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解毒祛瘀滋肾方对强的松所致MRL/lpr小鼠脂质代谢紊乱的调控作用

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中国中西医结合杂志 2024年第9期44卷 1079-1085页

作者：吴德鸿张夏风郭翊煊尹梦迪周佳浙江中医药大学附属第二医院风湿科杭州310005 浙江中医药大学基础医学院中医临床基础研究所杭州310053

目的研究糖皮质激素对系统性红斑狼疮(SLE)模型小鼠脂质代谢的影响,以及解毒祛瘀滋肾方对脂质的调节作用。方法12只MRL/lpr小鼠按随机数字表法分为模型组、西药组(10 mg/kg强的松)和中西药组(10 mg/kg强的松+20 g生药/kg解毒祛瘀滋肾方)... 详细信息

目的研究糖皮质激素对系统性红斑狼疮(SLE)模型小鼠脂质代谢的影响,以及解毒祛瘀滋肾方对脂质的调节作用。方法12只MRL/lpr小鼠按随机数字表法分为模型组、西药组(10 mg/kg强的松)和中西药组(10 mg/kg强的松+20 g生药/kg解毒祛瘀滋肾方),每组4只。分别于给药后10、30天采血。采用鸟枪法脂质组学技术分析血清脂质组,经方差归一化法标度后进行主成分分析,进一步应用非参数检验筛选在组间存在显著性差异的脂质分子。结果与模型组比较,10 mg/kg强的松干预10天和30天,脂质谱均发生了显著变化,强的松干预10天后,MRL/lpr小鼠血清中24种脂质与模型组差异有统计学意义(P<0.05),干预30天后,影响的脂质种类更多(51种)。解毒祛瘀滋肾方联合强的松干预10天后,16/24种脂质恢复到模型组的水平,联合干预30天后,25/51种脂质恢复到模型组的水平。结论强的松会干扰MRL/lpr小鼠脂质代谢,解毒祛瘀滋肾方对脂质代谢紊乱有显著的调节作用,可能是解其减轻糖皮质激素不良反应的机制之一。

关键词：系统性红斑狼疮鸟枪法技术脂质组学脂质代谢糖皮质激素解毒祛瘀滋肾方中药复方

经舌神经刺激加物理疗法治疗由轻度至中度创伤性脑损伤引起的慢性平衡缺陷的安全性和有效性

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河南医学研究 2024年第16期33卷 2932-2935页

作者：王永兵梁会超武德河南大学附属郑州颐和医院康复医学科河南郑州450018

目的探讨经舌外神经刺激(TLNS)加物理疗法治疗由轻度至中度创伤性脑损伤引起的慢性平衡缺陷的安全性和有效性。方法选取2018年4月至2022年6月诊治的117例创伤性脑损伤致慢性平衡缺陷患者作为研究对象,按照随机数字表法分为观察组(给予T... 详细信息

目的探讨经舌外神经刺激(TLNS)加物理疗法治疗由轻度至中度创伤性脑损伤引起的慢性平衡缺陷的安全性和有效性。方法选取2018年4月至2022年6月诊治的117例创伤性脑损伤致慢性平衡缺陷患者作为研究对象,按照随机数字表法分为观察组(给予TLNS联合物理疗法治疗,58例)与对照组(给予TLNS治疗,59例),对比Fugl-Meyer运动功能(FMA)、Berg平衡量表(BBS)评分、修订版跌倒效能量表(MFES)评分、步态参数(步长、步宽、步频、步速)、Barthel指数、共济失调疾病神经功能量表(ICARS)评分。结果治疗3个月后,观察组的FMA评分(上肢、下肢及总分)、BBS评分、MFES评分、Barthel指数、ICARS评分、步长、步频、步速均高于对照组,而步宽低于对照组(P<0.05)。结论TLNS联合物理疗法治疗轻中度创伤性脑损伤致慢性平衡缺陷具有较为理想效果,有利于改善患者的平衡能力。

