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鹿特丹地区膳食脂肪酸和帕金森病发病风险关系的研究

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世界核心医学期刊文摘（神经病学分册） 2005年第10期1卷 47-48页

作者： de lau l.m.l. Bornebroek m. Witteman J.C.m. m.m.B. Breteler 史利利 department of Epidemiology and Biostatistics Erasmus Medical Center PO Box 1738 3 000 DR Rotterdam Netherlands Dr.

Background: Unsaturated fatty acids are important constituents of neuronal ce ll membranes and have neuroprotective, antioxidant, and anti- inflammatory prop erties. Objective: To determine if a high intake of unsaturated fatty acids migh t be associated with a lower risk of Parkinson disease (PD). methods: In the Rot terdam Study, a prospective population- based cohort study of people ages ≥ 55 , the association between intake of unsaturated fatty acids and the risk of inci dent PD was evaluated among 5,289 subjects who were free of dementia and parkins onism and underwent complete dietary assessment at baseline. PD was assessed thr ough repeated in- person examination, and the cohort was continuously monitored by computer linkage to medical records. The data were analyzed using Cox propor tional hazards regression models. Results: After a mean follow- up of 6.0 years , 51 participants with incident PD were identified. Intakes of total fat, monoun saturated fatty acids (mUFAs), and polyunsatu rated fatty acids (PUFAs) were significantly associated with a lower risk of PD, with an adjusted hazard ratio per SD increase of energy- adjusted intake of 0.69 (95% CI 0.52 to 0.91) for total fat, of 0.68 (95% CI 0.50 to 0.94) for mUFAs, and 0.66 (95% CI 0.46 to 0.96) for PUFAs. No associations were found f or dietary saturated fat, cholesterol, or trans- fat. Conclusion: These finding s suggest that high intake of unsaturated fatty acids might protect against Park inson disease.

关键词：帕金森病发病风险患病风险神经细胞膜队列研究患者病历无痴校正值连续监测试验结果

饮食中叶酸、维生素B12和维生素B6与帕金森病风险的关系

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 32-33页

作者： de lau l.m.l. Koudstaal P.J. Witteman J.C.m. m.m.B.Breteler 郭俊 Dr.department of Epidemiology and Biostatistics Erasmus Medical CenterPO Box 17383000 DR RotterdamNetherlands

BACKGROUND:Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson disease(PD),through neurotoxic *** dietary intakes of folate,vitamin B12,and vitamin B6(cofactors in homocysteine metabolism)might decrease the risk of PD through decreasing plasma ***,vitamin B6 might influence the risk of PD through an tioxidant effects unrelated to homocysteine metabolism and through its role in dopamine ***:In the Rotterdam Study,a prospective,population-based cohort study of people aged 55 years and older,the authors evaluated the association between dietary intake of folate,vitamin B12,and vitamin B6 and the risk of incident PD among 5,289 participants who were free of dementia and parkinsonism and underwent complete dietary assessment at *** was assessed through repeated in-person examination and continuous monitoring by computer linkage to medical *** were analyzed using Cox proportional hazards regression ***:After a mean follow-up of 9.7 years,the authors identified 72 participants with incident *** dietary intake of vitamin B6 was associated with a significantly decreased risk of PD(hazard ratio per SD,0.69 [95%CI 0.50 to 0.96];for highest vs lowest tertile,0.46 [0.22 to 0.96]).Stratified analyses showed that this association was restricted to *** association was observed for dietary folate and vitamin ***:Dietary vitamin B6 may decrease the risk of Parkinson disease,probably through mechanisms unrelated to homocysteine metabolism.

关键词：叶酸蝶酰谷氨酸维生素B 帕金森病 B6 维生素饮食

普通人群中帕金森综合征和帕金森病的发病率:鹿特丹研究

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世界核心医学期刊文摘（神经病学分册） 2005年第3期1卷 53-53页

作者： de lau l.m.l. Giesbergen P.C.l.m. de Rijkm.C. m.m.B. Breteler 姚庆和 dept. of Epidemiol. and Biostatist. Erasmus Medical Cent er P.O. Box 1738 3000 DR Rotterdam Netherlands Dr.

