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A semi-analytical multi-harmonic balance method on full-3D contact model for dynamic analysis of dry friction systems

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Chinese Journal of Aeronautics 2024年第2期37卷 309-329页

作者： He sUN dayi ZHANG Yaguang WU Qingyang sHEN Dianyin HU Research Institute of Aero-Engine Beihang UniversityBeijing 100191China school of Energy and Power Engineering Beihang UniversityBeijing 100191China Beijing Key Laboratory of Aero-Engine structure and strength Beijing 100191China sino-French Engineering school Beihang UniversityBeijing 100191China AECC sichuan Gas Turbine Research Establishment Chengdu 610500China

Dry friction damping structures are widely-used in aero-engines to mitigate *** nonlinear nature of friction and the two-dimensional in-plane motion on the contact interface bring challenges to accurately and efficiently predict the forced response of frictionally damped *** state-of-the-art Multi-Harmonic Balance Method(MHBM)on quasi-3D contact model in engineering cannot precisely capture the kinematics on the friction interface although the efficiency is *** full-3D contact model can describe the constitutive relationship of the interface in a more accurate manner;however,the efficiency and convergence are not guaranteed for large-scale *** this paper,a semi-analytical MHBM on full-3D contact model is *** original Trajectory Tracking Method(TTM)for evaluating the contact force is reformulated to make the calculation more concise and the derivation of the Analytical Jacobian Matrix(AJM)*** on the chain rule of derivation,the AJM which is the core to upgrade the performance is *** a shrouded blade finite element model,the accuracy and efficiency of the proposed method are compared with both the MHBM on full-3D contact model with numerical Jacobian matrix and the MHBM on quasi-3D contact model with *** results show that the AJM improves significantly the efficiency of the MHBM on full-3D contact *** time cost of the proposed method is in the same order of magnitude as that of the MHBM on quasi-3D contact *** also confirm that the full-3D contact model is necessary for the dynamic analyses of shrouded *** one uses the quasi-3D model,the estimation relative error of damping can even reach 31.8%in some *** addition,the AJM also brings benefits for stability *** is highly recommended that engineers use the MHBM on full-3D contact model for the dynamic analysis and design of shrouded blades.

关键词： Dry friction damping Multi-harmonic balance method Trajectory tracking method Jacobian matrix shrouded blade

Comparative analysis of DNA-sIP and magnetic-nanoparticle mediated isolation (MMI) on unraveling dimethoate degraders

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Frontiers of Environmental science & Engineering 2024年第1期18卷 59-69页

作者： Luning Lian Yi Xing dayi Zhang Longfei Jiang Mengke song Bo Jiang school of Energy and Environmental Engineering University of Science&Technology BeijingBeijing 100083China Beijing Key Laboratory of Resource-oriented Treatment of Industrial Pollutants University of Science&Technology BeijingBeijing 100083China National Environmental and Energy science and Technology International Cooperation Base University of Science&Technology BeijingBeijing 100083China College of New Energy and Environment Jilin UniversityChangchun 130021China Guangzhou Institute of Geochemistry Chinese Academy of SciencesGuangzhou 510640China College of Natural Resources and Environment South China Agricultural UniversityGuangzhou 510642China National Engineering Laboratory for site Remediation Technologies Beijing 100015China

Microorganisms are crucial in the bioremediation of organophosphorus pesticides. However, most functional microorganisms (> 99%) are yet to be cultivated. This study applied two cultivation-independent approaches, DNA-sIP and magnetic-nanoparticle mediated isolation (MMI), to identify the functional microorganisms in degrading dimethoate in agricultural soils. MMI identified five dimethoate degraders: Pseudomonas, Bacillus, Ramlibacter, Arthrobacter, and Rhodococcus, whereas DNA-sIP identified three dimethoate degraders: Ramlibacter, Arthrobacter, and Rhodococcus. Also, MMI showed higher resolution than DNA-sIP in identifying functional microorganisms. Two organic phosphohydrolase (OPH) genes: ophC2 and ophB, were involved in dimethoate metabolism, as revealed by DNA-sIP and MMI. The degradation products of dimethoate include omethoate, O,O,s-trimethyl thiophosphorothioate, N-methyl-2-sulfanylacetamide, O,O-diethyl s-hydrogen phosphorodithioate, O,O,O-trimethyl thiophosphate, O,O,s-trimethyl thiophosphorodithioate, and O,O,O-trimethyl phosphoric. This study emphasizes the feasibility of using sIP and MMI to explore the functional dimethoate degraders, expanding our knowledge of microbial resources with cultivation-independent approaches.

