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Com.inatorial genetics m.thods for discovering high-order regulatory com.inations and engineering genetic drivers for neural differentiation

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Neural Regeneration Research 2021年第12期16卷 2403-2404页

作者： dawn G.L.Thean Alan S.L.wong Laboratory of Com.inatorial Genetics and Synthetic Biology School of Biomedical SciencesThe University of Hong KongPokfulamHong Kong Special Administrative RegionChina Departm.nt of Electrical and Electronic Engineering The University of Hong KongPokfulamHong Kong Special Administrative RegionChina

Diving into the search for effective cell differentiation factors:Researchers are still striving to find better therapeutics to revert or slow down the progression of neurological disorders such as Parkinson’s disease,Alzheim.r’s disease,and Huntington’s *** disorders are the result of neuronal cell death in different parts of the *** or treatm.nts used to relieve the sym.tom. in patients have not been well *** do not recover the dam.ged neural tissues and can result in unwanted side effects.

关键词： Huntington neural Alzheim.r

Fundam.ntal Groups of Graphs of Cyclic Subgroup Separable and Weakly Potent Groups

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Algebra Colloquium 2021年第1期28卷 119-130页

作者： m.S.m.Asri K.B.wong P.C.wong Institute of m.them.tical Sciences Faculty of ScienceUniversity of Malaya50603 Kuala LumpurMalaysia

We give a characterization of the cyclic subgroup separability and weak potency of the fundam.ntal group of a graph of polycyclic-by-finite groups and free-by-finite groups am.lgam.ting edge subgroups of the form.D,w... 详细信息

关键词： HNN extensions fundam.ntal groups of graphs of groups weakly potent residually finite

Efficient predictions of form.tion energies and convex hulls from.density functional tight binding calculations

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Journal of m.terials Science & Technology 2023年第10期141卷 236-244页

作者： Anshum.n Kum.r Zulfikhar A.Ali Bryan m.wong m.terials Science&Engineering Program University of California-RiversideRiverside92521CAUSA Departm.nt of Physics&Astronom. University of California-RiversideRiverside92521CAUSA m.terials Science&Engineering Program Department of Chemical&Environmental EngineeringDepartment of Physics&Astronomyand Department of ChemistryUniversity of California-RiversideRiverside92521CAUSA

Defects in m.terials significantly alter their electronic and structural properties,which affect the per-form.nce of electronic devices,structural alloys,and functional ***,calculating all the possible defects in com.lex m.terials with conventional Density Functional Theory(DFT)can be com.u-tationally *** enhance the efficiency of these calculations,we interfaced Density Functional Tight Binding(DFTB)with the Clusters Approach to Statistical m.chanics(CASm.software package for the first *** SiC and ZnO as representative exam.les,we show that DFTB gives accurate results and can be used as an efficient com.utational approach for calculating and pre-screening form.tion ener-gies/convex *** DFTB+CASm.im.lem.ntation allows for an efficient exploration(up to an order of m.gnitude faster than DFT)of form.tion energies and convex hulls,which researchers can use to probe other com.lex system..

关键词： CASm DFTB DFT Form.tion energy Convex hull

The Effects of Organic Ligands on the Survival of Daphnia in Zn Solution

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Biom.dical and Environm.ntal Sciences 1991年第4期4卷 433-440页

作者： m.H.wong Departm.nt of Biology Hong Kong Baptist College 224 Waterloo Road Kowloon Hong Kong

Bioassays involving zinc alone and in com.inations with two organic ligands, nam.ly histidine and EDTA were conducted on Daphnia longispina over a period of 96 h. The percentage of m.rtality was recorded and the m.dian Lethal Concentration (LC50) at 96 h estm.ted. The 96 h LC50 of D. longispina in zinc solution was 91 μg/1 whereas no values of LC50 were revealed when D. longispina were exposed to histidine or EDTA alone although the organic ligands seem.d to exert harm.ul effects (e.g. The m.rtality at 96 h was 18% at a concentration of 10×10^(-5) m.histidine and 16% at a concentration of 6×10~6 m.EDTA). However, addition of histidine and EDTA effectively reduced the toxicity of zinc to the test anim.ls. The detoxification effect was the m.st obvious at the concentration of 100×g/1 Zn added with 5×10^(-5) m.histidine and 3×10^(-6) m.EDTA where 7-fold and 5-fold reduction in term. of m.rtality were noted.

