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Asian Journal of Andrology 2000年第4期2卷 301-303页

作者： QiangFU de-hongyao Yue-QinJIANG departmentofUrology theNinthPeople＇sHospitalShanghaiSecondMedicalUniversityShanghai200011China departmentofUrology theNinthPeople＇sHospitalShanghaiSecondMedicalUniversityShanghai200011China

Aim: To study the effect of intracavemous sodium nitropmsside (SNP), a nitric oxide (NO) donor, on penile erec-tion. Methods: Forty-two patients with erectile dysfunction (ED) were randomly assigned to receive SNP 300μgor the control drags (papaverine 30 mg + phentolamine 1 mg) intracavemously crosswise one week apart. The penilelength, circumference and hardness after the administration of the experimental and control drags were assessed andcompared statistically. Results: (1) There was no significant difference between the changes in penile length andcircumference in the two occasions; (2) In 25 SNP and 28 control cases, the hardness of the penis was scored above100 as evaluated by the Vimg method (P > 0.05); (3) The duration of erection in the controls was longer than that inthe SNP, but there were three priapism in the controls and not a single one in the SNP; (4) there was no apparentchange in the heart rate and blood pressure in both occasions; other side effects were minimal except slight local pain ina few controls. Conclusion: SNP facilitates relaxation of the penile smooth muscle and penile erection without sig-nificant side effects. SNP may be used in ED patients that experience pain and priapism with papaverine/phentolamine.(Asian J Androl 2000 dec; 2: 301-303)

关键词： erectile dysfuntion intracavemous injection sodium nitroprusside nitric oxide

Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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Neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-Jan Serneels Julie D.de Schutter Lies de Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RNA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Beam tracking method based on reconfigurable intelligent surface for obstructed communication

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Chinese Journal of Aeronautics 2022年第8期35卷 158-167页

作者： hongyao LI Jianxiang XI Ming HE Xicong WANG School of Missile Engineering Rocket Force University of EngineeringXi’an 710025China

This paper proposes a new reconfigurable intelligent surface based three-dimensional beam tracking method to solve the beam tracking problems for the unmanned aerial vehicle with obstacles in communication *** proposed beam tracking method can not only regulate the reconfigurable intelligent surfaces to achieve the beam tracking of the obstructed communications,but also optimize the transmission efficiency of the ***,a reconfigurable intelligent surface is proposed,which can correlate the transmission signals by adjusting the phaseshift ***,a new communication channel is constructed according to the reconfigurable intelligent surface,which consists of two *** first one is the channel between the unmanned aerial vehicle and the reconfigurable intelligent surface,the other is the channel between the reconfigurable intelligent surface and the ground base *** that the transmission performance of the communications can be optimized by adjusting the phase shift of each uniform linear array on the reconfigurable intelligent ***,a new beam tracking method for the unmanned aerial vehicle with obstructed communications is proposed on the basis of the reconfigurable intelligent *** proposing the mixed genetic algorithm,the estimation accuracy of the azimuth and elevation angles is improved to enhance the performance of the beam ***,the simulations are provided to verify the effectiveness of the proposed three-dimensional beam tracking method with reconfigurable intelligent surface.

关键词： Beam tracking Obstacle Phase shift Reconfigurable intelligent surface Unmanned aerial vehicle

Gut-liver axis in sepsis-associated liver injury:Epidemiology,challenges and clinical practice

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World Journal of Gastroenterology 2025年第1期31卷 163-166页

作者： Fabiana Andréa Moura Aryana Isabelle de Almeida Neves Siqueira College of Nutrition Federal University of AlagoasMaceio 57072-970AlagoasBrazil College of Medicine Federal University of AlagoasMaceio 57072-970AlagoasBrazil