关键词：经舌神经刺激物理疗法轻中度创伤性脑损伤慢性平衡缺陷

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牡丹皮正丁醇部位化学成分研究

天然产物研究与开发 2024年第10期36卷 1714-1720页

作者：陆彩侠孔垂皓唐旭吴丝雨张翠吴德玲王仁中许凤清安徽中医药大学药学院安徽省中药饮片制造新技术重点实验室合肥230012 太和县中医院太和236600

研究牡丹皮85%乙醇提取物正丁醇萃取部位化学成分及其抗炎、抗菌的活性。采用大孔树脂柱色谱、硅胶柱色谱、Sephadex LH-20凝胶柱色谱结合反相中压柱色谱和半制备色谱技术,分离纯化牡丹皮的正丁醇萃取部位,并利用核磁共振波谱、质谱数... 详细信息

研究牡丹皮85%乙醇提取物正丁醇萃取部位化学成分及其抗炎、抗菌的活性。采用大孔树脂柱色谱、硅胶柱色谱、Sephadex LH-20凝胶柱色谱结合反相中压柱色谱和半制备色谱技术,分离纯化牡丹皮的正丁醇萃取部位,并利用核磁共振波谱、质谱数据与文献比对鉴定化合物的结构。从牡丹皮乙醇提取部位的正丁醇萃取物中得到16个化合物,分别为5-hydroxy-3 S-hydroxymethyl-6-methyl-2,3-dihydrobenzofuran(1)、(S)-(6-methyl-2,3-dihydrobenzofuran-3-yl)methanol(2)、4-thujone-7-hydroxyl-8-O-β-D-glucopyranoside(3)、resacetophenone(4)、acetoisovanillone(5)、2,5-二羟基-4-甲氧基-苯乙酮(6)、3-(4-hydroxy-3-methoxy phenyl)propan-1,2-diol(7)、erythro-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol(8)、thero-1-(3-methoxy-4-hydroxy-phenyl)-propan-1,2-diol(9)、(+)-儿茶素(10)、(+)-儿茶素-7-O-β-D-吡喃葡萄糖苷(11)、对羟基苯甲酸-β-D-吡喃葡萄糖苷(12)、苯甲酸-β-D-吡喃葡萄糖苷(13)、没食子酸乙酯(14)、没食子酸甲酯(15)、香草酸(16)。化合物2、7~9和11~16均首次从芍药属中分离得到。活性筛选发现化合物1能够抑制脂多糖诱导的RAW 264.7细胞中的炎症因子水平(NO、TNF-α和IL-6),其IC 50值分别为15.67±1.20、18.59±1.27和15.79±1.20μmol/L。

关键词：牡丹皮单萜酚酸结构鉴定抗炎抗菌

Does gemcitabine-based combination therapy improve the prognosis of unresectable pancreatic cancer?

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World Journal of Gastroenterology 2012年第35期18卷 4944-4958页

作者： Chen Sun Daniel Ansari Roland Andersson de-Quan wu department of Surgery Second Af-filiated Hospital of Harbin Medical University Harbin 150086Heilongjiang Province China department ofSurgery Clinical Sciences Lund Lund University Sk~ne Univer-sity Hospital SE-22185 Lurid Sweden

AIM:To assess whether gemcitabine-based combination therapy improves the prognosis of unresectable pancreatic cancer compared with gemcitabine treatment ***:A quantitative up-to-date meta-analysis was undertaken to investigate the efficacy of gemcitabine-based combination treatment compared with gemcitabine monotherapy in locally advanced or metastatic pancreatic *** was limited to highquality randomized clinical ***:Twenty-six studies were included in the present analysis,with a total of 8808 patients *** studies were divided into four subgroups based on the different kinds of cytotoxic agents,including platinum,fluoropyrimidine,camptothecin and targeted *** treated with gemcitabine monotherapy had significantly lower objective response rate [risk ratio(RR),0.72;95% confidence interval(CI):0.63-0.83;P de 3-4 toxicities:including vomiting(RR,0.75;95%CI:0.62-0.89;P = 0.001),diarrhea(RR,0.66;95%CI:0.49-0.89;P = 0.006),neutropenia(RR,0.88;95%CI:0.72-1.06;P = 0.18),anemia(RR,0.96;95%CI:0.82-1.12;P = 0.60),and thrombocytopenia(RR,0.76;95%CI:0.60-0.97;P = 0.03) compared with gemcitabine combination ***:Gemcitabine combination therapy provides a modest improvement of survival,but is associated with more toxicity compared with gemcitabine monotherapy.

