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A study of the ameliorating effects of carnitine on hepatic steatosis induced by total parenteral nutrition in rats

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World Journal of Gastroenterology 1999年第4期5卷 40-43页

作者： LIANG Li Jian, YIN Xiao Yu, LUO Shi Min, ZHENG Jin Fang, LU ming de and huang Jie Fu

AIM To investigate the effects of carnitine on ameliorating hepatic steatosis induced by total parenteral nutrition (TPN) in animal model. METHODS Eighteen normal Wistar rats and 19 cirrhotic Wistar rats induced by carbon tetrachloride were randomly divided into three groups, i.e., free access to food and drink (group A), TPN (group B) and TPN+carnitine (group C) for one week, respectively. Hepatic function, histology and its fat content were determined on the 7th day. RESULTS Hepatic triglyceride (TG) and cholesterol (CHO) contents were significantly higher in groups B and C than in group A, and significantly lower in group C than in group B in both normal and cirrhotic rats (all P <0 05). Histopathological examinations revealed that hepatic steatosis was more severe in group B than in group C in both normal and cirrhotic rats. CONCLUSION Carnitine can ameliorate hepatic steatosis associated with TPN in both non cirrhotic and cirrhotic rats.

关键词： carnitine hepatic steatosis total parenteral nutrition rats

Influence of forging process on microstructure and mechanical properties of large section Ti-6.5Al-1Mo-1V-2Zr alloy bars

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Transactions of Nonferrous Metals Society of China 2013年第8期23卷 2276-2282页

作者：黄德明王怀柳陈鑫陈永郭华攀钢集团研究院有限公司钒钛资源综合利用国家重点实验室攀枝花617000 攀钢集团江油长城特殊钢有限公司江油621700

The mechanical properties, microstructure and tensile fracture of Ti-6.5AI-IMo-IV-2Zr large section bars produced by three diffrent forging processes were investigated. The results show that when billet forging and finish forging were conducted by means of fullering at high and low temperature of r-region, respectively; the microstructure of forged bar is coarse Widmanstaten structure; the mechanical properties, especially the reduction of cross-sectional area, are poor, and the room temperature tensile fracture presents a brittle feature. While billet forging was carried out by upset-fullering at high temperature of the r-region, and finish forging was proceeded through fullering at （a＋fl）-region, the microstructure of forged bar was a duplex structure, the bar has better comprehensive mechanical properties, and the room temperature tensile fracture reveals a ductile feature. In order to obtain qualified ***-IMo-IV-2Zr alloy bar, it is the key that as-cast microstructure should be completely broken during billet forging, and the forging temperature and deformation are also well controlled upon finishing forging.

关键词： Ti-6.SAI-IMo-IV-2Zr bar forging microstructure mechanical properties

Theoretical Analysis and Experiment of Temperature Stability for Fiber-optic Mach-Zehnder Interferometer Filter

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Semiconductor Photonics and Technology 2002年第3期8卷 150-152页

作者： LU Ping, LIU de ming, huang de xiu, SUN Jun qiang (dept. of Optoelectrn. Eng., Huazhong University of Science and Technology, Wuhan 430074, CHN) dept. of Optoelectrn. Eng. Huazhong University of Science and Technology Wuhan 430074

Fiber optic Mach Zehnder interferometer(MZI) can be used as wavelength multiplexers and demultiplexers. The △ L and △  directly influence the properties of MZI. To lengthen the △ L can demultiplex much more wavelengths, but when the △ L is longer, the temperature will influence MZI more seriously. A method to solve this problem is proposed, which enables MZI to work stably. The wavelength distance is 0.8 nm, and the extinction ratio is high.

关键词： Mach-Zehnder interferometer Coupler Wavelength multiplexers and demultiplexers

分布光纤拉曼放大器多路干涉的两种新分析方法

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中国激光 2003年第6期30卷 537-540页

作者：梅进杰刘德明黄德修华中科技大学光电子工程系湖北武汉430074

在总结目前存在的分布光纤拉曼放大器瑞利散射噪声性能分析方法的基础上 ,提出了两种新分析方法。第一种方法给出一个简单的解析表达式。第二种分析方法是在解析式的基础上进行迭代 ,计算精度得到较大提高。

关键词：光电子学分布光纤拉曼放大器多路干涉瑞利散射

Long Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer Cell Proliferation through Epigenetically Regulating LATS2 Expression

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Long Noncoding RNA PVT1 Promotes Non-Small Cell Lung Cancer ...

