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大堆积密度骨料配制的混凝土的性能(英文)

硅酸盐学报 2012年第1期40卷 27-32页

作者： jacob HENSCHEN David lange University of Illinois Urbana IL 61820-5711 USA

当今世界对可持续发展的关注促进了低水泥用量混凝土建筑工程的产生。增加混凝土中骨料体系的堆积密度是降低水泥用量的一个策略。增加骨料体系的堆积密度可以降低填充骨料颗粒间隙所需要的水泥浆体的量。研究了大堆积密度骨料配制的混... 详细信息

当今世界对可持续发展的关注促进了低水泥用量混凝土建筑工程的产生。增加混凝土中骨料体系的堆积密度是降低水泥用量的一个策略。增加骨料体系的堆积密度可以降低填充骨料颗粒间隙所需要的水泥浆体的量。研究了大堆积密度骨料配制的混凝土。这些混凝土比普通的结构混凝土低15%～25%的水泥用量,当骨料体系级配合理时混凝土工作性好。水泥浆体体积的降低在明显改进混凝土干缩与徐变性能的同时,也会对其工作性产生不利影响。骨料含量不会显著影响不同配比混凝土的抗压强度和劈裂强度。

关键词：可持续发展骨料级配配比设计浆体含量

Behavioral assessment of hippocampal function following dietary intervention

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Food Science and Human Wellness 2018年第3期7卷 229-233页

作者： Klaus W.lange Ewelina Stollberg Yukiko Nakamura joachim Hauser department of Experimental psychology University of Regensburg93040 RegensburgGermany

pattern separation keeps items distinct in memory and is mediated by the hippocampus.A relationship between hippocampal function and diet quality has been suggested by findings in both humans and *** the present study,rats were fed over seven generations a diet containing increased amounts of sugar and saturated fatty acids,reduced levels of polyunsaturated fatty acids and an increased ratio of omega-6/omega-3 fatty acids(“Western”diet).Spatial pattern separation(or local discrimination)performance of these animals was compared with that of rats fed a standard diet.A separation-dependent difference between the standard and Western diet groups was found in the number of discriminations performed in the pattern separation task,with rats of the“Western”group performing fewer *** present results suggest that behavioral assessment of spatial pattern separation can detect effects of dietary interventions in rats and that pattern separation can be impaired by transgenerational administration of a“Western”*** studies should determine which components of this diet induce the memory impairments related to the *** translational relevance of these findings in regard to mental disorders such as dementia and depression needs to be investigated.

关键词： Memory Hippocampus Western diet Fatty acids Sugar

Modification of the full-length cDNA clone of Newcastle disease virus isolated from an outbreak in the goose

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Frontiers in Biology 2006年第4期1卷 389-393页

作者： LIU Yuliang HU Shunli ZHANG Yanmei WU Yantao LIU Xiufan röemer-Oberdoerfer Angela Veits jutta lange Martina Key Laboratory of Animal Infectious Diseases Ministry of AgricultureYangzhou UniversityYangzhou 225009China Institute of Molecular Biology Friedrich-Loeffler-InstitutesFederal Research Centre for Virus Diseases of AnimalsD-17498 Insel RiemsGermany

A 6.5-kb specific fragment containing the T7 promoter and the transcription vector was excised from the full-length cDNA clone of the Newcastle disease virus(NDV)strain ZjI of goose origin,and thereafter it was self-ligated to form a high quality plasmid for ***-directed mutagenesis was used for inserting three additional G nucleotides(nts)into the region between the T7 promoter and the leader sequence of the NDV ***-pCr was employed to amplify the F/HN gene fragments,and then they were ligated by the shared restriction enzyme ***,the corresponding fragment in the mutant full-length cDNA was substituted with the new *** sequencing results showed that the three additional G nts were successfully inserted and the mutant nts in the full-length cDNA were *** study lays a good foundation for research on the reverse genetics of NDV strain ZjI.

关键词： Newcastle disease virus goose site-directed mutagenesis genomic cDNA clone modification

respiratory protection and emerging infectious diseases: lessons from severe acute respiratory syndrome

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Chinese Medical journal 2005年第1期118卷 62-68页

作者： johnH.lange EnvirosafeTrainingandConsultants P.O.Box114022PittsburghPA15239U.S.A

The severe acute respiratory syndrome (SArS) that emerged 2002 -2003 and apparently again 2004 (reported by the news media on december 27, 2003) as the first confirmed case by the World Health Organization (WHO) raised awareness of emerging infectious diseases. Every year there are both new and old infectious diseases emerging as potential pandemic agents. However, few of these diseases receive the public attention and concern expressed as occurred during the emergence of SArS. Much of this concern was a result of the rapid spread of the novel coronavirus (CoV) to different regions of the world and its high infactivity, especially for health care workers (HCW). In many ways, the high percent of HCW infected is a warning of the potential hazards of old and emerging infectious diseases. However, SArS was not the only disease (e. g. monkeypox) that emerged in 2003, rather it received the greatest attention.

