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Conditioned medium from human dental pulp stem cells treats spinal cord injury by inhibiting microglial pyroptosis

Neural Regeneration Research 2024年第5期19卷 1105-1111页

作者： Tao liu Ziqian Ma Liang liu Yilun pei Qichao Wu Songjie Xu Yadong liu Nan Ding Yun Guan Yan Zhang Xueming Chen department of Orthopedic Surgery Beijing Luhe HospitalCapital Medical UniversityBeijingChina department of Orthopedic Surgery Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina department of Stomatology Beijing Luhe HospitalCapital Medical UniversityBeijingChina department of Anesthesiology and Critical Care Medicine School of MedicineJohns Hopkins UniversityBaltimoreMDUSA department of Neurological Surgery School of MedicineJohns Hopkins UniversityBaltimoreMDUSA

Human dental pulp stem cell transplantation has been shown to be an effective therapeutic strategy for spinal cord ***,whether the human dental pulp stem cell secretome can contribute to functional recovery after spinal cord injury remains *** the present study,we established a rat model of spinal cord injury based on impact injury from a dropped weight and then intraperitoneally injected the rats with conditioned medium from human dental pulp stem *** found that the conditioned medium effectively promoted the recovery of sensory and motor functions in rats with spinal cord injury,decreased expression of the microglial pyroptosis markers NLRP3,GSDMD,caspase-1,and interleukin-1β,promoted axonal and myelin regeneration,and inhibited the formation of glial *** addition,in a lipopolysaccharide-induced BV2 microglia model,conditioned medium from human dental pulp stem cells protected cells from pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1β*** results indicate that conditioned medium from human dental pulp stem cells can reduce microglial pyroptosis by inhibiting the NLRP3/caspase-1/interleukin-1βpathway,thereby promoting the recovery of neurological function after spinal cord ***,conditioned medium from human dental pulp stem cells may become an alternative therapy for spinal cord injury.

关键词： BV2 conditioned medium dental pulp stem cells GSDMD microglia neuroinflammation NLRP3 pyroptosis spinal cord injury

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A study on temperature monitoring method for inverter IGBT based on memory recurrent neural network

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High-Speed Railway 2024年第1期2卷 64-70页

作者： Yunhe liu Tengfei Guo Jinda Li Chunxing pei Jianqiang liu School of Electrical Engineering Beijing Jiaotong UniversityBeijing 100044China

The power module of the Insulated Gate Bipolar Transistor(IGBT)is the core component of the traction transmission system of high-speed *** module's junction temperature is a critical factor in determining device *** temperature monitoring methods based on the electro-thermal coupling model have limitations,such as ignoring device interactions and high computational *** address these issues,an analysis of the parameters influencing IGBT failure is conducted,and a temperature monitoring method based on the Macro-Micro Attention Long Short-Term Memory(MMALSTM)recursive neural network is proposed,which takes the forward voltage drop and collector current as *** with the traditional electricalthermal coupling model method,it requires fewer monitoring parameters and eliminates the complex loss calculation and equivalent thermal resistance network establishment *** simulation model of a highspeed train traction system has been established to explore the accuracy and efficiency of MMALSTM-based prediction methods for IGBT power module junction *** simulation outcomes,which deviate only 3.2% from the theoretical calculation results of the electric-thermal coupling model,confirm the reliability of this approach for predicting the temperature of IGBT power modules.

关键词： IGBT Electro-thermal coupling model Junction temperature monitoring Loss model Neural networks

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Efficacy and Safety of Ganyushu Granule in Treatment of Premenstrual Syndrome with Gan(Liver)depression and Qi Stagnation Syndrome:A Randomized,Double-Blind,Multicenter,Phase-ⅡClinical Trial

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Chinese Journal of Integrative Medicine 2024年第9期30卷 771-779页

作者： TENG Xiu-xiang XU Lian-wei LIN Jie ZHANG Jin-feng ZHANG Qin SUN Yun YANG de-feng LI Hong-mei ZHAO pei liu Jun department of Gynecology Beijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing100700China department of Gynecology Longhua HospitalShanghai University of Traditional Chinese MedicineShanghai200032China department of Gynecology The First Hospital of Hunan University of Chinese MedicineChangsha410021China department of Gynecology Shanxi Traditional Chinese Medicine HospitalTaiyuan030024China department of Gynecology Hangzhou Hospital of Traditional Chinese MedicineHangzhou310005China department of Gynecology Wenzhou Hospital Affiliated to Zhejiang University of Traditional Chinese MedicineWenzhouZhejiang Province325000China department of Gynecology Luoyang First People’s HospitalLuoyangHenan Province471000China department of Gynecology The Second Affiliated Hospital of Heilongjiang University of Chinese MedicineHarbin150001China

