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Experimental study on the gas-stripping chamber of an E//B neutral particle analyzer

Nuclear Science and Techniques 2024年第11期35卷 98-107页

作者： Long Ma de-hao xie Yan-Xi Wang Shuo Wang Ji-Feng Han Wei-Ping Lin Jian-Li Liu Xing-Quan Liu Yu-Guo Liu Xiao-Bing Luo Yuan Luo Guo-Feng Qu Yu-Fan Qu Pei-Pei Ren Roy Wada Lin-Ge Zang Jing-Jun Zhu Key Laboratory of Radiation Physics and Technology of the Ministry of Education Institute of Nuclear Science and TechnologySichuan UniversityChengdu 610064China Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China Southwestern Institute of Physics Chengdu 610218China Cyclotron Institute Texas A&M UniversityCollege StationTX 77843USA

Stripping units take a key role in the neutral particle analyzer(NPA).A renovated gas-stripping unit was constructed for the newly designed E//B *** H_(2)as the working gas,we measured the gas inlet pressure(P_(0))and vacuum chamber pressure(P_(3)).The pressure distribution inside the gas-stripping room was calculated with Ansys Fluent,using the measured P_(0)and P_(3)as boundary *** stripping efficiency of the stripping unit was then simulated utilizing the Geant4 Monte Carlo code for the H and D *** pressure P_(0)=40 Pa,which is one-sixth of what found in the previous design and corresponds to a thickness of 1.27×10^(17)atoms∕cm^(2),was obtained as the optimum working pressure for the upgraded stripping *** 50 kV electron cyclotron resonance(ECR)ion source platform was designed and constructed for E//B NPA calibration,and its performance has been *** the ECR ion source platform,we measured the efficiency of the stripping unit through an inverse experiment with proton *** compared the current ratios of measurements with and without H_(2)gas to Geant4 simulation *** found adequate agreement between the overall trends of the experiment and the *** significant deviation for incident energies below 20 keV may result from the scattering effects of low-energy protons,leading to reduced accuracy in single-scattering physics in Geant4 *** the scattering corrections observed in the reverse experiments obtains more accurate stripping efficiencies for H and D atoms in the energy range of 20–200 keV and the global efficiency with the maximum values of 95.0%for H atoms and 78.9%for D atoms at 200 keV.

关键词： NPA Gas-stripping ECR ion source Stripping efficiency Geant4

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AZD1775 synergizes with SLC7A11 inhibition to promote ferroptosis

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Science China Life Sciences 2025年第1期 204-218页

作者： Chen Xiong Hong Ling Yingdan Huang Hanzhi Dong Bangxiang xie Qian hao Xiang Zhou Fudan University Shanghai Cancer Center and Institutes of Biomedical Sciences Fudan University department of Oncology Shanghai Medical CollegeFudan University department of Breast Surgery Fudan University Shanghai Cancer CenterFudan University department of Oncology First Affiliated Hospital of Nanchang University Beijing Institute of Hepatology Beijing Youan HospitalCapital Medical University Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer CenterFudan University Shanghai Key Laboratory of Medical Epigenetics International Co-laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology)Institutes of Biomedical SciencesFudan University