关键词： respirator · severe acute respiratory syndrome · hospital epidemiology · emergency management

Comprehensive evaluation of microrNA as a biomarker for the diagnosis of hepatocellular carcinoma

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World journal of Gastroenterology 2022年第29期28卷 3917-3933页

作者： juliane Malik Martin Klammer Vinzent rolny Henry Lik-Yuen Chan Teerha piratvisuth Tawesak Tanwandee Satawat Thongsawat Wattana Sukeepaisarnjaroen juan Ignacio Esteban Marta Bes Bruno Kohler Magdalena Swiatek-de lange Diagnostics GmbH Penzberg 82377Germany Faculty of Medicine The Chinese University of Hong KongHong Kong 999077China NKC Institute of Gastroenterology and Hepatology Songklanagarind HospitalHat Yai 90112Thailand Division of Gastroenterology Faculty of MedicineSiriraj HospitalMahidol UniversityBangkok 10700Thailand department of Internal Medicine Maharaj Nakorn Chiang Mai HospitalChiang Mai UniversityChiang Mai 50200Thailand Faculty of Medicine Srinagarind HospitalKhon Kaen UniversityKhon Kaen 40000Thailand Liver Unit Vall d’Hebron University HospitalBarcelona 08035Spain Transfusion Safety Laboratory Banc de Sang i TeixitsBarcelona 08005Spain department of Medical Oncology National Center for Tumor DiseasesUniversity Hospital HeidelbergHeidelberg 69120Germany Liver Cancer Center Heidelberg University Hospital HeidelbergHeidelberg 69120Germany

BACKGrOUND Hepatocellular carcinoma(HCC) is the most common type of primary liver cancer. Current guidelines for HCC management recommend surveillance of high-risk patients every 6 mo using ultrasonography. Serum biomarkers, like alpha-fetoprotein(AFp), protein induced by vitamin K absence/antagonist-Ⅱ(pIVKA-Ⅱ) and lectin-reactive AFp, show suboptimal performance for detection of HCC, which is crucial for successful resection or treatment. Thus, there is a significant need for new biomarkers to aid early diagnosis of HCC. Studies have shown that the expression level of human microrNAs(mirNAs), a small, non-coding rNA species released into the blood, can serve as an early marker for various diseases, including *** To evaluate the diagnostic role of mirNAs in HCC as single markers, signatures or in combination with known protein *** Our prospective, multicenter, case-control study recruited 660 participants(354 controls with chronic liver disease and 306 participants with HCC) and employed a strategy of initial screening by two independent methods, real-time quantitative pCr(n = 60) and next-generation sequencing(n = 100), to assess a large number of mirNAs. The results from the next-generation sequencing and real-time quantitative pCr screening approaches were then combined to select 26 mirNAs(including two putative novel mirNAs). Those mirNAs were analyzed for their diagnostic potential as single markers or in combination with other mirNAs or established protein biomarkers AFp and pIVKA-Ⅱ via real-time quantitative pCr in training(n = 200) and validation cohorts(n = 300).rESULTS We identified 26 mirNAs that differentiated chronic liver disease controls from(early) HCC via two independent discovery approaches. Three mirNAs, mir-21-5p(mir-21), mir-320a and mir-186-5p, were selected by both methods. In the training cohort, only mir-21, mir-320d and mir-423could significantly distinguish(Q ronic liver disease control grou

关键词： Carcinoma Hepatocellular MicrorNAs Biomarkers Alpha-fetoprotein protein induced by vitamin K absence-Ⅱ Diagnosis

交联密度和交联键分布对Nr/TBIr硫化胶应用性能的影响

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弹性体 2024年第2期34卷 51-58页

作者：王浩李兰阁刘晓孟夏王日国山东京博控股集团有限公司山东滨州256500 山东京博中聚新材料有限公司山东滨州256500 山东华聚高分子材料有限公司山东滨州256500

通过在普通硫磺硫化体系(CV)、半有效硫磺硫化体系(SEV)和有效硫磺硫化体系(EV)中变化促进剂/硫磺用量调控硫化胶的交联密度和交联键分布,研究其对天然橡胶(Nr)和Nr/反式丁戊橡胶(TBIr)硫化胶应用性能的影响。结果表明,交联密度是影响... 详细信息

通过在普通硫磺硫化体系(CV)、半有效硫磺硫化体系(SEV)和有效硫磺硫化体系(EV)中变化促进剂/硫磺用量调控硫化胶的交联密度和交联键分布,研究其对天然橡胶(Nr)和Nr/反式丁戊橡胶(TBIr)硫化胶应用性能的影响。结果表明,交联密度是影响硫化胶应用性能的关键,在CV、SEV和EV硫化体系中提高交联密度,Nr和Nr/TBIr硫化胶的硬度、定伸应力、耐磨耗性能逐渐提高,拉断伸长率、耐疲劳性能和滚动阻力逐渐降低。在同样的交联密度下调控交联键类型由多硫键向单硫键和双硫键转变,Nr和Nr/TBIr硫化胶的耐疲劳性能显著下降。在同样的交联密度和交联键分布下,Nr/TBIr硫化胶相比Nr硫化胶均具有更优异的耐磨耗性能和耐疲劳性能以及更低的滚动阻力,相比Nr硫化胶,降低交联密度会使Nr/TBIr硫化胶在耐磨耗性能上具有更大优势,降低交联密度、提高多硫键比例会使Nr/TBIr硫化胶在耐疲劳性能上具有更大优势。

