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Transarterial chemoembolization combined with lenvatinib and sintilimab vs lenvatinib alone in intermediate-advanced hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 52-61页

作者： Fei-Da Wu Hai-Feng zhou Wei Yang Di Zhu bi-Fei Wu Hai-bin Shi Sheng Liu Wei-Zhong zhou department of Interventional Radiology The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is the most common form of liver cancer that has limited treatment options and a poor *** chemoembolization(TACE)is the first-line treatment for intermediate-stage HCC but can induce tumour hypoxia,thereby promoting *** studies suggested that combining TACE with anti-angiogenic therapies and immunotherapy might im-prove ***,a tyrosine kinase inhibitor,has demonstrated superior outcomes compared to sorafenib,while immune checkpoint inhibitors such as sintilimab show potential when combined with ***,the efficacy and safety of TACE combined with lenvatinib and sintilimab(TACE+SL)compared to TACE with lenvatinib alone(TACE+L)in patients with intermediate-ad-vanced HCC has not yet been *** To evaluate the efficacy and safety of TACE+SL therapy in comparison to TACE+L therapy in patients with intermediate-advanced *** A retrospective analysis was performed on patients with intermediate-advanced HCC who received TACE plus lenvatinib with or without sintilimab between September 2019 and September *** characteristics were compared,and propensity score matching was *** survival(OS),progression-free survival(PFS),and objective response rate(ORR)were evaluated between the two groups,and adverse events were *** The study included 57 patients,with 30 in the TACE+SL group and 27 in the TACE+L *** TACE+SL group demonstrated significantly improved median PFS and OS compared to the TACE+L group(PFS:14.1 months vs 9.6 months,P=0.016;OS:22.4 months vs 14.1 months,P=0.039),along with a higher ORR(70.0%vs 55.6%).After propensity score matching,30 patients were included,with the TACE+SL group again showing longer median PFS and a trend toward improved OS(PFS:14.6 months vs 9.2 months,P=0.012;OS:23.9 months vs 16.3 months,P=0.063),and a higher ORR(73.3%vs 53.3%).No severe adverse events were *** TACE+SL demonstrat

关键词： Hepatocellular carcinoma Transarterial chemoembolization Sintilimab Lenvatinib Immunotherapy Programmed cell death 1 Prognosis

Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats

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Neural Regeneration Research 2025年第4期20卷 1164-1177页

作者： Pengfei Wang Yuewei bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming zhou Minjie Luo Wangming Zhang Neurosurgery Center Department of Pediatric NeurosurgeryGuangdong Provincial Key Laboratory on Brain Function Repair and RegenerationZhujiang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina

Long-term levodopa administration can lead to the development of levodopa-induced *** oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced ***,studies have reported increased oscillation power in cases of levodopa-induced ***,little is known about how the other electrophysiological parameters of gamma oscillations are altered in levodopa-induced ***,the role of the dopamine D3 receptor,which is implicated in levodopa-induced dyskinesia,in movement disorder-related changes in neural oscillations is *** found that the cortico-striatal functional connectivity of beta oscillations was enhanced in a model of Parkinson’s ***,levodopa application enhanced cortical gamma oscillations in cortico-striatal projections and cortical gamma aperiodic components,as well as bidirectional primary motor cortex(M1)↔dorsolateral striatum gamma *** of PD128907(a selective dopamine D3 receptor agonist)induced dyskinesia and excessive gamma oscillations with a bidirectional M1↔dorsolateral striatum ***,administration of PG01037(a selective dopamine D3 receptor antagonist)attenuated dyskinesia,suppressed gamma oscillations and cortical gamma aperiodic components,and decreased gamma causality in the M1→dorsolateral striatum *** findings suggest that the dopamine D3 receptor plays a role in dyskinesia-related oscillatory activity,and that it has potential as a therapeutic target for levodopa-induced dyskinesia.

关键词： aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials neuromodulation Parkinson’s disease primary motor cortex

不同土壤改良剂对土壤生化性质与烤烟产量的影响

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土壤通报 2005年第1期36卷 72-75页

作者：邢世和熊德中周碧青许茜福建农林大学资源与环境学院福建福州350002 福建农林大学测试中心福建福州350002 福建南平市烟草科学研究所福建南平353000

通过田间试验,探讨以石灰、粉煤灰、白云石、废菌棒和化肥构成的不同组合改良剂对土壤微生物数量、酶活性和烤烟产量的影响。结果表明施用不同组合改良剂后,耕层土壤细菌、放线菌、磷细菌、钾细菌和纤维素分解菌的数量、土壤过氧化氢酶... 详细信息

