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China Foundry 2024年第5期21卷 577-587页

作者： Wei-li Peng Jian-hua Zhao Cheng gu ya-jun Wang College of Materials Science and Engineering Chongqing UniversityChongqing 400045China National Engineering Research Center for Magnesium Alloys Chongqing UniversityChongqing 400044China National Key Laboratory of Advanced Casting Technologies Chongqing UniversityChongqing 400044China

The properties of the magnetic mold in magnetic mold casting directly determine the quality of the final cast *** this study,the magnetic mold properties in magnetic mold casting,were studied utilizing a coupled electromagnetic-structural method through numerical *** study investigated key factors including equivalent stress,the distribution of tensile and compressive stresses,and the area ratio of tensile *** compared molds made entirely of magnetic materials with those made partially of magnetic *** results indicate that as current increases from 4 A to 8 A,both the initial magnetic mold and the material-replaced magnetic mold initially show an increasing trend in equivalent stress,tensile-compressive stress,and the area ratio of tensile stress,peaking at 6 A before *** material replacement,the area ratio of tensile stress at 6 A decreases to 19.84%,representing a reduction of 29.72%.Magnetic molds comprising a combination of magnetic and non-magnetic materials exhibit sufficient strength and a reduced area ratio of tensile stress compared to those made entirely from magnetic *** study provides valuable insights for optimizing magnetic mold casting processes and offers practical guidance for advancing the application of magnetic molds.

关键词： magnetic mold casting coupled electromagnetic-structural method numerical simulation stress analysis

The dynamics beamline at SSRF

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Nuclear Science and Techniques 2024年第9期35卷 56-67页

作者： Zhen Liu Li-hua Wang Yong Jiang ya-Jun Tong hua-Chun Zhu Te Ji Min Chen Zheng Jiang Xiang-Jun Wei Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201204China ShanghaiTech University Shanghai 201210China

The dynamics beamline(D-Line),which combines synchrotron radiation infrared spectroscopy(SR-IR)and energy-disper-sive X-ray absorption spectroscopy(ED-XAS),is the first beamline in the world to realize concurrent ED-XAS and SR-IR measurements at the same sample position on a millisecond time-resolved *** combined technique is effective for investigating rapid structural changes in atoms,electrons,and molecules in complicated disorder systems,such as those used in physics,chemistry,materials science,and extreme ***,ED-XAS and SR-IR can be used independently in the two branches of the *** ED-XAS branch is the first ED-XAS beamline in China,which uses a tapered undulator light source and can achieve approximately 2.5×10^(12)photons/s·300 eV BW@7.2 keV at the sample *** exchange-able polychromator operating in the Bragg-reflection or Laue-transmission configuration is used in different energy ranges to satisfy the requirements for beam size and energy *** focused beam size is approximately 3.5μm(H)×21.5μm(V),and the X-ray energy range is 5–25 *** one-and two-dimensional position-sensitive detectors with frame rates of up to 400 kHz enables time resolutions of tens of microseconds to be *** distinctive techniques,such as the concurrent measurement of in situ ED-XAS and infrared spectroscopy,time-resolved ED-XAS,high-pressure ED-XAS,XMCD,and pump-probe ED-XAS,can be applied to achieve different scientific goals.

关键词： ED-XAS SR-IR Time-resolved D-line SSRF

In-situ SEM characterization of fracture mechanism of TiB/Ti-2Al-6Sn titanium matrix composites after electroshocking treatment

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Rare Metals 2024年第6期43卷 2805-2818页

作者： ya-ya Wu Jian Zhou guo-Lei Han yan Wen Zhou Wang Li-Qiang Wang Wei-Jie Lv Le-Chun Xie Lin hua Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China Faculty of Materials and Manufacturing Beijing University of TechnologyBeijing 100124China State Key Laboratory of Metal Matrix Composites School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China

In this article,in-situ scanning electron microscope characterization of the tensile properties of TiB/Ti-2Al-6Sn titanium matrix composite(TMC)was conducted before and after electroshocking treatment(EST).After EST,the tensile strength increased by 113.2 *** effect of EST on the tensile strength and fracture behavior of TiB was investigated using in-situ characterization of the fracture morphology and crack propagation path of the matrix and *** EST,TiB fracture introduced cracks that extended into the matrix,resulting in material *** EST,the refined TiB improved the bearing capacity of the matrix,thereby improving TMC ***,after EST,the cracks were introduced into the matrix,and resulting the fracture of matrix *** an increase in the external load,cracks in the matrix were observed to propagate to TiB,and the refined TiB was fractured,detached,and pulled out,resulting in the formation of *** the propagation path of the main crack after EST showed that the deflection angle of the main crack *** micro structure of the fracture surface indicated that the fracture of the matrix was plastic,whereas that of TiB was *** EST,the size and area of the dimples increased,confirming the increase in *** results revealed that the comprehensive mechanical properties of TiB/Ti-2Al-6Sn improved after ***,EST is an efficient method for tailoring the micro structures and mechanical properties of TMCs.