关键词： stable isotope probing(sIP) Magnetic-nanoparticle mediated isolation(MMI) Dimethoate Biodegradation Cultivation-independent approach

Branched glycopolymer prodrug-derived nanoassembly combined with a sTING agonist activates an immuno-supportive status to boost anti-PD-L1 antibody therapy

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Acta Pharmaceutica sinica B 2024年第5期14卷 2194-2209页

作者： Zhilin Li Qianfeng Zhang Zhiqian Li Long Ren dayi Pan Qiyong Gong Zhongwei Gu Hao Cai Kui Luo Department of Radiology Huaxi MR Research Center(HMRRC)Clinical Research Center for BreastDepartment of Breast SurgeryDepartment of Thoracic Surgery and Institute of Thoracic OncologyFrontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China Hospital Sichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China Key Laboratory of Medicinal Chemistry for Natural Resource Ministry of EducationYunnan Key Laboratory of Research and Development for Natural ProductsSchool of PharmacyYunnan UniversityKunming 650500China

Despite the great potential of anti-PD-L1 antibodies for immunotherapy,their low response rate due to an immunosuppressive tumor microenvironment has hampered their *** address this issue,we constructed a cell membrane-coated nanosystem(mB4s)to reverse an immunosuppressive microenvironment to an immuno-supportive one for strengthening the anti-tumor *** this system,Epirubicin(EPI)as an immunogenic cell death(ICD)inducer was coupled to a branched glycopolymer via hydrazone bonds and diABZI as a stimulator of interferon genes(sTING)agonist was encapsulated into *** internalization of mB4s,EPI was acidic-responsively released to induce ICD,which was characterized by an increased level of calreticulin(CRT)exposure and enhanced ATP ***,diABZI effectively activated the sTING *** with mB4s in combination with an anti-PD-L1 antibody elicited potent immune responses by increasing the ratio of matured dendritic cells(DCs)and CD8+T cells,promoting cytokines secretion,up-regulating M1-like tumor-associated macrophages(TAMs)and down-regulating immunosuppressive myeloid-derived suppressor cells(MDsCs).Therefore,this nanosystem for co-delivery of an ICD inducer and a sTING agonist achieved promotion of DCs maturation and CD8+T cells infiltration,creating an immuno-supportive microenvironment,thus potentiating the therapy effect of the anti-PD-L1 antibody in both 4T1 breast and CT26 colon tumor mice.

关键词： Glycopolymer Polymer prodrug Immunogenic cell death Nanoassembly Epirubicin sTING pathway Immuno-supportive microenvironment Immunotherapy

Dendritic nanomedicine enhances chemoimmunotherapy by disturbing metabolism of cancer-associated fibroblasts for deep penetration and activating function of immune cells

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Acta Pharmaceutica sinica B 2024年第8期14卷 3680-3696页

作者： Yunkun Li Xiaoding shen Haitao Ding Yuxin Zhang dayi Pan Liping su Yahui Wu Zaixiang Fang Jie Zhoua Qiyong Gong Kui Luo Department of Radiology Huaxi MR Research Center(HMRRC)Frontiers Science Center for Disease-Related Molecular NetworkState Key Laboratory of BiotherapyWest China HospitalSichuan UniversityChengdu 610041China Functional and Molecular Imaging Key Laboratory of sichuan Province and Research Unit of PsychoradiologyChinese Academy of Medical SciencesChengdu 610041China Department of Radiology West China Xiamen Hospital of Sichuan UniversityXiamen 361021China

Inefficient drug penetration hurdled by the stroma in the tumor tissue leads to a diminished therapeutic effect for drugs and a reduced infiltration level of immune ***,we constructed a PEGylated dendritic epirubicin(Epi)prodrug(Epi-P4D)to regulate the metabolism of cancer-associated fibroblasts(CAFs),thus enhancing Epi penetration into both multicellular tumor spheroids(MTss)and tumor tissues in mouse colon cancer(CT26),mouse breast cancer(4T1)and human breast cancer(MDA-MB-231)*** cytotoxicity against CT26 MTss and remarkable antitumor efficacy of Epi-P4D were ascribed to reduced fibronectin,α-sMA,and collagen ***,thinning of the tumor tissue stroma and efficient eradication of tumor cells promoted the immunogenic cell death effect for dendritic cell(DC)maturation and subsequent immune activation,including elevating the CD4^(+)T cell population,reducing CD4^(+)and CD8^(+)T cell hyperactivation and exhaustion,and amplifying the natural killer(NK)cell proportion and effectively activating *** a result,this dendritic nanomedicine thinned the stroma of tumor tissues to enhance drug penetration and facilitate immune cell infiltration for elevated antitumor efficacy.

