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接受直接冠状动脉介入治疗的急性心肌梗死患者中梗死区域对经酶学估测梗死面积校正后左室射血分数的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 17-18页

作者： Elsman P. van't Hof A.W.j. de boer M.-j. 罗亮 department of Cardiology Isala Klinieken location Weezenlanden Zwolle Netherlands Dr.

Background: Left ventricular function and infarct size are strong predictors for prognosis after acute myocardial infarction(MI). Anterior MI is associated with greater reduction of left ventricular ej.ction fraction(LVEF) and worse prognosis. Our obj.ctive was to study whether the impact of infarct size on global LVEF is dependent of infarct location. Methods: We analyzed 888 patients treated with primary percutaneous coronary intervention for acute MI. Enzymatic infarct size and LVEF within 1 week were measured. In 490 patients(55%), LVEF was measured a second time at 6 months. Results: Every 1000 U/L of cumulative lactate dehydrogense release corresponded to a decrease of 4.7%(95%CI 4.1-5.3) in LVEF measured within 1 week post MI for left anterior descending coronary artery(LAD)related infarcts and to a decrease of 2.4%(95%CI 1.7-3.1) in LVEF measured within 1 week post MI for non-LAD-related infarcts(Pj.ction fraction measured 6 months post MI showed a decrease for every 1000 U/L cumulative lactate dehydrogense release of 4.8%(95%CI 4.2-5.3) for LAD and 2.4%(95%CI 1.7-3.1) for non-LAD-related infarcts(Pdetermined by enzymatic infarct size, a lower residual LVEF when compared with non-LAD-related infarcts.

关键词：后左室梗死面积梗死区域急性心肌梗死射血分数介入治疗左室功能酶学乳酸脱氢酶释放量

一个有关赖诺普利治疗炎症性黄斑水肿的随机、双盲、交叉试验研究

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世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 25-25页

作者： Van Kooij.B. Fij.heer R. de boer j. 王大江 F.C. Donders Institute of Ophthalmology Departments of Hematology and Pharmacy University Medical Center Utrecht Netherlands Dr.

PURPOSE: To analyze the effect of angiotensin-converting enzyme (ACE) inhibitor lisinopril on inflammatory cystoid macular edema and visual acuity. deSIGN: Randomized, double-blind, placebo-controlled cross-over trial. METHODS: setting: Outpatient clinic of the department of Ophthalmology at the University Medical Center of Utrecht. Patients: Forty patients with inflammatory cystoid macular edema were included. intervention: Each patient received lisinopril (10 mg daily) or placebo for three months. After two months of a lisinopril/placebo free wash-out period, the groups received the reverse study medication for three months. Fluorescein angiography was performed to evaluate the retina. main outcome measures: Cystoid macular edema, best-corrected visual acuity and contrast sensitivity. RESULTS: Lisinopril had no effect on cystoid macular edema, visual acuity, papillary leakage, retinal vasculitis, and choroidal leakage. In a subgroup analysis, we observed a decrease in blood pressure (lisinopril, 14 of 36 patients; placebo, 5 of 36 patients; P=.02) and a decrease in morning urinary albumin excretion (lisinopril, 23 of 35 patients; placebo 10 of 34 patients, P=.003) was observed. CONCLUSIONS: Although lisinopril had no effect on inflammatory cystoid macular edema and visual acuity, we found a positive effect on the vascular system.

关键词：黄斑水肿赖诺普利交叉试验视网膜血管炎安慰剂对照矫正视力对比敏感度荧光造影尿白蛋白排泄

非类固醇抗炎药治疗炎症性黄斑囊样水肿的疗效

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世界核心医学期刊文摘(眼科学分册) 2006年第1期 18-18页

作者： Van Kooij.B. de boer j. Ten Dam N. 潘佳鸿 F.C. Donders Institute Department of Ophthalmology University Medical Center Utrecht P.O Box 85500 3508 GA Utrecht Netherlands Dr

PURPOSE: To assess the role of systemic non-steroidal antiinflammatory drugs (NSAIDs) in the treatment of inflammatory cystoid macular edema (iCME). deSIGN: Pilot study. METHODS: We included 66 patients with iCME and treated them with naproxen (2 × 250 mg daily; n=28) or rofecoxib (1 × 25 mg daily; n=38). After 4 months of therapy, visual acuity and in-flammation activity were measured. We evaluated the grade of CME, retinal vasculitis, and papillary leakage with fluorescein angiography. RESULTS: No clear effect of NSAIDs on iCME, visual acuity, and intraocular inflammation was observed. A beneficial effect was noted in less than 8% of the affected eyes. The drop-out rate after 4 months of treatment was 52% , because of adverse effects or inefficacy of the treatment. Improvement of visual acuity was slightly better in patients who were treated with naproxen compared with rofecoxib (P ≤ .05). CONCLUSION: Systemic NSAIDs have a limited role (if any) in the treatment of iCME.