Although the liver has a remarkable regenerative capacity,sepsis-associated liver injury(SLI)is a complication often seen in intensive care *** to its role in immune and inflammatory regulation,the liver is particularly vulnerable during severe *** the global prevalence,causes,and management of SLI is essential to improve outcomes and reduce healthcare *** paper aims to explore these factors,with an emphasis on identifying effective strategies for clinical *** et al’s bibliometric analysis of 787 publications(745 original articles and 42 reviews,mostly in animal models)from 2000 to 2023 highlights the growing interest in SLI,focusing on oxidative stress,gut microbiota,and inflammatory *** components such as nuclear factor-kappa B and the NOD-like receptor thermal protein domain associated protein 3 inflammasome pathway,along with their links to gut microbiota imbalance and oxidative stress,are crucial for understanding SLI *** gut-liver axis,particularly the role of intestinal permeability and bacterial translocation in liver inflammation,is *** this context,bacterial translocation is especially relevant for critically ill patients,as it can exacerbate liver *** findings underscore the need for integrated care in intensive care units,prioritizing gut health and careful antibiotic use to prevent *** extensive research,there remains a lack of clinical trials to validate therapeutic *** abundance of experimental studies highlights potential therapeutic targets,stressing the need for high-quality randomized clinical trials to translate these findings into clinical practice.

关键词： Dysbiosis Oxidative stress Inflammation Microbiota Sepsis-associated liver injury

Hybrid electrodes effective for both electrowetting-and dielectrowetting-driven digital microfluidics

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Droplet 2023年第3期2卷 60-67页

作者： hongyao Geng Sung Kwon Cho department of Mechanical Engineering and Materials Science University of PittsburghPittsburghPennsylvaniaUSA

Electrowetting on dielectric(EWOD)and dielectrowetting(deW)are two major principles to drive droplets in digital *** is effective to manipulate(create,transport,split,and merge)conductive droplets being currently used for many biological,chemical,and optical *** can also manipulate droplets but more efficiently with dielectric(nonconductive)fluids.A digital microfluidic platform efficiently operable by both EWOD and deW would offer higher versatility in handling a wide range of fluids,regardless of their *** this regard,this article presents a new hybrid electrode design enabling EWOD and deW to drive various kinds of droplet fluids on a single *** addition,a slippery liquid-infused surface(SLIPS)is integrated with the hybrid *** SLIPS is well known to resist biofouling and repel sticky fluids,which endows the hybrid electrodes with much wider application *** a result,the present SLIPS-integrated hybrid electrodes facilitate actuating various kinds of fluids which would not be driven by conventional EWOD and/or deW *** paper presents the successful transportation of not only conductive fluids including water,protein solution,glycerol,and honey but also nonconductive fluids including dodecane,silicone oil,and light and heavy crude oil,all driven by the SLIPS-integrated hybrid *** performance comparisons among solid,interdigitating,and hybrid electrodes are made by testing both conductive and nonconductive droplets.

关键词： dielectric fluid fouling

Controllable oxygen vacancies and morphology engineering:Ultra-high HER/OER activity under base–acid conditions and outstanding antibacterial properties

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Journal of Energy Chemistry 2022年第8期31卷 639-651,I0017页

作者： hongyao Xue Alan Meng Tongqing Yang Zhenjiang Li Chunjun Chen College of Electromechanical Engineering Qingdao University of Science and TechnologyQingdao 266061ShandongChina Key Laboratory of Optic-electric Sensing and Analytical Chemistry for Life Science MOECollege of Chemistry and Molecular EngineeringQingdao University of Science and TechnologyQingdao 266061ShandongChina Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Colloid and Interface and ThermodynamicsCAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences 2Beijing 100190China School of Chemistry and Chemical Engineering University of Chinese Academy of SciencesBejing 100049China

