检索结果-南通市图书馆

Adenosine 2A receptor contributes to the facilitation of postinfectious irritable bowel syndrome by γδ T cells via the PKA/CREB/NF-κB signaling pathway

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2023年第9期29卷 1475-1491页

作者： Li-Wei Dong Yi-Yao Chen Chao-Chao Chen Zhi-Chao Ma Jiao Fu Bai-Li Huang Fu-Jin Liu Dong-Chun Liang de-ming sun Cheng Lan department of Gastroenterology Hainan General HospitalAffiliated Hainan HospitalHainan Medical UniversityHaikou 570311Hainan ProvinceChina Doheny Eye Institute Department of OphthalmologyDavid Geffen School of MedicineUniversity of California Los AngelesLos AngelesCA 90033United States

BACKGROUND Immunological dysfunction-induced low-grade inflammation is regarded as one of the predominant pathogenetic mechanisms in post-infectious irritable bowel syndrome(PI-IBS).γδT cells play a crucial role in innate and adaptive *** receptors expressed on the surface ofγδT cells participate in intestinal inflammation and immunity *** To investigate the role ofγδT cell regulated by adenosine 2A receptor(A2AR)in *** The PI-IBS mouse model has been established with Trichinella spiralis(***)*** intestinal A2AR and A2AR inγδT cells were detected by immunohistochemistry,and the inflammatory cytokines were measured by western *** role of A2AR on the isolatedγδT cells,including proliferation,apoptosis,and cytokine production,were evaluated in *** A2AR expression was measured by western blot and reverse transcription polymerase chain reaction(RT-PCR).The animals were administered with A2AR agonist,or A2AR ***,γδT cells were also injected back into the animals,and the parameters described above were examined,as well as the clinical ***,the A2AR-associated signaling pathway molecules were assessed by western blot and *** PI-IBS mice exhibited elevated ATP content and A2AR expression(Pdemonstrated that the A2AR antagonist improved the function ofγδT cells through the PKA/CREB/NF-κB signaling *** Our results revealed that A2AR contributes to the facilitation of PI-IBS by regulating the function ofγδT cells via the PK

关键词： Irritable bowel syndrome Adenosine 2A receptor γδT cells Post-infectious irritable bowel syndrome Signaling pathway Regulation

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

计算掺铥光纤放大器增益的解析方法

中国激光 2003年第10期30卷 925-927页

作者：刘琳张明德孙小菡东南大学电子工程系江苏南京210096

从稳态条件铥离子 (Tm3 + )粒子速率方程出发 ,进行合理的近似 ,得出掺铥光纤放大器 (TDFA)增益的解析表达式。计算了三种不同参数的TDFA的增益 ,解析解与实验数据及数值求解结果比较显示。

关键词：光纤通信技术增益速率方程掺铥光纤放大器

计算多波长抽运光纤拉曼放大器传输方程的新方法

在线全文

学校读者我要写书评

暂无评论

中国激光 2004年第5期31卷 579-582页

作者：常建华张明德孙小菡东南大学电子工程系江苏南京210096

提出了一种直接用龙格库塔迭代算法全面求解光纤拉曼放大器传输方程的方法。求解中不作任何假设近似 ,综合考虑了抽运、信号、噪声在传输过程中的相互作用。该方法推导过程简单 ,计算速度较快 ,能达到较高的精度要求 ,且有助于深入理... 详细信息

提出了一种直接用龙格库塔迭代算法全面求解光纤拉曼放大器传输方程的方法。求解中不作任何假设近似 ,综合考虑了抽运、信号、噪声在传输过程中的相互作用。该方法推导过程简单 ,计算速度较快 ,能达到较高的精度要求 ,且有助于深入理解光纤拉曼放大器中各种效应在传输过程中的相互影响。采用此方法成功地在 10 0nm带宽上求得信号增益 ,取得了较好的增益平坦度。同时给出了抽运功率在光纤传输线上的分布 ,进而给出了各个波长上的噪声系数。