关键词： Dendritic prodrug Enhanced penetration Metabolic intervention Cancer-associated fibroblasts Immunogenic cell death Chemotherapy Immunotherapy Immune microenvironment reconstitution

Tracking the Confiscated Green sea Turtles in the south China sea:Where Did They Come From?Where Will They Go?

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Asian Herpetological Research 2024年第3期15卷 173-182页

作者： Min CHEN Tong HUANG dayi NIE Liu LIN Fang CHEN Jing WANG Jinyan YANG Jing ZHANG Tong LIU Yiqiong CUI school of Life sciences Institute of Eco-ChongmingShanghai Institute of Wildlife EpidemicsEast China Normal UniversityShanghai 200241China Hainan Institute of East China Normal University Sanya 572025HainanChina Ministry of Education Key Laboratory for Ecology of Tropical Islands Key Laboratory of Tropical Animal and Plant Ecology of Hainan ProvinceCollege of Life SciencesHainan Normal UniversityHaikou 571158HainanChina Aquatic Wildlife Conservation Branch of China Wildlife Conservation Association Beijing 100013China society of Entrepreneurs and Ecology Beijing 100012China Commonwealth scientific and Industrial Research Organisation Canberra ACT 2601Australia

The population of the green sea turtle(Chelonia mydas)is under decline,threatened by bycatch and illegal acquisition despite worldwide protection ***,the confiscation of illegally acquired sea turtles could aid in tracking their origin and movement patterns,crucial for effective conservation *** satellite tracking and genetic analysis offers an opportunity to investigate the relationship between the origins and migration directions of green sea turtles in the western ***,we applied two methods to investigate the spatial ecology of 18 green turtles caught as bycatch in the south China *** results revealed the genetic origins and diverse movements of the *** Mixed stock Analysis(MsA)suggested that these turtles originated from the rookery of the Xisha Islands(49.6%),central Ryukyu(24.6%),NE Borneo(8%),and the sulu sea(5.2%),with other rookeries in meagre proportions(satellite tracking showed the ranges of their travel were smaller than the whole contributed rookery range,but *** haplotype diversity of these turtles is high,and CmP19 stands out as both the most frequent and the most diverse haplotype in terms of swimming *** results indicate that the south China sea is likely an important transportation hub and mating spot for green *** findings provided evidence for the rehabilitation of these green turtles in the wild and illustrated the complexity of movement during the green turtle’s life history,and the“mixed backgrounds”of the green turtles also highlight the need for joint conservation efforts of neighbouring countries in the south China sea.

关键词： conservation genetics green sea turtle(Chelonia mydas) movement rookery satellite tracking

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当下世界电影史主流写作框架的适用性辨析

电影艺术 2024年第2期 75-81页

作者：周达祎北京师范大学艺术与传媒学院

在当下的世界电影史写作中,各种研究框架不断涌现,同样也存在亟待厘清的概念误用现象。“民族电影/国别电影”体现了反好莱坞中心主义的多元视野,但无法解决电影史研究中的“跨国性”问题。“少数电影/小国电影”可以有效描绘“后冷战... 详细信息

在当下的世界电影史写作中,各种研究框架不断涌现,同样也存在亟待厘清的概念误用现象。“民族电影/国别电影”体现了反好莱坞中心主义的多元视野,但无法解决电影史研究中的“跨国性”问题。“少数电影/小国电影”可以有效描绘“后冷战—全球化”时期弱势国家的电影境况,但“小国”概念需要被严格界定。“世界电影/全球电影”虽然被指忽略了帝国主义在国际贸易中对殖民地的压迫,但更具理论的包容性和开放性。