Objective:To confirm the efficacy and safety of Ganyushu Granule(GYSG)in treating premenstrual syndrome(PMS)in patients with Gan(Liver)depression and qi stagnation syndrome(GDQSS)and determine its effective ***:From June 2018 to March 2021,a total of 240 PMS women with GDQSS were included and randomly divided into 3 groups in a 1:1:1 ratio using central block randomization:high-dose GYSG group(n=78,GYSG 2 packs/time),low-dose GYSG group(n=82,GYSG and its simulant 1 pack/time),and placebo group(n=80,GYSG simulant 2 packs/time).Treatment with GYSG or placebo was given thrice daily and for up to 3 menstrual *** outcomes were PMS diary(PMSD)score and premenstrual tension syndrome self-rating scale(PMTS).Secondary outcomes were Chinese medicine(CM)syndrome ***,PMTS,and efficacy of CM were evaluated with menstrual cycles during the treatment *** indicators were analyzed after each menstrual *** analyses were performed using an intention-to-treat method,and clinical safety was ***:Of the 216 patients included in the effectiveness analysis,70,75,and 71 patients were in the high-,low-dose GYSG,and placebo groups,*** the 2nd treatment cycle,the change in PMSD scores in the high-and low-dose groups was lower than that in the placebo group(P<0.05).PMTS scores in the high-dose GYSG group after the 1st treatment cycle was lower than that in the placebo group(P<0.05),while after the 3rd treatment cycle,that in the low-dose group was lower than that in the placebo group(P<0.05).After the 2nd treatment cycle,the high-dose GYSG group had the best CM syndrome efficacy(P<0.05).No serious adverse reactions were ***:GYSG was safe and well-tolerated at both doses for treating PMS patients with ***-dose GYSG might be the optimal dose for a phaseⅢtrial.

关键词： premenstrual syndrome Chinese medicine Ganyushu Granule randomized controlled trial

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Multi-junction cascaded vertical-cavity surface-emitting laser with a high power conversion efficiency of 74%

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Light(Science & Applications) 2024年第3期13卷 555-565页

作者： Yao Xiao Jun Wang Heng liu pei Miao Yudan Gou Zhicheng Zhang Guoliang deng Shouhuan Zhou College of Electronics and Information Engineering Sichuan UniversityChengdu 610064China Suzhou Everbright Photonics Co. LtdSuzhou 215163China

High electro-optical conversion efficiency is one of the most distinctive features of semiconductor lasers as compared to other types of *** further increase remains a significant *** enhancing the efficiency of edgeemitting lasers(EEL),which represent the highest efficiency among semiconductor lasers at present,is *** efficiency of vertical cavity surface emitting lasers(VCSELs)has always been relatively low compared to *** paper,combining modeling with experiments,demonstrates the potential of multi-junction cascaded VCSELs to achieve high efficiency beyond that of EELs,our simulations show,that a 20-junction VCSEL can achieve an efficiency of more than 88%at room *** fabricated VCSEL devices with different numbers of junctions and compared their energy efficiency.15-junction VCSELs achieved a maximum efficiency of 74%at room temperature under nanosecond driving current,the corresponding differential quantum efficiency exceeds 1100%,being the largest electro-optical conversion efficiency and differential quantum efficiency reported until now for VCSELs.

关键词： cascaded power cavity

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SIRT1 promotes myeloid leukemogenesis through derepression of HOXA cluster genes

SIRT1 promotes myeloid leukemogenesis through derepression o...

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21st IUBMB and 12th FAOBMB International Congress of Biochemistry and Molecular Biology

作者： Miao Xu Guang-Nian Zhao Xiang Lv de-pei liu Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College

SIRT(silent mating type information regulation 2 homolog ***) is a NAD-dependent histone deacetylase(HDAC) and a key regulator of cell survival and *** is prominently upregulated in primary acute myeloid leukemia(AML) cells and probably related to drug resistance of AML. We report that SIRT plays a positive role in leukemia development and pro-

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Progress and prospects of graphene-based materials in lithium batteries

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Rare Metals 2024年第5期43卷 1886-1905页

作者： Shen Lai Tao Huang pei liu Hong-Bin Wang Shi-Chun Yang Xin-Hua liu Kai Yang Qian-Ling Zhang Jian-Hong liu Jiang-Tao Hu Graphene Composite Research Center College of Chemistry and Environmental EngineeringShenzhen UniversityShenzhen 518060China College of Physics and Optoelectronic Engineering Shenzhen UniversityShenzhen 518060China Shenzhen Eigen-Equation Graphene Technology Co.Ltd Shenzhen518060China School of Transportation Science and Engineering Beihang UniversityBeijing 100191China department of Electrical and Electronic Engineering Advanced Technology InstituteUniversity of SurreyGuildfordSurrey GU27XHUK