关键词：天然橡胶反式丁戊橡胶交联密度交联键分布耐疲劳性能

Alterations of attention and impulsivity in the rat following a transgenerational decrease in dietary omega-3 fatty acids

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Food Science and Human Wellness 2018年第1期7卷 49-56页

作者： joachim Hauser Ewelina Stollberg Andreas reissmann Ivo Kaunzinger Klaus W.lange department of Experimental psychology University of Regensburg93040 RegensburgGermany

polyunsaturated fatty acids(pUFAs),particularly the omega-3 pUFAs,are thought to be involved in neuronal processes,to play a role in neurodevelopmental disorders and to be important for the integrity of central nervous system *** present study investigated the effects of nutritional omega-3 pUFAs on attentional functions and impulsive behavior in Wistar *** this purpose,female Wistar rats were fed an omega-3 deficient diet over several generations,and the dams of the seventh generation were randomly assigned to two diet groups and fed an omega-3 deficient or an omega-3 sufficient *** addition,a group of previously untreated dams was fed an omega-3 sufficient *** male offspring of these three diet groups were tested using an established paradigm for the assessment of attention and impulsive behavior,i.e.a modified version of the five-choice-serial-reaction-time task(5CSrTT).The present data show that the deficiency of omega-3 pUFAs over generations led to substantial changes in attentional processes and impulsive *** impairments associated with an omega-3 deficiency were partly corrected by treatment with the omega-3 sufficient diet in the last generation of the omega-3 deficient group which showed substantial improvements in attention *** there were no significant effects of dietary modifications on psychomotor activity levels,there was some evidence for changes in impulsive *** conclusion,transgenerational dietary changes in the availability of omega-3 pUFAs led to changes in attentional processes and impulsive behavior in rats,supporting the hypothesis that omega-3 pUFAs play a role in cognitive and behavioral *** present findings offer a promising approach in the investigation of the role of omega-3 pUFAs in a variety of cognitive and behavioral domains.

关键词： Omega-3 fatty acid polyunsaturated fatty acids Attention Impulsivity Activity rat Neurodevelopmental disorders psychiatric disorders

Can the 5-colour nutrition label“Nutri-Score”improve the health value of food?

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未来食品学报(英文) 2023年第4期3卷 306-311页

作者： robin C.Hau Klaus W.lange Schmalkalden University of Applied Sciences Schmalkalden 98564Germany Faculty of Human Sciences University of RegensburgRegensburg 93040Germany

Obesity and other nutrition-related non-communicable diseases were virtually non-existent before the advent of industrialized food *** recent years,a 5-color front-of-package food label(“Nutri-Score”)seeking to demonstrate the overall nutritional value and healthiness of food products has been adopted for voluntary use in some European *** Nutri-Score is mainly based on the sugar,salt and calorie content of food *** present viewpoint discusses whether the Nutri-Score correctly identifies healthy and unhealthy food items and how large an impact the Nutri-Score may have on consumers’***,other benefits as well as hidden costs and drawbacks in implementing the Nutri-Score will be *** its reducing of the complex information regarding the contents of foods,the Nutri-Score may provide easily intelligible information regarding healthy nutrition and may become a valuable tool in educating consumers and influencing their food *** Nutri-Score may not become a game-changer in combating poor nutrition,but it is helpful in the right *** an inexpensive public policy,such as front-of-package labeling,makes some positive contribution,there is no reason to argue against its *** small effects may be relevant when a measure is adopted at population level.

关键词： Front-of-package food labeling Nutri-Score Food choice Food health value Obesity

Diet and food in attention-deficit hyperactivity disorder

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journal of Future Foods 2022年第2期2卷 112-118页

作者： Klaus W.lange Yukiko Nakamura Andreas reissmann department of Experimental psychology University of RegensburgRegensburg 93040Germany

deficiencies of nutrients,including vitamins,minerals and polyunsaturated fatty acids,and surpluses of food items,such as sucrose and artificial food additives,have not convincingly been shown to be involved in the etiology of *** group level,there is no conclusive evidence supporting dietary interventions for the treatment of *** identification of a role of food compounds in ADHD is hindered by the complex and ill-defined nature of *** view of the heterogeneity of the disorder,potential therapeutic benefits of nutritional interventions could be confined to subpopulations of children with ADHD as yet *** cumulative benefits of the range of ingredients comprising healthy diets may result in better outcomes compared to a supplementation of individual *** and nutrition interact with other lifestyle factors,such as physical activity,and the interrelationship between nutrition and lifestyle should play a more prominent role in research on treatment approaches to *** few-foods or oligoallergenic diet allows the design of individually tailored diets and may offer treatment opportunities in subgroups of children diagnosed with *** research is required to demonstrate the utility of nutrition-related interventions alone or in combination with other treatment approaches in ADHD.

关键词： Attention-deficit hyperactivity disorder Dietary patterns Food Nutrition Oligoallergenic diet