modeling(FEM)and deep learning to optimize the microstructure of de *** first calculates actuation performance and the effective modulus across varied filler combinations,with these data used to train a convolutional neural network(CNN).Integrating the CNN into a multi-objective genetic algorithm generates designs with enhanced actuation performance and material modulus compared to the conventional optimization approach based on FEM approach within the same *** framework harnesses artificial intelligence to navigate vast design possibilities,enabling optimized microstructures for high-performance de composites.

关键词： Dielectric elastomer composites Multi-objective optimization Finite element modeling Convolutional neural network

Nitric Oxide Signaling Molecules in Acupoints:Toward Mechanisms of Acupuncture

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Chinese Journal of Integrative Medicine 2017年第11期23卷 812-815页

作者： ma sheng-xing Los Angeles Biomedical Research Institute at Harbor-UCLAMedical Center and department of Obstetrics and Gynecology David Geffen School of MedicineUniversity of California at Los Angeles and Harbor-UCLA Medical CenterTorranceCA(90502)United States

Recent clinical trial studies have demonstrated that the effects of acupuncture on pain improvement are small and no difference between acupoints and non-points. Whether acupuncture needles must be inserted in specific points depends on whether acupoint specificity exists that is still not resolved, and is now urgent. Previous anatomical studies have demonstrated that acupoints exist higher number of nerve fibers/trunks, blood vessels, hair follicles, and sweat glands as well as density of the gap junction. Recent evidence shows that nitric oxide（NO） level is elevated in the acupoints/meridians and is associated with an enhanced expression of NO synthase endowed with transient receptor potential vanilloid type-1. There is growing evidence from international groups showing that acupuncture induces NO-mediated vasodilatation, which increases local blood flow and allows for a flush of algesic or sensitizing substances, leading to pain relief. Previous studies, using a novel biocapture system, have demonstrated that NOx–（total nitrite and nitrate） and cyclic guanosine monophosphate（c GMP） concentrations are consistently increased over skin acupoints compared to non-meridian control regions（NMCR） in humans. dermal microdialysis in humans showed that NO-c GMP releases in the subcutaneous tissue of acupoint are higher than those in NMCR and increased by electroacupuncture（EA）. Recent studies have demonstrated that low-frequency electrical stimulation and manual acupuncture with low stimulating force and rate produce an elevation of NO release predominantly over acupoints. In contrast, NO levels over the areas of the skin regions are moderately reduced by high-frequency EA stimulation. The results from anatomical and biochemical studies consistently show that acupoints exist higher levels of NO signaling molecules, and stimulus-evoked NO release is also with a higher level at acupoints. Results suggest that NO signaling molecules contribute to the specificity of acupoints,

关键词： acupoint nitric oxide electroacupuncture manual acupuncture reinforcement methods

Baishideng's century goal:Editing and publishing high-quality articles

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World Journal of Gastroenterology 2009年第31期15卷 3841-3844页

作者： Lian-sheng ma Beijing Baishideng BioMed Scientific Co. Ltd. Room 903 Building D Ocean International Center No. 62 Dongsihuan Zhonglu Chaoyang District Beijing 100025 China

Baishideng's goal over the next few years is to edit and publish high-quality articles through the open-access model, to maximize the benefits to members of the editorial board, authors and readers, as well as achievi... 详细信息

关键词： Access to information Baishideng maximization of the personal benefit Editorial policies Open access Periodicals Publishing