关键词：世界电影史全球电影世界电影小国电影民族电影

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要充分重视问诊

中华心血管病杂志 2024年第2期52卷 115-116页

作者：胡大一北京大学人民医院心血管病研究所北京100044

临床医学的基础是诊断学,诊断学的基础是症状学。每位患者都是因身体不适的症状(如胸闷、发热、腹痛、腹泻等)来就医的。问诊是了解患者症状的主要途径。1985年1月,我赴美国做访问学者时,读到美国住院医师的培训“口袋书”,其首页画的... 详细信息

临床医学的基础是诊断学,诊断学的基础是症状学。每位患者都是因身体不适的症状(如胸闷、发热、腹痛、腹泻等)来就医的。问诊是了解患者症状的主要途径。1985年1月,我赴美国做访问学者时,读到美国住院医师的培训“口袋书”,其首页画的是手掌五指。大拇指标示的便是“问诊”,其他手指依次代表:物理诊断(望触听),价廉无创、多年行之有效的临床检查(如心电图、X线胸片、血尿便常规等),成本不高、无创的临床检查拓展(如运动负荷心电图、动态心电图及此后陆续出现的超声心动图、动态血压监测等),最后是成本高、有一定创伤的影像检查(如冠状动脉造影及后来的冠状动脉CT等)。

关键词：动态血压监测血尿便常规住院医师影像检查超声心动图动态心电图冠状动脉造影诊断学

基于随机微分博弈的林业碳汇项目开发的风险化解机制研究

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系统工程理论与实践 2024年第7期44卷 2273-2292页

作者：孙睿何大义闫晶晶中国地质大学(北京)经济管理学院北京100083

企业采用“跑马占荒”的形式抢占森林资源,造成了资源浪费,不利于国家“双碳”目标的推进.本文以林业碳汇项目股份合作模式的开发为研究对象,考虑项目开发过程中的道德风险和监管部门的监管力度,构建项目开发企业与林农双方的随机微分... 详细信息

企业采用“跑马占荒”的形式抢占森林资源,造成了资源浪费,不利于国家“双碳”目标的推进.本文以林业碳汇项目股份合作模式的开发为研究对象,考虑项目开发过程中的道德风险和监管部门的监管力度,构建项目开发企业与林农双方的随机微分博弈模型,明确了项目内部自发合作的条件和不同的外部冲击对项目开发的作用机制.研究发现:首先,在监管部门对项目开发企业实施强监管、对林农弱监管时,且林农分得的碳汇收益比例低于项目开发企业的情况下,能够实现项目内部的自发合作,缓解了监管压力.其次,收紧碳配额将有助于提高碳汇价格均值;将更多的行业、企业纳入碳交易范围有助于降低碳汇价格方差.对于林业碳汇项目刚起步的现阶段,若要有效激发项目参与主体的积极性,应以实施紧缩碳配额或实行碳税政策为主,随后逐步将更多的行业纳入其中.最后,越严格的监管环境和越高的碳汇收益分配比例可以促使参与主体在更短的时间内进行策略调整,政府的财政补助不会对策略调整速度产生影响,但是会激励其行为努力水平.

关键词：林业碳汇项目开发监管机制随机微分博弈混沌

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心血管疾病共患精神心理障碍干预研究的进展

中华心血管病杂志 2024年第9期52卷 1110-1115页

作者：曲姗胡大一北京大学人民医院医学心理科北京100044 北京大学人民医院心血管病研究所北京100044

心血管疾病患者广泛存在精神心理问题, 两者相互影响, 加重疾病状态。双心医学是心血管疾病共患精神心理障碍是心脏病学和心理学交叉并综合形成的学科, 遵循生物-心理-社会医学模式, 强调关注心血管疾病的同时关注患者的精神心理状态。... 详细信息

心血管疾病患者广泛存在精神心理问题, 两者相互影响, 加重疾病状态。双心医学是心血管疾病共患精神心理障碍是心脏病学和心理学交叉并综合形成的学科, 遵循生物-心理-社会医学模式, 强调关注心血管疾病的同时关注患者的精神心理状态。该文对国内外心血管疾病共患精神心理障碍的研究现状进行综述, 总结其流行病学、发病机制、筛查及干预方法, 以期为心血管疾病共患精神心理障碍的治疗提供依据。

关键词：心血管疾病双心医学精神心理焦虑抑郁心理干预