检索结果-南通市图书馆

Phenotypic research on senile osteoporosis caused by SIRT6 deficiency

International Journal of Oral Science 2016年第2期8卷 84-92页

作者： de-mao zhang Di-Xin Cui Ruo-Shi Xu Ya-Chuan Zhou Li-Wei Zheng Peng Liu Xue-Dong Zhou State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

Osteoporosis is a serious public bone metabolic disease. However, the mechanisms underlying bone loss combined with ageing, which is known as senile osteoporosis, remains unknown. Here we show the detailed phenotype of this disease caused by SIRT6 knock out （KO） in mice. To the best of our knowledge, this is the first study to reveal that SIRT6 is expressed in both bone marrow stroma cells and bone-related cells in both mouse and human models, which suggests that SIRT6 is an important regulator in bone metabolism. SIRT6-KO mice exhibit a significant decrease in body weight and remarkable dwarfism. The skeleton of the SIRT6-KO mouse is deficient in cartilage and mineralized bone tissue. Moreover, the osteocalcin concentration in blood is lower, which suggests that bone mass is markedly lost. Besides, the tartrate-resistant acid phosphatase 5b （TRAP5b） concentration is much higher, which suggests that bone resorption is overactive. Both trabecular and cortical bones exhibit severe osteopenia, and the bone mineral density is decreased. Moreover, double-labelling analysis shows that bone formation is much slower. To determine whether SIRT6 directly regulates bone metabolism, we cultured primary bone marrow stromal cells for osteogenesis and osteoclastogenesis separately to avoid indirect interference in vivo responses such as inflammation. Taken together, these results show that SIRT6 can directly regulate osteoblast proliferation and differentiation, resulting in attenuation in mineralization. Furthermore, SIRT6 can directly regulate osteoclast differentiation and results in a higher number of small osteoclasts, which may be related to overactive bone resorption.

关键词： ageing osteoclastogenesis osteogenesis osteoporosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Impacts of information about COVID-19 on pig farmers'production willingness and behavior:Evidence from China

引用

Journal of Integrative Agriculture 2024年第4期23卷 1429-1441页

作者： Huan Chen Lei mao Yuehua zhang School of Public Affairs Zhejiang UniversityHangzhou 310058China School of Insurance Central University of Finance and EconomicsBeijing 100081China Innovation Center of Yangtze River delta Zhejiang UniversityJiaxing 314100China

This paper examines the impacts of information about COVID-19 on pig farmers'production willingness by using endorsement experiments and follow-up surveys conducted in 2020 and 2021 in *** results show that,first,farmers were less willing to scale up production when they received information about *** information in 2020 that the second wave of COVID-19 might occur without a vaccine reduced farmers'willingness to scale up by 13.4%,while the information in 2021 that COVID-19 might continue to spread despite the introduction of vaccine reduced farmers'willingness by 4.4%.Second,farmers whose production was affected by COVID-19 were considerably less willing to scale up,given the access to COVID-19 ***,farmers'production willingness can predict their actual production behavior.

关键词： COVID-19 randomized experiment information treatment production willingness

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Adversarial attacks and defenses for digital communication signals identification

引用

Digital Communications and Networks 2024年第3期10卷 756-764页

作者： Qiao Tian Sicheng zhang Shiwen mao Yun Lin College of Computer Science and Technology Harbin Engineering UniversityHarbin150001China College of Information and Communication Engineering Harbin Engineering UniversityHarbin150000China department of Electrical and Computer Engineering Auburn UniversityAuburnAL36849USA

As modern communication technology advances apace,the digital communication signals identification plays an important role in cognitive radio networks,the communication monitoring and management *** has become a promising solution to this problem due to its powerful modeling capability,which has become a consensus in academia and ***,because of the data-dependence and inexplicability of AI models and the openness of electromagnetic space,the physical layer digital communication signals identification model is threatened by adversarial *** examples pose a common threat to AI models,where well-designed and slight perturbations added to input data can cause wrong ***,the security of AI models for the digital communication signals identification is the premise of its efficient and credible *** this paper,we first launch adversarial attacks on the end-to-end AI model for automatic modulation classifi-cation,and then we explain and present three defense mechanisms based on the adversarial *** we present more detailed adversarial indicators to evaluate attack and defense ***,a demonstration verification system is developed to show that the adversarial attack is a real threat to the digital communication signals identification model,which should be paid more attention in future research.

