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Theorems of Erds-Ko-Rado type in geometrical settings

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Science China Mathematics 2013年第7期56卷 1333-1348页

作者： de BOECK Maarten STORME leo department of Mathematics Krijgslaan 281-Building S22 9000 GentFlanders Belgium

The original Erdos-Ko-Rado problem has inspired much research. It started as a study on sets of pairwise intersecting k-subsets in an n-set, then it gave rise to research on sets of pairwise non-trivially intersecting k-dimensional vector spaces in the vector space v（n, q） of dimension n over the finite field of order q, and then research on sets of pairwise non-trivially intersecting generators and planes in finite classical polar spaces. We summarize the main results on the Erdos-Ko-Rado problem in these three settings, mention the ErdSs-Ko-Rado problem in other related settings, and mention open problems for future research.

关键词： Erdos-Ko-Rado theorem finite sets finite vector spaces finite classical polar spaces

Carbon monoxide contributes to the constipating effects of granisetron in rat colon

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World Journal of Gastroenterology 2016年第42期22卷 9333-9345页

作者： Carmela Nacci Margherita Fanelli Maria Assunta Potenza valentina leo Monica Montagnani Maria Antonietta de Salvia department of Biomedical Sciences and Human Oncology - Pharmacology Section Medical School University of Bari "Aldo Moro" department of Interdisciplinary Medicine Medical School University of Bari "Aldo Moro"

AIM To investigate the mechanisms underlying the potential contribution of the heme oxygenase/carbon monoxide(HO/CO) pathway in the constipating effects of granisetron. METHODS For in vivo studies, gastrointestinal motility was evaluated in male rats acutely treated with granisetron [25, 50, 75 μg/kg/subcutaneous(sc)], zinc protoporphyrin IX [Zn PPIX, 50 μg/kg/intraperitoneal(ip)] and hemin(50 μmol/L/kg/ip), alone or in combination. For in vitro studies, the contractile neurogenic response to electrical field stimulation(EFS, 3, 5, 10 Hz, 14 v, 1 ms, pulse trains lasting 10 s), as well as the contractile myogenic response to acetylcholine(ACh, 0.1-100 μmol/L) were evaluated on colon specimens incubated with granisetron(3 μmol/L, 15 min), Zn PPIX(10 μmol/L, 60 min) or CO-releasing molecule-3(CORM-3, 100, 200, 400 μmol/L) alone or in combination. These experiments were performed under co-treatment withor without atropine(3 μmol/L, a muscarinic receptor antagonist) or NG-nitro-L-Arginine(L-NNA, 100 μmol/L, a nitric oxide synthase inhibitor).RESULTS Administration of granisetron(50, 75 μg/kg) in vivo significantly increased the time to first defecation(P = 0.045 vs vehicle-treated rats), clearly suggesting a constipating effect of this drug. Although administration of Zn PPIX or hemin alone had no effect on this gastrointestinal motility parameter, Zn PPIX co-administered with granisetron abolished the granisetron-induced constipation. On the other hand, co-administration of hemin and granisetron did not modify the increased constipation observed under granisetron alone. When administered in vitro, granisetron alone(3 μmol/L) did not significantly modify the colon's contractile response to either EFS or ACh. Incubation with Zn PPIX alone(10 μmol/L) significantly reduced the colon's contractile response to EFS(P = 0.016) but had no effect on contractile response to ACh. Co-administration of Zn PPIX and atropine(3 μmol/L) abolished the Zn PPIX-mediated decrease in contrac

关键词： Granisetron Carbon monoxide Heme oxygenase Colon Contraction Neurogenic response Myogenic response

Nonlinear frequency conversion in optical nanoantennas and metasurfaces:materials evolution and fabrication

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Opto-Electronic Advances 2018年第10期1卷 1-12页

作者： Mohsen Rahmani Giuseppe leo Igal Brener Anatoly v. Zayats Stefan A. Maier Costantino de Angelis Hoe Tan valerio Flavio Gili Fouad Karouta Rupert Oulton Kaushal vora Mykhaylo Lysevych Isabelle Staude Lei Xu Andrey E. Miroshnichenko Chennupati Jagadish Dragomir N. Neshev Research School of Physics and Engineering The Australian National University Canberra ACT 2601 Australia Matériaux et Phénomènes Quantiques Université Paris Diderot-Sorbonne Paris Cité 10 rue A. Domon et L. Duquet 75013 Paris France Center for Integrated Nanotechnologies Sandia National Laboratories Albuquerque New Mexico 87185 United States department of Physics King’s College London Strand London WC2R 2LS United Kingdom The Blackett Laboratory Department of Physics Imperial College London London SW7 2AZ United Kingdom Chair in Hybrid Nanosystems Nano Institute Munich Fakultat für Physik Ludwig-Maximilians-Universitat München München Germany deptartment of Information Engineering Universitàdegli Studi di Brescia and INO-CNR Via Branze 38 25123 Brescia Italy Institute of Applied Physics Abbe Center of Photonics Friedrich Schiller University Jena 07745 Jena Germany School of Engineering and Information Technology University of New South Wales Canberra ACT 2600 Australia

Nonlinear frequency conversion is one of the most fundamental processes in nonlinear *** has a wide range of applications in our daily lives,including novel light sources,sensing,and information *** is usually assumed that nonlinear frequency conversion requires large crystals that gradually accumulate a strong ***,the large size of nonlinear crystals is not compatible with the miniaturisation of modern photonic and optoelectronic ***,shrinking the nonlinear structures down to the nanoscale,while keeping favourable conversion efficiencies,is of great importance for future photonics *** the last decade,researchers have studied the strategies for enhancing the nonlinear efficiencies at the nanoscale,*** employing different nonlinear materials,resonant couplings and hybridization *** this paper,we provide a compact review of the nanomaterials-based efforts,ranging from metal to dielectric and semiconductor nanostructures,including their relevant nanofabrication techniques.

