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天然气长输管道场站电气设备安全运行探究

科技资讯 2022年第11期20卷 50-52页

作者：罗霄史大源陈钰婷国家管网集团联合管道有限责任公司北方哈尔滨输油气分公司黑龙江哈尔滨150010

该文主要以天然气长输管道场站电气设备安全运行探究为重点进行阐述,首先对影响天然气长输管道场站电气设备安全运行因素进行分析,其次从加强针对元件质量的控制、强化周围环境促进电磁干扰保护、构建完善且健全的管理制度、针对电气设... 详细信息

该文主要以天然气长输管道场站电气设备安全运行探究为重点进行阐述,首先对影响天然气长输管道场站电气设备安全运行因素进行分析,其次从加强针对元件质量的控制、强化周围环境促进电磁干扰保护、构建完善且健全的管理制度、针对电气设备选型和结构性因素的措施和提升养护人员的综合能力和后期维护效果等几个方面深入说明并探讨,旨在为相关研究提供参考资料。

关键词：天然气长输管道场站电气设备安全运行

教育科技人才一体改革的职教担当与时代使命——学习贯彻二十届三中全会《决定》笔谈

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中国职业技术教育 2024年第22期 3-16页

作者：姜大源石伟平和震宁玉红周建松聂强教育部职业教育发展中心金华职业技术大学浙江省现代职业教育研究中心华东师范大学华东师范大学职业教育与成人教育研究所北京师范大学教育学部、国家职业教育研究院北京劳动保障职业学院浙江金融职业学院中国高等教育学会职业技术教育分会重庆电子科技职业大学党委

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》提出“教育、科技、人才是中国式现代化的基础性、战略性支撑”,并对深化教育综合改革作出系列部署。职业教育与经济社会发展紧密相连,是深化... 详细信息

党的二十届三中全会审议通过的《中共中央关于进一步全面深化改革、推进中国式现代化的决定》提出“教育、科技、人才是中国式现代化的基础性、战略性支撑”,并对深化教育综合改革作出系列部署。职业教育与经济社会发展紧密相连,是深化中国式现代化系列改革的重要一环。为深入领会全会精神内涵,落实好职业教育领域的改革任务,本刊特组织“学习贯彻二十届三中全会《决定》”笔谈,邀约职教领域的专家学者撰文,就如何回答好“教育强国、职教何为”的时代命题,从系统推进技能型社会建设、促进就业创业与高质量对外开放、中国特色现代职业教育体系建设、发展职业本科教育、推动职业教育与服务经济社会共生发展等方面对全面深化职业教育领域改革、助力中国式现代化进行深入阐释,以期为职业教育领域学习贯彻落实三中全会精神提供参考。

关键词：三中全会职业教育中国式现代化教育综合改革

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石油天然气管道腐蚀及其防护措施研究

科技创新导报 2021年第35期18卷 112-114页

作者：史大源罗霄国家管网集团联合管道有限责任公司北方哈尔滨输油气分公司黑龙江哈尔滨150010

本文结合石油天然气的基本情况,对石油天然气管道的基本情况及造成管道腐蚀的相应内容进行研究,明确影响管道可靠性的主要因素,并采取有效的防护措施,降低石油天然气管道的腐蚀问题,避免其给管道带来的负面作用,提升石油天然气管道的服... 详细信息

本文结合石油天然气的基本情况,对石油天然气管道的基本情况及造成管道腐蚀的相应内容进行研究,明确影响管道可靠性的主要因素,并采取有效的防护措施,降低石油天然气管道的腐蚀问题,避免其给管道带来的负面作用,提升石油天然气管道的服务能力,满足石油天然气的应用需求。

关键词：石油天然气管道腐蚀防护措施

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石油天然气管道的防腐保护

科技创新导报 2021年第36期18卷 45-47页

作者：史大源罗霄朱蕾刘白杨国家管网集团联合管道有限责任公司北方哈尔滨输油气分公司黑龙江哈尔滨150010 国家管网集团北方管道有限责任公司河北廊坊065000 国家管网集团北方管道有限责任公司压缩机组维检修中心河北廊坊065000