Tumor suppressor p53-mediated cell cycle arrest and DNA damage repair may exert cytoprotective effects against cancer therapies, including WEE1 inhibition. Considering that p53 activation can also lead to multiple types of cell death, the role of this tumor suppressor in WEE1 inhibitor-based therapies remains disputed. In this study, we reported that nucleolar stress-mediated p53 activation enhanced the WEE1 inhibitor AZD1775-induced ferroptosis to suppress lung cancer growth. Our findings showed that AZD1775 promoted ferroptosis by blocking cystine uptake, an action similar to that of Erastin. Meanwhile, inhibition of WEE1 by the WEE1 inhibitors or si RNAs induced compensatory upregulation of SLC7A11, which conferred resistance to ferroptosis. Mechanistically, AZD1775 prevented the enrichment of H3K9me3, a histone marker of transcriptional repression, on the SLC7A11 promoter by repressing the expression of the histone methyltransferase SETDB1, thereby enhancing NRF2-mediated SLC7A11 transcription. This finding was also validated using the H3K9me3 inhibitor BRD4770. Remarkably, we found that the nucleolar stress-inducing agent Actinomycin D(Act. D) inhibited SLC7A11 expression by activating p53, thus augmenting AZD1775-induced ferroptosis. Moreover, the combination of AZD1775 and Act. D synergistically suppressed wild-type p53-harboring lung cancer cell growth both in vitro and in vivo. Altogether, our study demonstrates that AZD1775 promotes ferroptosis by targeting cystine uptake but also mediates the adaptive activation of SLC7A11 through the WEE1-SETDB1 cascade and NRF2-induced transcription, and inhibition of SLC7A11 by Act. D boosts the anti-tumor efficacy of AZD1775 by enhancing ferroptosis in cancers with wild-type p53.

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Advances in Graphene‑Based Electrode for Triboelectric Nanogenerator

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Nano-Micro Letters 2025年第1期17卷 378-403页

作者： Bin xie Yuanhui Guo Yun Chen hao Zhang Jiawei Xiao Maoxiang Hou Huilong Liu Li Ma Xin Chen Chingping Wong State Key Laboratory of Precision Electronic Manufacturing Technology and Equipment Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Electromechanical Engineering Guangdong University of TechnologyGuangzhou 510006People’s Republic of China School of Materials Science and Engineering Georgia Institute of TechnologyAtlantaGA 30332USA

With the continuous development of wearable electronics,wireless sensor networks and other micro-electronic devices,there is an increasingly urgent need for miniature,flexible and efficient nanopower generation *** nanogenerator(TENG)technology can convert small mechanical energy into electricity,which is expected to address this *** the core component of TENG,the choice of electrode materials significantly affects its *** metal electrode materials often suffer from problems such as durability,which limits the further application of ***,as a novel electrode material,shows excellent prospects for application in TENG owing to its unique structure and excellent electrical *** review systematically summarizes the recent research progress and application prospects of TENGs based on graphene *** precision processing methods of graphene electrodes are introduced,and the applications of graphene electrode-based TENGs in various scenarios as well as the enhancement of graphene electrodes for TENG performance are *** addition,the future development of graphene electrode-based TENGs is also prospectively discussed,aiming to promote the continuous advancement of graphene electrode-based TENGs.

关键词： Triboelectric nanogenerator Precision processing Graphene electrode Self-powered sensor

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Robust resource allocation for NOMA-assisted heterogeneous networks

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Digital Communications and Networks 2022年第2期8卷 208-214页

作者： hao xie Yongjun Xu School of Communication and Information Engineering Chongqing University of Posts and TelecommunicationsChongqing400065China

As a promising technology to improve spectrum efficiency and transmission coverage,Heterogeneous Network(HetNet)has attracted the attention of many scholars in recent ***,with the introduction of the Non-Orthogonal Multiple Access(NOMA)technology,the NOMA-assisted HetNet cannot only improve the system capacity but also allow more users to utilize the same frequency band resource,which makes the NOMA-assisted HetNet a hot ***,traditional resource allocation schemes assume that base stations can exactly estimate direct link gains and cross-tier link gains,which is impractical for practical HetNets due to the impact of channel delays and random *** further improve energy utilization and system robustness,in this paper,we investigate a robust resource allocation problem to maximize the total Energy Efficiency(EE)of Small-Cell Users(SCUs)in NOMA-assisted HetNets under imperfect channel state *** considering bounded channel uncertainties,the robust resource optimization problem is formulated as a mixed-integer and nonlinear programming problem under the constraints of the cross-tier interference power of macrocell users,the maximum transmit power of small base station,the Resource Block(RB)assignment,and the quality of service requirement of each *** original problem is converted into an equivalent convex optimization problem by using Dinkelbach's method and the successive convex approximation method.A robust Dinkelbach-based iteration algorithm is designed by jointly optimizing the transmit power and the RB *** results verify that the proposed algorithm has better EE and robustness than the existing algorithms.