关键词：黄斑囊样水肿非类固醇抗炎药炎症性疗效

Influence of Non-Magnetic Substitutional Atoms on Spontaneous Moment and Curie Temperature of Ce_2Co_(17) Compounds

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j.urnal of Rare Earths 2002年第4期20卷 273-277页

作者：胡社军刘正义 de boer F R Buschow K H j Faculty of Materials and Energy Guangdong University of Technology Guangzhou 510643 China

The structure and magnetic properties of Ce 2Co 17-xM x(M=Ga,Al and Si) compounds for M concentrations up to x=5 were studied by means of X-ray diffraction and magnetic measurements. The experimental results show that the Curie temperatures and Co spontaneous magnetization decrease significantly with increasing the addition of non-magnetic substitutional atoms, and that Si which has a minimum solid solubility in Ce 2Co 17 causes a largest reduction of Curie temperature, spontaneous magnetization and moment per Co atom compared with Ga and Al.

关键词： rare earths Ce 2Co 17 compounds Curie temperature spontaneous magnetization

Conflict resolution for connected automated vehicles at unsignalized roundabouts considering personalized driving behaviours

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Green Energy and Intelligent Transportation 2022年第1期1卷 26-36页

作者： Peng Hang Yiran Zhang Niels de boer Chen Lv School of Mechanical and Aerospace Engineering Nanyang Technological UniversitySingapore Energy Research Institute(ERIAN) Nanyang Technological UniversitySingapore

To address the driving conflicts of connected automated vehicles(CAVs)at unsignalized roundabouts,a cooperative decision-making framework is *** personalized driving preferences of CAVs are considered in the decision-making algorithm,which are reflected by different driving styles.A motion prediction algorithm is used to improve the decision-making *** effect of the motion prediction algorithm on the decisionmaking performance is evaluated,including the advancement of driving safety and the computational load for the *** cooperative game theoretic approach is applied to the interaction modelling and collaborative decision making of ***,hardware-in-the-loop(HIL)tests are carried out to evaluate the feasibility and real-time performance of the proposed algorithm.

关键词： decision making Connected automated vehicles Conflict resolution Cooperative game theory Unsignalized roundabout

Multimodal probe for optical coherence tomography epidetection and micron-scale indentation

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j.urnal of Innovative Optical Health Sciences 2017年第6期10卷 64-72页

作者： L.Bartolini F.Feroldi j.j.A.Weda M.Slaman j.F.de boer D.Iannuzzi department of Physics and Astronomy Vrij. Universiteit Amsterdam and LaserLab Amsterdam de Boelelaan 1081 1081HV AmsterdamThe Netherlands

We present a multimodal ferrule-top sensor designed to perform the integrated epidetection of Optical Coberence Tomognphy(OCT)depth-profiles and micron-scale indentation by all-optical *** scarning a sample under the probe,we can obtain structural crosse soction images and identify a region of interest in a nonhomogencous ***,with the same probe and setup,we can immediately target that area with a series of spherical indentation measurements,in which the applied load is known with aμN precision,the indentation depth with sub-/m precision and a maximum contact radius of 100 *** to the visualization of the internal structure of the sample,we can gain a better insi ght into the observed mechanical *** ability to impart a small,confined load,and perfomn OCT A scans at the same time,could lead to an altemative,high transverse resolution,Optical Coherence Elastography(OCE)sensor.

关键词： Optomechanical microindentation optical coherence tomography indentation multimodal sensor,epidetection

Efficacy of thioguanine treatment in inflammatory bowel disease: A systematic review

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World j.urnal of Gastroenterology 2016年第40期22卷 9012-9021页

作者： Berrie Meij.r Chris j. Mulder Godefridus j.Peters Adriaan A van Bodegraven Nanne KH de boer department of Gastroenterology and Hepatology VU University Medical Center department of Medical Oncology VU University Medical Center department of Gastroenterology Geriatrics Internal and Intensive Care Medicine (Co-MIK) Zuyderland Medical Center