Reasonable design and applications of graphene-based materials are supposed to be promising ways to tackle many fundamental problems emerging in lithium batteries,including suppression of electrode/electrolyte side reactions,stabilization of electrode architecture,and improvement of conductive ***,extensive fundamental research on this aspect has been performed so ***,when it comes to large-scale industrial applications,the utilization of graphene-based materials progresses at a very slow ***,there presents a severe technological decoupling between academic research and industrial application,and there is an urgent need to link ***,in order to address current issues of graphene-based materials used in lithium batteries,we present their latest advancements with stateof-the-art *** applications of graphenebased materials in practical lithium batteries are highlighted and predicted to bridge the gap between the academic progress and industrial manufacture,thereby paving the way for accelerating the development of graphenebased material as well as lithium battery industry.

关键词： Lithium batteries Graphene-based materials Academic research Industrial application development direction

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SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence

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Signal Transduction and Targeted Therapy 2023年第8期8卷 3737-3750页

作者： Yang-Nan Ding Ting-Ting Wang Shuang-Jie Lv Xiaoqiang Tang Zi-Yu Wei Fang Yao Han-Shi Xu Yi-Nan Chen Xiao-Man Wang Hui-Yu Wang He-Ping Wang Zhu-Qin Zhang Xiang Zhao de-Long Hao Li-Hong Sun Zhou Zhou Li Wang Hou-Zao Chen de-pei liu State Key Laboratory of Medical Molecular Biology Department of Biochemistry and Molecular BiologyInstitute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Key Laboratory of Birth defects and Related Diseases of Women and Children of MOE State Key Laboratory of BiotherapyWest China Second University HospitalSichuan UniversityChengduChina National Health Commission Key Laboratory of Chronobiology Development and Related Diseases of Women and ChildrenKey Laboratory of Sichuan ProvinceWest China Second University HospitalSichuan UniversityChengdu 610041China State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Medical Epigenetics Research Center Chinese Academy of Medical SciencesBeijingChina Center for Experimental Animal Research Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Beijing Key Laboratory for Molecular Diagnostics of Cardiovascular Diseases Center of Laboratory MedicineBeijingChina

Thoracic aortic aneurysms(TAAs)develop asymptomatically and are characterized by dilatation of the *** is considered a life-threating vascular disease due to the risk of aortic rupture and without effective *** current understanding of the pathogenesis of TAA is still limited,especially for sporadic TAAs without known genetic *** 6(SIRT6)expression was significantly decreased in the tunica media of sporadic human TAA *** knockout of Sirt6 in mouse vascular smooth muscle cells accelerated TAA formation and rupture,reduced survival,and increased vascular inflammation and senescence after angiotensin II *** analysis identified interleukin(IL)-1βas a pivotal target of SIRT6,and increased IL-1βlevels correlated with vascular inflammation and senescence in human and mouse TAA *** immunoprecipitation revealed that SIRT6 bound to the Il1b promoter to repress expression partly by reducing the H3K9 and H3K56 *** knockout of Il1b or pharmacological inhibition of IL-1βsignaling with the receptor antagonist anakinra rescued Sirt6 deficiency mediated aggravation of vascular inflammation,senescence,TAA formation and survival in *** findings reveal that SIRT6 protects against TAA by epigenetically inhibiting vascular inflammation and senescence,providing insight into potential epigenetic strategies for TAA treatment.

关键词： inflammation inhibiting epigenetic

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Exploring charge and spin fluctuations in infinite-layer cuprate SrCuO_(2)from a phonon perspective

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Science China(Physics,Mechanics & Astronomy) 2024年第8期67卷 159-167页

作者： Xin Du pei-Han Sun Ben-Chao Gong Jian-Feng Zhang Zhong-Yi Lu Kai liu department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-nano devices Renmin University of ChinaBeijing 100872China department of Physics School of ScienceJiangsu University of Science and TechnologyZhenjiang 212100China Institute of Physics Chinese Academy of SciencesBeijing 100190China Key Laboratory of Quantum State Construction and Manipulation(Ministry of Education) Renmin University of ChinaBeijing 100872China

