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Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl_4-induced hepatic fibrosis

World Journal of Gastroenterology 2008年第13期14卷 2100-2105页

作者： Xiao-Ling Wu Wei-Zheng Zeng Ming-de jiang jian-Ping Qin Hui Xu department of Digestion General Hospital of Chengdu Military Command Chengdu 610083 Sichuan Province China

AIM： To explore the anti-fibrotic effect of Oxymatrine on CCl4-induced liver fibrosis in rats and its modulation on the TGFbeta-Smad signaling pathway. METHODS： One hundred healthy male SD rats were randomly divided into three groups： normal group （n = 20）, treatment group of Oxymatrine （n = 40） and CCh-induced fibrosis group （n = 40）. Experimental hepatic fibrosis was induced by subcutaneous injection of carbon tetrachloride （CCh soluted in liquid paraffin with the concentration of 300 g/L, the dosage of injection was 3 mL/kg, twice per week for 8 wk）. The treated rats received Oxymatrine via celiac injection at a dosage of 10 mg/kg twice a week at the same time. The deposition of collagen was observed with H＆E and Masson staining. The concentration of serum TGF-β1 was assayed with ELISA. The gene expression of Smads and CBP （CREB binding protein） was detected with in situ hybridization （ISH） and immunohistochemistry （IH）, respectively. All the experimental figures were scanned and analyzed with special figure-analysis software. RESULTS： A significant reduction of collagen deposition and rearrangement of the parenchyma was noted in the liver tissue of Oxymatrine-treated rats. The semi- quantitative histological scores （2.43 ± 0.47 μm^2 vs 3.76 ±0.68, P 〈 0.05） and average area of collagen/in those rats were significantly decreased when compared with hepatic cirrhosis model rats （94.41 ± 37.26 μm^2 vs 290.86 ± 89.37 μm^2, P 〈 0.05）. The gene expression of Smad 3 mRNA was considerably decreased in the treated animals. The A value of Smad 3 mRNA was lower in the treated rats than the model rats （0.034 ± 0.090 vs 0.167 ± 0.092, P 〈 0.05）. Contrarily, the A value of Smad 7 mRNA was increased considerably in the treated animals （0.175 ± 0.065 vs 0.074 vs 0.012, P 〈 0.05）. There was an obvious decrease in the expression of CBP mRNA in treated rats as illuminated by a reduction of its A value when compared with model rats （0.065±0.049 vs 0.235 ± 0.025, P 〈 0.001）. CONCLUSI

关键词： Oxymatrine Hepatic Fibrosis TGF-Smad signaling

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Effect of simvastatin on endothelium-dependent vaso-relaxation and endogenous nitric oxide synthase inhibitor

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Acta Pharmacologica Sinica 2004年第7期25卷 47-55页

作者： Jun-lin jiang, de-jian jiang, Yu-hai TANG, Nian-sheng LI, Han-wu deNG, Yuan-jian LI1 department of Pharmacology, Schoolof Pharmaceutic Sciences, Central South University, Changsha 410078, China department of Pharmacology School of Pharmaceutic Sciences Central South University Changsha 410078

AIM: To investigate the effect of simvastatin on endothelium-dependent vasorelaxation and endogenous nitric oxide synthesis inhibitor asymmetric dimethylarginine (ADMA) in rats and cultured ECV304 cells. METHODS: Endothe- lial injury was induced by a single injection of low density lipoprotein (LDL) (4 mg/kg, 48 h) in rats or incubation with LDL (300 mg/L) or oxidative-modified LDL (100 mg/L) in cultured ECV304 cells, and vasodilator responses to acetylcholine (ACh) in the aortic rings and the level of ADMA, nitrite/nitrate (NO) and tumor necrosis factor- alpha (TNF-α) in the serum or cultured medium were determined. And the adhesion of the monocytes to endothe- lial cells and the activity of dimethylarginine dimethylaminohydrolase (DDAH) in the cultured ECV304 cells were measured. RESULTS: A single injection of LDL decreased endothelium-dependent relaxation to ACh, markedly increased the serum level of endogenous ADMA and TNF-α, and reduced serum level of NO. Pretreatment with simvastatin (30 or 60 mg/kg) markedly attenuated inhibition of vasodilator responses to ACh, the increased level of TNF-α and the decreased level of NO by LDL, but no effect on serum concentration of endogenous ADMA. In cultured ECV304 cells, LDL or ox-LDL markedly increased the level of ADMA and TNF-α and potentiated the adhesion of monocytes to endothelial cells, concomitantly with a significantly decrease in the activity of DDAH and serum level of NO. Pretreatment with simvastatin (0.1, 0.5, or 2.5 μmol/L) markedly decreased the level of TNF- α and the adhesion of monocytes to endothelial cells, butdid not affectthe concentration of endogenous ADMA and the activity of DDAH. CONCLUSION: Simvastatin protect the vascular endothelium against the damages induced by LDL or ox-LDL in rats or cultured ECV304 cells, and the beneficial effects of simvastatin may be related to the reduction of inflammatory cytokine TNF-α level.