AIM To critically assess the available literature regarding the efficacy of thioguanine treatment in inflammatory bowel disease(IBD) patients, irrespective of the(hepato-) toxicity *** A systematic literature search of the MEDLINE database using Pub Med was performed using the keywords "thioguanine", "6-TG", "thioguanine", "inflammatory bowel disease", "IBD", "Crohn's disease", "Ulcerative colitis" and "effectiveness" in order to identify relevant articles published in English starting from 2000. Reference lists of the included articles were crosschecked for missing articles. Reviewed manuscripts concerning the effectiveness of thioguanine treatment in IBD were reviewed by the authors and the data were extracted. Data were subsequently analyzed with descriptive statistics. Due to the lack of standardized outcomes, a formal meta-analysis was not *** A total of 11 applicable studies were found that involved the effectiveness of thioguanine therapy in IBD. Eight studies were conducted in a prospectivemanner, in the remaining three studies, data was collected retrospectively. In total, 353 IBD-patients(225 patients with Crohn's disease, 119 with ulcerative colitis and nine with unclassified IBD) with prior azathioprine/mercaptopurine resistance and/or intolerance(n = 321) or de novo thioguanine administration(n = 32) were included for analysis, of which 228(65%) had clinical improvement on thioguanine therapy, based on standard IBD questionnaires, biochemical parameters or global physician assessments. Short-term results were based on 268 treatment years(median follow-up 9 mo, range 3-22 mo) with a median daily dose of 20 mg(range 10-80 mg). Discontinuation, mostly due to adverse events, was reported in 72 patients(20%). CONCLUSION The efficacy of thioguanine therapy in IBD patients intolerant to conventional thiopurine therapy is observed in 65%, with short term adverse events in 20% of patients.

关键词： Thiopurines Thioguanine Inflammatory bowel disease Crohn’s disease Ulcerative colitis

Binaural masking level difference for pure tone signals

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j.urnal of Otology 2023年第3期18卷 160-167页

作者： Eva Ignatious Sami Azam Mirj.m j.nkman Friso de boer College of Engineering and IT Charles Darwin UniversityCasuarinaAustralia

The binaural masking level difference(BMLD)is a psychoacoustic method to determine binaural interaction and central auditory *** BMLD is the difference in hearing thresholds in homophasic and antiphasic *** duration,phase and frequency of the stimuli can affect the *** main aim of the study is to evaluate the BMLD for stimuli of different durations and frequencies which could also be used in future electrophysiological *** this end we developed a GUI to present different frequency signals of variable duration and determine the *** different durations and five different frequencies are *** results of the study confirm that the hearing threshold for the antiphasic condition is lower than the hearing threshold for the homophasic condition and that differences are significant for signals of 18ms and 48ms *** obj.ctive binaural processing studies will be based on 18ms and 48ms stimuli with the same frequencies as used in the current study.

关键词： Binaural hearing BMLD Auditory evoked potentials Binaural interaction Brain processing Phases

Responses of breeding waterbird communities to environmental changes in subsidence wetlands in the North China Plain

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Avian Research 2023年第3期14卷 336-344页

作者： Guangyao Wang j.nming Zhao Weiqiang Li Xiangrong Song Yong Zhang Chunlin Li Willem F.de boer School of Resources and Environmental Engineering Anhui UniversityHefei230601China School of Life Science Huaibei Normal UniversityHuaibei235000China College of Biology and the Environment Nanjing Forestry UniversityNanjing210037China Anhui Province Key Laboratory of Wetland Ecosystem Protection and Restoration Anhui UniversityHefei230601China Wildlife Ecology and Conservation Group Wageningen University&Research6708PBWageningenthe Netherlands

In the context of global degradation and loss of natural wetlands,waterbirds have been increasingly using artificial wetlands as alternative ***,waterbirds are facing various threats in these artificial wetlands,due to dramatic environmental changes induced by anthropogenic *** the effects of these changes on the temporal dynamics of the waterbird communities can help understand how waterbirds adapt to environmental changes and thus formulate effective management and conservation *** this study,we carried out field surveys on waterbirds and environmental factors across 20 subsidence wetlands created by underground coal mining in the Huainan coal mining area in the breeding seasons of 2016 and *** predicted that the waterbird assemblages(i.e.,number of individuals,species richness,Shannon-Wiener diversity,Pielou evenness and species composition) differed between the two years,and that these differences were correlated with the temporal changes in environmental *** the surveyed wetlands,we recorded 26 waterbird species in 2016 and 23 in *** individual wetlands,the number of waterbird individuals and species richness increased by 71.6% and 20.1%,respectively,over the five years,with no changes in Shannon-Wiener diversity and Pielou *** overall increase in the number of bird individuals was mainly caused by an increase in vegetation gleaners and gulls that adapt well to anthropogenic *** species composition was significantly different between the two years,which was mainly caused by changes in the number of individuals of dominant species under influence of changes in human *** most wetlands,the temporal pairwiseβ-diversities could be explained by species turnover rather than nestedness,probably due to high mobility of waterbird species and dramatic changes in local *** study suggests that waterbird communities could respond to environmental changes in subsidence wetlands,

关键词： Artificial wetlands Environmental changes Subsidence wetlands Waterbird community