检索结果-南通市图书馆

A systematic review of salivary biomarkers in Parkinson's disease

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第12期19卷 2613-2625页

作者： maria Ilenia de Bartolo Daniele Belvisi Romina Mancinelli Matteo Costanzo Claudia Caturano Giorgio Leodori Alfredo Berardelli Giovanni Fabbrini Giorgio Vivacqua IRCCS Neuromed PozzilliItaly department of Human Neurosciences Sapienza University of RomeRomeItaly department of Anatomical HistologicalForensic Medicine and Orthopedics SciencesSapienza University of RomeRomeItaly department of Experimental Morphology and Microscopy-Integrated Research Center(PRAAB)-Campus Biomedico University of Rome RomeItaly

The search fo r reliable and easily accessible biomarkers in Parkinson's disease is receiving a growing emphasis,to detect neurodegeneration from the prodromal phase and to enforce disease-modifying therapies.despite the need for non-invasively accessible biomarke rs,the majo rity of the studies have pointed to cerebrospinal fluid or peripheral biopsies biomarkers,which require invasive collection procedures.Saliva represents an easily accessible biofluid and an incredibly wide source of molecular biomarkers.In the present study,after presenting the morphological and biological bases for looking at saliva in the search of biomarkers for Parkinson's disease,we systematically reviewed the results achieved so far in the saliva of different cohorts of Parkinson's disease patients.A comprehensive literature search on PubMed and SCOPUS led to the discovery of 289articles.After screening and exclusion,34 relevant articles were derived fo r systematic review.Alpha-synuclein,the histopathological hallmark of Parkinson's disease,has been the most investigated Parkinson's disease biomarker in saliva,with oligomeric alphasynuclein consistently found increased in Parkinson's disease patients in comparison to healthy controls,while conflicting results have been reported regarding the levels of total alpha-synuclein and phosphorylated alpha-synuclein,and few studies described an increased oligomeric alpha-synuclein/total alpha-synuclein ratio in Parkinson's disease.Beyond alpha-synuclein,other biomarkers to rgeting diffe rent molecular pathways have been explored in the saliva of Parkinson's disease patients:total tau,phosphorylated tau,amyloid-β1-42(pathological protein aggregation biomarkers);DJ-1,heme-oxygenase-l,metabolites(alte red energy homeostasis biomarkers);MAPLC-3beta(aberrant proteostasis biomarker);cortisol,tumor necrosis factor-alpha(inflammation biomarkers);DNA methylation,miRNA(DNA/RNA defects biomarkers);acetylcholinesterase activity(synaptic and neuronal network dysfunction biomarkers);Raman spectra,proteome,a

关键词： alpha-synuclein amyloid-beta autophagy DJ-1 neurodegeneration neuroinflammation Parkinson's disease salivary biomarkers tau

Surgical management of tegmen defects of the temporal bone and meningoencephalic herniation: our experience

在线全文

学校读者我要写书评

暂无评论

Journal of Otology 2024年第1期19卷 30-34页

作者： Giuseppe de Donato Emanuela Fuccillo Alberto maria Saibene Elena Ferrari Giorgia Carlotta Pipolo Antonia Pisani Liliana Colletti Anastasia Urbanelli Luigi de Donato Giovanni Felisati Otorhinolaryngology Unit Head and Neck DepartmentASST Santi Paolo e Carlo HospitalVia Antonio di Rudinì820142MilanItaly department of Health Sciences University of MilanVia Festa del Perdono720122MilanItaly department of Biomedical Surgical and Dental SciencesUniversity of MilanVia Festa del Perdono720122MilanItaly ENT Unit Department of Surgical SciencesUniversity of TurinVia Verdi810124TurinItaly

1. Introduction The tegmental wall of the tympanic cavity is a thin plate of the temporal bone that separates the middle cranial fossa(MCF) from the ear. This anatomical region consists of two areas: an anterior one, comprised of the tegmen tympani(To′th et al., 2007), and a posterior one, formed by the tegmen antri and the tegmen mastoideum(Makki et al., 2011). In some patients, the tegmental region of the temporal bone can be interrupted, causing a tegmen defect(TD). A TD is sometimes associated with a meningoencephalic herniation(MEH), in which brain tissue herniates through a TD.