通过田间试验,探讨以石灰、粉煤灰、白云石、废菌棒和化肥构成的不同组合改良剂对土壤微生物数量、酶活性和烤烟产量的影响。结果表明施用不同组合改良剂后,耕层土壤细菌、放线菌、磷细菌、钾细菌和纤维素分解菌的数量、土壤过氧化氢酶、脲酶、磷酸酶和纤维素酶的活性及烤烟产量均比对照有不同程度提高,其中添加废菌棒处理的微生物数量、酶活性和烤烟产量变化明显高于无添加废菌棒处理,且均以“石灰+菌棒+常规化肥”改良剂组合变化最明显,差异显著性检验表明该组合处理的5种微生物数量、4种酶活性及烤烟生物和经济产量与对照相比差异均达极显著水平。相关分析表明耕层土壤5种微生物数量和4种酶活性与烤烟生物及经济产量均呈极显著的正相关。表明施用不同组合改良剂能促进土壤细菌、放线菌、磷细菌、钾细菌及纤维素分解菌的繁殖,增强过氧化氢酶、脲酶、磷酸酶及纤维素酶的活性,促进烤烟产量的提高,其中以“石灰+菌棒+常规化肥”组合改良剂的效果最好。

关键词：改良剂土壤微生物土壤酶烤烟产量

Liquid phase heterogeneous photocatalytic ozonation of phenol in liquid-solid fluidized bed:Simplified kinetic modeling

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Particuology 2010年第1期8卷 60-66页

作者： Shuangshi Dong Dandan zhou Xiaotao bi College of Environment and R esources Jilin University Changchun China department of Chemical and biological Engineering. University of British Columbia Vancouver Canada V6T 1Z3

The isotherms of original AC （activated carbon） and photocatalysts （TiO2-AC） calcined at 500 ℃ for phenol were measured. The results showed a reversible adsorption of phenol onto both kinds of particles at 25 ℃, and could be fitted well to the Freundlich adsorption equation for the dilute solution. Five oxidation processes, namely O3, O3 [UV, O3/UV/AC, O2/UV/TiO2 and O3/UV/TiO2, for phenol degradation in fluidized bed were evaluated and compared, and the photocatalytic ozonation was found to give the highest phenol conversion because of the combined actions of homogenous ozonafion in the liquid phase, heterogeneous ozonation on the surface of the catalyst support, i.e. activated carbon, and heterogeneous photocatalytic oxidation on the TiO2 catalyst surface. With the simplified kinetic model, photolytic ozonation was confirmed to predominantly take place on the particle surface in comparison with the heterogeneous and homogeneous photolytic ozonation. Additionally, the heterogeneous photocatalytic oxidation constant was found to be enhanced by 3.73 times in photocatlaytic ozonation process with ozone as the scavenger compared to the photocatalytic oxidation process with oxygen as the scavenger.

关键词： Titanium dioxide Activated carbon Ozone Photocatalytic ozonation Phenol

Effector modularity promotes functional diversification and evolutionary processes

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Science China(Life Sciences) 2023年第12期66卷 2955-2957页

作者： Guozhi bi Jian-Min zhou State Key Laboratory of Plant Environmental Resilience College of Biological SciencesChina Agricultural UniversityBeijing 100193China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental Biology Chinese Academy of SciencesBeijing 100101China

The deadly plant killer Phytophthora contains more than 100 species, which together attack a wide range of host plants to cause failure of crops and forest plants(Kamoun et al.,2015). During the infection, each Phytophthora secrets numerous effectors into plant cells to manipulate host cellular processes for successful colonization. How these effectors are evolved to target diverse host proteins and the underlying biochemical mechanisms are key to our understanding of the adaptation of Phytophthora on their host plants.

关键词： crops forest Phytophthora

Generalization of the mixed-space cluster expansion method for arbitrary lattices

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npj Computational Materials 2023年第1期9卷 1598-1608页

作者： Kang Wang Du Cheng bi-Cheng zhou department of Materials Science and Engineering University of VirginiaCharlottesvilleVA 22904USA

Mixed-space cluster expansion(MSCE),a first-principles method to simultaneously model the configuration-dependent short-ranged chemical and long-ranged strain interactions in alloy thermodynamics,has been successfully applied to binary FCC and BCC ***,the previously reported MSCE method is limited to binary alloys with cubic crystal symmetry on a single *** the current work,MSCE is generalized to systems with multiple sublattices by formulating compatible reciprocal space interactions and combined with a crystal-symmetry-agnostic algorithm for the calculation of constituent strain *** generalized approach is then demonstrated in a hypothetical HCP system and Mg-Zn *** current MSCE can significantly improve the accuracy of the energy parameterization and account for all the fully relaxed structures regardless of lattice *** generalized MSCE method makes it possible to simultaneously analyze the short-and long-ranged configuration-dependent interactions in crystalline materials with arbitrary lattices with the accuracy of typical first-principles methods.