社会的进步发展加大了对石油和天然气的使用需求,同时,在中国能源、化工行业持续发展背景下,使得社会范围内对石油、天然气的进口需求也在不断扩大。在石油、天然气进口数量日益增多的背景下,人们对石油、天然气管道的防腐蚀工作也提出... 详细信息

社会的进步发展加大了对石油和天然气的使用需求,同时,在中国能源、化工行业持续发展背景下,使得社会范围内对石油、天然气的进口需求也在不断扩大。在石油、天然气进口数量日益增多的背景下,人们对石油、天然气管道的防腐蚀工作也提出了更高的要求。基于此,本文在阐述石油天燃气管道防腐蚀类型的基础上,结合石油天然气管道腐蚀原理和发展现状,就如何优化石油天然气管道防腐蚀管理进行探究。

关键词：石油天然气管道腐蚀机理防腐蚀

激光大屏幕显示中改善振镜输出特性曲线的研究

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中国激光 1990年第3期17卷 182-185页

作者：诸葛向彬吴大元石宝驹浙江大学物理系

激光大屏幕显示中光学振镜处于临界阻尼状态是最佳工作状态,这时振镜到达稳定角时间(即步应响时间)为最短。理论计算表明,对于固有频率ω_0=2.21×10~3s^(-1)的振镜,若输入为一电流阶跃脉冲,那末在临界阻尼状态下的步响应时间为2.9ms(误... 详细信息

激光大屏幕显示中光学振镜处于临界阻尼状态是最佳工作状态,这时振镜到达稳定角时间(即步应响时间)为最短。理论计算表明,对于固有频率ω_0=2.21×10~3s^(-1)的振镜,若输入为一电流阶跃脉冲,那末在临界阻尼状态下的步响应时间为2.9ms(误差1％)。为了使光学振镜能扫描出一幅逼真、复杂和视觉上稳定的图像,就必须减少失真和增加像点数,这些都要求振镜的步响应时间愈小愈好。为此。

关键词：激光大屏幕显示振镜输出扫描器

Mitochondrial ROS promote macrophage pyroptosis by inducing GSDMD oxidation

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Journal of Molecular Cell Biology 2019年第12期11卷 1069-1082页

作者： Yufang Wang Peiliang shi Qin Chen Zan Huang dayuan Zou Jingzi Zhang Xiang Gao Zhaoyu Lin State Key Laboratory of Pharmaceutical Biotechnology Department of Hepatopancreatobiliary SurgeryNanjing Drum Tower HospitalThe Affiliated Hospital of Nanjing University Medical SchoolMOE Key Laboratory of Model Animals for Disease StudyModel Animal Research CenterNanjing UniversityNanjing 210061China Jiangsu Province Key Laboratory of Gastrointestinal Nutrition and Animal Health Nanjing Agriculture UniversityNanjing 210095China

Disrupted mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) generation are often associated with macrophage pyroptosis. It remains unclear how these forms of mitochondrial dysfunction relate to inflammasome activation and gasdermin-D (Gsdmd) cleavage, two central steps of the pyroptotic process. Here, we also found MMP collapse and ROS generation induced by Nlrp3 inflammasome activation as previous studies reported. The elimination of ROS alleviated the cleavage of Gsdmd, suggesting that Gsdmd cleavage occurs downstream of ROS release. Consistent with this result, hydrogen peroxide treatment augmented the cleavage of Gsdmd by caspase-1. Indeed, four amino acid residues of Gsdmd were oxidized under oxidative stress in macrophages. The efficiency of Gsdmd cleavage by inflammatory caspase-1 was dramatically reduced when oxidative modification was blocked by mutation of these amino acid residues. These results demonstrate that Gsdmd oxidation serves as a de novo mechanism by which mitochondrial ROS promote Nlrp3 inflammasome-dependent pyroptotic cell death.