第九届中国肿瘤学术大会暨第十五届海峡两岸肿瘤学术大会

作者： Li Wan ming Sun Guo-Jian Liu Chen-Chen Wei Er-Bao Zhang Rong Kong Tong-Peng Xu ming-de huang Zhao-Xia Wang department of Oncology Second Affiliated Hospital Nanjing Medical University department of Oncology Huai'an First People's Hospital Nanjing Medical University department of Biochemistry and Molecular Biology Nanjing Medical University department of Oncology First Affiliated Hospital Nanjing Medical University

＜正＞研究目的:探讨PVT1在NSCLC中的表达及发挥的生物学功能,研究其潜在机制。研究方法:（1）通过GEO数据库中高通量数据分析NSCLC组织中lnc RNAs的相对表达量。（2）q RT-PCR检测NSCLC组织及细胞中PVT1的相对表达量。（3）MTT、克隆...

＜正＞研究目的:探讨PVT1在NSCLC中的表达及发挥的生物学功能,研究其潜在机制。研究方法:（1）通过GEO数据库中高通量数据分析NSCLC组织中lnc RNAs的相对表达量。（2）q RT-PCR检测NSCLC组织及细胞中PVT1的相对表达量。（3）MTT、克隆形成实验检测干扰PVT1对NSCLC细胞增殖能力的影响;流式细胞术检测干扰PVT1对NSCLC细胞周期及凋亡的影响。（4）构建裸鼠移植瘤模型研究干扰PVT1对A549细胞体内成瘤能力的影响。（5）q RT-PCR及western blot实验检测PVT1的下游靶基因。（6）RNA免疫共沉淀（RIP）、RNA pull down及染色质免疫共沉淀（CHIP）实验研究PVT1调控下游靶基因LATS2的分子

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交叉增益型波长转换器的参数优化

中国激光 2001年第2期28卷 183-185页

作者：张新亮孙军强刘德明黄德修华中科技大学光电子工程系武汉430074

在考虑放大自发辐射消耗载流子的前提下 ,运用放大器的分段模型和传输矩阵方法 ,理论分析了交叉增益(XGM)型波长转换器应用于通信系统中的误码率特性。基于误码率特性的分析 ,对波长转换器中放大器有源腔长度和内部损耗、转换波长间隔... 详细信息

在考虑放大自发辐射消耗载流子的前提下 ,运用放大器的分段模型和传输矩阵方法 ,理论分析了交叉增益(XGM)型波长转换器应用于通信系统中的误码率特性。基于误码率特性的分析 ,对波长转换器中放大器有源腔长度和内部损耗、转换波长间隔、探测功率和平均抽运功率等参数进行了优化。

关键词：交叉增益型波长转换器误码率参数优化光电子器件

基于GA的Tokamak聚变堆芯参数优化方法研究

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核科学与工程 2017年第1期37卷 73-79页

作者：孙林陈德鸿王明煌蒋洁琼中国科学院核能安全技术研究所中子输运理论与辐射安全重点实验室安徽合肥230031 合肥工业大学电子科学与应用物理学院安徽合肥230009

托卡马克(Tokamak)聚变堆芯参数优化设计是聚变及聚变驱动次临界堆设计的重要步骤之一。本文发展了基于遗传算法(GA)的堆芯参数优化方法并与中国科学院核能安全技术研究所·FDS团队研发的系统程序SYSCOde堆芯物理模块相耦合,对堆芯参数... 详细信息

托卡马克(Tokamak)聚变堆芯参数优化设计是聚变及聚变驱动次临界堆设计的重要步骤之一。本文发展了基于遗传算法(GA)的堆芯参数优化方法并与中国科学院核能安全技术研究所·FDS团队研发的系统程序SYSCOde堆芯物理模块相耦合,对堆芯参数进行优化。通过优化指定的聚变堆芯设计参数(如几何尺寸、等离子体电流、环向磁场等),并满足给定的约束条件,使得单个或多个目标达到全局"最优",对于堆芯设计具有一定参考价值。

