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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua Ma zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

Painlevé-Kuratowski Convergences of the Solution Sets for Perturbed Vector Equilibrium Problems without Monotonicity

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Acta Mathematicae Applicatae Sinica 2014年第4期30卷 845-858页

作者： zai-yun PENG Xin-min YANG College of Science Chongqing JiaoTong University department of Mathematics Chongqing Normal University

In this paper, we obtain some stability results for perturbed vector equilibrium problems. Under new assumptions, which are weaker than the assumption of C-strict monotonicity, we provide sufficient conditions for the Painlev^-Kuratowski Convergence of the weak efficient solution sets and efficient solution sets for the perturbed vector equilibrium problems with a sequence of mappings converging in real linear metric spaces. These results extend and improve some known results in the literature.

关键词： stability Painlev6-Kuratowski convergence efficient solution perturbed vector equilibrium prob-lem scalarization

Multiproduct and multistage integrated production planning model and algorithm based on an available production capacity network

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International Journal of minerals,Metallurgy and Materials 2021年第8期28卷 1343-1352页

作者： Zhi-min Lü Tian-ru Jiang zai-wei Li Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China Institute of Engineering Technology University of Science and Technology BeijingBeijing 100083China China Ordins Group CO. LTDBeijing 100089China

This research attempts to devise a multistage and multiproduct short-term integrative production plan that can dynamically change based on the order priority and virtual occupancy for application in steel plants. Considering factors such as the delivery time, varietal compatibility between different products, production capacity of variety per hour, minimum or maximum batch size, and transfer time, we propose an available production capacity network with varietal compatibility and virtual occupancy for enhancing production plan implementation and quick adjustment in the case of dynamic production changes. Here available means the remaining production capacity after virtual *** quickly build an available production capacity network and increase the speed of algorithm solving, constraint selection and cutting methods with order priority were used for model solving. Finally, the genetic algorithm improved with local search was used to optimize the proposed production plan and significantly reduce the order delay rate. The validity of the proposed model and algorithm was numerically verified by simulating actual production practices. The simulation results demonstrate that the model and improved algorithm result in an effective production plan.

关键词： short-term integrated plan constraint satisfaction model available production capacity varietal compatibility virtual capacity occupancy

Multiobjective extremal optimization with applications to engineering design

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第12期8卷 1905-1911页

作者： CHEN min-rong LU Yong-zai YANG Gen-ke department of Automation Shanghai Jiao Tong University Shanghai 200240. China College of information Science and Technology Jinan Universitly Guangzhou 510632 China College of Automation Science and Engineering. South China University of Technology Guangzhou 510641 China

In this paper, we extend a novel unconstrained multiobjective optimization algorithm, so-called multiobjective extremal optimization （MOEO）, to solve the constrained multiobjective optimization problems （MOPs）. The proposed approach is validated by three constrained benchmark problems and successfully applied to handling three multiobjective engineering design problems reported in literature. Simulation results indicate that the proposed approach is highly competitive with three state-of-the-art multiobjective evolutionary algorithms, i.e., NSGA-11, SPEA2 and PAES. Thus MOEO can be considered a good alternative to solve constrained multiobjective optimization problems.

关键词： Multiobjective optimization Extremal optimization (EO) Engineering design

Boundary Layer Solution of the Boltzmann Equation for Specular Boundary Condition

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Acta Mathematicae Applicatae Sinica 2023年第1期39卷 65-94页

作者： Fei-min HUANG zai-hong JIANG Yong WANG Academy of Mathematics and Systems Science Chinese Academy of SciencesBeijing100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100049China department of Mathematics Zhejiang Normal UniversityJinhua 321004China

In the paper,we establish the existence of steady boundary layer solution of Boltzmann equation with specular boundary condition in Lx,v2∩Lx,v∞in *** uniqueness,continuity and exponential decay of the solution are obtained,and such estimates are important to prove the Hilbert expansion of Boltzmann equation for half-space problem with specular boundary condition.

关键词： Botlzmann equation boundary layer steady problem specular boundary condition a priori estimate

Active Profiling and Polishing Model and Validation Based on Rotor Spiral Groove

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Chinese Journal of Mechanical Engineering 2018年第2期31卷 198-207页

作者： Guo Yu Feng Li Yong-min Yu Shou-Xiang zai School of Earth Sciences and Resources China University of Geosciences department of Mechanical Engineering College of Information & Business Zhongyuan University of Technology Electrical and Mechanical College Zhongyuan University of Technology Automotive Institute Henan Mechanical Electrical Secondary School