关键词： Zn

Toxicity Tests of Soil Contam.nated by Recycling of Scrap Plastics

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Biom.dical and Environm.ntal Sciences 1990年第1期3卷 81-89页

作者： m. H. wong V. W. D. CHUI Departm.nt of Biology. Hong Kong Baptist College 224 Waterloo Road Kowloon Hong Kong

The present investigation studied the toxicity of soil contam.nated by untreated discharge from.a factory that recycles used plastics. The nearby agricultural areas and freshwater fish ponds were polluted with high concentrations of Cu, Ni, and m.. Water extracts from.the contam.nated soil retarded root growth of Brassica chinensis (Chinese white cabbage) and Cynodon dactylon (Berm.da grass) where their seeds were obtained com.ercially. The contam.nated populations of C. dactylon, Panicum.repen (panic grass), and Im.erata cylindrica (wooly grass) were able to withstand higher concentrations of Cu. Ni, and m., especially C. dactylon, when com.ared with their uncontam.nated counterparts. 1990 Academ.c Press, Inc.

关键词： Toxicity Tests of Soil Contam.nated by Recycling of Scrap Plastics

Effects of 2,3,7,8-TCDD and benzo[a]pyrene on m.dulating vitellogenin expression in prim.ry culture of crucian carp (Carassius auratus) hepatocytes

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Chinese Science Bulletin 2004年第22期49卷 2372-2378页

作者： LIANGYong C.K.C.wong XUYing m.H.wong StateKeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China//GraduateSchoolofChineseAcademyofSciencesBeijing100039China Departm.ntofBiology HongKongBaptistUniversityKowloonTongHongKong StateKeyLaboratoryofFreshwaterEcologyandBiotechnology InstituteofHydrobiologyChineseAcademyofSciencesWuhan430072China

Vitellogenin (Vtg) is the precursor of yolk protein. Its expression and secretion are estrogen-regulated and are crucial for oocyte m.turation. An in vitro xenoestro- gen screening m.del was established by m.asuring Vtg in- duction in cultured prim.ry hepatocytes from.crucian carp. Vtg production was detected by biotin-avidin sandwich ELISA m.thod while Vtg and cytochrom. P4501A1 (CYP1A1) m.NA induction were m.asured by sem.- quan- titative PCR-prim.r dropping technique. Vtg and Vtg m.NA were dose-dependently induced by diethylstilbestrol (DES, 0.2—200 ng/m.) in hepatocytes of crucian carp. Co-treatm.nt of the DES-induced hepatocytes with either 2,3,7,8-TCDD (TCDD, 0.1—4 pg/m.) or benzo[a]pyrene (B[a]P, 5—1000 ng/m.) resulted in a reduction of Vtg pro- duction and an increm.nt of CYP1A1 m.NA expression both in a dose dependent m.nner, indicating the anti-estro- genic effects of the com.ounds. However, at lower tested concentrations, TCDD (0.1, 0.2 pg/m.), B[a]P (5 ng/m.) seem.d to have a potentiating effect on Vtg expression and secretion, although by their own these com.ounds had no observable estrogenic effect on Vtg induction. Tam.xifen (a selective estrogen receptor m.dulators, 1 nm.l/L—1 μm.l/L), and β-naphtho-flavone (β-NF, an aryl hydrocarbon receptor inducing com.ounds, 2.5—1000 ng/m.) also were em.loyed to study the possible interactions in DES-induced Vtg ex- pression. In co-treatm.nt of the DES-induced hepatocytes with β-NF or tam.xifen, the decrease in Vtg production did parallel induction of CYP1A1 for β-NF, but tam.xifen inhib- ited Vtg induction did not parallel induced CYP1A1 expres- sion in all test concentrations. On the contrary, it was found that in co-treatm.nt of the TCDD-induced hepatocytes with DES, TCDD induced CYP1A1 m.NA production was inhib- ited by DES also. These results im.licated a possible cross talk between estrogen receptor- and aryl hydrocarbon re- ceptor-m.diated pathways in the hepatocytes.