关键词： TiB/Ti-2Al-6Sn In-situ microstructure characterization Tensile properties Reinforcement Electroshocking treatment(EST)

METTL5 promotes gastric cancer progression via sphingomyelin metabolism

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World Journal of gastrointestinal Oncology 2024年第5期16卷 1925-1946页

作者： ya-Qiong Zhang Jian Li Zhe Qin de-Ming Li Fang-Zhou Ye Song-hua Bei Xiao-Hong Zhang Li Feng Endoscopy Center Minhang Hospital Affiliated to Fudan UniversityShanghai 201100China

BACKgROUND The treatment of gastric cancer(gC)has caused an enormous social burden *** studies have reported that N6-methyladenosine(m6A)is closely related to tumor ***5 is a m6A methyltransferase that plays a pivotal role in maintaining the metabolic stability of ***,its aberrant regulation in gC has not been fully *** To excavate the role of METTL5 in the development of *** METTL5 expression and clinicopathological characteristics were analyzed via The Cancer genome Atlas dataset and further verified via immunohistochemistry,western blotting and real-time quantitative polymerase chain reaction in tissue microarrays and clinical *** tumor-promoting effect of METTL5 on HgC-27 and AgS cells was explored in vitro by Cell Counting Kit-8 assays,colony formation assays,scratch healing assays,transwell assays and flow *** tumor-promoting role of METTL5 in vivo was evaluated in a xenograft tumor *** EpiQuik m6A RNA Methylation Quantification Kit was used for m6A ***,liquid chromatography-mass spectrometry was used to evaluate the association between METTL5 and sphingomyelin metabolism,which was confirmed by Enzyme-linked immunosorbent assay and rescue *** addition,we investigated whether METTL5 affects the sensitivity of gC cells to cisplatin via colony formation and transwell *** Our research revealed substantial upregulation of METTL5,which suggested a poor prognosis of gC *** METTL5 expression indicated distant lymph node metastasis,advanced cancer stage and pathological *** increased level of METTL5 correlated with a high degree of m6A ***5 markedly promotes the proliferation,migration,and invasion of gC cells in ***5 also promotes the growth of gC in animal ***5 knockdown resulted in significant changes in sphingomyelin metabolism,which implies that METTL5 may impact the development of gC via sphin

关键词： gastric cancer METTL5 Sphingomyelin metabolism Cisplatin

Solidification crack characteristics and sensitivity of peritectic steel

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Journal of Iron and Steel Research International 2024年第7期31卷 1668-1679页

作者： ya-qiang Li Jian-hua Liu Zi-ming Wang Ying-ying Li ya.g He Xiao-wei Li department of Automotive Engineering Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Hebei Special Vehicle Modification Technology Innovation Center Hebei Vocational University of Technology and EngineeringXingtai 054000HebeiChina Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China School of Petroleum and Natural gas Engineering Changzhou UniversityChangzhou 213164JiangsuChina

The characteristics and sensitivity of solidification cracks in peritectic steels were investigated using directional solidifi-cation *** cracks were observed in both hypoperitectic steels(12CrlMoV,15CrMo)and hyper-peritectic steel(20CrMo)during solidification at growth velocities of 15,50,and 80 pm/*** the dendritic boundaries,sulphide precipitates were found,promoting crack *** on the statistical analysis of interdendritic cracks in peritectic steels,the area ratio(RA)of interdendritic cracks in a directional solidification structure was proposed to evaluate the crack sensitivity of peritectic ***,the crack sensitivities of peritectic steels(12CrlMoV,15CrMo,and 20CrMo)were tested,evaluated,and compared with the surface crack rates of three types of steels produced from a steel *** results demonstrated that RA was in good agreement with that of the steel plant,and the crack sensitivity of 12CrlMoV steel was the strongest,followed by that of 15CrMo and 20CrMo ***,RA can be used to evaluate the crack sensitivity of peritectic steel.