关键词： al. herniation bone

Long-term assessment of collagenase treatment for Dupuytren’s contracture:A 10-year follow-up study

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第4期15卷 355-362页

作者： Marco Passiatore Vitale Cilli Adriano Cannella Ludovico Caruso Giulia maria Sassara Giuseppe Taccardo Rocco de Vitis department of Bone and Joint Surgery ASST-Spedali CiviliBrescia 25123Italy department of Chirurgie de la Main Centre Hospitalier Interregional Edith CavellBruxelles 1160Belgium department of Orthopedics Fondazione Policlinico Universitario Agostino Gemelli IRCSSRome 00168Italy

BACKGROUND Enzymatic fasciotomy with collagenase clostridium histolyticum(CCH)has revolutionized the treatment for Dupuytren’s contracture(DC).despite its benefits,the long-term outcomes remain unclear.This study presented a comprehensive 10-year follow-up assessment of the enduring effects of CCH on patients with DC.AIM To compare the short-term(12 wk)and long-term(10 years)outcomes on CCH treatment in patients with DC.METHODS A cohort of 45 patients was treated with CCH at the metacarpophalangeal(MCP)joint and the proximal interphalangeal(PIP)joint and underwent systematic reevaluation.The study adhered to multicenter trial protocols,and assessments were conducted at 12 wk,7 years,and 10 years post-surgery.RESULTS Thirty-seven patients completed the 10-year follow-up.At 10 years,patients treated at the PIP joint exhibited a 100%recurrence.However,patients treated at the MCP joint only showed a 50%recurrence.Patient satisfaction varied,with a lower satisfaction reported in PIP joint cases.Recurrence exceeding 20 degrees on the total passive extension deficit was observed,indicating a challenge for sustained efficacy.Significant differences were noted between outcomes at the 7-year and 10-year intervals.CONCLUSION CCH demonstrated sustained efficacy when applied to the MCP joint.However,caution is warranted for CCH treatment at the PIP joint due to a high level of recurrence and low patient satisfaction.Re-intervention is needed within a decade of treatment.

关键词： Collagenase Xiapex Dupuytren disease Dupuytren recurrence Long term follow-up

Arlenea delicata gen.et sp.nov.,a new ephedroid plant from the Early Cretaceous Crato Formation,Araripe Basin,Northeast Brazil

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Plant Diversity 2024年第3期46卷 362-371页

作者： Alita maria Neves Ribeiro Yong Yang Antonio Alamo Feitosa Saraiva Renan Alfredo Machado Bantim Joao Tavares Calixto Junior Flaviana Jorge de Lima Programa de Pos-Graduaçao em Diversidade Biologica e Recursos Naturais Universidade Regional do CaririRua Carolino SucupiraPimenta63105-160CratoCearaBrazil Co-Innovation Center for Sustainable Forestry in Southern China College of Biology and the Environment159 Longpan RoadNanjing Forestry UniversityNanjing210037China Laboratorio de Paleontologia Universidade Regional do CaririRua Carolino SucupiraPimenta63105-160CratoCearaBrazil Laboratorio de Estudos da Flora Regional Universidade Regional do CaririRua Carolino SucupiraPimenta63105-160CratoCearaBrazil Gondwanan Plants Lab Universidade Federal de PernambucoCentro Academico de VitoriaRua Do Alto Reservatorio S/nBela Vista55608-680Vitoria de Santo AntaoPernambucoBrazil Programa de Pos-Graduaçao em Geociencias(PPGEOC) Universidade Federal de Pernambuco(UFPE)Rua Av.da ArquiteturaS/n°CEP-50740-550Cidade UniversitariaRecifePernambucoBrazil

Ephedroid macrofossils have been widely documented in Cretaceous deposits,including numerous from the Lower Cretaceous Yixian Formation of NE China.However,few ephedroid macrofossils have been reported from South America.Herein,we describe a new plant of the family Ephedraceae,Arlenea delicata gen.et sp.nov.,from the Lower Cretaceous Crato Formation of the Araripe Basin,Northeast Brazil,based on the vegetative and reproductive structures.It has the typical morphological characteristics of ephedroid plants,including fertile reproductive branches,opposite phyllotaxy,terminal female cones,a sympodial branching system,longitudinally striated internodes,and swollen nodes.Our new finding is unusual in having inner chlamydosperms subtended by two pairs of bracts,reproductive units connected to branches through swollen receptacles and a smooth seed surface.This new ephedroid taxon from the Crato Formation increases our understanding of plant diversity of this group during the Early Cretaceous.Furthermore,the general morphology(fleshy bracts and enlarged receptacles)of this new fossil discovery indicates that seeds of this plant may have been dispersed by animals such as pterosaurs(mainly the Tapejaridae)and birds(Enantiornithes and Ornituromorpha).If true,this would explain the cosmopolitan distribution of Ephedraceae in the Lower Cretaceous.