关键词： Pancreatic cancer Gemcitabine Combina-tion therapy Outcome Meta-analysis

Fluid Mud Measurement and Siltation Analysis in A Trial Excavated Channel in the Approach Channel of the Xiangshan Port

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China Ocean Engineering 2020年第3期34卷 421-431页

作者： DING Jian HU Guo-dong WANG Zhen-xiang SHI Jian wu de-an Key Laboratory of Coastal Disasters and defence Ministry of EducationHohai UniversityNanjing 210098China Yangtze River Estuary Investigation Bureau of Hydrology and Water Resource Shanghai 200136China

In order to clarify the distribution and variation of silt and fluid mud in the Waiganmen shallow section of the 50000-ton intake channel of the Xiangshan Port,and to understand the influence of the channel excavation on the surrounding flow conditions and the strength of the backsilting,especially the impact of typhoon on the sudden silting of the channel,so as to demonstrate the feasibility and stability of the channel *** fluid mud,hydraulic,sediment and topographic measurements were carried out in the study area,and the thickness of the fluid mud layers,tidal current,sediment and topographic data were ***-frequency sounder,gamma-ray densitometer and SILAS navigational fluid mud measurement system were used to monitor the fluid mud,and the results were compared and *** adaptability and accuracy of the three methods were *** SILAS navigational continuous density measurement system and gamma-ray fixed-point fluid mud measurement are used to detect the density,thickness and variation of the fluid mud *** on the hydrological observation data,the process of erosion and deposition in excavation channel and its influence mechanism are analyzed,and the distribution characteristics and evolution law of siltation in engineering area are given in the form of empirical *** research shows that the super typhoon can produce large siltation,which results in sudden siltation of the *** tidal current is the main dynamic factor of the change of erosion and siltation of the excavation *** the influence of reciprocating tidal current and excavation topography,the trial excavation trench is silted on the *** is fluid mud in the monitoring area of the trench,and the distribution of fluid mud is different in *** thickness of the fluid mud at the bottom of the trench is generally larger than that outside the trench and the slope of the trench,and the siltation of the trench tends to be *** re

关键词： excavation trench fluid mud backsilting measurement tidal current dynamic mechanism

应用物联网技术加速畜禽精准饲喂:从概念到实施

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Science Bulletin 2024年第14期69卷 2156-2160页

作者：苏家宜谭碧娥蒋宗勇吴德 C.M.Nyachoti Sung Woo Kim 印遇龙王婧 Key Laboratory of Hunan Province for the Products Quality Regulation of Livestock and Poultry College of Animal Science and TechnologyHunan Agricultural UniversityChangsha 410128China Institute of Animal Science Guangdong Academy of Agricultural SciencesGuangzhou 510640China Key Laboratory for Animal Disease-Resistant Nutrition of the Ministry of Education of China and Animal Nutrition InstituteSichuan Agricultural UniversityChengdu 611130China department of Animal Science University of ManitobaWinnipeg R3T 2N2Canada department of Animal Science North Carolina State UniversityRaleigh 27695USA Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-Ecological Processes in Subtropical RegionNational Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry ProductionInstitute of Subtropical AgricultureChinese Academy of SciencesChangsha 410128China Yuelushan Laboratory Changsha 410128China

Maximizing sow reproductive performance is vital for ensuring healthy piglet supply,feed efficiency,and profitability,which requires understanding factors such as nutrition,disease control,genetics,herd management,and their *** is well documented that most reproductive issues in sows stem from extreme fluctuations in body reserves[1].Thus,optimizing reproduction should prioritize regulating body reserves and making continuous nutritional adjustments throughout a sow’s life[1,2].However,the traditional one-size-fits-all feeding strategy may not meet individual sow needs under varying *** feeding strategy leads to nutrient under-or over-feeding,which may result in a lack of performance and health issues on the one hand,and economic loss and negative environmental effects on the other.