关键词： Peritectic steel-Directional solidification growth velocity dendritic structure Solidification crack Crack sensitivity

A highly selective electrochemical impedimetric sensor for imidacloprid determination based on WO_(3)/MoS_(2)nanosheets/molecularly imprinted polymer composite

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Rare Metals 2024年第3期43卷 1309-1315页

作者： Long-hua Ding ya-Wen Wang Qiu-Wen Li Li-Li Zhang Ai-Zhu Wang Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan250022China HCA Florida Healthcare Westside/Northwest Hospital Internal Medicine PlantationFL33324USA

In this study,an electrochemical impedimetric sensor was established for imidacloprid(IMI)detection based on WO_(3)/MoS_(2)and molecular imprinted polymer(MIP)*** layer was prepared on electrode surface by electropolymerization of o-phenylenediamine(o-PD)in the presence of IMI template,which ensured the specific rec-ognization toward IMI.

关键词： electrochemical polymer polymerization

Plastid phylogenomics provides new insights into the systematics,diversification,and biogeography of Cymbidium(Orchidaceae)

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Plant Diversity 2024年第4期46卷 448-461页

作者： Hai-yao Chen Zhi-Rong Zhang Xin yao Ji-Dong ya Xiao-hua Jin Lin Wang Lu Lu de-Zhu Li Jun-Bo ya.g Wen-Bin Yu Center for Integrative Conservation&Yunnan Key Laboratory for the Conservation of Tropical Rainforests and Asian Elephants Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Huairou DistrictBeijing 101408China Plant germplasm and genomics Center Germplasm Bank of Wild SpeciesKunming Institute of BotanyChinese Academy of SciencesKunmingYunnan 650201China State Key Laboratory of Plant Diversity and Specility Crops Institute of BotanyChinese Academy of SciencesHaidian DistrictBeijing 100093China School of Pharmaceutical Sciences Yunnan Key Laboratory of Pharmacology for Natural Productsand Yunnan College of Modern Biomedical IndustryKunming Medical UniversityKunmingYunnan 650500China Southeast Asia Biodiversity Research Institute Chinese Academy of SciencesYezinNay Pyi Taw 05282Myanmar

Cymbidium(Orchidaceae:Epidendroideae),with around 60 species,is widely-distributed across Southeast Asia,providing a nice system for studying the processes that underlie patterns of biodiversity in the ***,phylogenetic relationships of Cymbidium have not been well resolved,hampering investigations of species diversification and the biogeographical history of this *** this study,we construct a plastome phylogeny of 56 Cymbidium species,with four well-resolved major clades,which provides a framework for biogeographical and diversification rate *** dating and biogeographical analyses show that Cymbidium likely originated in the region spanning northern IndoBurma to the eastern Himalayas during the early Miocene(~21.10 Ma).It then rapidly diversified into four major clades in East Asia within approximately a million years during the middle *** *** to the adjacent regions(Borneo,Philippines,and Sulawesi)primarily occurred during the Pliocene-Pleistocene *** analyses indicate that the net diversification rate of Cymbidium has decreased since its origin,and is positively associated with changes in temperature and monsoon *** hydrothermal conditions brought by monsoon intensification in the early Miocene possibly contributed to the initial rapid diversification,after which the net diversification rate was reduced with the cooling climate after the middle *** transition from epiphytic to terrestrial habits may have enabled adaptation to cooler environments and colonization of northern niches,yet without a significant effect on diversification *** study provides new insights into how monsoon activity and temperature changes affected the diversification dynamics of plants in Southeast Asia.

关键词： Cymbidium East Asia Asian monsoons Climate change Biogeographical patterns

Simulation of fire emergency evacuation in a large-passenger-flow subway station based on the on-site measured data of Shenzhen Metro

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Transportation Safety and Environment 2024年第1期6卷 47-55页

作者： hua Chen Chenya.g Zhang Jieyu Zhang ya Shu Xinjian Qi Chaozhe Jiang Sichuan FAST Fire Safety Assessment Co. LTD.Chengdu 610036SichuanChina School of Transportation and Logistics Southwest Jiaotong UniversityChengdu 611756SichuanChina Sichuan Fire Research Institute of MEM Chengdu 610036SichuanChina Shenzhen Metro group Co. LTD.Shenzhen 518026GuangdongChina

Because of its large capacity,high efficiency and energy savings,the subway has gradually become the primary mode of transportation for citizens.A high density of passengers exists within a large-passenger-flow subway station,and the number of casualties and injuries during a fire emergency is *** this paper,Pathfinder software and on-site measured data of Pingzhou station in Shenzhen(China)were utilized to simulate a fire emergency evacuation in a large-passenger-flow subway *** Required Safe Egress Time(RSET),number of passengers and flow rates of stairs and escalators were analysed for three fire evacuation scenarios:train fire,platform fire and hall *** evacuation time of the train fire,which was 1173 s,was the longest,and 3621 occupants needed to evacuate when the train was fully *** could not complete the evacuation within 6 mins in all three fire evacuation scenarios,which does not meet the current standard requirements and *** changing the number of passengers and the number of stairs for evacuation,the flow rate capacity and evacuation time were explored,which have reference values for safety management and emergency evacuation plan optimization during peak hours of subway operation.