关键词： Tokamak聚变堆芯遗传算法优化

Success of intravenous immunoglobulin and steroids in managing severe COVID-19 following lung transplantation:A case report

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World Journal of Transplantation 2025年第1期15卷 178-184页

作者： Yen-Shou Kuo Kuan-Hsun Lin Ying-Yi Chen Yuan-ming Tsai Ti-Hui Wu Hsu-Kai huang Tsai-Wang huang Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114202Taiwan

BACKGROUND Coronavirus disease 2019(COVID-19)pneumonia with severe septic shock and acute respiratory distress syndrome(ARDS)are critical illnesses for patients following *** immunoglobulin(IVIG)plays a role in both immune support and inflammation control,especially in immunocompromised *** case report describes the first successful experience using IVIG and pulse steroids to manage this critical condition following lung *** SUMMARY A 65-year-old male patient reported a history of chronic obstructive pulmonary disease and poor lung function and received bilateral sequential lung ***,he developed COVID-19 pneumonia,severe septic shock,and *** recovered from this critical condition after empirical antibiotics administration and veno-venous extracorporeal membrane oxygenation,in addition to IVIG and pulse *** IVIG is a valuable adjunct in managing severe sepsis in lung transplant recipients after COVID-19 *** aim,for the first time,to report the success of such a management approach for COVID-19 ARDS and sepsis in the post-lung transplant *** further investigations,this is a starting point for wider analysis of such an approach in this setting and consequently helps guide clinical practice for such a challenging patient population moving forward.

关键词： COVID-19 Septic shock Intravenous immunoglobulin Lung transplantation Post-transplant complications Case report

血清25-羟维生素D水平与类风湿性关节炎疾病活动度的相关性分析

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中国现代医学杂志 2020年第13期30卷 27-30页

作者：黄明德杨明峰吴华军嘉兴学院附属医院(嘉兴市第一医院)检验科浙江嘉兴314000 嘉兴学院附属医院(嘉兴市第一医院)风湿科浙江嘉兴314000

目的探讨25-羟维生素D[25-(OH)D]与类风湿性关节炎(RA)患者疾病活动度的相关性。方法收集2015年1月-2018年12月嘉兴市第一医院收治的RA患者(456例)作为RA组及同期健康体检者作为健康对照组(270例),按照血中25-(OH)D浓度不同分为缺乏组(<... 详细信息

目的探讨25-羟维生素D[25-(OH)D]与类风湿性关节炎(RA)患者疾病活动度的相关性。方法收集2015年1月-2018年12月嘉兴市第一医院收治的RA患者(456例)作为RA组及同期健康体检者作为健康对照组(270例),按照血中25-(OH)D浓度不同分为缺乏组(<20 ng/ml)、不足组(20~<30 ng/ml)及正常组(≥30 ng/ml),记录各组患者压痛关节计数(TJC28)、肿胀关节计数(SJC28),用28处疾病活动度评分(DAS28)评估RA疾病活动度,分析比较25-(OH)D水平与RA患者的抗环瓜氨酸肽抗体(ACPA)阳性率、类风湿因子(RF)阳性率、D-二聚体、Ca^2+、血沉(ESR)、TJC28、SJC28和DAS28的相关性。结果两组25-(OH)D水平比较,差异有统计学意义(P<0.05),RA组低于健康对照组;456例RA患者中,25-(OH)D正常组仅占11.4%(52/456);正常组、不足组和缺乏组在ACPA阳性率、DAS28≥2.6分的百分率、25-(OH)D、D-二聚体、Ca^2+、ESR、TJC28及SJC28值比较,差异均有统计学意义(P<0.05)。Pearson相关性分析显示:25-(OH)D水平与ESR、D-二聚体、ACPA阳性率、SJC28、TJC28和DAS28呈负相关(均P<0.05),与Ca^2+呈正相关(P<0.05)。结论RA患者的血清25-(OH)D水平普遍较低,与疾病的活动度相关,可作为RA患者疾病活动度的参考指标。

关键词：类风湿性关节炎 25-羟维生素D 抗环瓜氨酸多肽抗体