关键词： Digital communication signals identification AI model Adversarial attacks Adversarial defenses Adversarial indicators

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dynamic steric confinement effect expands the frontier of Cu-catalyzed asymmetric propargylic aminations

引用

Science China Chemistry 2024年第10期67卷 3181-3183页

作者： Peng Chen mao-mao zhang Wen-Jing Xiao Liang-Qiu Lu Engineering Research Center of Photoenergy Utilization for Pollution Control and Carbon Reduction Ministry of EducationCollege of ChemistryCentral China Normal UniversityWuhan 430079China Wuhan Institute of Photochemistry and Technology Wuhan 430082China State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics(LICP)Chinese Academy of SciencesLanzhou 730000China School of Chemistry and Chemical Engineering Henan Normal UniversityXinxiang 453007China

Chiralα-tertiary amines and related azacycles are commonly found in many natural products,pharmaceuticals and agrochemicals[1].Copper-catalyzed asymmetric propargylic amination(APA)reactions have been established as a reliable method to access enantio-enriched propargylic amines,largely due to the seminal contribution of Nishibayashi et al.[2]and van Maarseveen et al.[3]in 2008.

关键词： catalyzed asymmetric amines

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

ContextAug:model-domain failing test augmentation with contextual information

引用

Frontiers of Computer Science 2024年第2期18卷 43-60页

作者： Zhuo zhang Jianxin XUE deheng YANG Xiaoguang mao School of Information Technology and Engineering Guangzhou College of CommerceGuangzhou 511363China School of Computer and Information Engineering Institute for Artificial IntelligenceShanghai Polytechnic UniversityShanghai 201209China College of Computer National University of Defense TechnologyChangsha 410073China

In the process of software development,the ability to localize faults is crucial for improving the efficiency of *** speaking,detecting and repairing errant behavior at an early stage of the development cycle considerably reduces costs and development *** have tried to utilize various methods to locate the faulty ***,failing test cases usually account for a small portion of the test suite,which inevitably leads to the class-imbalance phenomenon and hampers the effectiveness of fault ***,in this work,we propose a new fault localization approach named *** obtaining dynamic execution through test cases,ContextAug traces these executions to build an information model;subsequently,it constructs a failure context with propagation dependencies to intersect with new model-domain failing test samples synthesized by the minimum variability of the minority feature *** contrast to traditional test generation directly from the input domain,ContextAug seeks a new perspective to synthesize failing test samples from the model domain,which is much easier to augment test *** conducting empirical research on real large-sized programs with 13 state-of-the-art fault localization approaches,ContextAug could significantly improve fault localization effectiveness with up to 54.53%.Thus,ContextAug is verified as able to improve fault localization effectiveness.

关键词： context fault localization test cases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Probabilistic-Ellipsoid Hybrid Reliability Multi-Material Topology Optimization Method Based on Stress Constraint

引用

Computer Modeling in Engineering & Sciences 2024年第7期140卷 757-792页

作者： Zibin mao Qinghai Zhao Liang zhang College of Mechanical and Electrical Engineering Qingdao UniversityQingdao266071China National Engineering Research Center for Intelligent Electrical Vehicle Power System Qingdao UniversityQingdao266071China

This paper proposes a multi-material topology optimization method based on the hybrid reliability of the probability-ellipsoid model with stress constraint for the stochastic uncertainty and epistemic uncertainty of mechanical loads in optimization *** probabilistic model is combined with the ellipsoidal model to describe the uncertainty of mechanical *** topology optimization formula is combined with the ordered solid isotropic material with penalization(ordered-SIMP)multi-material interpolation *** stresses of all elements are integrated into a global stress measurement that approximates the maximum stress using the normalized p-norm ***,the sequential optimization and reliability assessment(SORA)is applied to transform the original uncertainty optimization problem into an equivalent deterministic topology optimization(DTO)*** response surface and sparse grid technique are combined with SORA to get accurate information on the most probable failure point(MPP).In each cycle,the equivalent topology optimization formula is updated according to the MPP information obtained in the previous *** adjoint variable method is used for deriving the sensitivity of the stress constraint and the moving asymptote method(MMA)is used to update design ***,the validity and feasibility of the method are verified by the numerical example of L-shape beam design,T-shape structure design,steering knuckle,and 3D T-shaped beam.