The infinite-layer cuprate ACu O_(2)(A=Ca,Sr,Ba)possesses the simplest crystal structure among numerous cuprate superconductors and can serve as a prototypical system to explore the unconventional *** on the first-principles electronic structure calculations,we have studied the electronic and magnetic properties of the infinite-layer cuprate SrCuO_(2)from a phonon *** find that interesting fluctuations of charges,electrical dipoles,and local magnetic moments can be induced by the atomic displacements of phonon modes in SrCuO_(2)upon the hole *** all optical phonon modes of SrCuO_(2)in the antiferromagnetic Néel state,only the A_(1g)mode that involves the full-breathing O vibrations along the Cu-O bonds can cause significant fluctuations of local magnetic moments on O atoms and dramatic charge redistributions between Cu and O ***,due to the atomic displacements of the A_(1g)mode,both the charge fluctuations on Cu and the electrical dipoles on O show a dome-like evolution with increasing hole doping,quite similar to the experimentally observed behavior of the superconducting T_(c);in comparison,the fluctuations of local magnetic moments on O display a monotonic enhancement along with the hole *** analyses indicate that around the optimal doping,there exists a large softening in the frequency of the A_(1g)phonon mode and a van Hove singularity in the electronic structure close to the Fermi level,suggesting potential electron-phonon *** work reveals the important role of the full-breathing O phonon mode playing in the infinite-layer SrCuO_(2),which may provide new insights in understanding the cuprate superconductivity.

关键词： first-principles calculations cuprate superconductors phonon charge and spin fluctuations

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Vanadium(V) Complexes Containing Unsymmetrical N-Heterocyclic Carbene Ligands: Highly Efficient Synthesis and Catalytic Behavior towards Ethylene/Propylene Copolymerization

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Chinese Journal of Polymer Science 2024年第1期42卷 32-41,I0006页

作者： Yi-Cong Wang Hui Zhat pei-Yi Cheng Shu Zhang Xiang-Wei liu Yi-Xian Wu State Key Laboratory of Chemical Resource Engineering Beijing University of Chemical TechnologyBejing 100029China

The highly efficient method has been developed for the synthesis of NHC·VOCl_(3) containing symmetrical or unsymmetrical Nheterocyclic carbene(NHC) ligands by the transmetallation reaction of NHC·AgCl with VOCl_(3).The total isolated yield of VOCl_(3)[1,3-(2,4,6-Me_(3)C_(6)H_(2))_(2)(NCH=)_(2)C:](V4') reached 86% by transmetallation reaction,which is much higher than that(48%) by direct coordination *** methodology has also been used to synthesize the novel vanadium complexes containing unsymmetrical NHC ligands of VOCl_(3)[PhCH_(2)NCH=CHNR)C:](V5',R=2,4,6-Me_(3)C_(6)H_(2);V6',R=2,4-Me_(2)-6-Ph-C_(6)H_(2);V7',R=2,6-^(i)Pr_(2)-C_(6)H_(3)) with high yield,which could not be obtained by direct coordination *** catalytic activity and copolymerization ability would be improved by introducing unsymmetrical NHC ligands due to their less steric bulky *** vanadium complex V5' containing unsymmetrical NHC ligand exhibits higher catalytic activity(3.7×10^(5)g_(copolymer)·mol^(-1) of V·h^(-1)) than that of V4' containing symmetrical NHC ***,the higher propylene incorporation ratio(45.6 mol%) in the copolymers of ethylene with propylene could be obtained by using V5' than that(39.9%) by using V4'.The results would provide a highly efficient strategy for the synthesis of early transition metal complexes containing versitile NHC ligands,affording the catalyst with both high catalytic activity and copolymerization ability for the synthesis of high performance polyolefin elastomers.

关键词： Vanadium complex N-heterocyclic carbene ligand Transmetallation reaction Copolymerization of ethylene with propylene

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Modularized and Parametric Modeling Technology for Finite Element Simulations of Underground Engineering under Complicated Geological Conditions

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Computer Modeling in Engineering & Sciences 2024年第7期140卷 621-645页

作者： Jiaqi Wu Li Zhuo Jianliang pei Yao Li Hongqiang Xie Jiaming Wu Huaizhong liu State Key Laboratory of Hydraulics and Mountain River Engineering College of Water Resource and HydropowerSichuan UniversityChengdu610065China Research Institute of Testing and Inspection Sinohydro Bureau 7 Co.Ltd.Chengdu610213China

The surrounding geological conditions and supporting structures of underground engineering are often updated during construction,and these updates require repeated numerical *** improve the numerical modeling efficiency of underground engineering,a modularized and parametric modeling cloud server is developed by using Python *** basic framework of the cloud server is as follows:input the modeling parameters into the web platform,implement Rhino software and FLAC3D software to model and run simulations in the cloud server,and return the simulation results to the web *** modeling program can automatically generate instructions that can run the modeling process in Rhino based on the input modeling *** main modules of the modeling program include modeling the 3D geological structures,the underground engineering structures,and the supporting structures as well as meshing the geometric *** particular,various cross-sections of underground caverns are crafted as parametricmodules in themodeling *** and parametric modeling program is used for a finite element simulation of the underground powerhouse of the Shuangjiangkou Hydropower *** complicatedmodel is rapidly generated for the simulation,and the simulation results are ***,this modularized and parametric modeling program is applicable for three-dimensional finite element simulations and analyses.

关键词： Underground engineering modularized and parametric modeling finite element method complex geological structure cloud modeling

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