Introducing vacancy defects and unique morphology is an effective strategy to improve the catalytic performance of transition metal ***,precisely controlling the amount of vacancy defects remains ***,we propose a facile and efficient hydrothermal accompanying an annealing method to synthesize a series of Mn-doped CoO nanomaterials with controllable oxygen vacancies and unique *** oxygen vacancies amount can be precisely controlled by adjusting the Mndoping content and is positively correlated with catalytic *** was found that the oxygen vacancies amount can reach up to 38.2%over the Mn-doped CoO nanomaterials,resulting in ultra-high hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)catalytic activity(HER:25.6 and 37 m V at 10 m A cm^(-2);OER:301 and 322 m V at 50 m A cm^(-2))under both basic and acidic conditions,while reaching 10 m A cm^(-2) for an ultra-low cell voltage of only 1.52 V,which exceeds that of Pt/C/RuO_(2) and all reported non-noble metal oxide *** DFT calculations reveal oxygen vacancies can optimize H*and HOO*intermediates adsorption free energy,thus improving the HER and OER ***,the Mn-doped CoO with rich oxygen vacancies exhibits excellent antibacterial properties in vitro of *** work provides new ideas and methods for the rational design and precise control of vacancy defects in transition metal compounds and explores their potential application value in electrochemical water splitting and biomedical fields.

关键词： Oxygen vacancies Mn-doping HER OER Antibacterial

6AZO-CONTAINING SELF-ASSEMBLY ULTRA-THIN FILMS AND THEIR PHOTOVOLTAIC PROPERTIES

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Chinese Journal of Polymer Science 2005年第1期23卷 23-27页

作者： Mao-fengZhang Qiao-hongyao Chun-huiHuang Wei-xiaoCao CollegeofChemistryandMolecularEngineering PekingUniversityBeijing100871China StateKeyLaboratoryofRareEarthMaterialsChemistryandApplications PekingUniversityBeijing100871China

A kind of azo-containing resin(Azo-R)was synthesized by a simple way through the coupling reaction of 2-nitro-N-methyldiphenylamine-4-diazoresin(NDR)with phenol,and a new covalentely attached multilayer film from Azo-R asH-donor and photosensitive diazoresin,diphenylamine-4-diazoresin(DR)as H-acceptor via H-bonding attraction by self-assembly technique has been *** the decomposition of diazonium group of DR under exposure to UVlight,the H-bonds between the layers of the film convert to covalent bonds and the film becomes very stable toward polarsolvents or electrolyte aqueous *** the UV-irradiated azo-containing films can be used to measure photocurrentin a conventional three-electrode photoelectrochemical cell using KCl as supporting *** was confirmed that theazo-containing multilayer film is responsible for the photocurrent generation.

关键词： Azo-containing resin Self-assembly film Photovoltaic property.

Origin of off-centering effect and the influence on heat transport in thermoelectrics

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Materials Futures 2024年第1期3卷 142-149页

作者： hongyao Xie Li-Dong Zhao School of Materials Science and Engineering Beihang UniversityBeijing 100191People’s Republic of China

Recently,off-centering behavior has been discovered in a series of thermoelectric *** behavior indicates that the constituent atoms of the lattice displace from their coordination centers,leading to the locally distorted state and local symmetry breaking,while the material still retains its original crystallographic *** effect has been proved to be the root cause of ultralow thermal conductivity in off-centering materials,and is considered as an effective tool to regulate the thermal conductivity and improve the thermoelectric ***,we present a collection of recently discovered off-centering compounds,discuss their electronic origins and local coordination structures,and illuminate the underlying mechanism of the off-centering effect on phonon transport and thermal *** paper presents a comprehensive view of our current understanding to the off-centering effect,and provides a new idea for designing high performance thermoelectrics.