关键词： ROS Nlrp3 gasdermin-D oxidation mitochondria

Effects of ubiquitin-protea-some pathway on mouse sperm capacitation, acrosome reaction and in vitro fertilization

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Chinese Science Bulletin 2002年第2期47卷 127-132页

作者： WANG Hongmei SONG Changcheng DUAN Chongwen shi Weixian LI Cunxi CHEN dayuan WANG Yongchao State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100080China Institute of Cell Biology College of Life SciencesBeijing Normal UniversityBeijing 100875China

Chlortetracycline (CTC) fluorescence patterns were used to study changes in the patterns B and AR of mouse sperm after incubation with reagents that would block the UPP. They were the monoclonal antibody againstubiquitinated proteins——UCPi; the polyclonal antibodyagainst ubiquitin-anti-Ub, and a special inhibitor againstproteasome——ALLN. Furthermore, we treated the capaci-tated sperm or the eggs with these reagents separately and tested whether the normal in vitro fertilization was blocked or not. Results illustrate that UCP1, anti-Ub, and ALLN have little effects on sperm capacitation and acrosome reaction, but they do inhibit fusion of mouse sperm with eggs, which suggests that UPP play an important role in mouse in vitro fertilization.

关键词： ubiquitin-proteasome pathway capacitation acrosome reaction in vitro fertilization.

GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

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Journal of Molecular Cell Biology 2019年第6期11卷 496-508页

作者： Qin Chen Peiliang shi Yufang Wang dayuan Zou Xiuwen Wu Dingyu Wang Qiongyuan Hu Yujie Zou Zan Huang Jianan Ren Zhaoyu Lin Xiang Gao State Key Laboratory of Pharmaceutical Biotechnology and Nanjing Drum Tower Hospital Model Animal Research Center Nanjing University Nanjing 210061 China Department of Surgery Jinling Hospital Medical School of Nanjing University Nanjing 210061 China Jiangsu Province Key Laboratory of Gastrointestinal Nutrition and Animal Health Nanjing Agriculture University Nanjing 210095 China

Gasdermin B (GSDMB) has been reported to be associated with immune diseases in humans, but the detailed molecular mechanisms remain unsolved. The N-terminus of GSDMB by itself, unlike other gasdermin family proteins, does not induce cell death. Here, we show that GSDMB is highly expressed in the leukocytes of septic shock patients, which is associated with increased release of the gasdermin D (GSDMD) N-terminus. GSDMB expression and the accumulation of the N-terminal fragment of GSDMD are induced by the activation of the non-canonical pyroptosis pathway in a human monocyte cell line. The downregulation of GSDMB alleviates the cleavage of GSDMD and cell death. Consistently, the overexpression of GSDMB promotes GSDMD cleavage, accompanied by increased LDH release. We further found that GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. Our study reveals a GSDMB-mediated novel regulatory mechanism for non-canonical pyroptosis and suggests a potential new strategy for the treatment of inflammatory diseases.

关键词： GSDMB GSDMD pyroptosis sepsis

Microsatellite DNA analysis proves nucleus of interspecies reconstructed blastocyst coming from that of donor giant panda

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Chinese Science Bulletin 2000年第20期45卷 1883-1885页

作者： DING Bo shi Peng XIANGYU Jinggong ZHANG Yaping CHEN dayuan SUN Qingyuan LI Guangpeng WANG Minkang LIU Yilong KANG Li HAN Zhiming SONG Xiangfen LI Jingsong CHEN Yuchun Laboratory of Cellular and Molecular Evolution Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China State Key Laboratory of Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100080China Fuzhou Panda Institute Center Fuzhou 350001China 不详

A method for DNA isolation from early development of blastocyst and further analysis of nuclear and mitochondrial DNA was developed in present study. Total DNA was prepared from interspecies reconstructed blastocyst and a giant panda specific microsatellite locus g010 was successfully amplified. DNA sequencing of the PCR product showed that two sequences of reconstructed blastocysts are the same as that of positive control giant panda. Our results prove that the nucleus of interspecies reconstructed blastocyst comes from somatic nucleus of donor giant panda.

关键词： giant panda (Ailuropoda melanoleuca) interspecies cloning microsatellite DNA nucleus.