Objective: To investigate the incidence of parkinsonism and Parkinson disease (PD) in the general population using inperson screening along with clinical data . methods: In the Rotterdam study, a prospective population based cohort study of people aged ≥55 years, the authors assessed age and sex specific incidence r ates of parkinsonism and PD among 6,839 participants who were free of parkinsoni sm at baseline. Case finding involved in person screening at baseline and two f ollow up visits, and additional information was obtained through continuous mon itoring of the cohort by computer linkage to general practitionersand pharmacy records. Results: After a mean follow up period of 5.8 years, 132 subjects wit h incident parkinsonism were identified, of whom 67 (51%) had PD. The incidence of parkinsonism and PD increased with age, with incidence rates for PD increasi ng from 0.3 per 1000 person years in subjects aged 55 to 65 years, to 4.4 per 1 000 person years for those aged ≥85 years. The overall age adjusted incidence rate of any parkinsonism was not different in men and women, but men seem to ha ve a higher risk for PD (male to female ratio, 1.54; 95%CI, 0.95 to 2.51). Co nclusion: Incidence rates for parkinsonism and Parkinson disease were higher tha n those reported by most previous studies, possibly because of the authorsinte nsive case finding methods involving in person screening.

关键词：帕金森综合征用药资料临床数据队列研究总体发病率基线水平

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William J.Flerlage mark l.dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Efficient photocatalytic reduction of CO2 to formate by a molecular noble metal-free system

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Science China Chemistry 2025年第1期 152-156页

作者： lihua Zhang lingjing Chen Huatian Shi Yue Wei Gui Chen Tai-Chu lau School of Environment and Civil Engineering Research Center for Eco-environmental Engineering Dongguan University of Technology department of Chemistry and Institute of molecular Functional materials City University of Hong Kong

Reducing CO2to carbon-neutral solar fuels can not only alleviate the energy demand but also mitigate the greenhouse *** present,developing an efficient non-noble metal photo/electrocatalytic system for converting CO2to a specific product beyond CO is still a big ***,we report a new cobalt complex bearing 2,2′-bi-1,10-phenanthroline ligand that can photocatalytically reduce CO2to formate （HCOO-）.Turnover number （TON） for HCOO-up to 677 with 99%selectivity can be achieved using organic dyes purpurin as photosensitizer and 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole （BIH） as sacrificial reductant in a CO2-saturated NmP/TEA （v/v,3:1） solution under visible light *** potential electrolysis at-1.41 V （***/Ag Cl） in the presence of 12 m m Et3NHBF4also produced HCOO-with Faradaic efficiency of 39%.Spectroscopic and electrochemical studies suggest that a[CoI-H]species is the key intermediate for CO2reduction.

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Getting physical with medical education:Exercise based virtual anatomy review classes for medical students

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World Journal of methodology 2025年第1期15卷 20-25页

作者： Nadeesha R Samarasinghe Taniya S Nagpal michele l Barbeau Charys m martin Division of General Surgery Faculty of MedicineUniversity of British ColumbiaVancouver V6T 1Z3BCCanada Faculty of Kinesiology Sport and RecreationUniversity of AlbertaEdmonton T6G 2R3ABCanada Anatomy and Cell Biology University of Western OntarioLondon N6A 3K7ONCanada department of Anatomy and Cell Biology Schulich School of Medicine and DentistryThe University of Western OntarioLondon N6A 3K7ONCanada

The benefits of regular physical activity are well ***,few studies have examined the effectiveness of integrating physical activity(PA)into curricula within a post-secondary *** investigate the incorporation of PA into medical curriculum,we developed a series of optional exercise-based review sessions designed to reinforce musculoskeletal(mSK)anatomy course *** synchronous sessions were co-taught by a group fitness instructor and an anatomy *** fitness instructor would lead students through both strength and yoga style exercises,while the anatomy instructor asked questions about relevant anatomical structures related to course material previously *** the sessions,participants were asked to evaluate the classes on their self-reported exam preparedness in improving mSK anatomy knowledge,PA levels,and mental *** participants completed surveys;a majority agreed that the classes increased understanding of mSK concepts(90.0%)and activity levels(97.7%).many(70.0%)felt that the classes helped reduce *** majority of respondents(90.0%)agreed that the classes contributed to increased feelings of social ***,medical students saw benefit in PA based interventions to supplement mSK course *** with increasing activity levels and promoting health behaviours,integrating PA into medical curriculum may improve comprehension of learning material,alleviate stress and foster social connectivity among medical students.