关键词： thermoelectric thermal conductivity off-centering behavior acoustic-optical phonon scattering

Study of pre-processing model of coal-mine hoist wire-rope fatigue damage signal

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International Journal of Mining Science and Technology 2015年第6期25卷 1017-1021页

作者： Tian Jie Wang hongyao Zhou Junying Meng Guoying School of Mechanical Electronic and Information Engineering China University of Mining and Technology

In this paper, we propose a pre-processing method for the detection of wire-rope signals. This is necessary because of the lack of processing methods that are currently employed. First, we investigated the one-dimensional discrete morphological and wavelet transform. Then, we developed a pre-processing model that is based on the morphological wavelet-filtering algorithm. We then proposed a modified morphology filtering algorithm. We also designed an experiment platform for wire-rope *** levels of localized flaws(LFs) and damage were formed in the wire-rope specimen. We performed a series of experimental studies, and the results show that the proposed method can effectively filter the drift signal. The signal-to-noise ratio of the new filtering algorithm was over 26 d B. The signal-to-noise ratio of the existing method is less than 15 d B, and the noise-signal ratio of the new filtering algorithm has improved by 73%. Based on our results, the filtering effect of the proposed method is better than that of the present method. This study has great significance and practical value in engineering applications.

关键词： Coal-mineHoist wire ropeSignal processingFast morphological wavelet-filteringalgorithm

In silico analysis of lncRNA-miRNA-mRNA signatures related to Sorafenib effectiveness in liver cancer cells

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World Journal of Gastroenterology 2025年第3期31卷 84-102页

作者： Patricia de la Cruz-Ojeda Ester Parras-Martínez Raquel Rey-Pérez Jordi Muntané Functional Genomics of Solid Tumors Laboratory Centre de Recherche des CordeliersParis 75006France department of Oncology Surgery Cell Therapy and Organ TransplantationInstitute of Biomedicine of SevilleVirgen del Rocio University HospitalSeville 41013Spain Biomedical Research Center for Hepatic and Digestive Diseases CIBERehdMadrid 28029Spain department of Medical Physiology and Biophysics University of SevilleSeville 41009Spain

BACKGROUND Hepatocellular carcinoma(HCC)is the most common subtype of primary liver cancer with varied incidence and epidemiology *** is still a recommended treatment for a large proportion of patients with advanced *** patterns of treatment responsiveness have been identified in differentiated hepatoblastoma HepG2 cells and metastatic HCC SNU449 *** To define the long non-codingRNA-microRNA-mRNA(lncRNA-miRNA-mRNA)predicted signatures related to selected hallmarks of cancer(apoptosis,autophagy,cell stress,cell dedifferentiation and invasiveness)in RNAseq studies using Sorafenib-treated HepG2 and SNU449 *** available software analyses allowed us to establish the lncRNA-miRNA-mRNA regulatory axes following treatment in HepG2 and SNU449 *** HepG2 and SNU449 cells were treated with Sorafenib(10μmol/L)for 24 *** RNA,including small and long RNA,was extracted with a commercial miRNeasy *** was carried out for the identification of changes in lncRNA-miRNA-mRNA regulatory *** MALAT,THAP9-AS1 and SNGH17 appeared to coordinately regulate miR-374b-3p and miR-769-5p that led to upregulation of SMAD7,TIRARP,TFAP4 and FAXDC2 in HepG2 ***12,EPB41 L4A-AS1,LINC01578,SNHG12 and GAS5 interacted with let-7b-3p,miR-195-5p and VEGFA in SNU449 *** axes MALAT1/hsamir-374b-3p/SMAD7 and MALAT1/hsa-mir-769-5p/TFAP4 were of high relevance for Sorafenib response in HepG2 cells,whereas PVT1/hsa-miR-195-5p/VEGFA was responsible for the differential response of SNU449 cells to Sorafenib *** Critical lncRNAs acting as sponges of miRNA were identified that regulated mRNA expression,whose proteins mainly increased the antitumor effectiveness of the treatment(SMAD7,TIRARP,TFAP4,FAXDC2 and ADRB2).However,the broad regulatory axis leading to increased VEGFA expression may be related to the side effect of Sorafenib in SNU449 cells.

关键词： Cell culture Hepatocellular carcinoma Non-coding RNA RNAseq Sorafenib