关键词： simvastatin vasodilation tumor necrosis factor endogenous nitric oxide synthase inhibitor LDL lipoproteins

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A new flavonoid from Selaginella tamariscina

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Chinese Chemical Letters 2009年第5期20卷 595-597页

作者： jian Feng Liu Kang Ping Xu de jian jiang Fu Shuang Li jian Shen Ying Jun Zhou Ping Sheng Xu Bin Tan Gui Shan Tan School of Pharmaceutical Sciences Central South University Changsha Hunan 410013 China Xiangya Hospital of Central South University Changsha Hunan 410008 China Xiangnan University Chenzhou Itunan 423000 China

6-（2-Hydroxy-5-acetylphenyl）-apigenin （1）, a new flavonoid with a phenyl substituent, was first isolated from Selaginella tamariscina. Its structure was elucidated on the basis of 1D and 2D NMR as well as ESI-HR-M... 详细信息

关键词： Selaginella tamariscina Flavonoids 6-(2-Hydroxy-5-acetylphenyl)-apigenin

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Asymmetric dimethylarginine induces apoptotic death in vascular smooth muscle cells: a preliminary result

Asymmetric dimethylarginine induces apoptotic death in vascu...

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第十五届国际药理学大会

作者： Qiong Yuan, de-jian jiang, Han-Wu deng, Yuan-jian Li department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha 410078, China

＜正＞ Objective: Endogenous nitric oxide synthase inhibitor asymmetric dimethylargi-nine （ADMA） is recently ascribed as a novel pro-atherogenic molecular. The aim of the present study was to investigate the effect of ADMA on apoptosis of vascular smooth muscle cells （VSMC）. Methods: Rat primary VSMC were cultured and freated with different concentrations （1-30 μM） of ADMA for various periods （24-72 h）. Cell viability and apoptosis were evaluated by MTT test and DNA fragmentation analysis, respectively. Results: As shown by MTT. ADMA decreased cellular viability of VSMC in a dose- and time-dependent manner. Apop-totic DNA fragments were observed when VSMC is freated with 10 μM ADMA for 48 h. Conclusion: ADMA has cell toxic effect and induces the apoptosis in VSMC. which may contribute to its pro-atherogenic activity. The precise mechanisms involved in such effects of ADMA need to be further investigated.

关键词： Asymmetric dimethylarginine Apoptosis Vascular smooth muscle cells

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Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： jian Yang jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu Lei Bai Xiang Li Zhengquan Yu Haiying Li department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

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The Anatomy of Leaf and the Cellular Localization of Rubisco and ItsActivase in Amaranthus tricolor L

The Anatomy of Leaf and the Cellular Localization of Rubisco...

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中国植物生理学会第九次全国会议

作者： de-An jiang jian HONG Wei-Bing WANG Dong-Wei HU State Key Laboratory of Plant Physiology and Biochemistry of College of Life Sciences Institute of Biotechnology, Zhejiang University, Hangzhou 310029, China

＜正＞ Amaranthus tricolor L., a vegetable widely cultivated in China as well in the world, belongs to the NADME photosynthetic subpathway of C4dicot. However, there is no report available on Amaranthus tricolorL. leaf anatomic structure, chloroplast ultrastructure, Rubisco and RCA locations so far. In present paper we illustrate further the photosynthetic characteristic from the leaf anatomy, chloroplast ultrastructure and the subcellular location of Rubisco and *** leaf structure feature exhibits 3 layers of chlorenchyma on the vascular bundle periphery, mesophyll parenchyma cells （MSCs） with a few of chloroplasts, outer larger