关键词： Heterogeneous network Imperfect channel state information Non-orthogonal multiple access Robust resource allocation Energy efficiency maximization

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Patch-based variational image approximation

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Science China(Information Sciences) 2017年第3期60卷 78-87页

作者： hao xie Ruofeng TONG Artificial Intelligence Institute Zhejiang University College of New Media Zhejiang University of Media and Communications

Vector graphic gives us a new solution to the representation of raster images. Among many types of vectorized representations, the most popular is mesh representation, which inherits the benefits of vector graphics. Inspired by mesh, we propose a novel patch-based representation for raster images, in which pixels are partitioned into regions, and pixels belonging to the same region are converted into a 3D point cloud and approximated by a 3D planar patch with proper boundaries in a variational way. The resulting patches are then encoded via a half-edge structure for storage. The key point is that the vertices of boundaries are not located on the very positions of sample points, i.e. converted pixels, but dependent on the optimal position of the patch,which theoretically reduces the fitting errors. Experiments show that our algorithm produces better results.

关键词： image approximation vector graphics image representation plane optimization boundary extrac tion

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Image meshing via hierarchical optimization

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Frontiers of Information Technology & Electronic Engineering 2016年第1期17卷 32-40页

作者： hao xie Ruo-feng TONG Institute of Artificial Intelligence Zhejiang University

Vector graphic, as a kind of geometric representation of raster images, has many advantages, e.g.,definition independence and editing facility. A popular way to convert raster images into vector graphics is image meshing, the aim of which is to find a mesh to represent an image as faithfully as possible. For traditional meshing algorithms, the crux of the problem resides mainly in the high non-linearity and non-smoothness of the ob jective,which makes it difficult to find a desirable optimal solution. To ameliorate this situation, we present a hierarchical optimization algorithm solving the problem from coarser levels to finer ones, providing initialization for each level with its coarser ascent. To further simplify the problem, the original non-convex problem is converted to a linear least squares one, and thus becomes convex, which makes the problem much easier to solve. A dictionary learning framework is used to combine geometry and topology elegantly. Then an alternating scheme is employed to solve both parts. Experiments show that our algorithm runs fast and achieves better results than existing ones for most images.

关键词： Image meshing, Hierarchical optimization, Convexification

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Stabilization with Arbitrary Convergence Rate for the Schr?dinger Equation Subjected to an Input Time delay

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Journal of Systems Science & Complexity 2021年第3期34卷 975-994页

作者： LI Yanfang CHEN hao xie Yaru College of Mathematics and Information Science Henan Normal UniversityXinxiang 453007China School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China department of Mathematics Civil Aviation University of ChinaTianjin 300300China

The stabilization problem for the Schr?dinger equation with an input time delay is considered from the view of system ***,a linear transform from the original system into an exponentially stable system with arbitrary decay rate,also called"target system",is *** linear transform is constructed via a kind of Volterra-type integration with singular kernels *** a result,a feedback control law for the original system is ***,a linear transform from the target system into the original closed-loop system is ***,the exponential stability with arbitrary decay rate of the closed-loop system is obtained through the established equivalence between the original closed-loop system and the target *** authors conclude this work with some numerical simulations giving support to the results obtained in this paper.

