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Phytoconstituent Screening and Antibacterial Activity of the Leaf Extracts from Canarium odontophyllumMiq.

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American Journal of Plant Sciences 2014年第19期5卷 2878-2888页

作者： dayang fredalina basri Nur Hafidzah Mohd Nor School of Diagnostic & Applied Health Sciences Faculty of Health Sciences Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz 50300 Kuala Lumpur Malaysia

Canarium odontophyllum is one of the underutilized fruits among the local community in Sarawak, Malaysia. The leaf extracts from C. odontophyllum (6.25 mg/ml to 50 mg/m) were screened against two Gram-positive bacteria (Staphylococcus aureus and Bacillus cereus) and two Gram-negative bacteria (Escherichia coli and Pseudomonas aeruginosa). Extraction of the C. odontophyllum leaves using methanol produced the highest yield (5.46%) followed by water (4.0%) and acetone (2.83%) whereas hexane extracted the lowest yield (0.98%). Out of the four bacterial species tested, only S. aureus was found to be susceptible towards the C. odontophyllum leaves extract. Screening result using agar well diffusion method showed that the antimicrobial activity of the acetone and methanol extracts from C. odontophyllum leaves was concentration-dependent towards the growth inhibition of S. aureus. The MIC values for both MeOH and acetone extracts were 0.391 mg/ml. The MBC value of MeOH extract was twice its MIC value whereas the MBC and MIC values of acetone extract against S. aureus were the same. Phytochemical analysis showed that acetone, MeOH and water extracts contain flavonoid, tannin, terpenoid and phenol. These findings conclude that the leaves of C. odontophyllum may contain therapeutically-useful compounds against S. aureus, which are mostly concentrated in the acetone extract. As such, C. odontophyllum have the potential to be developed as an alternative treatment against Staphylococcus aureus-associated skin and soft tissue infections.

关键词： Leaves Canarium odontophyllum Flavonoid Saponin Antibacterial Agar Well Diffusion Staphyloccocus aureus MIC MBC

Cytotoxic Activity of Stem Bark Extracts from Canarium odontophyllum Miq (Dabai) against Human Colorectal Carcinoma HCT 116 Cell Line

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American Journal of Plant Sciences 2014年第26期5卷 3925-3933页

作者： dayang fredalina basri Muhammad Arifuddin Al Rasyid Mohd Chan Kok Meng Elda Surhaida Latif Fahrul Zaman Huyop School of Diagnostic & Applied Health Sciences Faculty of Health Sciences Universiti Kebangsaan Malaysia Kuala Lumpur Malaysia Faculty of Biosciences and Medical Engineering Universiti Teknologi Malaysia Johor Malaysia

The preliminary study is aimed at evaluating the cytotoxic activity of crude extracts from the stem bark of Canarium odontophyllum against colorectal carcinoma cell HCT 116. Result of the extraction yield showed that distilled water produced the highest yield (10.58%) followed by methanol (6.55%) whereas acetone extracted the lowest yield (4.58%) from C. odontophyllum stem bark. Phytochemical screening test revealed the presence of terpenoid, flavonoid, tannin, saponin and phenolic compound in all the stem bark extracts of C. odontophyllum. Acetone extract of C. odontophyllum stem bark showed significantly higher (p < 0.05) cytotoxic effect with IC50 of 0.062 ± 1.04 mg/ml compared to methanol extract with IC50 0.122 ± 4.92 mg/ml. No cytotoxic effect was observed by the aqueous extract despite its high extraction yield. In conclusion, acetone and methanol extracts from C. odontophyllum stem bark exhibited promising cytotoxic activity against human colorectal cancer cell line HCT 116 and paves way for further investigation in view of its mode of cancer cell death.

关键词： Canarium odontophyllum Stem Bark Burseraceae HCT 116 Cytotoxic Activity Colorectal Carcinoma

Analysis of Two-Dimensional Gel Electrophoresis Map of Methicillin-Resistant Staphylococcus aureusTreated with Acetone Extract from Canarium odontophyllumMiq. Leaves

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American Journal of Plant Sciences 2021年第1期12卷 37-52页

作者： Nur Amira Mohd Shamsuddin dayang fredalina basri Noraziah M. Zin Ahmad Raha Raus Nur Faizah Abu Bakar Centre for Diagnostic Therapeutic & Investigative Studies (CODTIS) Faculty of Health Sciences Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz Kuala Lumpur Malaysia Department of Biotechnology Engineering Faculty of Engineering International Islamic University Malaysia Kuala Lumpur Malaysia

Methicillin-resistant Staphylococcus aureus (MRSA) infection is a global health concern that has caused severe health threats over the past decade. Leaves extract of C. odontophyllum has been proven previously as an anti MRSA agent. Proteomics provide a technique that used to analyze the differential of protein expression profile between untreated and treated MRSA with subinhibitory concentrations of acetone extract from C. odontophyllum leaves. This study aims to determine the optimum parameter for analysis of protein expression profile using two-dimension gels electrophoresis (2-DE) for MRSA protein after treatment with acetone extract from C. odontophyllum leaves. Comparison of the Protein Expression Profile (PEP) between the untreated and treated MRSA was analyzed using PDQuest software. The optimum condition for MRSA protein treated with acetone extract from C. odontophyllum leaves to produce the best resolution with greater spot distribution was as follows: 100 μg volume of MRSA protein that loaded after passive rehydration then was run until reaching 25 kVrhs during IEF using 17 cm IPG strip within ranges of pH 4 - 7. Analysis of protein expr

关键词： Canarium odontophyllum MRSA 2-DE IEF SDS-PAGE Protein Expression Profile

LCO flutter of cantilevered woven glass/epoxy laminate in subsonic flow

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Acta Mechanica Sinica 2008年第1期24卷 107-110页

作者： dayang Laila Abang Haji Abdul Majid ShahNor basri Department of Aerospace Engineering Faculty of Engineering Universiti Putra Malaysia. 43400 UPM Serdang Selangor Darul Ehsan Malaysia

The paper presents a cantilevered composite wing, aeroelastic characteristics of idealized as a composite flat plate laminate. The composite laminate was made from woven glass fibers with epoxy matrix. The elastic and dynamic properties of the laminate were determined experimentally for aeroelastic calculations. Aeroelastic wind tunnel testing of the laminate was performed and the result showed that flutter, a dynamic instability occurred. The cantilevered laminate also displayed limit cycle amplitude, post-flutter oscillation. The experimental flutter velocity and frequency were verified by our computational analysis.

关键词： Limit cycle oscillation Flutter Laminate