关键词： Early Cretaceous Gnetophytes Arlenea delicata Ephedrales Crato Formation

Non-invasive prenatal testing can detect silent cancers in expecting mothers

在线全文

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第2期11卷 585-588页

作者： Alessandro Ottaiano Monica Ianniello Nadia Petrillo mariachiara Santorsola Luigia de Falco Salvatore Giovanni Castaldi maria Antonietta Castaldi Valentina Giudice Carmine Selleri Giovanni Savarese Unit of Innovative Therapies for Abdominal Metastases Istituto Nazionale Tumori di NapoliIRCCS “G.Pascale”Via Mariano SemmolaNapoli 80131Italy AMES Centro Polidiagnostico Strumentale SRLVia Padre Carmine Fico 24Casalnuovo Di Napoli 80013Italy Specialization School of Clinical Pathology Università degli Studi di SalernoVia Giovanni Paolo II 132Fisciano 84084Italy Unit of High-Risk Pregnancy and Prenatal Diagnosis University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy Hematology and Transplant Center University Hospital “San Giovanni di Dio e Ruggi d'Aragona”Via San LeonardoSalerno 84125Italy department of Medicine Surgery and Dentistry“Scuola Medica Salernitana”Via Salvador Allende 43Baronissi 84081Italy

Pregnancy is a unique physiological state in which several changes occur.One of the most important aspects is the maternal immune system,which sets to tolerate the presence of thedeveloping fetus(a semi-allogeneic organism),while at the same time providing protection against pathogens.1 Pregnancy has long been known to affect the risk of certain cancers including breast cancer in the short term,gestational trophoblastic disease(GTD),cervical cancer,and melanoma.2,3 The reasons for the increased risk of these cancers during pregnancy are not fully understood,but several hypotheses have been proposed as the hormonal and immune system changes.

关键词： mother cancers fetus

Hemiarthroplasty for irreparable distal radius fractures in the elderly:A comprehensive review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2024年第6期15卷 578-584页

作者： Adriano Cannella Ludovico Caruso Giulia maria Sassara Giuseppe Taccardo Marco Passiatore Marina Marescalchi Rocco de Vitis department of Orthopaedics Fondazione Policlinico Universitario A Gemelli IRCCSRome 00168Italy department of Bone and Joint Surgery ASST-Spedali CiviliBrescia 25123Italy

BACKGROUND Elderly patients maintaining functional independence can now be candidates for primary wrist hemiarthroplasty to manage acute irreparable distal radius fractures(DRFs).However,further investigation with long-term follow-up is required to validate these initial findings.AIM To review the literature on the outcomes of distal radius hemiarthroplasty with available implants to assess its viability as a treatment option.METHODS A comprehensive review of the literature was conducted using electronic databases,including PubMed,Medline,and Scopus.The search terms employed were"distal radius fracture","hemiarthroplasty","wrist arthroplasty",and related terminology.The search was restricted to articles published in English from 1980 until June 2023.Inclusion criteria encompassed cases or case series of DRF treated with hemiarthroplasty,providing clinical or radiographic outcomes,and published in peer-reviewed journals.RESULTS A total of 2508 articles from PubMed and 883 from Scopus were identified initially.Following screening and removal of duplicates,13 articles met the inclusion criteria.These articles,predominantly clinical retrospective studies,provided insights into hemiarthroplasty outcomes,including functional improvements and complications.Hemiarthroplasty was a treatment option for complex DRF,particularly those cases with severe comminution,intraarticular involvement,or severe osteoporosis.Functional outcomes demonstrated improvements in pain relief,wrist mobility,and grip strength,with variability across studies.Complications included implant loosening,infection,nerve injury,and stiffness,with varying incidence rates influenced by surgical techniques and implant choice.Long-term outcomes were inadequately documented,warranting further research.CONCLUSION Hemiarthroplasty is a promising treatment for irreparable DRF in the elderly.Long-term outcomes and complications require further study.