When a spiral groove is formed using superplastic molding, precision casting, additive manufacturing, or other non?mechanical processing technology, it is diffcult to meet the molding precision required for direct use, and the surface quality and accuracy of the shape need to be improved through a finishing process. In view of the poor reachability of the current tool?based polishing process, a tool?less polishing method using free?abrasive grains for complex spiral grooves is proposed. With this method, by controlling the movement of the workpiece, the design basis and relative motion of the abrasive particles along a helical path remain consistent, resulting in a better polishing profile. A spiral groove of a revolving body is taken as the research object; the influence of the installation method and the position of the parts, as well as the effect of the rotational speed of the abrasive ball on its relative motion along a helical trajectory, are studied, and the polishing cutting process of an abrasive ball is reasonably simplified. A consistent math?ematical model of the trajectory of an abrasive ball relative to the design helix is constructed. The grooved drum parts are verified through a polishing experiment. The spiral groove of the revolving body is modified and polished. Experiments show that the process not only corrects the shape a spiral groove error, but also reduces the surface roughness of a spiral groove. This study provides a theoretical basis for achieving free?abrasive, tool?free polishing.

关键词： Revolving body Spiral groove Abrasive ball Active profiling Modified and polished Model verification

Optimization of polyacrylonitrile-cysteine resin synthesis and its selective removal of Cu(Ⅱ) in aqueous solutions

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Chinese Chemical Letters 2017年第2期28卷 319-323页

作者： Yang Chang Chen Shen Pin-Yi Li Lei Fang zai-zai Tong min min Chun-Hua Xiong department of Applied Chemistry Zhejiang Congshang University Hangzhou 310012 China department of Food Science and Human Nutrition University of Florida Bldg 475 Newell Drive FL 32611 USA Zhejiang Provincial Key Laboratory of Fiber Materials and Manufacturing Technology Hangzhou 310018 China department of Materials Engineering Zhejiang Sci-Tech University Hangzhou 310018 China

Polyacrylonitrile beads（PAN） cysteine（CS） was synthesized from polyacrylonitrile beads（PAN） and cysteine（CS）.The content of the functional group and the percentage conversion of the functional group of PAN-CS prepared under the optimum condition using response surface methodology（RSM） for the first attempt were 3.22 mmol/g and 35.78%.The structure was characterized by ET-IR and elemental *** adsorption properties of the resin for Cu（Ⅱ） were investigated by batch and column *** adsorption results suggested that PAN-CS had higher adsorption capability for Cu（Ⅱ）than other metal ions and maximum saturated adsorption capacity was 184.7 mg/*** resin and its metal complexes were studied by ***,the resin can be eluted easily using 1 mol/L ***-CS can provide a potential application for selective removal of copper from waste solution.

关键词： Chelating resin Cysteine RSM Adsorption Cu(Ⅱ)

Painlevé-Kuratowski Stability of the Solution Sets to Perturbed Vector Generalized Systems

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Acta Mathematicae Applicatae Sinica 2018年第2期34卷 304-317页

作者： zai-yun PENG Yong ZHAO Xin-min YANG College of Mathematics and Statistics Chongqing Jiao Tong University Chongqing 400074 China department of Mathematics Sichuan University Chengdu 610064 China department of Mathematics Chongqing Normal University Chongqing 400047 China

In this paper, stability results of solution mappings to perturbed vector generalized system are studied. Firstly, without the assumption of monotonicity, the Painleve-Kuratowski convergence of global efficient solution sets of a family of perturbed problems to the corresponding global efficient solution set of the generalized system is obtained, where the perturbations are performed on both the objective function and the feasible set. Then, the density and Painleve-Kuratowski convergence results of efficient solution sets are established by using gamma convergence, which is weaker than the assumption of continuous convergence. These results extend and improve the recent ones in the literature.

关键词： Painleve-Kuratowski convergence global efficient solution sets efficient solution sets~ perturbedgeneralized systems

Preparation and visible-light photocatalytic property of nanostructured Fe-doped TiO_2 from titanium containing electric furnace molten slag

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International Journal of minerals,Metallurgy and Materials 2013年第10期20卷 1012-1020页

作者： Yang Li Yi Yue zai-qing Que Mei Zhang min Guo State Key Laboratory of Advanced Metallurgy School of Metallurgical and Ecological EngineeringUniversity of Science and Technology Beijing

Nanostructured Fe-doped titanium dioxide was synthesized from titanium containing electric furnace molten slag （TCEFMS） by using an alkali fusion, followed by a hydrolyzation-acidolysis-cMcination route. The effects of Mkali/slag mass ratio, calcinating temperature, calcinating time, and water/slag mass ratio on the extraction efficiency and purity of products were systematically studied in this paper. It is indicated that the best extraction efficiency of nanostructured Fe- doped titanium dioxide is 99.35%, when the molten slag is calcinated at 700℃ for 1 h with the mass ratio of alkali/molten slag of 1.5：1. The influence of alkali/slag mass ratio on the photocatalytic activity of final products was evaluated by the photodegradation of methyl blue under visible light irradiation. A maximum photodegradation efficiency of 88.12% over 30 min was achieved under the optimum conditions.

关键词： nanostructured materials titanium dioxide iron doping photocatalysts slag extraction alkali fusion