关键词： Arbitrary decay rate exponential stability input delay Schr?dinger equation stabilization

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Near-Surface Anisotropic Structure Characterization by Love Wave Inversion for Assessing Ground Conditions in Urban Areas

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Journal of Earth Science 2015年第6期26卷 807-812页

作者： hao xie Lanbo Liu department of Civil & Environmental Engineering University University of Connecticut Center for Integrative Geosciences University University of Connecticut

In many geophysical applications, neglecting of anisotropy is somehow an oversimplification. The mismatch between prediction based on isotropic theory and near-surface seismic observations indicates the need for the inclusion of medium anisotropy. In this paper, surface wave（Love wave） dispersion properties are used to estimate the anisotropic structure of the near-surface layered earth, which is modeled as media possess vertical transverse isotropy（VTI）, a reasonable assumption for near-surface sedimentary layers. Our approach utilizes multi-mode surface waves to estimate both the velocity structure and the anisotropy structure. This approach consists of three parts. First, the dispersion analysis is used to extract dispersion curves from real data. Second, the forward modeling is carried out based on the dispersion equation of Love wave in a multi-layered VTI medium. Dispersion curves of multi-modes, which are the numerical solutions of the dispersion equation, are obtained by a graphic-based method. Finally, the very fast simulated annealing（VFSA） algorithm is used to invert velocity structure and anisotropy structure simultaneously. Our approach is verified by the synthetic dispersion curve generated by a VTI medium model. The estimation of shear wave velocity and anisotropy structure of surface wave data acquired at Rentschler Field, an urban center site on sediments in the Connecticut River valley reveals a simple structure of the sediment layer over a bedrock half space. The results are verified by other inversion results based on different data set obtained on the same site. The consistency of inversion results shows the feasibility and efficiency of the approach.

关键词： Love wave dispersion multi-modes anisotropy very fast simulated annealing.

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Numerical Study of Flow and Heat Transfer Characteristics of Impingement/Effusion Cooling

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Chinese Journal of Aeronautics 2009年第4期22卷 343-348页

作者： Zhang Jingzhou xie hao Yang Chengfeng College of Energy and Power Engineering Nanjing University of Aeronautics and Astronautics Nanjing 210016 China College of Power Engineering Nanjing Normal University Nanjing 210042 China

Three-dimensional numerical simulation is carried out to investigate the flow and heat transfer characteristics of impingement/effusion cooling systems. The impingement/effusion holes are arranged on two parallel perforated plates respectively in a staggered manner. Every effusion hole has an inclined angle of 30° with respect to the surface. The two parallel plates are spaced three times the diameter of the effusion hole. The ratio of center-to-center spacing of adjacent holes to the diameter of the effusion hole is set to be 3.0, 4.0 and 5.0 respectively. The flow field, temperature field and wall film cooling effectiveness are calculated for different blowing ratios ranging from 0.5 to 1.5. In general, the wall cooling effectiveness increases as the center-to-center spacing of adjacent holes decreases or the blowing ratio increases.

关键词： impingement/effusion blowing ratio cooling effectiveness heat transfer numerical simulation

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Enhanced Supercapacitance with Porous Single-crystalline GaN Electrode

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Chinese Journal of Structural Chemistry 2021年第8期40卷 1005-1011,968页

作者： LI hao xie Kui College of Chemical Engineering Fuzhou UniversityFuzhou 350116China Key Laboratory of design and Assembly of Functional Nanostructures Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Capacitance is generally determined by the porous microstructure,electron conduction and the synergy effect of active sites in the porous *** this work,we grew centimeter-scale metallic porous GaN single crystals with conductivity up to 18 S/cm at room *** Cu-catecholates(Cu–CAT)nanowire arrays were grown on porous GaN single crystal to form porous single-crystalline electrode with enhanced supercapacitor *** Cu–CAT/GaN single crystalline electrode exhibits specific capacitance of 216 F/g and normalized capacitance of 40μF/cm^(2).After 5000 cycles,it retains 80%of its initial *** porous single-crystalline GaN electrode has high porosity and excellent conductivity showing high surface capacitance.

关键词： supercapacitance GaN single crystal Cu–CAT nanowire arrays single-crystalline electrode

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