关键词： Irreparable distal radius fracture Hemiarthroplasty Osteoporosis Wrist prosthesis Elderly

Motivations for and barriers to innovation in non-profit organizations: The case of nursing homes in Northern Portugal

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

International Journal of Innovation Studies 2024年第1期8卷 25-44页

作者： Ana Rita Gonçalves Lopes Aldina Isabel de Azevedo Correia Alexandra maria da Silva Braga Center for Research and Innovation in Business Sciences and Information Systems School of Management and TechnologyPolitecnico do PortoRua do Curral-Margaride4610-156 FelgueirasPortugal

To contribute to the empirical literature on innovation in non-profit organizations,this study examines innovation in Private Social Solidarity Institutions with social responses for the elderly in Northern Portugal.It enriches the literature by clarifying the concept of innovation applied to non-profit organizations,which represents a perspective different from the business context.Moreover,it is important to support the innovation decisionmaking process in similar non-profit organizations.For this study,the population was surveyed through questionnaires based on the PUBLIN research project,which has already been applied in different countries,and the targets were employees of organizations with social responses for the elderly.Our sample is small,with 28 respondent institutions and 51 employees,but it is representative,as it includes institutions from all districts in Northern Portugal.The study employed a quantitative approach,particularly factor analysis,multiple linear regression,and correlation analyses,using scales already applied in other dimensions of the social sector,to understand the effect of each innovation dimension/determinant on creativity and innovation in nonprofit organizations.The results show that in these organizations with social responses for the elderly,learning orientation,risk-taking,and job satisfaction have a positive impact on innovation.

关键词： determinants of innovation non-profit organizations social responses for the elderly Northern Portugal

Metabolic characterization of selected probiotic consortia during gluten and wheat bread simulated digestion

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Mirco Vacca Giuseppe Celano Olga Nikoloudaki Bodo Speckmann Francesco maria Calabrese Marco Gobbetti maria de Angelis Faculty of Science and Technology Free University of Bozen Evonik Operations GmbH department of Soil Plant and Food Sciences University of Bari Aldo Moro

While exerting their metabolic activities in the gastrointestinal milieu， probiotics impact the host well-being by boosting immunity， treating metabolic disorders， and modulating microbiota and metabolome. Due to the high incidence of gluten-based disorders， the present work aims to deeply explore the metabolism of two selected microbial consortia (MCs) during gluten digestion under simulated gastrointestinal conditions. Featured by high protease and peptidase activity， both MCs accounted for different lactic acid bacteria and Bacillus strains that were combined with two commercial protease enzymes. Gluten substrates were used as purified extracts， white and whole wheat breads. Control samples， instead， relied onto the microbial enzyme lack. Twenty-four hours of simulated digestion were sufficient to completely hydrolyze gluten in one of the two MC-containing experimental sets， and the relative 48 h-digested extract did not alter the cytokine expression in duodenal biopsies from celiac disease (CeD) patients. When digested samples were assayed for antioxidant and phytase activities， microbial enzymes demonstrated to significantly improve both ABTS and DPPH values and to decrease the phytic acid concentration. The inspection of the free amino acid profiles allowed for distinguishing the two MCs， whereas the detection of a heterogeneous panel of volatile organic compounds supported the presence/activity of microbial enzymes without statistically significant differences between MCs. As functional contribution， digested extracts with MCs also proved to reduce the inflammatory cytokine concentrations in cell lines exposed to lipopolysaccharide trigger. Therefore， in line with studies exploring novel adjuvant therapies， the present innovative probiotic consortium featured by high gluten-hydrolyzing metabolism also showed the capability to improve various parameters usually found to be altered in patients affected by gluten-based disorders or CeD.

关键词：

Current Topics in Acute Abdomen: Causes, Diagnostics, and Emerging Therapies

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Biosciences and Medicines 2024年第5期12卷 171-177页

作者： Lucas de Oliveira Varca maria Carolina de Almeida Santo department of Medicine Universidade do Oeste Paulista Guaruj&#225 Brazil

Acute abdomen is a serious clinical condition that requires immediate attention due to its association with intense pain and rapid progression. This article reviews important aspects of the causes, diagnostics, and treatments of acute abdomen. The research highlights the diversity of etiologies, ranging from the most common, such as acute appendicitis, to the less frequent, such as intestinal perforations by foreign bodies. Complex diagnostic methods, including clinical examinations and imaging such as computed tomography, are essential to guide accurate diagnosis, given the overlap of symptoms among different conditions. Therapeutic approaches range from conservative treatments with clinical observation and antibiotic therapy to urgent surgical interventions, such as appendectomy and cholecystectomy. Laparoscopy stands out as a promising approach, offering advantages in terms of recovery and post-operative morbidity. However, the impact of the COVID-19 pandemic has brought additional challenges to the diagnosis and treatment of acute abdomen, with delays and difficulties in accessing healthcare. This review underscores the importance of a multidisciplinary approach and constant updates among healthcare professionals in addressing acute abdomen, aiming for accurate diagnoses and appropriate therapeutic interventions to improve clinical outcomes and reduce morbidity and mortality associated with this complex clinical condition.

关键词： Component Formatting Style Styling Insert