关键词： nonlinear nanophotonics metallic nanoantennas dielectric nanoantennas III-v semiconductor nanoantenna nanofabrication

一种适用于零中频接收机的CMOS高IIP2混频器

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微电子学 2008年第4期38卷 569-573,577页

作者：张琼娜 leo de vreedes 闵昊复旦大学专用集成电路与系统国家重点实验室上海201203 delft University of Technology 荷兰

讨论了混频器IIP2对于零中频接收机的重要性,对导致CMOS双平衡Gilbert混频器IIP2下降的因素进行了系统而深入的分析。在考虑电路的不匹配性和寄身参数的情况下,介绍了多种提高混频器IIP2的方法。同时,提出了一种鲁棒性非常好,并且适合... 详细信息

讨论了混频器IIP2对于零中频接收机的重要性,对导致CMOS双平衡Gilbert混频器IIP2下降的因素进行了系统而深入的分析。在考虑电路的不匹配性和寄身参数的情况下,介绍了多种提高混频器IIP2的方法。同时,提出了一种鲁棒性非常好,并且适合低电源电压应用的高IIP2混频器结构:"交流耦合"混频器。该电路采用CMOS 90 nm工艺实现。仿真结果显示,该混频器可达到92 dBm的IIP2和9 dB的电压转换增益,在1.2 v电源电压下,功耗为9.6 mW。

关键词：直接混频(零中频) 接收机混频器输入二阶截取点

Two electron utilization of methyl viologen anolyte in nonaqueous organic redox flow battery

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Journal of Energy Chemistry 2018年第5期27卷 1326-1332页

作者： Bo Hu T.leo Liu The department of Chemistry and Biochemistry Utah State University

Methyl viologen （Mv） as a bench-mark anolyte material has been frequently applied in aqueous organic redox flow batteries （AORFBs） towards large-scale renewable energy storage. However, only the first re- duction of Mv was utilized in aqueous electrolytes because of the insoluble Mv0generated from the second reduction of Mv. Herein, we report that methyl viologen with bis（trifluoromethane）sulfonamide counter anion, MvTFSI, can achieve two reversible reductions in a nonaqueous supporting elec- trolyte. Paired with （Ferrocenylmethyl）trimethylammonium bis（trifluoromethanesulfonyl）imide, FcNFFSI, as catholyte, the MvTFS/FcNTFSI nonaqueous organic redox flow battery （NOARFB） can take advantage of either one electron or two electron storage of the methyl viologen moiety and provide theoretical energy density of 24.9Wh/L and a cell voltage of up to 1.5v. Using a highly conductive LiTFSI/CH_3CN supporting electrolyte and a porous Daramic separator, the NOARFB displayed excellent cycling performance, includ- ing up to a 68.3g energy efficiency at 40 mA/cm2, and more than 88g total capacity retention after 100 cycles.

关键词： Redox flow battery viologen Ferrocene Energy storage

In vitro 3D phenotypic drug screen identifies celastrol as an effective in vivo inhibitor of polycystic kidney disease

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Journal of Molecular Cell Biology 2020年第8期12卷 644-653页

作者： Tijmen H.Booij Wouter N.leonhard Hester Bange Kuan Yan Michiel Fokkelman Anna J.Plugge Kimberley A.M.veraar Johannes G.Dauwerse Gerard J.P.van Westen Bob van de Water leo S.Price Dorien j.M.Peters Division of Toxicology Leiden Academic Centre for Drug Research(LACDR)Leiden UniversityLeidenThe Netherlands Present address:NEXUS Personalized Health Technologies ETH ZurichSwitzerland department of Human Genetics Leiden University Medical Center(LUMC)LeidenThe Netherlands OcellO B.v. LeidenThe Netherlands Division of Medicinal Chemistry Leiden Academic Centre for Drug Research(LACDR)LeidenThe Netherlands

Polycystic kidney disease(PKD)is a prevalent genetic disorder,characterized by the formation of kidney cysts that progressively lead to kidney *** currently available drug tolvaptan is not well tolerated by all patients and there remains a strong need for alternative *** signalling rewiring in PKD that drives cyst formation is highly complex and not fully *** a consequence,the effects of drugs are sometimes difficult to *** previously established a high-throughput microscopy phenotypic screening method for quantitative assessment of renal cyst ***,we applied this 3D cyst growth phenotypic assay and screened 2320 small drug-like molecules,including approved *** identified 81 active molecules that inhibit cyst ***-parametric phenotypic profiling of the effects on 3D cultured cysts discriminated molecules that showed preferred pharmacological effects above genuine toxicological ***,a triterpenoid from Tripterygium wilfordii,was identified as a potent inhibitor of cyst growth in *** an in vivo iKspCre-Pkd1^lox,lox mouse model for PKD,celastrol inhibited the growth of renal cysts and maintained kidney function.

关键词： PKD celastrol pyrvinium pamoate high-content screening 3D