关键词： feeding extreme reserves

Effect of tidal currents on the transport of saline water from the North Branch in the Changjiang River estuary

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Journal of Oceanology and Limnology 2018年第6期36卷 2085-2097页

作者： DING Jian SHAO Yuchen wu de’an Key Laboratory of Coastal Disaster and defence Ministry of EducationHohai UniversityNanjing 210098China Nanjing Water Planning and design Institute Corp.Ltd. Nanjing 210022China

Based on the MIKE 21 numerical model combined with measured data, a numerical model for the coupling of water and salinity in the Changjiang(Yangtze) River estuary was established, and based on good verification, the influence of the tidal current intensity on the transport and variations of salinity concentrations in saline water from the North Branch to the South Branch was numerically evaluated. The time and space mean root mean square of the tidal current velocity can be expressed as a parabolic function of an adjustment coefficient for the amplitude of the M2 tidal constituent along the open boundaries of the model. Under the advection of runof f and tidal currents, the saline pool is transported downstream in an oscillatory pattern. With the enhancement of tidal current intensity, the oscillatory motion of the saltwater pool is increasingly significant in a tidal cycle forced by rising and falling tides. Along four set paths, the daily average concentrations of the saline core were generally similar, and in the process of transportation downstream, the concentrations of saltwater declined. The decay of the tidal-period-averaged salinity of the saltwater was linearly related to the square of the tidal current. Thus, the tidal current has a significant and direct impact on saltwater transport and diffusion in the Changjiang River estuary.

关键词： Changjiang River estuary saltwater intrusion numerical simulation transport and diffusion attenuation

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牛羊全混合日粮的配制与利用的研究进展

饲料研究 2024年第1期47卷 148-152页

作者：刘金洋钟文迪胡长胜邓铭刘德武华南农业大学动物科学学院广东广州510642

我国牛羊集约规模化饲养与传统放牧模式共同存在。传统放牧易受气候、季节等因素影响,牧草供应不稳定、饲料营养不均衡等成为牛羊产业发展的制约因素。使用全混合日粮不仅能够解决牛羊饲料营养不稳定问题,提高生产效率,还可以充分利用... 详细信息

我国牛羊集约规模化饲养与传统放牧模式共同存在。传统放牧易受气候、季节等因素影响,牧草供应不稳定、饲料营养不均衡等成为牛羊产业发展的制约因素。使用全混合日粮不仅能够解决牛羊饲料营养不稳定问题,提高生产效率,还可以充分利用农业和工业副产品,保护环境,实现牛羊产业绿色健康、可持续发展。文章对全混合日粮配制原则、工艺以及其在牛羊各生产阶段的影响效果进行综述,为全混合日粮在牛羊生产中的使用提供参考。

关键词：全混合日粮日粮加工工艺牛羊

Effects of glycine on phagocytosis and secretion by Kupffer cells in vitro

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World Journal of Gastroenterology 2012年第20期18卷 2576-2581页

作者： Hui-Wen wu Ke-Ming Yun de-wu Han Rui-Ling Xu Yuan-Chang Zhao Institute of Hepatology Shanxi Medical University Taiyuan 030001 Shanxi Province China

AIM:To investigate the effects and mechanisms of action of glycine on phagocytosis and tumor necrosis factor(TNF)-α secretion by Kupffer cells in vitro. METHODS:Kupffer cells were isolated from normal rats by collagenase digestion and Percoll density gradient differential *** culture for 24 h,Kupffer cells were incubated in fresh Dulbecco's Modification of Eagle's Medium containing glycine (G1:1 mmol/L,G2:10 mmol/L,G3:100 mmol/L and G4:300 mmol/L)for 3 h,then used to measure phagocytosis by a bead test,TNF-α secretion after lipopolysaccharide stimulation by radioactive immunoassay,and microfilament and microtubule expression by staining with phalloidin-fluorescein isothiocyanate (FITC)or a monoclonal anti-α tubulin-FITC antibody, respectively,and evaluated under a ultraviolet fluorescence microscope. RESULTS:Glycine decreased the phagocytosis of Kupffer cells at both 30 min and 60 min(Pdecrease in secretion was dose-dependent(Pderly manner. The fluorescence densities of microtubules in G1(53.4± 10.5),G2(54.1±14.6),G3(64.9±12.1)and G4(52.1 ±14.2)were all lower than those in the controls(102.2 ±23.7,Pdecrease in microtubule fluorescence density was not dose-dependant. CONCLUSION:Glycine can decrease the phagocytosis and secretion by Kupffer cells in vitro,which may be related to the changes in the expression of microfilaments and microtubules induced by Kupffer cells.

关键词： Glycine Kupffer cell Phagocytosis Secretion