关键词： medical education musculoskeletal Anatomy Exercise Online learning

Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications

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Neural Regeneration Research 2025年第5期20卷 1324-1335页

作者： Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian mustroph David Gimbel Jonathan Grossberg Daniel l.Barrow matthew F.Gary Ali m.Alawieh department of Neurosurgery Emory University School of MedicineAtlantaGAUSA department of Neurology Yale UniversityNew HavenCTUSA Center for Neurotrauma Multiomics&Biomarkers(CNMB)Morehouse School of MedicineAtlantaGAUSA

Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery in this *** the thorough investigation of the complement system in triggering and propagating cerebral neuroinflammation,a similar role for complement in spinal neuroinflammation is a focus of ongoing *** this work,we survey the current literature investigating the role of complement in spinal cord injury including the sources of complement proteins,triggers of complement activation,and role of effector functions in the *** study relevant data demonstrating the different triggers of complement activation after spinal cord injury including direct binding to cellular debris,and or activation via antibody binding to damage-associated molecular *** effector functions of complement have been implicated in spinal cord injury,and we critically evaluate recent studies on the dual role of complement anaphylatoxins in spinal cord injury while emphasizing the lack of pathophysiological understanding of the role of opsonins in spinal cord *** this pathophysiological review,we systematically review the different translational approaches used in preclinical models of spinal cord injury and discuss the challenges for future translation into human *** review emphasizes the need for future studies to dissect the roles of different complement pathways in the pathology of spinal cord injury,to evaluate the phases of involvement of opsonins and anaphylatoxins,and to study the role of complement in white matter degeneration and regeneration using translational strategies to supplement genetic models.

关键词： complement neuroinflammation neuroplasticity regeneration spinal cord injury targeted therapy

Effect of Training on Two-way Shape memory Effect and Its Stability in a Ti-Ni-Hf High Temperature Shape memory Alloy

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Journal of materials Science & Technology 2003年第6期19卷 590-592页

作者： XianglongmENG WeiCAI K.T.lau l.m.ZHOU lianchengZHAO SchoolofmaterialsScience&Engineering HarbinInstituteofTechnologyHarbin150001China departmentofmechanicalEngineering TheHongKongPolytechnicUniversityHungHomKowloonHongKongChina

The Effect of the thermal cycling training under constant strain on the two-way shape memory effect (TWSmE) in a Ti36l\li49Hf15 high temperature shape memory alloy (SmA) has been investigated by bending tests. The results indicated that the training procedure is beneficial to get the better TWSmE. The two-way shape memory strain increases with increasing the training strain. And it decreases with increasing the training temperature. The TWSmE obtained in the present alloy shows poorer stability compared with that obtained in the TiNi alloys.

关键词： TiNiHf alloy High temperature shape memory alloy Two-way shape memory effect Training

Phase Transformation and Thermal Stability of Aged Ti-Ni-Hf High Temperature Shape memory Alloys

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Journal of materials Science & Technology 2006年第5期22卷 691-695页

作者： Xianglong mENG Wei CAI K.T.lau l.m.Zhou liancheng ZHAO School of materials science ＆ Engineering Harbin Institute of Technology Harbin 150001 China department of mechanical Engineering The Hong Kong Polytechnic umversity Hung Horn KowloonHong Kong China

The use of Ni-rich TiNiHf alloys as high temperature shape memory alloys （SmAs） through aging has been presented. For Ni-rich Ti80-xNixHf20 alloys, their phase transformation temperatures are averagely increased more than 100 K by aging at 823 K for 2 h. Especially for the alloys with Ni-content of 50.4 at. pct and 50.6 at. pct, their martensitic transformation start temperatures （ms） are more than 473 K after aging. TEm observation confirmed that some fine particles precipitate from the matrix during aging. The aged Ni-rich TiNiHf SmAs show the better thermal stability of phase transformation temperatures than the solutiontreated TiNiHf alloys. The fine particles precipitated during aging should be responsible for the increase of phase transformation temperatures and its high stability.

关键词： TiNiHf alloy High temperature shape memory alloy Aging Phase transformation