关键词：光纤通信技术光纤拉曼放大器密集波分复用龙格-库塔法

Inter‑Skeleton Conductive Routes Tuning Multifunctional Conductive Foam for Electromagnetic Interference Shielding,Sensing and Thermal Management

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第3期17卷 19-36页

作者： Xufeng Li Chunyan Chen Zhenyang Li Peng Yi Haihan Zou Gao deng ming Fang Junzhe He Xin sun Ronghai Yu Jianglan Shui Caofeng Pan Xiaofang Liu School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China Institute of Atomic Manufacturing Beihang UniversityBeijing 100191People’s Republic of China Tianmushan Laboratory Xixi Octagon CityYuhang DistrictHangzhou 310023People’s Republic of China Science and Technology On Electromagnetic Scattering Laboratory Beijing Institute of Environmental FeaturesBeijing 100854People’s Republic of China

Conductive polymer foam(CPF)with excellent compressibility and variable resistance has promising applications in electromagnetic interference(EMI)shielding and other integrated functions for wearable ***,its insufficient change amplitude of resistance with compressive strain generally leads to a degradation of shielding performance during ***,an innovative loading strategy of conductive materials on polymer foam is proposed to significantly increase the contact probability and contact area of conductive components under *** inter-skeleton conductive films are constructed by loading alginate-decorated magnetic liquid metal on the polymethacrylate films hanged between the foam skeleton(denoted as AMLM-PM foam).Traditional point contact between conductive skeletons under compression is upgraded to planar contact between conductive ***,the resistance change of AMLM-PM reaches four orders of magnitude under ***,the inter-skeleton conductive films can improve the mechanical strength of foam,prevent the leakage of liquid metal and increase the scattering area of EM ***-PM foam has strain-adaptive EMI shielding performance and shows compression-enhanced shielding effectiveness,solving the problem of traditional CPFs upon *** upgrade of resistance response also enables foam to achieve sensitive pressure sensing over a wide pressure range and compression-regulated Joule heating function.

关键词： Inter-skeleton conductive films Conductive polymer foam Liquid metal Electromagnetic interference shielding

Chondroitinase ABC combined with Schwann cell transplantation enhances restoration of neural connection and functional recovery following acute and chronic spinal cord injury

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第5期20卷 1467-1482页

作者： Wenrui Qu Xiangbing Wu Wei Wu Ying Wang Yan sun Lingxiao deng Melissa Walker Chen Chen Heqiao Dai Qi Han Ying Ding Yongzhi Xia George Smith Rui Li Nai-Kui Liu Xiao-ming Xu Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA department of Hand Surgery the Second Hospital of Jilin UniversityChangchunJilin ProvinceChina Shriners Hospitals Pediatric Research Center Temple University School of MedicinePhiladelphiaPAUSA department of Anatomy&Cell Biology Indiana University School of MedicineIndianapolisINUSA

Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal *** we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord *** report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal *** Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder ***,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord *** findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.

关键词： axonal regrowth bladder function chondroitinase ABC functional recovery glial scar lentivirus migration Schwann cell spinal cord injury transplantation

在线全文

学校读者我要写书评

暂无评论

体效应振荡器特性观测与使用实验教学研究

物理实验 2003年第2期23卷 9-13页

作者：姚秀伟魏德祥孙明周辉东北师范大学物理系吉林长春130024

探讨了体效应振荡器特性观测与使用实验中 ,编写实验原理要应用能带结构解释负阻特性并通过对偶极畴生长和运动过程的描述说明振荡原理 ,提出了实验教学方案。

关键词：观测实验教学体效应振荡器负阻特性能带结构偶极畴

Activatable chemiluminescence probe based on four-arm PEGconjugated-pyropheophorbide-a for in vivo autofluorescence-free imaging of peroxynitrite

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年

作者： Jianmei Ke Lei Ding Ronggui Lian Cheng Zheng Wenjun Li Aixian Zheng Yupeng sun ming Wu Yongyi Zeng Xiaolong Liu Maochun Hong Xiaolong Zhang The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Ganjiang Innovation Academy Chinese Academy of Sciences School of Rare Earths University of Science and Technology of China College of Chemistry Fuzhou University State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences

Peroxynitrite（ONOO-） is a highly reactive nitrogen species that plays pivotal roles in cell signal transduction and physiological or pathological progresses. However, commonly used ONOO-optical imaging probes are still hampered by high background/autofluorescence（fluorescence probe）, short emission wavelength, or poor selectivity in the case of chemiluminescence. Herein,we report a facile method to prepare an activatable chemiluminescence probe（PPA-PEG） with good biocompatibility and functionality for in vivo autofluorescence-free imaging of ONOO-. The PPA-PEG consists of pyropheophorbide-a（PPA）, a typical deep red photosensitizer that acts as both the recognition and signaling element, and 4-arm poly（ethylene glycol）(4-arm PEG), which improves the biosafety and water solubility of probe. These components can self-assemble into nanoparticles（namely PPA-PEG nanoprobe） in aqueous solution. The PPA-PEG nanoprobe showed an ultra-low chemiluminescence signal before interacting with ONOO-, but exhibited good selectivity, high sensitivity and a fast response toward ONOO-. The PPAPEG was successfully applied to image cellular ONOO-changes, as well as the endogenous ONOO-changes in inflammation models and subcutaneous or orthotopic hepatocellular carcinoma（HCC） tumors models in living mice. In vitro and in vivo studies verified the good detection and imaging capabilities of PPA-PEG for peroxynitrite, demonstrating suitable tissue penetration and a high signal-to-background ratio（SBR）. Thus, our nanoprobe can serve as a valuable activatable chemiluminescence imaging tool for studying important peroxynitrite-related chemical and biological applications.

关键词：

Homoclinic and Periodic Orbits Arising Near the Heteroclinic Cycle Connecting Saddle-focus and Saddle Under Reversible Condition

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2007年第8期23卷 1495-1504页

作者： de ming ZHU Ying sun department of Mathematics East China Normal University Shanghai 200062 P. R. China School of Science University of Ji'nan Ji'nan 250022 P. R. China

In this paper, we study the dynamical behavior for a 4-dimensional reversible system near its heteroclinic loop connecting a saddle-focus and a saddle. The existence of infinitely many reversible 1-homoclinic orbits to the saddle and 2-homoclinic orbits to the saddle-focus is shown. And it is also proved that, corresponding to each 1-homoclinic （resp. 2-homoclinic） orbit F, there is a spiral segment such that the associated orbits starting from the segment are all reversible 1-periodic （resp. 2-periodic） and accumulate onto F. Moreover, each 2-homoclinic orbit may be also accumulated by a sequence of reversible 4-homoclinic orbits.

关键词： reversible condition homoclinic orbit Poincare map periodic orbit saddle-focus

在线全文

学校读者我要写书评

暂无评论

蚕丝强力与结茧条件的关系

苏州丝绸工学院学报 1985年第4期 29-34页

作者：吴澂宇励德堉孙明栋苏州丝绸工学院制丝化学教研室上海测试技术研究所

本文采用X射线衍射法,以不同上簇条件所得蚕茧为样品,研究了桑蚕丝素的晶区取向度与蚕丝强力、蚕茧解舒率等的关系,并从蚕丝结构的角度讨论了簇中小气候对蚕丝质量的影响.实验表明,在良好条件(24.1℃,RH 63.9%,0.13米/秒气流速率)下结的... 详细信息

本文采用X射线衍射法,以不同上簇条件所得蚕茧为样品,研究了桑蚕丝素的晶区取向度与蚕丝强力、蚕茧解舒率等的关系,并从蚕丝结构的角度讨论了簇中小气候对蚕丝质量的影响.实验表明,在良好条件(24.1℃,RH 63.9%,0.13米/秒气流速率)下结的茧,蚕丝丝素晶区取向度、蚕丝强力和蚕茧解每率均优于不良结茧条件(30.1℃、RH 92.7%无气流)下结的茧.由此说明,蚕丝丝素的晶区取向度是造成生丝强力和蚕茧解舒率不同的一个重要因素.

关键词：结茧营茧解舒率晶区取向上簇