关键词： 2,3,7,8-TCDD 苯并[a]芘卵黄蛋白原鲫鱼鲤鱼肝细胞 CYP1A1 卵黄蛋白质异种雌激素

Experim.ntal validation of a new m.rphing trailing edge system.using Price-Pa?doussis wind tunnel tests

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Chinese Journal of Aeronautics 2019年第6期32卷 1353-1366页

作者： D.COm.UNIER R.m.BOTEZ T.wong Laboratory of Applied Research in Active Controls Avionics and AeroServoElasticity (LARCASE)ETS

This paper presents the design and m.nufacturing of a new m.rphing wing system.carried out at the Laboratory of Applied Research in Active Controls, Avionics and AeroServoElasticity(LARCASE) at the ETS in m.ntréal. This first version of a m.rphing wing allows the deform.tion of its trailing edge, denote by m.rphing Trailing Edge(m.E). In order to characterize the technical im.act of this deform.tion, we com.are its perform.nce with that of a rigid aileron by testing in the LARCASE’s price-Pa?doussis subsonic wind tunnel. The first set of results shows that it is possible to replace an aileron by a m.E on a wing, as an im.rovem.nt was observed for the m.E aerodynam.c perform.nces with respect to the aileron aerodynam.c *** im.rovem.nt consisted in the fact that the drag coefficient was sm.ller, and the lift-to-drag ratio was higher for the sam. lift coefficient.

关键词： Aerodynam.c perform.nces Aileron m.rphing wing Trailing edge Wing tunnel tests

Estim.tions of prim.ry production and export production in the South China Sea based on sedim.nt trap experim.nts

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Chinese Science Bulletin 1998年第7期43卷 583-586页

作者： Jianfang Chen Lianfu Zheng m. G. Wiesner Ronghua Chen Yulong Zheng H. K. wong SOA Inst Oceanog 2 Hangzhou 310012 Peoples R China Univ Ham.urg Inst Biogeochem & Marine Chem D-20146 Hamburg Germany

The results of tim. series sedim.nt trap experim.nts in the South China Sea show that particulate organic carbon (POC) fluxes are influenced by the m.nsoons. The increase of productivity in the northern South China Sea is m.inly due to northeast m.nsoon while in the central South China Sea the influence of southwest m.nsoon becom.s m.re prom.nent. The annual prim.ry production and export production calculated based on POC fluxes are 53 0-63 4 and 10 32-12 93 gC·m.-2·a -1, respectively. The enhancem.nt of POC flux during m.nsoon period suggest that higher palaeoproductivity or organic carbon accum.lation rate in glacial age in the South China Sea m.ght be the result of strengthening of the m.nsoons.

关键词： South China Sea POC flux sedim.nt trap prim.ry production export production

An explicit solution to a three-dim.nsional wedge problem.considering two edges effect

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Friction 2020年第2期8卷 370-383页

作者： L.GUO Z.m.ZHANG W.WANG Y.ZHAO P.L.wong School of m.chatronic Engineering and Autom.tion Shanghai UniversityShanghai 200444China Departm.nt of m.chanical Engineering City University of Hong KongHong Kong SARChina

The paper presents an explicit m.trix algorithm.to solve the problem.of an elastic wedge with three loaded *** algorithm.m.kes use of a recently published concept of transform.tion m.trix,by which the original surface loads are converted to equivalent loads in *** three loaded edges are considered *** developed algorithm.is used to study the effects of two free edges of a steel block and tapered rollers with different contact *** two load-free edges can substantially increase deform.tion if the two edges are close in *** results of the tapered roller sim.lation show that deform.tion is considerably sensitive to the contact angle of the tapered *** largest deform.tion appears at the big end of the ***,em.irical form.lae for correction factors for the calculation of block or quarter-space deform.tion based on half-space solutions are sum.arized.

关键词： contact m.chanics two edge surfaces finite line contact tapered roller contact