关键词： fire emergency evacuation large-passenger-flow subway station on-site measured data Pathfinder

Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2748-2760页

作者： hua-ya.g Fan Ming-da Zhao Hong-jie Jiang Zhen-wei Yu Yu-jiang Fan Xin-hua Liang ya-ling Tang Yong Sun State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Oral and Maxillofacial Surgery West China Hospital of StomatologySichuan UniversityChengdu 610041China National Engineering Research Center for Biomaterials Sichuan UniversityChengdu 610065China State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases&department of Oral Pathology West China Hospital of StomatologySichuan UniversityChengdu 610041China

Circular RNAs(circRNAs)are ideal biomarkers of oral squamous cell carcinoma(OSCC)because of their highly stable closed-loop structure,and they can act as microRNA(miRNA)sponges to regulate OSCC *** analyzing clinical samples,we identified circCPNE1,a dysregulated circRNA in OSCC,and its expression level was negatively correlated with the clinical stage of OSCC ***-of-function assays revealed the tumor-suppressive effect of circCPNE1,which was then identified as a miR-330-3p ***-330-3p was recognized as a tumor promoter in multiple studies,consistent with our finding that it could promote the proliferation,migration,and invasion of OSCC *** results indicated that selective inhibition of miR-330-3p could be an effective strategy to inhibit OSCC ***,we designed cationic polylysine-cisplatin prodrugs to deliver antagomiR-330-3p(a miRNA inhibitory analog)via electrostatic interactions to form PP@miR nanoparticles(NPs).Paratumoral administration results revealed that PP@miR NPs effectively inhibited subcutaneous tumor progression and achieved partial tumor elimination(2/5),which confirmed the critical role of miR-330-3p in OSCC *** findings provide a new perspective for the development of OSCC treatments.

关键词： Oral squamous cell carcinoma CircRNA MiRNA sponge Antagomir MiRNA delivery Cisplatin-based nanoparticles Drug delivery systems Tumor elimination

Standardized ileal digestibility of amino acids in soybean meal fed to non-pregnant and pregnant sows

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Journal of Animal Science and Biotechnology 2024年第1期15卷 362-373页

作者： Ke Wang ya Wang Lei guo Yong Zhuo Lun hua Lianqiang Che Shengyu Xu Ruinan Zhang Jian Li Bin Feng Zhengfeng Fang Xuemei Jiang yan Lin de Wu Institute of Animal Nutrition Key Laboratory for Animal Disease‑Resistance Nutrition of ChinaMinistry of EducationSichuan Agricultural University211 Huimin RoadWenjiang DistrictChengdu 611130SichuanChina

Background Two studies were designed to determine standard ileal crude protein(CP)and amino acid(AA)digestibility of soybean meal(SBM)from different origins fed to non-pregnant and pregnant *** solvent-extracted SBMs from soybeans produced in the USA,Brazil,and China were *** Exp.1,eight different diets were created:a nitrogen(N)-free diet and 7 experimental diets containing SBM from different origins as the only N *** non-pregnant,multiparous sows were arranged in an 8×8 Latin square design(8 periods and 8 diets).In Exp.2,the diet formula was the same as in *** gestating sows(parity 3)were assigned to 4 different diets in a replicated 4×3 Youden square design(three periods and four diets)in mid-gestation and again in late-gestation *** When fed to non-pregnant and late-gestating sows,the standardized ileal digestibility(SID)of CP and most AAs from different SBM were not significantly different(P>0.05).When fed to mid-gestating sows,the SID values for Arg,His,Lys,Phe,Cys,gly,Ser,and Tyr in SBM 1 were lower than in SBM 4 and 5(Pgher than in SBM 1 and 4(Pgnificantly greater SID values for Lys,Ala,and Asp during mid-gestation when compared with late-gestation stages(Pgestating sows had greater SID value for Val and lower SID value for Tyr when compared with non-pregnant and late-gestating sows(Pgnant sows had significantly greater SID value for Met when compared with gestating sows(Pgestating sows,the SID values for most AAs varied among SBM *** SID values for Lys,Met,Val,Ala,Asp,and Tyr in SBM were affected by sow gestation *** findings provide a cornerstone for accurate SBM use in sow diets.

关键词： Amino acids Sows Soybean meal Standardized ileal digestibility