关键词： alloy cluster expansion

Accurately predicting hypersonic transitional flow on cone via a symmetry approach

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Chinese Journal of Aeronautics 2023年第7期36卷 337-347页

作者： Weitao bi Kexin ZHENG zhou WEI Zhensu SHE State Key Laboratory for Turbulence and Complex Systems and department of Mechanics and Engineering Science College of EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Aerodynamics and Computational Aerodynamics Institute China Aerodynamics Research and Development CenterMianyang 621000China

A new algebraic transition model is proposed based on a Structural Ensemble Dynamics(SED)theory of wall turbulence,for accurately predicting the hypersonic flow heat transfer on *** model defines the eddy viscosity in terms of a two-dimensional multi-regime distribution of a Stress Length(SL)function,and hence is named as *** paper presents clear evidence of precise predictions of transition onset location and peak heat flux of a wide range of hypersonic Transitional Boundary Layers(TrBL)around straight cone at zero incidence,to an unprecedented accuracy as validated by over 70 measurements for varying five crucial influential factors(Mach number,temperature ratio,cone half angle,nose Reynolds number and noise level).The results demonstrate the universality of the postulated multi-regime similarity structure,in characterizing not only the spatial non-uniform distribution of the eddy viscosity in hypersonic TrBL on cone,but also the dependence of the transition onset location on the five influential *** latter yields a novel correlation formula for transition center Reynolds number which takes similar functional form as the SL function within the symmetry *** is concluded that the SED-SL model simulates TrBL around cone with uniformly high accuracy,and then points out to an optimistic alternative way to construct hypersonic transition model.

关键词： Cones Heat flux Hypersonic boundary layers Transition flow Turbulence models

Experimental and numerical study on dynamic mechanical behaviors of shale under true triaxial compression at high strain rate

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International Journal of Mining Science and Technology 2024年第2期34卷 149-165页

作者： Xiaoping zhou Linyuan Han Jing bi Yundong Shou School of Civil Engineering Wuhan UniversityWuhan 430072China College of Civil Engineering Guizhou UniversityGuiyang 550025China

High-energy gas fracturing of shale is a novel,high efficacy and eco-friendly mining technique,which is a typical dynamic perturbing *** effectively extract shale gas,it is important to understand the dynamic mechanical properties of *** experiments on shale subjected to true triaxial compression at different strain rates are first conducted in this *** dynamic stress-strain curves,peak strain,peak stress and failure modes of shale are *** results of the study indicate that the intermediate principal stress and the minor principal stress have the significant influence on the dynamic mechanical behaviors,although this effect decreases as the strain rate *** characteristics of compression-shear failure primarily occur in shale subjected to triaxial compression at high strain rates,which distinguishes it from the fragmentation characteristics observed in shale under dynamic uniaxial ***,a numerical three-dimensional Split Hopkinson Pressure Bar(3D-SHPB),which is established by coupling PFC3D and FLAC3D methods,is validated to replicate the laboratory characteristics of *** dynamic mechanical characteristics of shale subjected to different confining stresses are systematically investigated by the coupling PFC3D and FLAC3D *** numerical results are in good agreement with the experimental data.

关键词： Dynamic behaviors True triaxial compression High strain rates Dynamic failure mechanism PFC3D-FLAC3D coupled method

Genetic variation of Laminaria japonica (Phaeophyta) populations in China as revealed by RAPD markers

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Acta Oceanologica Sinica 2011年第2期30卷 103-112页

作者： bi Yanhui HU Yuanjie zhou Zhigang Key Laboratory of Genetic Resources and Ecology in Aquaculture Aquaculture E-Institute ofShanghai Municipal Education Committee Shanghai Ocean University Shanghai 201306 China

For the population genetics analysis of the naturally grown brown seaweed Laminaria japonica （Laminariales,Phaeophyta） sampled from Dalian,Yantai,Weihai,Rongcheng and Qingdao in China,ten primers were employed to produce 88 bands as revealed by randomly amplified polymorphic DNA （RAPD） markers,and all these bands were *** to these band patterns,there were 94 distinct phenotypes occurred in 100 samples indicating the high heterozygosity of this *** population samples showed the highest percentage of polymorphism （71.67%）,and also the higher diversity estimated on the basis of the Shannon’s index （8.498）,suggesting that this population could be chosen as the best resource for genetic *** highest diversity of Yantai population possibly resulted from the introduction of *** used for interspecific cross breeding with *** cultivated in *** Dalian southwards to Qingdao,the genetic variation of the five populations became less with a decrease in latitude,possibly due to the natural selection especially of high *** genetic distance （Φ ST values） of the five populations was a little significantly correlated with the geographical distance （r=0.496） at P =0.05 by Mantel’s ***,Rongcheng and Yantai populations were closely grouped genetically together by Neighbor-joining cluster analysis probably in that the dispersal of the kelp by propagules more easily occurring in the range of relatively short *** analysis of molecular variance （AMOVA） also demonstrated that the relatively higher variation occurred among populations （71.49%） at an extremely significant level （P 0.000 1）.All these evidence showed that there was a relatively distinct genetic differentiation among the sampled kelp populations,and *** grown in China was also rather heterozygous in heredity.

关键词： AMOVA brown seaweed Laminaria japonica Aresch. population genetics RAPD genetic variation