关键词： Stress constraint probabilistic-ellipsoid hybrid topology optimization reliability analysis multi-material design

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Autotomy does not affect the locomotor performance of a scorpion

引用

Integrative Zoology 2024年第2期19卷 336-338页

作者： Aijia mao Shichang zhang Centre for Behavioral Ecology and Evolution State Key Laboratory of Biocatalysis and Enzyme EngineeringSchool of Life SciencesHubei UniversityWuhanChina

Autotomy,the self-induced loss of a body part,is one of the most extreme forms of defense against *** occurs in a variety of animal taxa,including both vertebrates and invertebrates(Fleming et al.2007).The most commonly seen examples are spiders,lizards,and crustaceans(Emberts et al.2019)(Fig.1).By performing the autotomy behavior,animals can effectively survive predation or non-predatory entrapment,or reduce the cost of injury(Emberts et al.2019;Wuthrich et al.2022).

关键词： scorpion extreme performance

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Three-dimensional reconstruction of precession warhead based on multi-view micro-Doppler analysis

引用

Journal of Systems Engineering and Electronics 2024年第3期35卷 541-548页

作者： zhang Rongzheng WANG Yong mao Jian School of Electronics and Information Engineering Harbin Institute of TechnologyHarbin 150001China Laboratory of Pinghu Pinghu 314200China

The warhead of a ballistic missile may precess due to lateral moments during release. The resulting micro-Doppler effect is determined by parameters such as the target's motion state and size. A three-dimensional reconstruction method for the precession warhead via the micro-Doppler analysis and inverse Radon transform(IRT) is proposed in this paper. The precession parameters are extracted by the micro-Doppler analysis from three radars, and the IRT is used to estimate the size of targe. The scatterers of the target can be reconstructed based on the above parameters. Simulation experimental results illustrate the effectiveness of the proposed method in this paper.

关键词： time-frequency analysis inverse Radon transform(IRT) precession warhead

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Precise Asymptotics in Limit Theorems for a Supercritical Branching Process with Immigration in a Random Environment

引用

Acta Mathematica Sinica,English Series 2024年第8期40卷 1850-1874页

作者： Chun mao HUANG Rui zhang Zhi Qiang GAO department of Mathematics Harbin Institute of Technology(Weihai)Weihai 264209P.R.China School of Mathematical Sciences Beijing Normal UniversityBeijing 100875P.R.China

Let(Zn)be a supercritical branching process with immigration in an independent and identically distributed random *** necessary moment conditions,we show the exact convergence rate in the central limit theorem on log Zn and establish the corresponding local limit theorem by using the moments of the natural submartingale and the convergence rates of its *** similar approach and with the help of a change of measure,we also present the so-called integrolocal theorem and integral large deviation theorem to characterize the precise asymptotics of the upper large deviations.

关键词： Branching process with immigration random environment central limit theorem large deviation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Optimized numerical density functional theory calculation of rotationally symmetric jellium model systems

引用

Chinese Physics B 2024年第10期33卷 349-355页

作者： Guangdi zhang Li mao Hongxing Xu School of Physics and Technology Wuhan UniversityWuhan 430070China Wuhan Institute of Quantum Technology Wuhan 430205China School of Microelectronics Wuhan UniversityWuhan 430072China Henan Academy of Sciences Zhengzhou 450046China

In real space density functional theory calculations,the effective potential depends on the electron density,requiring self-consistent iterations,and numerous integrals at each step,making the process *** our research,we propose an optimization method to expedite density functional theory(DFT)calculations for systems with large aspect ratios,such as metallic nanorods,nanowires,or scanning tunneling microscope *** method focuses on employing basis set to expand the electron density,Coulomb potential,and exchange-correlation *** precomputing integrals and caching redundant results,this expansion streamlines the integration process,significantly accelerating DFT *** a case study,we have applied this optimization to metallic nanorod systems of various radii and lengths,obtaining corresponding ground-state electron densities and potentials.

关键词： density functional theory basis set integrals precomputation nanorod

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：