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直接转矩控制系统的两种速度估计器比较研究

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微电机 2010年第2期43卷 66-69页

作者：姬宣德蒋建虎洛阳理工学院电气工程与自动化系洛阳471023

采用全阶磁链闭环观测器以实现直接转矩控制系统定子磁链的准确观测。在此基础上推导了两种速度估计器,并对上述两种速度估计器对比仿真和实验。仿真和实验结果表明:依据模型参考自适应理论设计出的速度估计器比依据李亚普诺夫理论构造... 详细信息

采用全阶磁链闭环观测器以实现直接转矩控制系统定子磁链的准确观测。在此基础上推导了两种速度估计器,并对上述两种速度估计器对比仿真和实验。仿真和实验结果表明:依据模型参考自适应理论设计出的速度估计器比依据李亚普诺夫理论构造的速度估计器辨识速度收敛快,动态性能更好。

关键词：交流感应电动机直接转矩控制速度估计器模型参考自适应

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Clinicopathological differences between patients with schistosomal appendicitis and non schistosomal appendicitis:A retrospectively study of past ten years

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World Journal of Clinical Cases 2025年第2期13卷 24-32页

作者： Xiao-Yi Wang Yao Hao Zi-jian Wang Xiu-Liang Xu jiang-Hua Yang department of Infectious Diseases The First Affiliated of Wannan Medical CollegeWuhu 241001Anhui ProvinceChina

BACKGROUND Chronic schistosomiasis causes multiple organ and multiple system diseases,especially the digestive *** eggs are mainly deposited in the stomach,liver and colorectal,but a few eggs are deposited in the appendix and cause *** present,there are few studies on schistosomal *** To explore the differences in epidemiological,clinical and pathological characteristics between schistosomal appendicitis and non-schistosomal appendicitis over the past decade in order to assess the impact of schistosomiasis on *** The differences of general data,clinical data and laboratory examination data of patients with appendicitis from October 2013 to October 2023 were retrospectively *** patients were divided into two groups for *** were 136 patients in schistosomal appendicitis group and 5418 patients in non-schistosomal appendicitis *** Schistosomal appendicitis accounted for 2.45%of all patients with appendicitis,and the annual proportion in the past decade was 2.2%,2.9%,1.8%,1.9%,3.4%,3.1%,1.9%,1.6%,3%,2.6%,*** prevalence of schistosomal appendicitis was middle-aged and elderly males,with an average age of 61.73±15.335 *** main population of non-schistosomal appendicitis was middle-aged men,with an average age of 35.8±24.013 years(Pdence of acute suppurative appendicitis in non-schistosomal appendicitis was higher than that in schistosomal appendicitis[odds ratio(OR)=0.504;95%confidence interval(CI):0.349-0.728;P<0.001].The proportion of acute attack of chronic appendicitis in schistosomal appendicitis was higher than that in non-schistosomal appendicitis(OR=2.614;95%CI:1.815-3.763;P<0.001).The proportion of schistosomal appendicitis patients complicated with colorectal cancer was higher than that of nonschistosomal appendicitis patients(OR=5.087;95%CI:1.427-

关键词： Schistosomal appendicitis Schistosomiasis Appendix Colorectal cancer Clinicopathological characteristics

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Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

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World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui Yu Yan Xie jian Yu Kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang Yu-Ying Tan Li Zhang Wen-Tao jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

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Software Package: An Advanced Theoretical Tool for Inhomogeneous Fluids(Atif)

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Chinese Journal of Polymer Science 2022年第2期40卷 220-230页

作者： jian jiang Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

In spite of the impending flattening of Moore’s law,the complexity and size of the systems we are interested in keep on *** challenges the computer simulation tools due to the expensive computational ***,advanced theoretical methods can be considered as alternatives to accurately and efficiently capture the structural and thermodynamic properties of complex inhomogeneous *** the last decades,classical density functional theory(cDFT)has proven to be a sophisticated,robust,and efficient approach for studying complex inhomogeneous *** this work,we present a pedagogical introduction to a broadly accessible open-source density functional theory software package named"an advanced theoretical tool for inhomogeneous fluids"(Atif)and of the underlying *** demonstrate Atif,we take three cases as examples using a typical laptop computer:(i)electric double-layer of asymmetric electrolytes;(ii)adsorptions of sequencedefined semiflexible polyelectrolytes on an oppositely charged surface;and(iii)interactions between surfaces mediated by *** believe that this pedagogical introduction will lower the barrier to entry to the use of Atif by experimental as well as theoretical groups.A companion website,which provides all of the relevant sources including codes and examples,is attached.

关键词： Polyelectrolytes Complex fluids Software density functional theory Self-defined sequence

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