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多发性硬化征罕见的眼球运动功能表现

世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 7-8页

作者： de seze j. Vukusic S. Viallet-Marcel M. 潘佳鸿 department of Neurology Hpital R. Salengro CHRU de Lille 59037 Lille Cedex France

In multiple sclerosis (MS), nystagmus or internuclear ophthalmoplegia (INO) are the usual ocular motor dysfunctions. However, in patients with focal brainstem lesions, other rare manifestations may be observed, such as an isolated ocular motor nerve palsy or complex ocular motor disturbances. We report five MS patients with unusual ocular motor disturbances (bilateral third nerve palsy [n=2], opsoclonus, Horner’ s syndrome and one and-a-half syndrome). We discuss possible correlations between clinical disturbances and MRI abnormalities. Patients were seen in two MS centres. They had a confirmed diagnosis of MS and underwent a brain MRI and a complete neuro-ophthalmological work-up. In one case (opsoclonus), ocular motor manifestations were the first manifestation of MS. In the other four cases they occurred 3 months (Horner syndrome), 6 years and 12 years (bilateral third nerve palsy) and 2 years (one-anda-half syndrome) after the disease onset, respectively. Four out of five patients were still in a relapsing-remitting form of MS. In the opsoclonus case, there was no evidence of a brainstem lesion. A gadolinium-enhanced lesion (2 cases) or a new T2-weighted lesion located in the brainstem correlated with the clinical presentation. All patients completely or partially recovered after corticosteroid infusions. Our study shows some rare or previously undescribed complex ocular motor symptoms in MS.

关键词：多发性硬化眼球运动脑神经麻痹眼球震颤眼阵挛脑干损伤眼肌麻痹神经眼科临床症状皮质激素

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多发性硬化症患者的罕见眼运动表现

世界核心医学期刊文摘（神经病学分册） 2006年第9期2卷 61-62页

作者： de seze j. Vukusic S. Viallet-Marcel M. 郭中孟(译) department of Neurology H6pital R. Salengro CHRU de Lille 59037 Lille Cedex France 不详

In multiple sclerosis (MS), nystagmus or internuclear ophthalmoplegia (INO) are the usual ocular motor dysfunctions. However, in patients with focal brainstem lesions, other rare manifestations may be observed, such as an isolated ocular motor nerve palsy or complex ocular motor disturbances. We report five MS patients with unusual ocular motor disturbances (bilateral third nerve palsy [n = 2], opsoclonus, Horner’s syndrome and one-and-a-half syndrome). We discuss possible correlations between clinical disturbances and MRI abnormalities. Patients were seen in two MS centres. They had a confirmed diagnosis of MS and underwent a brain MRI and a complete neuro-ophthalmological work-up. In one case (opsoclonus), ocular motor manifestations were the first manifestation of MS. In the other four cases they occurred 3 months (Horner syndrome), 6 years and 12 years (bilateral third nerve palsy) and 2 years (one-and-a-half syndrome) after the disease onset, respectively. Four out of five patients were still in a relapsing-remitting form of MS. In the opsoclonus case, there was no evidence of a brainstem lesion. A gadolinium-enhanced lesion (2 cases) or a new T2-weighted lesion located in the brainstem correlated with the clinical presentation. All patients completely or partially recovered after corticosteroid infusions. Our study shows some rare or previously undescribed complex ocular motor symptoms in MS.

关键词：多发性硬化症运动表现罕见一个半综合征眼运动神经麻痹核间性眼肌麻痹运动障碍脑神经麻痹

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多发性硬化急性复发引起双侧第3脑神经麻痹

世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 8-8页

作者： Marcel-Viallet M. de seze j. defoort-Dhellemmes S. 邢咏新 Clini que Neurologique Hopital Roger-Salengro CHRU de Lille 59037 Lille Cedex France

Introduction. We report a case of bilateral third cranial nerve palsy in a pat ient with a secondary progressive multiple sclerosis. Observation. MRI revealed a large hyperintense lesion in T2-weighted images in the mesencephalic area. Th e clinical and radiological outcome was good after intravenous methylprednisolon e. The oculomotor signs were probably caused by this mesencephalic lesion. Concl usion. This case of bilateral third cranial nerve palsy is, to our knowledge, th e first one occurring in a patient with multiple sclerosis.

关键词：多发性硬化脑神经麻痹脑病变眼球运动加权像放射检查

颈腰曲弓形面积测量法——240例正常颈腰曲弓形面积报告

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中国医药导报 2007年第5Z期4卷 16-17页

作者：韦以宗谭树生安平林廷章王秀光韦春德北京光明骨伤医院北京102200 广西民族医院广西南宁530001 广西骨伤医院广西南宁530001 广东省潮州市中心医院广东潮州521000

目的:测量正常颈曲、腰曲的弓形面积,为临床观察颈、腰曲变化提供数据。方法:按Borden法和seze法的标准,测出正常颈曲和腰曲,然后按数学几何学扇形面积计算公式,即S_(弓形)=(πr^2α/360°)-(2/1)Lh,计算出正常的颈曲、腰曲的弓形面积,... 详细信息

目的:测量正常颈曲、腰曲的弓形面积,为临床观察颈、腰曲变化提供数据。方法:按Borden法和seze法的标准,测出正常颈曲和腰曲,然后按数学几何学扇形面积计算公式,即S_(弓形)=(πr^2α/360°)-(2/1)Lh,计算出正常的颈曲、腰曲的弓形面积,并统计正常颈曲126例,正常腰曲114例,经统计学处理得出均值和标准差。结果:正常颈曲弓形面积为均值(x)14.10cm2(标准差2.86cm2),正常腰曲弓形面积为均值(x)32.36cm2(标准差5.26cm2)。结论:对椎曲弓形面枳进行计算,统计出其正常值范围,将为临床观察椎曲的改变提供数据化的观测方法,为整脊疗法的标准化提供依据。

关键词：颈曲腰曲弓形面积正常颈曲弓形面积正常腰曲弓形面积